• YAKHAK HOEJI
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• v.54 no.6
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• pp.461-465
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• 2010

We investigated the role of L-type $Ca^{2+}$ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type $Ca^{2+}$ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type $Ca^{2+}$ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.

• Journal of the Korean Society of Safety
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• v.19 no.3 s.67
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• pp.78-83
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• 2004

The channel-type lining board that partial welded on many partition frames is used to normal servicing lining board type. On this study is to investigate existing channel-type lining board's capacity by using the static loading test. From this study, to develop new-type lining board which reflect well cross section area and sectional modulus of existing channel-type lining board. Six types FEM model are adopted. The accumulated test results of stress conditions and deflections by section shapes will be used to analyzed the relation between the capacity and the section shape. With the comparing the results of static loading test and FEM analysis.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.25-30
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• 2012

Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level of bile acids increases. Bile acids in circulation may affect the nervous system. We examined this possibility by studying the effects of bile acids on gating of neuronal (N)-type $Ca^{2+}$ channel that is essential for neurotransmitter release at synapses of the peripheral and central nervous system. N-type $Ca^{2+}$ channel currents were recorded from bullfrog sympathetic neuron under a cell-attached mode using 100 mM $Ba^{2+}$ as a charge carrier. Cholic acid (CA, $10^{-6}M$) that is relatively hydrophilic thus less cytotoxic was included in the pipette solution. CA suppressed the open probability of N-type $Ca^{2+}$ channel, which appeared to be due to an increase in (no activity) sweeps. For example, the proportion of sweep in the presence of CA was ~40% at +40 mV as compared with ~8% in the control recorded without CA. Other single channel properties including slope conductance, single channel current amplitude, open and shut times were not significantly affected by CA being present. The results suggest that CA could modulate N-type $Ca^{2+}$ channel gating at a concentration as low as $10^{-6}M$. Bile acids have been shown to activate nonselective cation conductance and depolarize the cell membrane. Under pathological conditions with increased circulating bile acids, CA suppression of N-type $Ca^{2+}$ channel function may be beneficial against overexcitation of the synapses.

• Journal of Ginseng Research
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• v.24 no.1
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• pp.18-22
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• 2000

In previous reports we have shown that ginsenosides inhibit high threshold voltage-dependent $Ca^{2+}$ channels in neuronal cells. However, these studies did not show whether ginsenosides-induced inhibition of $Ca^{2+}$ currents discriminates among the various $Ca^{2+}$ channel subtypes, although it is known that there are at least five different $Ca^{2+}$ channel subtypes in neuronal cells. In this study we investigated the effect of ginsenosides on high threshold voltage-dependent $Ca^{2+}$ channel subtypes using their selective $Ca^{2+}$ channel blockers nimodipine (L-type), $\omega$-conotoxin GVIA (N-type), or $\omega$-agatoxin IVA (P-type) in bovine chromaffin cells. We could observe that ginsenosides inhibited high threshold voltage-dependent $Ca^{2+}$ currents in a dose-dependent manner. The $IC_{50}$/ was about 120 $\mu$g/ml. Nimodipine had no effect on ginsenosides response. However, the effect of ginsenosides on $Ca^{2+}$ currents was reduced by $\omega$-conotoxin GVIA, $\omega$-agatoxin IVA, and mixture of nimodipine, $\omega$-contoxin GVIA, and $\omega$-agatoxin IVA. These data suggest that ginsenosides are negatively coupled to three types of calcium channels in bovine chromaffin cell, including an $\omega$-conotoxin GVIA-sensitive (N-type) channel, an $\omega$-agatoxin IVA-sensitive (P-type) channel and nimodipine/$\omega$-conotoxin GVIA/$\omega$-agatoxin IVA-resistant (presumptive Q-type) channel.Q-type) channel.

• Journal of Distribution Science
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• v.13 no.5
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• pp.91-102
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• 2015

Purpose - This study aims to build a systematic frame for effective marketing performances by prioritizing product type and pertinent channel that are appropriate for digital channel characteristics. FCB grid model was used to define a product type, and Internet communication satisfaction index was considered as a marketing performance measuring tool for digital channel. Research design, data, and methodology - As systematic understanding for Digital marketing is still unfamiliar to even professional marketer, the hypothesis was established based on preliminary research by conducting a qualitative survey of marketing experts who already experienced digital marketing in the fields as well as existing related study literature. Through a preliminary research, the degree for understanding for digital marketing, current digital marketing (including product/channel mix) execution status, and difficulties for marketers who had experienced digital marketing were figured out. Based on preliminary research, the main part of survey was designed to examine which type of product would be effective for digital marketing and which digital channel would be effective to achieve marketing performance in line with marketing objectives. To collect data, the questionnaire survey was conducted for professional marketers who had experienced digital marketing in 10 different fields including FMCG, cosmetics, distribution industry for one month (July, 10, 2014~Aug, 10, 2014). A total of 90 questionnaire were distributed and 66 questionnaires were used for the analysis, excluding the unanswered and insincere questionnaires. The data were analysed using SPSS ver.18.0. Results - The analysis for product type which is pertinent to digital marketing and prioritization for digital channel per digital marketing performance type could be summarized as followings. First, high involvement buying decision type of product and rational purchasing decision type of product in FCB grid are more effective for digital marketing in terms of marketing performance. Therefore, marketers in field would prioritize considering product type before executing digital marketing. Second, factor for sales increase, potential consumer creation and brand awareness was represented respectively 31.25%, 21.9%, and 20.8% as a result of factor analysis in terms of digital marketing channel performance. Third, effective major digital channel per digital marketing performance factor was differently identified as each digital channel has its own peculiarity. For instance, search engine is more effective for increasing sales while social media such as facebook and Kakaotalk is more effective for encouraging consumer participation. Conclusions - As a result of this study, product type and peculiarity which were pertinently fit to digital marketing were identified by using FCB grid model, and also suggested framework for decision making of digital channel selection in line with marketing objectives for effective marketing performance. It also provided insight to professional marketer which type of product could be effective for digital marketing execution as well as which factors should be measured for digital marketing performance.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.5
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• pp.51-58
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• 2012

Accurate transmission and estimation of the channel statistics affected by high Doppler spread is one of the main issues of concern for the latest and future mobile communication systems. Therefore, it is important to research in novel channel estimation techniques that overcome the limitations of conventional methods. In this paper, we propose a novel channel estimation method that, after a simple estimation in the first OFDM symbol, uses Kalman filter to predict the channel in the rest of OFDM symbols with pilot subcarriers. Our method is designed considering the lattice-type arrangement of pilot subcarriers in LTE-Advanced, since most of the studies so far focus on block-type or comb-type pilot arrangements. In addition, to optimize the results, we use the filtering of channel impulse response and Wiener Filter for the estimation of the channel frequency response in the rest of the subcarriers.

• ETRI Journal
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• v.39 no.3
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• pp.326-335
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• 2017

In the uplink transmission of massive (or large-scale) multi-input multi-output (MIMO) systems, large dimensional signal detection and its hardware design are challenging issues owing to the high computational complexity. In this paper, we propose low-complexity hardware architectures of Richardson iterative method-based massive MIMO detectors. We present two types of massive MIMO detectors, directly mapped (type1) and reformulated (type2) Richardson iterative methods. In the proposed Richardson method (type2), the matrix-by-matrix multiplications are reformulated to matrix-vector multiplications, thus reducing the computational complexity from $O(U^2)$ to O(U). Both massive MIMO detectors are implemented using a 65 nm CMOS process and compared in terms of detection performance under different channel conditions (high-mobility and flat fading channels). The hardware implementation results confirm that the proposed type1 Richardson method-based detector demonstrates up to 50% power savings over the proposed type2 detector under a flat fading channel. The type2 detector indicates a 37% power savings compared to the type1 under a high-mobility channel.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.20 no.7
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• pp.447-454
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• 2008

The regenerative evaporative cooler(REC) is to cool a stream of air using evaporative cooling effect without an increase in the humidity ratio. In the regenerative evaporative cooler, the air can be cooled down to a temperature lower than its inlet wet-bulb temperature. Besides the cooling performance, for practical application of the regenerative evaporative cooler, the compactness of the system is also a very important factor to be considered. In this respect, three different configurations, i.e., the flat plate type, the corrugated plate type, and the finned channel type are investigated and compared for the most compact configuration. The optimal structure of each configuration is obtained individually to minimize the volume for a given effectiveness within a limit of the pressure drop. Comparing the three optimal structures, the finned channel type is found to give the most compact structure among the considered configurations. The volume of the regenerative cooler can be reduced to 1/8 by adopting the finned channel type as compared to that of the flat plate type.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.3
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• pp.778-798
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• 2014

This paper proposes a novel exposed-terminal-eliminated medium access control (ETE-MAC) protocol by combining channel reservation, collision avoidance and concurrent transmissions to improve multi-access performance of the multihop wireless networks. Based on the proposed slot scheduling scheme, each node senses the control channel (CCH) or the data channel (DCH) to accurately determine whether it can send or receive the corresponding packets without collisions. Slot reservation on the CCH can be simultaneously executed with data packet transmissions on the DCH. Therefore, it resolves the hidden-terminal type and the exposed-terminal type problems efficiently, and obtains more spatial reuse of channel resources. Concurrent packet transmissions without extra network overheads are maximized. An analytical model combining Markov model and M/G/1 queuing theory is proposed to analyze its performance. The performance comparison between analysis and simulation shows that the analytical model is highly accurate. Finally, simulation results show that, the proposed protocol obviously outperforms the link-directionality-based dual-channel MAC protocol (DCP) and WiFlex in terms of the network throughput and the average packet delay.

• Journal of Ocean Engineering and Technology
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• v.27 no.4
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• pp.68-75
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• 2013

This paper investigates the characteristics of waves generated by a flap-type wave maker in a two-dimensional wave channel. Measurements are carried out for various water depths, wave heights, periods, and lengths capacitance-type wave height gages. The experimental results are shown to satisfy the dispersion relation of the linear wave theory. For waves with a small height and long period, the wave profiles agree well with those of the linear wave theory. However, as the wave height and period become higher and shorter, respectively, it is shown that the wave profiles measured in the present experiments are different from the linear wave profiles, and the measured wave heights are smaller than the target wave heights, which may be due to the non-linearity of the waves. As the wave progresses toward the channel end, the wave height gradually decreases. This reduction in the wave height along the wave channel is explained by the wave energy dissipation due to the friction of the side walls of the channel. The performance of the wave absorber in the channel is found to be acceptable from the results of the wave reflection tests.