• 약학회지
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• 제54권6호
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• pp.461-465
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• 2010

We investigated the role of L-type $Ca^{2+}$ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type $Ca^{2+}$ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type $Ca^{2+}$ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.

• 한국안전학회지
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• 제19권3호
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• pp.78-83
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• 2004

The channel-type lining board that partial welded on many partition frames is used to normal servicing lining board type. On this study is to investigate existing channel-type lining board's capacity by using the static loading test. From this study, to develop new-type lining board which reflect well cross section area and sectional modulus of existing channel-type lining board. Six types FEM model are adopted. The accumulated test results of stress conditions and deflections by section shapes will be used to analyzed the relation between the capacity and the section shape. With the comparing the results of static loading test and FEM analysis.

• The Korean Journal of Physiology and Pharmacology
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• 제16권1호
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• pp.25-30
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• 2012

Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level of bile acids increases. Bile acids in circulation may affect the nervous system. We examined this possibility by studying the effects of bile acids on gating of neuronal (N)-type $Ca^{2+}$ channel that is essential for neurotransmitter release at synapses of the peripheral and central nervous system. N-type $Ca^{2+}$ channel currents were recorded from bullfrog sympathetic neuron under a cell-attached mode using 100 mM $Ba^{2+}$ as a charge carrier. Cholic acid (CA, $10^{-6}M$) that is relatively hydrophilic thus less cytotoxic was included in the pipette solution. CA suppressed the open probability of N-type $Ca^{2+}$ channel, which appeared to be due to an increase in (no activity) sweeps. For example, the proportion of sweep in the presence of CA was ~40% at +40 mV as compared with ~8% in the control recorded without CA. Other single channel properties including slope conductance, single channel current amplitude, open and shut times were not significantly affected by CA being present. The results suggest that CA could modulate N-type $Ca^{2+}$ channel gating at a concentration as low as $10^{-6}M$. Bile acids have been shown to activate nonselective cation conductance and depolarize the cell membrane. Under pathological conditions with increased circulating bile acids, CA suppression of N-type $Ca^{2+}$ channel function may be beneficial against overexcitation of the synapses.

• Journal of Ginseng Research
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• 제24권1호
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• pp.18-22
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• 2000

앞의 연구에서 우리는 진세노사이드가 신경세포에 존재하는 high-threshold voltage-dependent $Ca^{2+}$ channel을 억제한다는 것을 발표하였다. 그러나, 이러한 연구는 진세노사이드가 여러 칼슘 채널subtypes중 어느 특정 칼슘 채널만을 선택적으로 조절한다는 것을 보여주지는 않았다. 따라서 이 연구에서 우리는 여러 칼슘 채널subtypes에 선택적으로 작용하는 약물 혹은 toxins을 이용하여 진세노사이드가 어느 종류의 칼슘 채널 subtypes를 억제하는가를 bovine chromaffin cell을 이용하여 연구하였다. 사용한 물질은nimodipine(L-type 칼슘 채널 길항제), $\omega$-conotoxin GVIA (N-type $Ca^{2+}$ channel 길항제), $\omega$-agatoxin IVA(P-type 칼슘 채널 길항제)이었다. 연구 결과 진세노사이드는 bovine chromaffin 세포에 존재하는 high-threshold 칼슘 current을 투여 농도별로 억제하였다. $IC_{50}$/은 약 120 $\mu$g/ml인 것으로 나타났다. nimodipine은 진세노사이드에 의한 칼슘 currents억제 작용에 영향을 미치지 않은 것으로 나타났다. 그러나, $\omega$-conotoxin GVIA, $\omega$-agatoxin IVA 및 nimodipine+$\omega$-conotoxin GVIA+$\omega$-agatoxin IVA을 처리한 세포에서는 진세노사이드에 의한 칼슘 currents억제 작용이 현저하게 줄어 들었다. 이러한 연구 결과들은 진세노사이드가 L-type 칼슘 채널은 억제하지 않고, 주로 N-, p-, 및 Q-type칼슘 채널을 억제한다는 것을 보여주고 있다

• 유통과학연구
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• 제13권5호
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• pp.91-102
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• 2015

Purpose - This study aims to build a systematic frame for effective marketing performances by prioritizing product type and pertinent channel that are appropriate for digital channel characteristics. FCB grid model was used to define a product type, and Internet communication satisfaction index was considered as a marketing performance measuring tool for digital channel. Research design, data, and methodology - As systematic understanding for Digital marketing is still unfamiliar to even professional marketer, the hypothesis was established based on preliminary research by conducting a qualitative survey of marketing experts who already experienced digital marketing in the fields as well as existing related study literature. Through a preliminary research, the degree for understanding for digital marketing, current digital marketing (including product/channel mix) execution status, and difficulties for marketers who had experienced digital marketing were figured out. Based on preliminary research, the main part of survey was designed to examine which type of product would be effective for digital marketing and which digital channel would be effective to achieve marketing performance in line with marketing objectives. To collect data, the questionnaire survey was conducted for professional marketers who had experienced digital marketing in 10 different fields including FMCG, cosmetics, distribution industry for one month (July, 10, 2014~Aug, 10, 2014). A total of 90 questionnaire were distributed and 66 questionnaires were used for the analysis, excluding the unanswered and insincere questionnaires. The data were analysed using SPSS ver.18.0. Results - The analysis for product type which is pertinent to digital marketing and prioritization for digital channel per digital marketing performance type could be summarized as followings. First, high involvement buying decision type of product and rational purchasing decision type of product in FCB grid are more effective for digital marketing in terms of marketing performance. Therefore, marketers in field would prioritize considering product type before executing digital marketing. Second, factor for sales increase, potential consumer creation and brand awareness was represented respectively 31.25%, 21.9%, and 20.8% as a result of factor analysis in terms of digital marketing channel performance. Third, effective major digital channel per digital marketing performance factor was differently identified as each digital channel has its own peculiarity. For instance, search engine is more effective for increasing sales while social media such as facebook and Kakaotalk is more effective for encouraging consumer participation. Conclusions - As a result of this study, product type and peculiarity which were pertinently fit to digital marketing were identified by using FCB grid model, and also suggested framework for decision making of digital channel selection in line with marketing objectives for effective marketing performance. It also provided insight to professional marketer which type of product could be effective for digital marketing execution as well as which factors should be measured for digital marketing performance.

• 대한전자공학회논문지TC
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• 제49권5호
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• pp.51-58
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• 2012

높은 도플러 확산에 의한 채널 통계의 정확한 전송 및 추정은 최근 및 미래의 이동 통신 시스템에서 고려되는 주요 문제중 하나이다. 따라서 기존 채널 추정 기법의 한계를 극복하는 새로운 채널 추정 기술을 연구하는 것이 중요하다. 본 논문에서는 첫 번째 OFDM symbol의 간단한 추정 후 새로운 채널 추정 방법인 파일럿 부반송파와 OFDM symbol의 나머지 채널을 추정하기 위해서 Kalman Filter를 사용하는 것을 제안한다. 또한 지금까지의 대부분 연구에서는 block-type이나 comb-type 파일럿 배열에 초점 맞춰져 있는 것과 달리 LTE-Advanced의 파일럿 부반송파의 lattice-type 배열을 고려하여 설계한다. 이 외에도 결과를 최적화하기 위해서 나머지 부반송파에 대한 채널 주파수 응답을 추정하기 위해 채널 임펄스 응답의 필터링과 Winer Filter를 사용한다.

• ETRI Journal
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• 제39권3호
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• pp.326-335
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• 2017

In the uplink transmission of massive (or large-scale) multi-input multi-output (MIMO) systems, large dimensional signal detection and its hardware design are challenging issues owing to the high computational complexity. In this paper, we propose low-complexity hardware architectures of Richardson iterative method-based massive MIMO detectors. We present two types of massive MIMO detectors, directly mapped (type1) and reformulated (type2) Richardson iterative methods. In the proposed Richardson method (type2), the matrix-by-matrix multiplications are reformulated to matrix-vector multiplications, thus reducing the computational complexity from $O(U^2)$ to O(U). Both massive MIMO detectors are implemented using a 65 nm CMOS process and compared in terms of detection performance under different channel conditions (high-mobility and flat fading channels). The hardware implementation results confirm that the proposed type1 Richardson method-based detector demonstrates up to 50% power savings over the proposed type2 detector under a flat fading channel. The type2 detector indicates a 37% power savings compared to the type1 under a high-mobility channel.

• 설비공학논문집
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• 제20권7호
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• pp.447-454
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• 2008

The regenerative evaporative cooler(REC) is to cool a stream of air using evaporative cooling effect without an increase in the humidity ratio. In the regenerative evaporative cooler, the air can be cooled down to a temperature lower than its inlet wet-bulb temperature. Besides the cooling performance, for practical application of the regenerative evaporative cooler, the compactness of the system is also a very important factor to be considered. In this respect, three different configurations, i.e., the flat plate type, the corrugated plate type, and the finned channel type are investigated and compared for the most compact configuration. The optimal structure of each configuration is obtained individually to minimize the volume for a given effectiveness within a limit of the pressure drop. Comparing the three optimal structures, the finned channel type is found to give the most compact structure among the considered configurations. The volume of the regenerative cooler can be reduced to 1/8 by adopting the finned channel type as compared to that of the flat plate type.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제8권3호
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• pp.778-798
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• 2014

This paper proposes a novel exposed-terminal-eliminated medium access control (ETE-MAC) protocol by combining channel reservation, collision avoidance and concurrent transmissions to improve multi-access performance of the multihop wireless networks. Based on the proposed slot scheduling scheme, each node senses the control channel (CCH) or the data channel (DCH) to accurately determine whether it can send or receive the corresponding packets without collisions. Slot reservation on the CCH can be simultaneously executed with data packet transmissions on the DCH. Therefore, it resolves the hidden-terminal type and the exposed-terminal type problems efficiently, and obtains more spatial reuse of channel resources. Concurrent packet transmissions without extra network overheads are maximized. An analytical model combining Markov model and M/G/1 queuing theory is proposed to analyze its performance. The performance comparison between analysis and simulation shows that the analytical model is highly accurate. Finally, simulation results show that, the proposed protocol obviously outperforms the link-directionality-based dual-channel MAC protocol (DCP) and WiFlex in terms of the network throughput and the average packet delay.

• 한국해양공학회지
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• 제27권4호
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• pp.68-75
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• 2013

This paper investigates the characteristics of waves generated by a flap-type wave maker in a two-dimensional wave channel. Measurements are carried out for various water depths, wave heights, periods, and lengths capacitance-type wave height gages. The experimental results are shown to satisfy the dispersion relation of the linear wave theory. For waves with a small height and long period, the wave profiles agree well with those of the linear wave theory. However, as the wave height and period become higher and shorter, respectively, it is shown that the wave profiles measured in the present experiments are different from the linear wave profiles, and the measured wave heights are smaller than the target wave heights, which may be due to the non-linearity of the waves. As the wave progresses toward the channel end, the wave height gradually decreases. This reduction in the wave height along the wave channel is explained by the wave energy dissipation due to the friction of the side walls of the channel. The performance of the wave absorber in the channel is found to be acceptable from the results of the wave reflection tests.