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Synthesis of 8-Aryloxycaffeines and Their Inhibitory Activities on Topoisomerase II  

Rahman, A.F.M. Motiur (College of Pharmacy, King Saud University)
Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University)
Publication Information
YAKHAK HOEJI / v.55, no.6, 2011 , pp. 441-445 More about this Journal
Abstract
A series of 8-(substituted)aryloxy- and 8-alkyloxy-caffenines were prepared from 8-bromocaffeine and (substituted) phenols as well as alkanols by Ullmann reaction and their inhibitory activities on topoisomerase II were evaluated. A compound, 8-(quinolin-2-yl)oxycaffeine showed the strongest inhibitory activity against topoisomerase II.
Keywords
caffeine; 8-bromocaffeine; 8-aryloxycaffeine; Ullmann reaction; topoisomerase II;
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