• Proceedings of the KSR Conference
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• 2011.10a
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• pp.556-562
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• 2011

Railroad started from invention of stream locomotive at the beginning of the industrial revolution. Development of diesel and electric locomotives in railroad induced science and technology since the industrial revolution. Korean high-speed train so-called high-speed train project, is localized 86.7%(compared to price), 92%(compared to number of parts). This technology has been contributed to KTX since 2004. High-speed railway was developed to integrated system, which is contained high technology such as civil, mechanical and electrical technology. This effects to advanced technology across the board science, technology, industry. High-speed railway is fast, safe, comfortable, eco-friendly as next generation's representative transportation. Furthermore it is inaugurate the era of the new railroad. Korea is opened the high-speed railway following Japan, France, Germany, Spain. Korea became the fifth nation of the high-speed railway. It joins the rank of developed countries operating at the speed of 300km/h. Especially, KTX is emerging as advanced transportation with reducing logistics costs significantly due to time advantage and transportation revolution. The purpose of this study is to present the strategy through internal and external railway market's analysis for Korea railway system's globalization expansion(overseas expansion).

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.10
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• pp.1421-1423
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• 2003

Cross fertility between wild Japanese quail and domestic quail was explored in an experiment conducted on 18（3♂, 15♀）wild Japanese quails in Weishan Lake area, 18（3♂, 15♀）medium-sized domestic quails and 18（3♂, 15♀）pint-sized domestic quails, which were divided into nine groups. This study demonstrated that wild quail could succeed in crossing with domestic quail,producing fertilized eggs and hatching first filial generation. The findings indicated that there were no reproduction isolation between the wild Japanese quail and domestic quail, and that the best cross combination was between wild male quail and medium-sized domestic female quail, in which the fertility rate and hatchability of fertilized eggs amounted to 42.86% and 29.63% respectively. Based on the results, a new way could be adopted to protect, exploit and utilize genetic resources of wild quail.

• Genomics & Informatics
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• v.15 no.4
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• pp.136-141
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• 2017

Accurate detection of genomic alterations, especially druggable hotspot mutations in tumors, has become an essential part of precision medicine. With targeted sequencing, we can obtain deeper coverage of reads and handle data more easily with a relatively lower cost and less time than whole-exome or whole-genome sequencing. Recently, we designed a customized gene panel for targeted sequencing of major solid cancers. In this study, we aimed to validate its performance. The cancer panel targets 95 cancer-related genes. In terms of the limit of detection, more than 86% of target mutations with a mutant allele frequency (MAF) <1% can be identified, and any mutation with >3% MAF can be detected. When we applied this system for the analysis of Acrometrix Oncology Hotspot Control DNA, which contains more than 500 COSMIC mutations across 53 genes, 99% of the expected mutations were robustly detected. We also confirmed the high reproducibility of the detection of mutations in multiple independent analyses. When we explored copy number alterations (CNAs), the expected CNAs were successfully detected, and this result was confirmed by target-specific genomic quantitative polymerase chain reaction. Taken together, these results support the reliability and accuracy of our cancer panel in detecting mutations. This panel could be useful for key mutation profiling research in solid tumors and clinical translation.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.04a
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• pp.129-132
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• 2000

The PDP(Plasma Display Panel) barrier rib material on the glass substrate was patterned for fabrication of the PDP cell using Nd:YAG laser(1064 nm) which can generate the second(532 nm) and forth(266 nm) harmonic wave by HGM(harmonic generation modules). At a scan speed of 20 ${\mu}m/s$ with the second harmonic wave(532 nm) of Nd:YAG laser, the etching threshold laser fluence of the PDP material was 6.5 $mJ/cm^2$ and a sample(thickness = 180 ${\mu}m$) on the glass substrate was removed clearly at a laser fluence of 19.5 $mJ/cm^2$. In order to increase the throughput of the fabrication we divided a single-beam into multi-beams by using a metal mask between the sample and the focusing lens. As a result, 10 lines of PDP cell were formed by one laser beam scanning at a scan speed of 200 ${\mu}m/s$ and a laser fluence of 2.86 $J/cm^2$.

• Journal of Life Science
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• v.18 no.2
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• pp.175-179
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• 2008

Cornus controversa is a long-lived woody species mostly distributed in East Asia. Random amplified polymorphic DNA (RAPD) markers were used to investigate the genetic diversity and population structure of Korean populations of this species. A high level of genetic variation was found in seven populations of C. controversa. The mean genetic diversity (H) was 0.222 across populations, varying from 0.200 to 0.238. Eighty of the 93 loci (86.0%) showed detectable polymorphism in at least one population. Total genetic diversity values ($H_T$) varied between 0.192 and 0.231, giving an average overall polymorphic loci of 0.212. The interlocus variation of genetic diversity within populations ($H_S$) was high (0.167). Mean of genetic diversity in C. controversa was higher than average values for species with similar life history traits. The sexual reproduction, perennial habitat, and longevity are proposed as possible factors contributing to high genetic diversity. On a per locus basis, the proportion of total genetic variation due to differences among populations ($G_{ST}$) ranged from 0.169 to 0.278 with a mean of 0.216, indicating that about 21.6% of the total genetic variation was among populations. An indirect estimate of the number of migrants per generation (Nm=1.893) indicated that gene flow was extensive among Korean populations of C. controversa.

• Journal of the Korean Society of Fashion and Beauty
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• v.4 no.4 s.10
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• pp.81-86
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• 2006

Numerous novel ingredients have been introduced for the hight functionality of whitening cosmetics. Tough the preliminary research, we have found water extracts Bombyx mori have high whitening efficacy. The results of the research for the whitening effect of Bombyx Mori L. are as follow 1. Bombyx Mori L. inhibited concentration dependently the generation of melanin increased by the stimulation of $\alpha$-MSH and protoporphyrin IX, and $IC_{50}$ value was 8.3, 9.2 ${\mu}M$ respectively. 2. Melanin increased by the stimulation of $\alpha$-MSH and protoporphyrin IX was five to seven times superior in the inhibiting effect, compared with kojic acid used as positive control group. 3. Bombyx Mori L. did not have a decolorizing effect on melanin already generated. 3. Bombyx Mori L. was observed to have toxicity of over 100 ${\mu}M$ for the mouse melanoma B16 cells. Therefore, These results suggest that water extracts of Bombyx mori have inhibitory activity against mushroom tyrosinase and inhibitory activity of melanin synthesis in B16 melanoma cells in vitro.

• Korean Journal of Human Ecology
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• v.9 no.2
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• pp.223-230
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• 2000

The survey was conducted by using questionnaires in order to investigate the expectation of over middle aged people on dietary living during their elderly life. Many persons(41.9%) anticipate that some kind of change will happen in dietary living during their elderly life. They are willing to prepare their own meals by themselves (73.5% of male and 86.6% of female). It is expected that they prefer various kinds of foods, korean traditional foods, home-made foods, natural food to processed food, and nutritionally balanced foods. The balance of nutrition and easiness of digestion should be primarily considered as a base of food choice, and then taste or convenience. The result of this study indicates that korean traditional food culture can not be easily changed. If food industries had a plan to produce some items for future silver generation, they should make efforts to develop processed foods considered the nutrition and digestibility, natural foods packed conveniently for home-cooking, and food preparation equipment used easily by elderly people.

• Journal of The Korean Society of Agricultural Engineers
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• v.52 no.5
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• pp.77-86
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• 2010

Hydrologic Simulation Program-Fortran (HSPF) coupled with PEST which is optimization program was calibrated and validated at Bochung watershed by using monitoring data of water quantities and nutrient loading. Although the calibrated data were limited, model parameters of each land use type were optimized and coefficient of determinations were ranged from 0.94 to 0.99 for runoff, from 0.89 to 1.00 for TN loading, and from 0.92 to 1.00 for TP loading. The optimized hydrological parameters indicated that the forested land could retain rainfall within soil layer with high soil layer depth and infiltration rate compared with other land use type. Hydrological characteristics of paddy rice field are low infiltration rate and coefficient of roughness. The calibrated parameters related to nutrient loading indicated generation of nutrient pollution from agricultural area including upland and paddy rice field higher than other land use type resulting from fertilizer application. Overall PEST program is useful tool to calibrate HSPF automatically without consuming time and efforts.

• Asian Journal for Public Opinion Research
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• v.2 no.1
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• pp.15-31
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• 2014

This descriptive study evaluated the satisfaction in daily life of Thai people according to participants' socioeconomic characteristics. The accidental sample included 676 Thai people aged 20 and older who lived in Bangkok and urban Saraburi. The satisfaction in daily life questionnaire (${\alpha}=0.86$) was used to collect data. The ranking for each aspect of daily life satisfaction arranged from high to low are: family life (mean=3.39), human relations, housing, food, job, health, and income (mean=2.99). Females were found to have a significantly higher satisfaction with daily life than males (mean=22.81 vs. 21.91). Those who lived in Saraburi province were found to have a higher satisfaction with daily life than those in Bangkok. Married participants, participants age 50-59, participants from two-generation households of parents and unmarried children, participants who stated that they took better care of their health now compared to one year ago, and participants who consulted a doctor in the past month were found to have higher satisfaction with daily life than their counterparts.

• YAKHAK HOEJI
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• v.48 no.4
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• pp.219-225
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• 2004

The present investigation was undertaken to examine the anticancer activity of the methanol extract from Houttuynia cordata on ICR mouse with induced abdominal cancer and L1210 cancer cells. When the methanol extract of Houttuynia cordata (10∼200 $\mu\textrm{g}$/$m\ell$) was administered orally to ICR mouse with abdominal cancer, 47.8% of the best life prolonging effect was obtained. In case of cytotoxicity study (inhibition of cell proliferation) of Houttuynia cordata extract against L1210 cells, $IC_{50}$/ was found to be 62.8 $\mu\textrm{g}$/$m\ell$. In contrast to such considerable toxicity against cancer cell line, the toxicity demonstrated by the identical extract against normal lymphocytes was very meagre as shown to be < 5% compared with 86.5% in case of L1210 cells at the same condition. To get an insight into the reaction mechanism undelying the anticancer activity, $O_2$ion quantity and antioxidant enzyme activities such as superoxide dismiutase (SOD) and glutathione peroxidase (GPx) of L1210 cells in the presence of Houttuynia cordata extract were measured. The increased values of SOD and GPx enzyme activities in addition to the augmented generation of $O_2$ ion in L1210 cells implied that the reactive oxygen species induding $O_2$ion which were presumably induced by Houttuynia cordata extract might have participated in the process of L1210 cells cytotoxicity.