• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.6011-6017
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• 2015

Purpose: To investigate the efficacy and safety of selective radiotherapy after distant metastasis of nasopharyngeal carcinoma (NPC) treated with dose-dense cisplatin plus fluorouracil. Materials and Methods: Eligible patients were randomly assigned to a study group treated with dose-dense cisplatin plus fluorouracil following selective radiotherapy and a control group receiving traditional cisplatin plus fluorouracil following selective radiotherapy according to a 1:1 distribution using a digital random table method. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS), objective response rate, relapse or progression rate in the radiation field and treatment toxicity. Results: Of 52 patients in the study group, 20 cases underwent radiotherapy., while in the control group of 51 patients, 16 underwent radiotherapy. The median PFS, median OS, survival rates in 1, 2 and 3 years in study and control group were 20.9 vs 12.7months, 28.3 vs 18.8months, 85.2%vs 65.9%, 62.2% vs 18.3%, and 36.6%vs 5.2% (p values of 0.00, 0.00, 0.04, 0.00 and 0.00, respectively). Subgroup analysis showed that the median OS and survival rates of 1, 2, 3 years for patients undergoing radiotherapy in the study group better than that in control group( 43.2vs24.1 months, 94.1% vs 86.7%, 82.4% vs 43.3%, 64.7% vs 17.3%, (p=0.00, 0.57, 0.04 and 0.01, respectively). The complete response rate, objective response rate after chemotherapy and three months after radiotherapy, relapse or progression rate in radiation field in study group and in control group were 19.2% vs 3.9%, 86.5% vs 56.9%, 85% vs 50%, 95% vs 81.3% and 41.3% vs 66.7% (p =0.03, 0.00, 0.03,0.30, 0.01 respectively). The grade 3-4 acute adverse reactions in the study group were significantly higher than in the control group (53.8% vs 9.8%, p=0.00). Conclusions: The survival of patients benefits from selective radiotherapy after distant metastasis of NPC treated with dose-dense cisplatin plus fluorouracil.

• Nutrition Research and Practice
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• v.14 no.3
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• pp.276-285
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• 2020

BACKGROUND/OBJECTIVES: As watching food-related programs has become very popular among the young generation in Korea, this study sought to compare the Mukbang- and Cookbang-watching status of university students with their dietary life. SUBJECTS/METHODS: The participants were 380 students who were not majoring in food and nutrition at a university in Gyeonggi, Korea. Based on self- reports, the participants were grouped according to their frequency of watching Mukbang or Cookbang: frequent-watching (FW) 21.1% and 5.3%, respectively; moderate-watching (MW) 43.9% and 27.9%, respectively; and not-watching (NW) 35.0% and 66.8% respectively. RESULTS: In the FW group, up to 88.8% and 70.0% of participants reported watching Mukbang and Cookbang, respectively, ≥ 3 days/week. Almost all participants in the FW and MW groups reported intention to keep watching these shows. The most frequent watching route was "YouTube" and the most important criterion to select a program was "food". In the case of Mukbang, but not Cookbang, the participants in the FW group scored their diet significantly worse than those in the NW group (P < 0.05). A greater proportion of participants felt that watching Cookbang improved their diets rather than worsened them (14.3% vs. 0.8%, respectively), while more participants said that watching Mukbang worsened their diets rather than improved them (8.1% vs. 2.4%, respectively). In both cases, greater differences were shown in the FW groups compared to the MW groups (P < 0.05 and P < 0.01 for Cookbang and Mukbang, respectively). Moreover, the participants answered that Mukbang-watching prompted them to eat more of less desirable food, such as through eating out and purchasing convenient and delivered foods, whereas Cookbang-watching made them want to cook more of their own food. CONCLUSIONS: Our results suggested that Korean university students who frequently watch Mukbang, but not Cookbang, may be a nutritionally vulnerable group that needs attention.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.3
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• pp.243-250
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• 2020

Purpose: Gastric delta cells (D-cells), which are somatostatin-secreting cells, are the main paracrine inhibitor of acid secretion. The number of D-cells was studied in children presenting with upper gastrointestinal (UGI) disease. Methods: We retrospectively investigated the number of D-cells in the gastric body and antrum through immunofluorescence examinations according to symptoms, endoscopic findings, and Helicobacter pylori infection in 75 children who visited Hanyang University Hospital Pediatrics. Results: The mean patient age was 12.2±3.3 years. The male-to-female ratio was 1:1.4. The mean D-cell number per high-power field in the antrum and body was 20.5 and 12 in children with substernal pain, 18.3 and 10.3 in vomiting, 22.3 and 6 in diarrhea, and 9.3 and 6 in abdominal pain, respectively (p>0.05). According to endoscopic findings, the mean D-cell number in the antrum and body was 14.3 and 6 with gastritis, 14 and 9.3 with reflux esophagitis, 16.7 and 8.7 with duodeno-gastric reflux, 19.3 and 12.7 with gastric ulcer, 16 and 13.7 with duodenitis, and 12.3 and 4 with duodenal ulcer, respectively (p>0.05). The D-cell number in the gastric body was 2.7 and 8.7 in children with current H. pylori infection and non-infected children, respectively (p=0.01), while those in the antrum were 15.5 and 14, respectively, with no statistical significance. Conclusion: The D-cell number was lower in the gastric body of children with current H. pylori infection. Further studies concerning peptide-secreting cells with a control group would provide information about the pathogenic pathways of UGI disorder.

• Journal of the Korean Society of Radiology
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• v.15 no.5
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• pp.603-612
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• 2021

The effect of Advanced Modeled Iterative Reconstruction (ADMIRE) on the coronary artery calcium (CAC) score of computed tomography was evaluated. Coronary artery calcium images (348 calcium, 6 groups, total of 2088 calcium) were acquired by 128-slice dual-source CT of 89 patients.Volume score and Agatston score were measured from images reconstructed with filtered back projection (FBP) and ADMIRE (1-5). The difference between FBP and ADMIRE Strength (1-5) was confirmed through the Kruskal-Wallis test, and the post-hoc analysis was performed using the Mann-Whitney U test based on FBP. Both volume score and Agatston score showed statistically significant differences between FBP and ADMIRE (1-5) (P=0.015, P=0.0.38). As a result of post hoc analysis, the volume score decreased to 9.5% in ADMIRE 4 (Z=-2.359, P=0.018) and 13.2% in ADMIRE 5 (Z=-3.113, P=0.002) based on FBP. Agatston score decreased to 10.4% in ADMIRE 4 (Z=-2.051, P=0.040) and 14.0% in ADMIRE 5 (Z=-2.718, P=0.007) based on FBP. High ADMIRE strength affected the volume score and Agatston score due to the decrease in calcium area. In addition, the change in the Density factor due to the decrease in Maximum HU may affect the calculation of the Agatston score.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.1
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• pp.61-67
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• 1999

Data from 22837 lambings of Lohi and Kajli ewes from 1962 through 1994 were used to analyse productive and reproductive traits and wool production, Overall litter size at birth averaged 1.33 being 1.45 for Lohi and 1.21 for Kajli ewes. The corresponding values at weaning were 1.23, 1.32 and 1.14, respectively. Litter size was consistently lowest for one year old, with a substantial increase at two, three and four years of ewe age and marginal increase thereafter, Ewes lambing in spring weaned 0.08 more lambs per parturition than ewes lambed in Autumn (p<0,01). Lamb birth weights were affected by ewe breed (p<0.01) and increased with ewe age. Overall lamb weaning weight (120 d) of 17993 lambs was 20.3 kg. Weaning weight was affected by breed, sire, year of birth, sex, rearing rank and weaning age (p<0.01). The highest mean weaning weight was 21.9 kg for Lohi lambs followed by Kajli lambs (18.8 kg), Lambs from Kajli ewes were 9% heavier at birth but 14% lighter at weaning. Twin born lambs were 18% lighter at birth and 13% at weaning than single born lambs. Male lambs were 3% heavier at birth and 4.5% heavier at weaning than female lambs. Overall annual mean wool production was 2,64 kg, Kajli ewes were heavier at breeding than Lohi ewes (i.e. 46.2 vs 44.8 kg). Lohi ewes being 3% less body weight produced 38% more wool and 18% more litter weaning weight than Kajli ewes, When average weight of lamb weaned per ewe weaning lambs was adjusted for ewe average metabolic body size, Lohi ewes were most efficient (i.e. arbitrary assigned value of 100) compared to Kajli ewes achieving only 83% of Lohi level.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.7
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• pp.1125-1132
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• 2013

In the kimchi manufacturing process, the starter is cultured on a large-scale and needs to be supplied at a low price to kimchi factories. However, current high costs associated with the culture of lactic acid bacteria for the starter, have led to rising kimchi prices. To solve this problem, the development of a new medium for culturing lactic acid bacteria was studied. The base materials of a this novel medium consisted of Chinese cabbage extract, a carbon source, a nitrogen source, and inorganic salts. The optimal composition of this medium was determined to be 30% Chinese cabbage extract, 2% maltose, 0.25% yeast extract, and $2{\times}$ salt stock (2% sodium acetate trihydrate, 0.8% disodium hydrogen phosphate, 0.8% sodium citrate, 0.8% ammonium sulfate, 0.04% magnesium sulfate, 0.02% manganese sulfate). The newly developed medium was named MFL (medium for lactic acid bacteria). After culture for 24 hr at $30^{\circ}C$, the CFU/mL of Leuconostoc (Leuc.) citreum GR1 in MRS and MFL was $3.41{\times}10^9$ and $7.49{\times}10^9$, respectively. The number of cells in the MFL medium was 2.2 times higher than their number in the MRS media. In a scale-up process using this optimized medium, the fermentation conditions for Leuc. citreum GR1 were tested in a 2 L working volume using a 5 L jar fermentor at $30^{\circ}C$. At an impeller speed of 50 rpm (without pH control), the viable cell count was $8.60{\times}10^9$ CFU/mL. From studies on pH-stat control fermentation, the optimal pH and regulating agent was determined to be 6.8 and NaOH, respectively. At an impeller speed of 50 rpm with pH control, the viable cell count was $11.42{\times}10^9(1.14{\times}10^{10})$ CFU/mL after cultivation for 20 hr - a value was 3.34 times higher than that obtained using the MRS media in biomass production. This MFL media is expected to have economic advantages for the cultivation of Leuc. citreum GR1 as a starter for kimchi production.

• The Journal of Korean Society for Radiation Therapy
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• v.6 no.1
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• pp.154-170
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• 1994

The Purpose of this study was to determine the degree and contents composing the qualify of life and to analyze the relationships among the demographic characteristics, the degree of pain and the quality of life of the cancer patients experiencing a radiation therapy. The subjects for this study were 110 out-patients experiencing a radation therapy at C University Hospital in K-city, from April to October, 1992. The data were obtained using a convenience sampling technique. The tool of this study was the quality of life scale developed by Ro, You-Ja and the data were analyzed using a SAS program for percentages, mean & standard deviation. ANOVA and Scheffe test. The results were as follows : 1. the average total score of the quality of life of the subjects was 139.65(minimum score 121-maximum score 164), item mean score grange 1-5) was 2.97. For each factor in the quality of life scale, the mean scores (range 1-5) were 3.29 in emotional state, 3.14 in relationship with neighbors. 3.04 in physical state and function. 2.92 in self-esteem, 2.81 in economic life and 2.65 in relationship with family. 2. The incidence of physical symptoms was seen fatigue ($84.5\%$). anorexia ($65.5\%$) and weight loss ($47.3\%$) in order. The 50.9 percentage of the subjects complained of moderate or severe pain. 3. The results of the analysis of the relationships between the demographic variables and the quality of life were as follows : Gender (F=8.45, P=0.0044), age (F=6.29, P=0.0001). educational level (F=5.67, P=0.0046), marital status (F=6.82. P=0.0016), occupation (F=2.86, P=0.009), monthly income (F=6.90, P=0.0003), family living together (F=3.95, P=0.0494) and person paying a medical fee (F=5.14, P=0.0023). 4. The relationship between the degree of pain and the quality of life was significant difference (F=3.12, P=0.0482).

• Perspectives in Nursing Science
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• v.14 no.1
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• pp.1-9
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• 2017

Purpose: To study the internal psychological conflicts among nursing students during an infection control protocol carried out in the hospital by measuring their observation skills and performance during clinical training. Methods: Investigation of both pre- and post- infection control was conducted using questionnaires for clinical infection practices. We identified and evaluated the students' observation skills, clinical performance, clinical perception, and internal conflict regarding clinical infection control. We also interviewed the students as part of our study. Results: Among parameters such as clinical performance, observation skills, clinical perception, and internal conflict, the average observation skills (t=5.49, p<.001) were significantly lower, while internal conflict among students (t=-7.23, p<.001) was significantly higher than expected prior to clinical training. Generally, there was a negative correlation between observation skills and internal conflict in every aspect of infection control practice (r=-.281, p=.031). Internal conflict was significantly higher than expected in the context of hand hygiene (t=-2.135, p=.037), personal hygiene (t=-3.48, p=.002), and ventilator management (t=-3.69, p<.001). Clinical performance of students in the context of hand hygiene (t=4.69, p<.001), personal hygiene (t=2.06, p=.044), and ventilator management (t=2.68, p<.001) was significantly lower than expected prior to clinical training. Conclusion: Our findings showed that internal psychological conflict is higher when infection control practices are observed or performed to a lesser degree. Therefore, reinforcing education regarding infection control among students, such as developing a systematic program, or consecutive training and monitoring, is suggested.

• Journal of Embryo Transfer
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• v.14 no.1
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• pp.69-77
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• 1999

본 연구는 돼지 정액의 동결과정동안 flow cytometric 분석에 의한 정액내 생존정자의 비율을 조사하여 주관적으로 평가되는 활력 및 정상첨체율(normal apical ridge ; NAR)과 비교하여 정자의 손상과 생존성에 대한 적절한 평가법을 찾기 위하여 실시하였다. 동결과정 중 정액채취, 냉각, 예비동결 및 동결융해 후에 flow cytometric 분석에 의한 정자 생존율은 각각 93.0$\pm$3.6, 85.1$\pm$3.9, 28.9$\pm$6.8 및 26.1$\pm$5.9%이었다. 동결처리동안에 생존율은 예비동결 및 동결융해 후 가장 많은 정자사멸로 동결상태 이전의 생존율보다 유의적으로 낮게 나타났다. (p<0.05). 평가기법으로 정액 채취시 활력, NAR율 및 생존율을 조사한 결과 각각 91.0$\pm$4.2, 96.8$\pm$2.5 및 92.2$\pm$3.2%로 NAR율이 생존성 및 활력보다 높게 평가되었으며, 생존율이 활력보다 다소 높게 평가되었다. 그러나 동결융해 후에는 각각 44.0$\pm$8.9, 49.0$\pm$7.9 및 35.6$\pm$9.7%로 활력이 생존율보다 다소 높게 평가되었다. 전체적으로 NAR율은 활력은 생존율보다 높게 평가되었으며, SYBR-14 / PI(propidium iodide) 이중형광염색법에 의한 flow cytometric 평가법으로 생존율은 동결되지 않은 정액에서의 활력 및 NAR 평가보다 다소 민감하게 나타났다. 이러한 결과로 미루어보아 SYBR-14 / PI 형광염색에 의한 flow cytometry의 생존성 평가는 동결되지 않은 정액의 평가방법으로는 적절하지만 동결된 정액의 생존성 평가는 부적절한 것으로 사료되었다.

• Korean Journal of Agricultural Science
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• v.22 no.2
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• pp.163-169
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• 1995

This study was carried out to examine the genetic constitution of serum proteins and enzymes in Holstein Friesian cattle population. The genetic variants of post-transferrin-2(pTf-2), transferrin(Tf), post-albumin(pAlb), ceruloplasmin(Cp) and amylase-I(Am-I) were analyzed by using PAGE(polyacrylamide gel electrophoresis) and STAGE(starch gel electrophoresis). In serum proteins, the pTf-2 locus were observed to be controlled by codominant alleles designated F and S, and the distribution of genotypes were 76.34, 14.50 and 9.10% for pTf-2 FF, FS and SS types, respectively. The gene frequencies of the pTf-2 F and S allele were 0.836 and 0.164. The Tf locus were found to be controlled by four alleles, Tf A, D1, D2 and E at a single locus, and the distribution of genotypes were 6.11, 32.06, 19.08, 1.53, 10.69, 18.32, 9.92 and 2.29% for Tf AA, AD1, AD2, AE, D1D1, D1D2, D2D2 and D2E type, respectively. The gene frequencies of the Tf A, D1, D2 and E wee 0.321, 0.359, 0.298 and 0.019. The pAlb locus were identified to be genetically controlled by two alleles, pAlb F and S allele, and the distribution of genotypes were 32.06, 29.77 and 38.17% for pAlb FF, FS and SS types, respectively. The gene frequencies of the pAlb F and S allele were 0.461 and 0.531. The Alb locus were observed to be controlled by Alb A and B allele, and the gene frequencies of these were 0.996 and 0.004. In serum enzymes, the Cp locus were found to be controlled by F and S allele, and the distribution of genotypes were 46.57, 27.48 and 25.95% for Cp FF, FS and SS types, respectively. The gene frequencies of F and S allele were 0.603 and 0.394. The Am-I locus were observed to be controlled by Am-I B and C allele, and the distribution of genotypes were 39.69, 21.73 and 38.93% for Am-I BB, BC and CC types, the gene frequencies of Am-I B and C were 0.503 and 0.497, respectively.