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The Regulation of Osteoclastogenesis by L-Type Channel Agonist  

Noh, A-Long-Sae-Mi (College of Pharmacy, Sookmyung Women's University)
Yim, Mi-Jung (College of Pharmacy, Sookmyung Women's University)
Publication Information
YAKHAK HOEJI / v.54, no.6, 2010 , pp. 461-465 More about this Journal
Abstract
We investigated the role of L-type $Ca^{2+}$ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type $Ca^{2+}$ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type $Ca^{2+}$ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.
Keywords
L-type $Ca^{2+}$ channel; osteoclast; NFATc1; ERK; p38;
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