• Clinical and Experimental Pediatrics
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• 제55권12호
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• pp.487-490
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• 2012

We report a case of isodicentric chromosome 15 (idic(15) chromosome), the presence of which resulted in uncontrolled seizures, including epileptic spasms, tonic seizures, and global developmental delay. A 10-month-old female infant was referred to our pediatric neurology clinic because of uncontrolled seizures and global developmental delay. She had generalized tonic-clonic seizures since 7 months of age. At referral, she could not control her head and presented with generalized hypotonia. Her brain magnetic resonance imaging scans and metabolic evaluation results were normal. Routine karyotyping indicated the presence of a supernumerary marker chromosome of unknown origin (47, XX +mar). An array-comparative genomic hybridization (CGH) analysis revealed amplification from 15q11.1 to 15q13.1. Subsequent fluorescence in situ hybridization analysis confirmed a idic(15) chromosome. Array-CGH analysis has the advantage in determining the unknown origin of a supernumerary marker chromosome, and could be a useful method for the genetic diagnosis of epilepsy syndromes associated with various chromosomal aberrations.

• PNF and Movement
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• 제17권3호
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• pp.487-497
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• 2019

Purpose: This tutorial review investigated the effect of prior fatigue and passive stretches on eccentric contraction-induced muscle injuries, as well as the underlying mechanisms of eccentric contraction-related injuries. Methods: Contraction-induced muscle damage is the most common disabling problem in sports and routines. The mechanisms underlying the pathology and prevention of muscle damage lessened by prior fatigue or stretches are critical in assessing musculoskeletal injuries. Even though there are treatments to reduce eccentric contraction-induced muscle injuries, fatigue negatively influences them. Therefore, we reviewed previous studies on eccentric contraction-induced muscle injuries with prior treatments using the MEDLINE and PubMed databases. Results: Prior passive stretching had a preventative and therapeutic effect, but prior lengthening contractions did not. On the other hand, prior isometric contractions involving relatively small forces may not provide a sufficient stimulus to induce protection. As a result, high force isometric contractions may be necessary. The studies supported the positive effects of prior fatigue, concluding that it was a factor in determining the amount of damage caused by eccentric exercise. This was due to a reduction in force and increased temperature. Studies that did not support the positive effects of prior fatigue concluded that a shift in optimal length to a longer length and reduced energy absorption during lengthening are evidence that fatigue is not related to muscle injuries induced by lengthening. Conclusion: The variability of the experiment models, conditions, muscles, and treatment methods make it necessary to interpret the conditions of previous studies carefully and draw conclusions without making direct comparisons. Thus, additional studies should be carefully conducted to investigate the positive effect of fatigue on lengthening.

• 한국콘텐츠학회논문지
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• 제22권6호
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• pp.487-494
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• 2022

이 연구의 목적은 대중문화예술인들의 행복감에 긍정적인 효과를 줄 수 있는 성격강점기반 집단상담프로그램을 구성하고 그 효과를 검증하는 것이다. 이를 위하여 서울시 및 경기도 소재 연예기획사와 예술고등학교 소속 예술인 중 16명을 모집하여 실험집단과 통제집단으로 배정하고, 두 집단 모두에게 성격강점과 행복검사지로 사전·사후 검사를 실시하였다. 프로그램의 효과 검증을 위해 실험집단은 주 1회, 회기당 60분씩 총 8회기의 성격강점 프로그램을 시행하였으며, 통제집단은 무처치 하였다. 연구결과 프로그램에 참여한 집단의 성격강점과 행복감이 통제집단에 비해 유의하게 향상되어 성격강점을 강화하는 훈련은 청소년 대중문화 예술인들의 행복을 증진시켜 보다 행복한 삶을 영위할 수 있음을 보여주었다. 이는 대중문화 주체들의 정신건강을 관리하는 시작점을 만들었다는데 그 의미가 있으며, 결과를 토대로 후속연구를 위한 제언과 시사점을 논의하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.487-492
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• 2012

Trace element zinc deficiency or excess is implicated in the development or progression of some cancers. The exact role of zinc in the etiology of colon cancer is unclear. To cast light on this question, an experimental model of colon carcinogenesis was applied here. Six week old rats were given sub cutaneous injections of DMH (30 mg/kg body weight) twice a week for three months and sacrificed after 4 months (precancer model) and 6 months (cancer model). Plasma zinc levels showed a significant decrease (p<0.05) at 4 months and a greater significant decrease at 6 months (p<0.01) as compared with controls. In the large intestine there was a significant decrease in tissue zinc levels (p<0.005) and in CuZnSOD, and alkaline phosphatase activity (p<0.05) in the pre-cancerous model and a greater significant decrease in tissue zinc (p<0.0001), and in CuZnSOD and alkaline phosphatase activity (p<0.001), in the carcinoma model. The tissue zinc levels showed a significant decrease in the small intestine and stomach (p<0.005) and in liver (p<0.05) in the cancer model. 87% of the rats in the precancer group and 92% rats in the cancer group showed histological evidence of precancerous lesions and carcinomas respectively in the colon mucosa. This study suggests that the decrease in plasma zinc, tissue zinc and activity of zinc related enzymes are associated with the development of preneoplastic lesions and these biochemical parameters further decrease with progression to carcinoma in the colon.

• Structural Engineering and Mechanics
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• 제75권4호
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• pp.487-496
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• 2020

Most of the previous works on numerical analysis of galloping of transmission lines are generally based on the quasisteady theory. However, some wind tunnel tests of the rectangular section or hangers of suspension bridges have shown that the galloping phenomenon has a strong unsteady characteristic and the test results are quite different from the quasi-steady calculation results. Therefore, it is necessary to check the applicability of the quasi-static theory in galloping analysis of the ice-covered transmission line. Although some limited unsteady simulation researches have been conducted on the variation of parameters such as aerodynamic damping, aerodynamic coefficients with wind speed or wind attack angle, there is a need to investigate the numerical simulation of unsteady galloping of two-dimensional iced transmission line with comparison to wind tunnel test results. In this paper, it is proposed to conduct a two dimensional (2-D) unsteady numerical analysis of ice-covered transmission line galloping. First, wind tunnel tests of a typical crescent-shapes iced conductor are conducted firstly to check the subsequent quasisteady and unsteady numerical analysis results. Then, a numerical simulation model consistent with the aeroelastic model in the wind tunnel test is established. The weak coupling methodology is used to consider the fluid-structure interaction in investigating a two-dimension numerical simulation of unsteady galloping of the iced conductor. First, the flow field is simulated to obtain the pressure and velocity distribution of the flow field. The fluid action on the iced conduct at the coupling interface is treated as an external load to the conductor. Then, the movement of the conduct is analyzed separately. The software ANSYS FLUENT is employed and redeveloped to numerically analyze the model responses based on fluid-structure interaction theory. The numerical simulation results of unsteady galloping of the iced conduct are compared with the measured responses of wind tunnel tests and the numerical results by the conventional quasi-steady theory, respectively.

• 한국건축시공학회지
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• 제16권6호
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• pp.487-495
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• 2016

보험통계포털에 따르면 건설 부문의 사고로 인한 손실액이 최근 10년 동안 크게 증가하였다. 이처럼 국내 건설 공사의 리스크 관리 방안에 대한 연구가 매우 중요해지고 있으며, 이를 위해서는 내재된 리스크 요인을 도출하고 분석해야하며, 불확실성을 다루기위한 통계학적인 기법이 요구된다. 하지만 건설 리스크에 관한 연구는 대부분 정성적이며 포괄적으로 진행되었으나, 신뢰성있는 리스크 분석을 위해서는 영향이 큰 리스크 인자에 집중하고 정량적인 분석이 요구된다. 따라서 본 연구에서는 공사 현장에 집중된 리스크 요인을 수집하기 위해 A보험사의 건설 현장 사고 데이터를 이용하였다. 이를 토대로 피해율과 상관 관계있는 인자를 분석하기 위해 상관분석을 수행하였다. 또한 본 연구의 목적인 건설 현장의 사고데이터를 활용한 적정 피해액 정량화 모델을 개발하고자 회귀분석을 수행하였다. 본 연구의 결과는 향후 지속적인 피드백을 통해서 데이터의 축적 및 효과검증을 통해 발전해 나갈 수 있으리라 기대된다.

• 제어로봇시스템학회논문지
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• 제18권5호
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• pp.487-495
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• 2012

In this paper, a Smart Home Service Robot, McBot II, which performs mess-cleanup function etc. in house, is designed much more optimally than other service robots. It is newly developed in much more practical system than McBot I which we had developed two years ago. One characteristic attribute of mobile platforms equipped with a set of dependent wheels is their omni- directionality and the ability to realize complex translational and rotational trajectories for agile navigation in door. An accurate coordination of steering angle and spinning rate of each wheel is necessary for a consistent motion. This paper develops trajectory controller of 3-wheels omni-directional mobile robot using fuzzy azimuth estimator. A specialized anthropomorphic robot manipulator which can be attached to the housemaid robot McBot II, is developed in this paper. This built-in type manipulator consists of both arms with 4 DOF (Degree of Freedom) each and both hands with 3 DOF each. The robotic arm is optimally designed to satisfy both the minimum mechanical size and the maximum workspace. Minimum mass and length are required for the built-in cooperated-arms system. But that makes the workspace so small. This paper proposes optimal design method to overcome the problem by using neck joint to move the arms horizontally forward/backward and waist joint to move them vertically up/down. The robotic hand, which has two fingers and a thumb, is also optimally designed in task-based concept. Finally, the good performance of the developed McBot II is confirmed through live tests of the mess-cleanup task.

• Journal of Ginseng Research
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• 제35권4호
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• pp.487-496
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• 2011

Good manufacturing practice (GMP)-based quality control is an integral component of the common technical document, a formal documentation process for applying a marketing authorization holder to those countries where ginseng is classified as a medicine. In addition, authentication of the physico-chemical properties of ginsenoside reference materials, and qualitative and quantitative batch analytical data based on validated analytical procedures are prerequisites for certifying GMP. Therefore, the aim of this study was to propose an authentication process for isolated ginsenosides $Rb_1$ and $Rg_1$ as reference materials (RM) and for these compounds to be designated as RMs for ginseng preparations throughout the world. Ginsenoside $Rb_1$ and $Rg_1$ were isolated by Diaion HP-20 adsorption chromatography, silica gel flash chromatography, recrystallization, and preparative HPLC. HPLC fractions corresponding to those two ginsenosides were recrystallized in appropriate solvents for the analysis of physico-chemical properties. Documentation of the isolated ginsenosides was made according to the method proposed by Gaedcke and Steinhoff. The ginsenosides were subjected to analyses of their general characteristics, identification, purity, content quantitation, and mass balance tests. The isolated ginsenosides were proven to be a single compound when analyzed by three different HPLC systems. Also, the water content was found to be 0.940% for $Rb_1$ and 0.485% for $Rg_1$, meaning that the net mass balance for ginsenoside $Rb_1$ and $Rg_1$ were 99.060% and 99.515%, respectively. From these results, we could assess and propose a full spectrum of physicochemical properties for the ginsenosides $Rb_1$ and $Rg_1$ as standard reference materials for GMP-based quality control.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2011년도 제40회 동계학술대회 초록집
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• pp.487-487
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• 2011

Recently graphene has emerged as a fascinating 2D system in condensed-matter physics as well as a new material for the development of nanotechnology. The unusual electronic band structure of graphene allows it to exhibit a strong ambipolar electric field effect with high mobility. These properties lead to the possibility of its application in high-performance transparent conducting films (TCFs). Compared to indium tin oxide (ITO) electrodes, which have a typical sheet resistance of ${\sim}60{\Omega}$/sq and ~85 % transmittance in the visible range (400?900 nm), the CVD-grown graphene electrodes have a higher/flatter transmittance in the visible to IR region and are more robust under bending. Nevertheless, the lowest sheet resistance of the currently available CVD graphene electrodes is higher than that of ITO. Here, we report an ingenious strategy, irradiation of MeV electron beam (e-beam) at room temperature under ambient condition, for obtaining size-homogeneous gold nanoparticle decorated on graphene. The nano-particlization promoted by MeV e-beam irradiation was investigated by transmission electron microscopy, electron energy loss spectroscopy elemental mapping, and energy dispersive X-ray spectroscopy. These results clearly revealed that gold nanoparticle with 10 ~ 15 nm in mean size were decorated along the surface of the graphene after 1.5 MeV-e-beam irradiation. A chemical transformation and charge transfer for the metal gold nanoparticle were systematically explored by X-ray photoelectron spectroscopy and Raman spectroscopy. This approach advances the numerous applications of graphene films as transparent conducting electrodes.

• Steel and Composite Structures
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• 제34권4호
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• pp.487-497
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• 2020

During the last few decades, fluid viscous dampers have been significantly improved in terms of performance and reliability. Viscous dampers dissipate the input energy into heat and the increased temperature may damage internal seals of the damper. As a result, thermal compensation is crucial for almost all fluid viscous dampers. In this study, while referring to the main working principles of the recently developed bypass viscous damper in Iran, a comprehensive case study is conducted on a RC building having diagonal braces equipped with such viscous dampers. Experimental results of a small-scale bypass viscous damper is presented and it is shown that the currently available simplified Maxwell models can simulate behavior of the bypass viscous damper with good accuracy. Using a case study, contribution of bypass viscous dampers to seismic behavior of structural and non-structural elements are investigated. A designed procedure is adopted to increase damping ratio of the building from 3% to 15%. In this way, reductions of 25% and 13% in the required concrete and steel rebar materials have been achieved. From nonlinear time history analyses, it is observed that bypass viscous dampers can greatly improve seismic behavior of structural elements and non-structural elements.