• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.1
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• pp.84-90
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• 2010

In this paper, a novel voltage-controlled oscillator (VCO) using the harmonic control circuit based on the composite right/left-handed (CRLH) transmission lines (TLs) is presented to reduce the phase noise without the reduction of the frequency tuning range and miniaturize the circuit size. The phase noise is reduced by the novel harmonic control circuit having the short impedances for the second- and third-harmonic components. The proposed harmonic control circuit is designed by using the CRLH TLs with the dual-band characteristic by the frequency offset and phase slope of the CRLH TLs. The high-Q resonator has been used to reduce the phase noise, but has the problem of the frequency tuning range reduction. However, the frequency tuning range of the proposed VCO has not been reduced because the phase noise has been reduced without the high-Q resonator. The miniaturization of the circuit size is achieved by using the CRLH TLs instead of the conventional right-handed (RH) TLs. The phase noise of VCO is -119.17 ~ -117.50 dBc/Hz at 100 kHz in the tuning range of 5.731 ~ 5.938 GHz.

• Journal of Korean Society for Atmospheric Environment
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• v.29 no.2
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• pp.186-198
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• 2013

The present work is an attempt to improve the performance of a regional air quality model by means of liking it with a global chemistry transport model. The global chemical transport model of GEOS-Chem is used to provide BC (Boundary Condition)s which reflect temporal and spatial variations at boundaries of regional chemical transport model of CMAQ over East Asia. First, GEOS-Chem outputs are evaluated by comparing predicted concentrations with observed monthly data of gas phase species and secondary inorganic aerosols from EANET (Acid Deposition Monitoring Network in East Asia) sites. The results show that predicted PM10 concentrations are in good agreement with the observations. This implies that GEOS-Chem outputs could be used to provide BCs to CMAQ. Simulated daily and monthly mean PM10 concentrations of CMAQ with the linkage of GEOS-Chem's BCs and constant BCs are then evaluated by comparing predicted concentrations with observations at API (Air Pollution Index) sites in China as well as EANET sites in Korea. CMAQ with the GEOS-Chem outputs improves model simulation in depicting observed PM10 concentrations comparing with those with constant BCs. It is also found that influence of aerosol species are largely dependent on the BCs over East Asia and Korea. Mean biases between simulated versus observed daily and monthly mean concentrations of PM10 with the GEOS-chem were improved by 1~8 ${\mu}g/m^3$ in China region, 3.26 ${\mu}g/m^3$ in Korea.

• Journal of Sasang Constitutional Medicine
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• v.18 no.3
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• pp.131-144
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• 2006

1. Objectives This research uses the DNA chip, which includes 16,383 gene code, and various statistic prediction way that shows objectification index for the objectification of constitution diagnosis. 2. Methods Drawing blood whose constitution is confirmed, and analyze its gene information by using 1.7k DNA chip to find the gene correlation through multivariate statistical method. 3. Results and Conclusions Distinctive genes such as AK001919, U09384, NM_001805, X99962, NM_004796, AK026738, AL050148, BC002538, AK027074, AK026219, AF087962, AL390142, NM_015372, AL157466, NM_002446, AK024523, NM_014706, NM_014746 and AL137544 were related to Taeumin; AL157448, NM_005957, NM_005656, NM_017548, AK027246, NM_003025, NM_012302 and NM_005905 were represented in Soeumin, while AK026503, AF147325, NM_002076, AF147307, AK001375, NM_003740, NM_005114, AB007890, NM_005505, NM_015900, NM_014936, Z70694, AB023154, U52076, NM_004360, NM_005835, NM_017528, AF087987, NM_014897, AK021720, NM_006420, AJ277915, AK002118 and AK021918 were for Soyangin. This study figured out the possibility to develop the prediction system by sorting each constitution's gene, and research each constitution's distinctive character of manifestation pattern.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.4
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• pp.1-12
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• 2011

Objectives: This study was carried out in order to examine the effects of Gastrodiae rhizoma(GR) ethanol extract on neuronal apoptosis in intracerebral hemorrhage(ICH)-induced rats. Methods: ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type VII in Sprague-Dawley rats. GR was orally given once a day for 3 days after ICH. Histological changes of the peri-hematoma regions were observed by cresyl vioIet staining. Bcl-2-associated X protein(Bax), B-cell blastoma 2(BcI-2) and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL) expressions in the affected regions were performed by immunohistochemistry. Results: 1. GR reduced apoptotic bodies and swelling neurons in the peri-hematoma regions of ICH-induced rats. 2. GR significantly reduced TUNEL positive cells in the peri-hematoma regions of ICH-induced rats. 3. GR significantly reduced Bax positive cells in the peri-hematoma regions of ICH-induced rats. 4. GR did not influence Bcl-2 expression in the peri-hematoma regions of ICH-induced rats. Conclusions: These results suggest that GR has neuroprotective effects against ICH-induced apoptosis.

• Journal of Environmental Health Sciences
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• v.37 no.2
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• pp.94-101
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• 2011

Objectives: The purpose of this study is to evaluate the noise exposures of firefighters according to their time-dependent activity patterns. Methods: Personal exposure levels were measured for six days and nights using noise dosimeters; three days and nights for on-duty tasks, the other days and nights for off-duty activities. Results: The total amount of time spent in the workplace was 13,677 min (67%), outside areas 4,833 min (23%), in transit 1,002 min (5%), and other indoor area 807 min (4%) during a working period. However, during off-days they spent 10,858 min (76%) at home, 1,382 min (10%) outdoors, 1,225 min (9%) other indoors, and 493 min (3%) in transit. As a result of individual exposure levels, TWA did not exceed 90 dBA of the occupational exposure limit for the majority of the firefighters, whereas the levels of Lmax were 119 dBA, which were higher than the noise levels of firefighters in USA. Sometimes during dispatching the levels of Lpeak exceeded the ACGIH exposure standard (140 dBC). The Leq levels in transit were higher than the levels in home and other indoors even though the activity time is short. Conclusions: This paper characterized the noise exposure patterns of firefighters in Korea. We suggest that special noise sources, including sirens and speaker phones, should be readjusted to reduce noise exposure.

• Journal of Life Science
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• v.17 no.8 s.88
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• pp.1027-1033
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• 2007

Although paclitaxel induces apoptosis of cancer cells, its exact mechanism of action is not yet known. The present study has been performed to determine whether influence of paclitaxel in HeLa $S_{3}$ uterine cancer cells. Three assays were employed in this study: cell cytotoxicity, morphological assessments of apoptotic cells (DAPI staining assay), and western blot analysis. The results indicated that paclitaxel has cytotoxic effects in HeLa $S_{3}$ cells. Especially, the $IC_{50}$ value of paclitaxel was about 1 ${\mu}M$. And morphological changes (fragmentation) of cells were observed by paclitaxel in HeLa $S_{3}$ cells. The flow cytometric analysis of paclitaxel-treated cells indicated a block of G2/M phase. The results that pacli-taxel regulates the cell cycle, especially Sub-$G_{1}$ phase. Paclitaxel induces apoptosis of HeLa $S_{3}$ cells via PARP-dependent fashion, and this apoptosis is related to disappearance of Bcl-2 proteins.

• Development and Reproduction
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• v.14 no.1
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• pp.13-19
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• 2010

We developed a novel dicistronic system for the expression of target cDNA sequences in the milk of transgenic animals using goat beta-casein/hGH fusion construct, pGbc5.5hGH (Lee, 2006) and internal ribosome entry site (IRES) sequences of encephalomyocarditis virus (EMCV). Granulocyte colony-stimulating factor (hG-CSF) cDNA was linked to 3' untranslated region of hGH gene in the pGbc5.5hGH via EMCV IRES sequences. Transgenic mice were generated by microinjection and transgene expression was examined in the milk and mammary gland of transgenic mice at 10 days of lactation. Northern blot analysis showed that hGH gene and hG-CSF cDNA were transcribed as a single dicistronic mRNA. The hG-CSF and hGH proteins were independently translated from the dicistronic mRNA and secreted into the milk of transgenic mice. The highest concentration of hG-CSF and hGH in the milk of transgenic mice were $237{\mu}g/m{\ell}$ and $8,990{\mu}g/m{\ell}$, respectively. In contrast, another hG-CSF expression cassette, in which hG-CSF genomic sequences were inserted into a commercial milk-specific expression vector (pBC1), generated a lower level ($91{\mu}g/m{\ell}$) of hG-CSF expression in the milk of transgenic mice. These results demonstrated that the novel pGbc5.5hGH-based dicistronic construct could be useful for an efficient cDNA expression in the milk of transgenic animals.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.10
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• pp.758-765
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• 2018

This paper presents a 24-GHz frequency-modulated continuous wave(FMCW) radar transceiver with two Rx and one Tx channels in 65-nm complementary metal-oxide-semiconductor(CMOS) process and implemented it on a radar system using the developed transceiver chip. The transceiver chip includes a $14{\times}$ frequency multiplier, low-noise amplifier, down-conversion mixer, and power amplifier(PA). The transmitter achieves >10 dBm output power from 23.8 to 24.36 GHz and the phase noise is -97.3 GHz/Hz at a 1-MHz offset. The receiver achieves 25.2 dB conversion gain and output $P_{1dB}$ of -31.7 dBm. The transceiver consumes 295 mW of power and occupies an area of $1.63{\times}1.6mm^2$. The radar system is fabricated on a low-loss Duroid printed circuit board(PCB) stacked on the low-cost FR4 PCBs. The chip and antenna are placed on the Duroid PCB with interconnects and bias, gain blocks and FMCW signal-generating circuitry are mounted on the FR4 PCB. The transmit antenna is a $4{\times}4$ patch array with 14.76 dBi gain and receiving antennas are two $4{\times}2$ patch antennas with a gain of 11.77 dBi. The operation of the radar is evaluated and confirmed by detecting the range and azimuthal angle of the corner reflectors.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.5 s.108
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• pp.461-475
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• 2006

In this paper, it is described about the tri-band mobile antenna system design to provide broadband multimedia and direct broadcasting services using goo-stationary Koreasat 3, simultaneously operated in Ka/K/Ku band. The radiating part of the antenna system with a fan beam characteristic in the elevation plane is composed of the quasi-offset dual shaped reflector and the tri-band feeder. The tri-band feeder is also composed of the Ka/K dual band feeder with the protruding dielectric rod, the circular polarizer, the ortho-mode transducer and the circular-polarized Ku band feed array. Especially, the Ka/K dual band circular polarizer was realized firstly using the comb-type structure. For fast satellite-tracking on the movement, the Ku band feed array has the structure of the $2{\times}2$ active phased array which can make electrical beams. And, the circular-polarized characteristic in the feed array was improved by $90^{\circ}$ rotating arrangement of four radiating elements polarized circularly by a $90^{\circ}$ hybrid coupler, respectively. Four beam forming channels to make electrical beams at Ku band are divided into the main beam channel and the tracking beam channel in the output, and noise temperature characteristics of each channel were analyzed on the basis of the contributions of internal sub_units. From the fabricated antenna system, the output power at $P_{1dBc}$ of Ka_Tx channel was measured more than 34.1 dBm and the measured noise figures of K/Ku_Rx channels were less than 2.4 dB and 1.5 dB, respectively, over the operating band. The radiation patterns with co- and cross-polarization in the tri-band were measured using a near-field measurement in the anechoic chamber. Especially, Ku radiation patterns were measured after correcting each initial phase of active channels with partial radiation patterns obtained from the independent excitation of each channel. The antenna gains measured in Ka/K/Ku band of the antenna system were more than 39.6 dBi, 37.5 dBi, 29.6 dBi, respectively. And, the antenna system showed good system performances such as Ka_Tx EIRP more than 43.7 dBW and K/Ku_Rx G/T more than 13.2 dB/K and 7.12 dB/K, respectively.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.24 no.2
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• pp.317-326
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• 1994

Panoramic radiographs of a dry skull were used to evaluate the accuracy of four panoramic dental X-ray systems in determining tooth angulations in the buccal segments. The four machines evaluated were the Philips Oralix Pan DC, the GE panelipse, the SS White panorex 1, and the SS White Panorex 2. Panoramic radiographs were taken at six different patient positions for each machine to evaluate the effects of patient positioning on determining tooth angulations in the buccal segments. All of the machines studied showed a significant correlation between the mean radiographic estimates and the actual measurements regardless of positioning(p<0.05). With correct placement of the skull, the results were analyzed for an error tolerance of +/-3/sup 0/ between the actual measurements and the radiographic estimates for tooth angulation. The SS White Panorex 1 was accurate 74% of the time, the GE Panelipse was accurate 67% of the time, the Philips Oralix Pan DC and the SS White Panorex 2 were accurate 64% of the time. When an error tolerance of +/-5/sup 0/ was permitted, the accuracy was 89% for the SS White Panorex 1 and the GE Panelipse, 85% for the Philips Oralix Pan DC, and 81% for the SS White Panorex 2.