• Journal of Ginseng Research
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• v.36 no.4
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• pp.375-382
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• 2012

Ginsenoside Rp1 (G-Rp1) is a saponin derivate that provides anti-metastatic activities through inhibition of the NF-${\kappa}B$ pathway. In this study, we examined the effects of G-Rp1 on regulatory T cell (Treg) activation. After treatment of splenocytes with G-Rp1, Tregs exhibited upregulation of IL-10 expression, and along with dendritic cells (DCs), these Tregs showed increased cell number compared to other cell populations. The effect of G-Rp1 on Treg number was augmented in the presence of lipopolysaccharide (LPS), which mimics pathological changes that occur during inflammation. However, depletion of DCs prevented the increase in Treg number in the presence of G-Rp1 and/or LPS. In addition, G-Rp1 promoted the differentiation of the memory types of $CD4^+Foxp3^+CD62L^{low}$ Tregs rather than the generation of new Tregs. In vivo experiments also demonstrated that Tregs and DCs from mice that were fed G-Rp1 for 7 d and then injected with LPS exhibited increased activation compared with those from mice that were injected with LPS alone. Expression of TGF-${\beta}$ and CTLA4 in Tregs was increased, and upregulation of IL-2 and CD80/CD86 expression by DCs affected the suppressive function of Tregs through IL-2 receptors and CTLA4. These data demonstrate that G-Rp1 exerts anti-inflammatory effects by activating Tregs in vitro and in vivo.

• International Journal of Industrial Entomology and Biomaterials
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• v.28 no.2
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• pp.51-57
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• 2014

Bumblebees are important pollinators of crops and wildflowers. The Korean native bumblebee, Bombus ignitus, undergoes one generation per year, and induction of artificial hibernation is essential for year-round rearing of the bumblebee. Keeping queens under cold treatment conditions for several mo is an effective method for terminating their diapause and promoting colony development. In the present study, we investigated how the timing and duration of chilling affect the artificial hibernation of B. ignitus queens. In the timing assessment, cold treatment was instituted at 12 d, 40 d, or 100 d after eclosion under a constant temperature of $5^{\circ}C$ and 80% humidity. The queens that entered cold treatment at 12 d after emergence evidenced the highest survival rates: 86.7% at two mo, 73.3% at three mo, and 46.4% at 4 mo. Survival rates were reduced under storage conditions at 12 d, 40 d, and 100 d after emergence. When queens were subjected to chilling at 8 d, 12 d, or 16 d after eclosion with constant 80% humidity, the queens stored at 12 d after eclosion exhibited the highest survival rates, which were 84.6 at one mo, 25.0% at two mo, and 7.9% at three mo. In regards to the duration of the cold period, the queens that hibernated for at least two mo evidenced optimal colony development rates. The rates of oviposition, colony foundation, and progeny-queen production of queens hibernated for two mo were 60.0%, 30.0%, and 13.3%, respectively. These values were 6.0 to 13.3 times higher than those in the queens that hibernated for 15 d. Therefore, a cold period of at least 2 mo applied 12 d after emergence were found to be the most favorable conditions for diapause break in B. ignitus queens.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.2
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• pp.79-86
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• 2020

To make a satisfactory decision regarding project scheduling, a trade-off between the resource-related cost and project duration must be considered. A beneficial method for decision makers is to provide a number of alternative schedules of diverse project duration with minimum resource cost. In view of optimization, the alternative schedules are Pareto sets under multi-objective of project duration and resource cost. Assuming that resource cost is closely related to resource leveling, a heuristic algorithm for resource capacity reduction (HRCR) is developed in this study in order to generate the Pareto sets efficiently. The heuristic is based on the fact that resource leveling can be improved by systematically reducing the resource capacity. Once the reduced resource capacity is given, a schedule with minimum project duration can be obtained by solving a resource-constrained project scheduling problem. In HRCR, VNS (Variable Neighborhood Search) is implemented to solve the resource-constrained project scheduling problem. Extensive experiments to evaluate the HRCR performance are accomplished with standard benchmarking data sets, PSPLIB. Considering 5 resource leveling objective functions, it is shown that HRCR outperforms well-known multi-objective optimization algorithm, SPEA2 (Strength Pareto Evolutionary Algorithm-2), in generating dominant Pareto sets. The number of approximate Pareto optimal also can be extended by modifying weight parameter to reduce resource capacity in HRCR.

• Korean Journal of Materials Research
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• v.25 no.1
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• pp.1-8
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• 2015

This study suggested comprehensive structural characterization methods for the commercial blue light emitting diodes(LEDs). By using the Z-contrast intensity profile of Cs-corrected high-angle annular dark field scanning transmission electron microscope(HAADF-STEM) images from a commercial lateral GaN-based blue light emitting diode, we obtained important structural information on the epilayer structure of the LED, which would have been difficult to obtain by conventional analysis. This method was simple but very powerful to obtain structural and chemical information on epi-structures in a nanometer-scale resolution. One of the examples was that we could determine whether the barrier in the multi-quantum well(MQW) was GaN or InGaN. Plan-view TEM observations were performed from the commercial blue LED to characterize the threading dislocations(TDs) and the related V-pit defects. Each TD observed in the region with the total LED epilayer structure including the MQW showed V-pit defects for almost of TDs independent of the TD types: edge-, screw-, mixed TDs. The total TD density from the region with the total LED epilayer structure including the MQW was about $3.6{\times}10^8cm^{-2}$ with a relative ratio of Edge- : Screw- :Mixed-TD portion as 80%: 7%: 13%. However, in the mesa-etched region without the MQW total TD density was about $2.5{\times}10^8cm^{-2}$ with a relative ratio of Edge- : Screw- :Mixed-TD portion of 86%: 5%: 9 %. The higher TD density in the total LED epilayer structure implied new generation of TDs mostly from the MQW region.

• Convergence Security Journal
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• v.2 no.1
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• pp.77-86
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• 2002

In this paper, we propose a segmentation algorithm that can reliably separate moving objects from noisy background in the image sequence received from a camera at the fixed position. Image segmentation is one of the most difficult process in image processing and an adoption in the change of environment must be considered for the increase in the accuracy of the image. The proposed algorithm consists of four process : generation of the difference image between the input image and the reference image, removes the background noise using the background nois modeling to a difference image histogram, then selects the candidate initial region using local maxima to the difference image, and gradually expanding the connected regions, region by region, using the shape information. The test results show that the proposed algorithm can detect moving objects like intruders very effectively in the noisy environment.

• Journal of Electrical Engineering and Technology
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• v.13 no.4
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• pp.1504-1514
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• 2018

The objective of this study is to compare the suitability of a non-parametric and 3 parametric distributions in the characterization of prediction intervals of photovoltaic power forecasts with high confidence levels. The prediction intervals of the forecasts are calculated using a method based on recent past data similar to the target forecast input data, and on a distribution assumption for the forecast error. To compare the suitability of the distributions, prediction intervals were calculated using the proposed method and each of the 4 distributions. The calculations were done for one year of day-ahead forecasts of hourly power generation of 432 PV systems. The systems have different sizes and specifications, and are installed in different locations in Japan. The results show that, in general, the non-parametric distribution assumption for the forecast error yielded the best prediction intervals. For example, with a confidence level of 85% the use of the non-parametric distribution assumption yielded a median annual forecast error coverage of 86.9%. This result was close to the one obtained with the Laplacian distribution assumption (87.8% of coverage for the same confidence level). Contrasting with that, using a Gaussian and Hyperbolic distributions yielded median annual forecast error coverage of 89.5% and 90.5%.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.13 no.4
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• pp.82-86
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• 1999

Electron Energy Distribution Function(EEDF) were treasured In Radio-Frequency Inductively Coupled Plasma(RFlCP) using a probe rrethocl Measurerrents were conducted in argon discharge for pressure from 10[mTorr] to 4O[mTorr] and input rf power from 100[W] to 600[W] and flow rate from 3[sccm] to 12[sccm]. Spatial distribution of electron energy distribution function were measured for discharge with same aspoct ratio (R/L=2). Electron energy distribution function strongly depended on both pressure and power. Electron energy distribution function increased with increasing flow rate. Radial distribution of the electron energy distribution function were peaked in the plasma center. Normal distribution of the electron energy distribution function were peaked in the center between quartz plate and substrate. From the results, we can find out the generation mechanism of Radio Frequency Inductively Coupled Plasma. And these results contribute the application of a simple Inductively Coupled Plasma(ICP).a(ICP).

• Journal of The Korean Society of Agricultural Engineers
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• v.52 no.1
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• pp.1-11
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• 2010

Generation and transportation of runoff and pollutant loads within watershed generated eutrophication at Daecheong reservoir. To improve water quality at Daecheong reservoir, the best management practices should be developed and applied at upper watersheds for water quality improvement at downstream areas. In this study, two small watersheds of upper Daecheong reservoir were selected. The Long-Term Hydrologic Impact Assessment (L-THIA) model has been widely used for the estimation of the direct runoff worldwide. To apply the L-THIA ArcView GIS model was evaluated for direct runoff and water quality estimation at small watershed. And the Web-based Hydrograph Analysis Tool (WHAT) was used for direct runoff separating from total flow. As a result, the $R^2$ (Coefficient of determination) value and Nash-Sutcliffe coefficient value for direct runoff comparison at An-nae watershed were 0.81 and 0.71, respectively. And the $R^2$ value and Nash-Sutcliffe coefficient value at Wol-oe were 0.95 and 0.93. The $R^2$ value of BOD, TOC, T-N and T-P at An-nae watershed were BOD 0.94, TOC 0.81, T-N 0.94 and T-P 0.89. And the $R^2$ value of BOD, TOC, T-N and T-P at Wol-oe watershed were BOD 0.80, TOC 0.93, T-N 0.86 and T-P 0.65. The result that estimated pollutant loadings using the L-THIA ArcView GIS model reflected well the measured pollutant loadings except for T-P in Wol-oe watershed. With L-THIA ArcView GIS model, the direct runoff and non-point pollutant (NPS) loadings in the watershed could be analyzed through simple input data such as daily rainfall, land uses, and hydrologic soil group.

• Korean Institute of Interior Design Journal
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• v.17 no.3
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• pp.86-93
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• 2008

The purpose of this study is to find out how the otherness philosophy reveals itself in the principle of F.O.A construction space creation. The traditional philosophy of totality is self-centered and thoughts are based on the subject. It couldn't escape from the world associated with the self, and has subordinated the other to the main body. But the philosophy of otherness transcends the subject, to the open, creative way of thinking which acknowledges deconstruction, decentralization, and non-hierarchy. This is very similar to contemporary architecture, which pursuits change, and also to the current state of society. In construction by the construction group F.O.A, which is doing notable activity this generation, there is an attempt to transcend the fixed subject which is seen in the otherness discussion, and realize recategorization by overcoming the boundaries of subject and object. First, by the realization of landscape architecture using a topographical folding technique, boundaries of the subject and object are demolished in the relationship of the landscape construction, and recategorization. Second, by breaking up the meaning of the surface which is a visual and physical boundary for both the internal and external, recategorization is being done. Third, by making the boundary between the interior and exterior indistinct, cognitive threshold is dissolved, and the relationship between the subject and object is being recategorization. In conclusion, we can see that the many recategorization phenomenons that are happening in the F.O.A construction show the otherness that escapes from the conventional and stationary relationship, and recognizes each other at the same time, forming new relationships.

• Korean Journal of Pharmacognosy
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• v.46 no.2
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• pp.109-115
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• 2015

This study was investigated the radical scavenging effect and the protective activity of caffeic acid (CA) against oxidative stress. CA showed strong 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and hydroxyl radical ( OH) scavenging activity, showing 42.00% and 87.22% at 5 μM concentration of DPPH and ·OH scavenging activity, respectively. Furthermore, we studied protective activity of CA from amyloid beta (A${\beta}$_25-35) and lipopolysaccharide (LPS) induced neuronal cell damage and neuronal inflammation using C6 glial cells. The treatment of A${\beta}$_25-35 to C6 glial cell showed declines in cell viability and high generation levels of reactive oxygen species (ROS). However, the treatment of CA increased cell viability. The treatment of 5 ${{\mu}M}$ CA led to the elevation of cell viability from 59.28% to 81.22%. In addition, the production of ROS decreased cellular levels of ROS by the treatment of CA. The treatment of LPS to C6 glial cells increased significant elevation of nitric oxide (NO) production, while CA decreased NO production significantly. The production of NO increased by the treatment of LPS to 131.08%, while CA at the concentration of 1 ${{\mu}M}$ declined the NO production to 104.86%. The present study indicated thatCA attenuated A${\beta}$_25-35-induced neuronal oxidative stress and inflammation by LPS, suggesting as a promising agent for the neurodegenerative diseases.