• Biomolecules & Therapeutics
• /
• 제20권3호
• /
• pp.352-356
• /
• 2012

The present study was undertaken to determine whether ethanol influences on the agonist-induced vascular smooth muscle contraction and, if so, to investigate the related mechanism. The measurement of isometric contractions using a computerized data acquisition system was combined with molecular experiments. Ethanol significantly inhibited thromboxane $A_2$ mimetic-induced contraction with intact endothelial function, but there was no relaxation on thromboxane $A_2$ mimetic U-46619-induced contraction irrespective of endothelium suggesting that the pathway such as Rho-kinase activation, $Ca^{2+}$ entry or thin filament regulation was not affected. In addition, ethanol didn't decrease thromboxane $A_2$ mimetic-induced increase of phospho-myosin phosphatase targeting subunit protein 1 (pMYPT1) or pERK1/2. Interestingly, ethanol didn't inhibit significantly phorbol ester-induced contraction in denuded muscles suggesting that thin filament regulation is less important on the ethanol-induced regulation in the muscle than endothelial NO synthesis. In conclusion, this study provides the evidence and possible related mechanism concerning the effect of ethanol on the agonist-dependent contraction in rat aortic rings with regard to endothelial function.

• 호남수학학술지
• /
• 제41권1호
• /
• pp.19-34
• /
• 2019

The article is written with a view to introducing the new idea of an F-contraction on a closed ball and have new ${\acute{C}}iri{\acute{c}}$ type fixed point theorems in the framework of a complete metric space. That is why this outcome becomes useful for the contraction of the mapping on a closed ball instead of the whole space. At the same time, some comparative examples are constructed which establish the superiority of our results. It can be stated that the results that have come into being give proof of extension as well as substantial generalizations and improvements of several well known results in the existing comparable literature.

• Journal of applied mathematics & informatics
• /
• 제42권2호
• /
• pp.433-444
• /
• 2024

Our study explores the connection between the Pythagorean theorem and the Fixed-point theorem in metric spaces. Both of which center around the concepts of distance transformations and point relationships. The Pythagorean theorem deals with right triangles in Euclidean space, emphasizing distances between points. In contrast, fixed-point theorems pertain to the points that remain unchanged under specific transformations thereby preserving distances. The article delves into the intrinsic correlation between these concepts and presents a novel study in Euclidean metric spaces, examining the relationship between contraction mapping and Pythagorean Right Triangles. Practical applications are also discussed particularly in the context of image compression. Here, the integration of the Pythagorean right triangle paradigm with contraction mappings results in efficient data representation and the preservation of visual data relation-ships. This illustrates the practical utility of seemingly abstract theories in addressing real-world challenges.

• Archives of Plastic Surgery
• /
• 제38권5호
• /
• pp.576-584
• /
• 2011

Purpose: The shape and location, the amount of the wound and the characteristics of the remaining tissues are known to influence wound contraction. The previous studies using small animals have not been an appropriate model because the wound healing mechanisms and skin structures are different from those of the human. The purpose of this study is to evaluate wound contraction according to the shape and location of the wound using a $Micropig^{(R)}$. Methods: Four $Micropigs^{(R)}$ (Medikinetics, Pyeongtaek, Korea) that were 10 months of age weighed 25 kg were used. Full thickness skin defects were made by clearing all the tissues above the fascial layer in the shape of square, a regular triangle and a circle of 9 $cm^2$ each on the back around the spine. Eight wounds were created on the back of each pig, 50 mm apart from each other. The randomly chosen wound shapes included 11 squares, 11 regular triangles, and 10 circles. Wound dressing was done every other day with polyurethane foam. The wound size was measured using a Visitrak $Digital^{(R)}$ (Smith & Nephew, Hull, UK) on every other day after surgery from day 2 to day 28. A biopsy was performed on day 3, and 1, 2, 3 and 4 weeks to investigate the degree of acute and chronic inflammation, the number of microvesssel and myofibroblast density using H & E stain and immunohistochemistry. The wound contraction rate was calculated to figure out the differences among each of the shapes and the locations. Results: The ultimate shape of the circle wound was oval, and that of the regular triangle and square were stellate. The maximum contraction rate was obtained on 8 to 10 days for all the shapes, which corresponds with the immunohistochemical finding that myofibroblast increases in the earlier 2 weeks whereas it decreases in the later 2 weeks. Epithelialization was seen in the wound margin on day 7 and afterwards. The final wound contraction rates were highest for the regular triangle shapes; however, there were no statistically significant differences. The wound contraction rates by locations showed statistically significant differences. The wound in the cephalic area presented more contractions than that of the wounds in the caudal area. Conclusion: The location of a wound is more important factor than the wound shape in wound contraction.

• Journal of applied mathematics & informatics
• /
• 제16권1_2호
• /
• pp.383-405
• /
• 2004

We study the incomprssible Navier Stokes equations for the flow inside contraction geometry. The governing equations are expressed in the vorticity-stream function formulations. A rectangular computational domain is arised by elliptic grid generation technique. The numerical solution is based on a technique of automatic numerical generation of acurvilinear coordinate system by transforming the governing equation into computational plane. The transformed equations are approximated using central differences and solved simultaneously by successive over relaxation iteration. The time dependent of the vorticity equation solved by using explicit marching procedure. We will apply the technique on several irregular-shapes.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• 제7권1호
• /
• pp.79-86
• /
• 2003

A myoelectric signal, under sustained isometric contraction of muscle the modelled as the output of a linear time-varying system whose input is constant number of pulse train. The proposed model considered localized muscle fatigue by metabolic by-products during sustained fatiguing contraction. To characterize muscle fatiguing model of myoelectric signal, We calculated median frequency of generated signal as fatiguing index of muscle during sustained isometric contraction.

• 한국한의학연구원논문집
• /
• 제2권1호
• /
• pp.236-254
• /
• 1996

This study was carried out to investigate the tracheal muscle relaxation of water extracts of three kinds of Coptis rhizoma and also compare their effects with berberine and palmatine, which are the important alkaloid components of Coptis rhizoma, in isolated rat tracheal smooth muscle. As a result Coptis chinenis showed significant tracheal muscle relaxation on KCI-induced contraction and more markedly on carbachol-induced contraction in dose-dependent manner. Coptis japoinin exhibited also tracheal muscle relaxation on both contraction with slightly weaker activities than those of Coptis chinensts. The activities of the root hair of Coptis chinensis were the most weakest in three rhizomas. Berberine and palmatine had strong tracheal muscle relaxation, especially, on carbachol-induced contraction, however, their activities on KCI-induced contraction were weaker than that of Coptis chinenis. The inhibitory effects of three kinds of Coptis rhizoma on the contraction by KCI and carbachol were investigated to explain the process of their tracheal muscle relaxation. All rhizomas inhibited the contraction by both agents, among them, Coptis japonica showed the most significant effect, so indicating that the tracheal muscle relaxation of Coptis rhizoma may be concerned with the blocking of muscarine receptor and $Ca^{2+}$channel.

• 전기학회논문지
• /
• 제66권11호
• /
• pp.1628-1633
• /
• 2017

The purpose of this study was to identify the difference and correlation in elbow joint maximal flexion strength according to measurement methods and characteristics of muscular contraction, and to develop the predictive equation of elbow joint maximal flexion strength for the optimal exercise intensity setting and accurate measurement. Subjects were 30 male university students. Elbow joint maximal flexion strength of isokinetic contraction, isometric contraction at $75^{\circ}$ elbow joint flexion position, isotonic concentric 1RM, manual muscle strength (MMT) were measured with isokinetic dynamometer, dumbbell, and manual muscle tester. Pearson's r, linear regression equation, and multiple regression equation between variables were calculated. As a result, the highest value was isometric contraction. The second highest value was MMT. The third highest value was isokinetic contraction. 1RM was the lowest. Predictive equations of elbow joint maximal flexion strength between isometric and isokinetic contraction, between isometric contraction and 1RM, among isometric contraction, 1RM, and body weight were developed. In conclusion, 1RM and isokinetic elbow joint maximal flexion strength could be seemed to underestimate the practical elbow joint maximal flexion strength. And it is suggested that the developed predictive equations in this study should be useful in criteria- and goal-setting for resistant exercise and sports rehabilitation after elbow joint injury.

• The Korean Journal of Physiology
• /
• 제30권1호
• /
• pp.21-31
• /
• 1996

To investigate the mechanisms of increased endothelium-dependent contraction by acetylcholine in hypertensive rats, the relationship between endothelium-dependent contraction by acetylcholine and blood pressure was studied in spontaneously hypertensive rats (SHR), one-kidney, one clip Goldblatt hypertension (1K,1C-GBH) rats, and Wistar-Kyoto rats (WKY). SHR were treated orally with enalapril or nicardipine in order to prevent development of hypertension or suppress the developed hypertension. 1K,1C-GBH rats were made by renal artery stenosis with contralateral nephrectomy in 8 week-WKY. 1. Endothelium-dependent contractions by acetylcholine $(10^{-6}{\sim}10^{-5}\;M)$ in SHR were significantly greater than those in WKY. 2. Chronic treatment with enalapril or nicardipine reduced the endothelium-dependent contraction in SHR 3. The degree of reduction of endothelium-dependent contraction was greater in SHR which was prevented from developing hypertension than in SHR of which high blood pressure was suppressed. 4. In aortic rings from 1K,1C-GBH rats, endothelium-dependent contractions by acetylcholine were augmented as compared with WKY. 5. There is good relationship between the value of blood pressure and magnitude of endothelium-dependent contraction. Thus, it is suggested that increased endothelium-dependent contraction in hypertensive rats may he due to the high blood pressure and endothelium-dependent contraction may not be a cause of the initiation of hypertension in SHR.

• 운동과학
• /
• 제26권3호
• /
• pp.229-237
• /
• 2017

PURPOSE: This study was to investigate the Glycolysis mediated sarcoplasmic reticulum (SR) $Ca^{2+}$ signal regulates mitochondria $Ca^{2+}$ during skeletal muscle contraction by using glycolysis inhibitor. METHODS: To examine the effect of Glycolysis inhibitor on SR and mitochondria $Ca^{2+}$ content, we used skeletal muscle fiber from gastrocnemius muscle. 2-deoxy glucose and 3-bromo pyruvate used as glycolysis inhibitor, it applied to electrically stimulated muscle contraction experiment. Intracellular $Ca^{2+}$ content, SR, mitochondria $Ca^{2+}$ level and mitochondria membrane potential (MMP) was detected by confocal microscope. Mitochondrial energy metabolism related enzyme, citric acid synthase activity also examined for mitochondrial function during the muscle contraction. RESULTS: Treatment of 2-DG and 3BP decreased the muscle contraction induced SR $Ca^{2+}$ increase however the mitochondria $Ca^{2+}$ level was increased by treatment of inhibitors and showed and overloading as compared with the control group. Glycolysis inhibitor and thapsigargin treatment showed a significant decrease in MPP of skeletal muscle cells compared to the control group. CS activity significantly decreased after pretreatment of glycolysis inhibitor during skeletal muscle contraction. These results suggest that regulation of mitochondrial $Ca^{2+}$ levels by glycolysis is an important factor in mitochondrial energy production during skeletal muscle contraction CONCLUSIONS: These results suggest that mitochondria $Ca^{2+}$ level can be regulated by SR $Ca^{2+}$ level and glycolytic regulation of intraocular $Ca^{2+}$ signal play pivotal role in regulation of mitochondria energy metabolism during the muscle contraction.