• Title/Summary/Keyword: 8-aryloxycaffeine

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Synthesis of 8-Aryloxycaffeines and Their Inhibitory Activities on Topoisomerase II (8-아릴옥시카페인의 합성과 그 Topoisomerase II 저해활성)

  • Rahman, A.F.M. Motiur;Jahng, Yurng-Dong
    • YAKHAK HOEJI
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    • v.55 no.6
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    • pp.441-445
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    • 2011

  • A series of 8-(substituted)aryloxy- and 8-alkyloxy-caffenines were prepared from 8-bromocaffeine and (substituted) phenols as well as alkanols by Ullmann reaction and their inhibitory activities on topoisomerase II were evaluated. A compound, 8-(quinolin-2-yl)oxycaffeine showed the strongest inhibitory activity against topoisomerase II.

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