• 한국임상약학회지
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• 제26권4호
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• 한국지리정보학회지
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• 제20권3호
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• pp.141-152
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• 2017

본 연구는 계측자료가 부족한 유역을 대상으로 위성강우 활용 및 위성강우의 보정방법을 통해 홍수량 추정의 기술적인 방법을 제시하는 것을 목적으로 하였다. 연구대상유역은 모로코 세부강 유역을 대상으로 하였다. 세부강 유역 홍수량 추정을 위한 모형은 IFAS(Integrated Flood Analysis System)와 GRM(Grid baed Rainfall-Runoff Model)을 이용하였다. 연구 유역에 대한 강우자료는 일일관측의 지상계측 자료와 시간계측 위성강우자료를 이용하였다. 위성강우를 이용한 홍수분석에서 일일 지상계측 강우량과 위성강우의 시간계측 자료를 합성하여 위성강우자료를 수정하였다. 지형자료는 90m 공간해상도의 Shuttle Radar Topographic Mission DEM(SRTM DEM)과, 1km 공간해상도의 Global map의 토지피복도와 US Food and Agriculture Organization(US FAO)의 Harmonized World Soil Database(HWSD) 토양도를 이용하였다. 과소추정되는 위성강우는 지상계측 자료를 활용하여 보정하였다. 수정된 위성강우를 이용한 유출분석에서는 첨두유출량이 IFAS는 $5,878{\sim}7,434m^3/s$, GRM은 $6,140{\sim}7,437m^3/s$의 유출이 발생하는 것으로 분석되었다. 그러므로 2009~2010년에 발생한 세부강 유역의 첨두홍수량은 $5,800m^3/s$에서 $7,500m^3/s$의 범위에서 발생한 것으로 추정되었다. 보정된 위성강우를 활용한 홍수량 추정결과는 두 모형 모두 유사한 홍수량을 나타내었다. 따라서 본 연구에서 제시한 위성강우의 보정기법은 계측자료가 부족한 지역의 적정 홍수량 추정에 적용될 수 있을 것으로 사료된다.

• 한국방재안전학회논문집
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• 제16권4호
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• pp.61-66
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• 2023

본 연구에서는 2020년 9월 태풍 마이삭·하이선으로 인한 침수가 일어난 삼척중학교 주변을 분석하였다. 삼척 오십천과 소하천인 등 봉천 합류 지점의 침수특성을 분석하기 위해 2차원 수리 모형인 Iber를 적용하였다. 연구에서는 2020년 9월 3일과 9월 7일의 최대유량 및 80년, 100년 빈도 홍수량을 기반으로 침수 깊이와 침수 범위를 모의하였다. 모의 결과, 9월 7일에는 80, 100년 빈도 홍수량에서 미미한 차이를 나타냈으나, 9월 3일에서 9월 7일에 최대 유량 차이가 401 m³/s로 나타나 침수 깊이에서는 0.8 m, 침수 범위에서는 7.1 m²의 상당한 차이를 보였다 또한, DEM을 이용한 등고선만을 고려한 분석에서는 삼척중학교 운동장뿐만 아니라 건물까지 침수가 예측되어 고정밀 지형자료인 DSM의 적용이 필요함을 확인하였다.

• Journal of Advanced Marine Engineering and Technology
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• 제38권7호
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• pp.821-827
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• 2014

본 연구에서는 FC-72를 작동유체로 사용하여 병렬 마이크로 채널에서의 2상 유동 마찰 압력 강하를 예측하기 위한 실험적 연구를 수행하였다. 병렬 마이크로 채널은 깊이 0.2 mm, 폭 0.45 mm, 길이 60 mm의 15개의 마이크로 채널로 구성되었으며, 실험은 질량유속 $152.2{\sim}584.2kg/m^2s$, 열유속 $7.5{\sim}28.3kW/m^2$ 범위에서 이루어졌다. 실험에서 얻어진 자료는 기존의 마찰 압력 강하를 예측하기 위한 상관식들과 비교 분석하였다. 기존의 상관식은 일반적으로 균질 모델과 분리류 모델을 사용한다. 본 연구에서는 분리류 모델을 사용한 기존의 상관식을 수정하여 새로운 상관식을 제안하였으며, 그 결과 Mean Absolute Error 9.6%내에서 실험 결과를 잘 예측하였다.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2001년도 학술발표회 발표논문집
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• pp.93-98
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• 2001

This study was performed to analyse the rainfall and the rainfall-runoff characteristics of a rural watershed. The Sangwha basin($105.9km^{2}$) in the Geum river system was selected for this study. The arithmetic mean method, the Thiessen's weighing method, and the isohyetal method were used to analyse areal rainfall distribution and the Huff's quartile method was used to analyse temporal rainfall distribution. In addition, daily runoff analyses were peformed using the DAWAST and tank model. In the model calibration, the data from June through November, 1999 were used. In the model calibration, the observed runoff depth was 513.7mm and runoff rate was 45.2%, and the DAWAST model simulated runoff depth was 608.6mm and runoff rate was 53.5%, and the tank model runoff depth was 596.5mm and runoff rate was 52.5%, respectively. In the model test, the data from June through November, 2000 were used. In the model test, the observed runoff depth was 1032.3mm and runoff rate was 72.5%, and the DAWAST model simulated runoff depth was 871.6mm and runoff rate was 61.3%, and the tank model runoff depth was 825.4mm and runoff rate was 58%, respectively. The DAWAST and tank model's $R^{2}$ and RMSE were 0.85, 3.61mm, and 0.85, 2.77mm in 1999, and 0.83, 5.73mm, and 0.87, 5.39mm in 2000, respectively. Both models predicted low flow runoff better than flood runoff.

• 디지털융복합연구
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• 제15권3호
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• pp.157-163
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• 2017

항만 물동량 예측은 항만관리 기관의 투자계획에 매우 중요한 요소이다. 더불어 최근 항만은 물동량 유치를 위한 치열한 경쟁을 이어가고 있기 때문에 항만 정책수립에 있어 국내외 주요국의 물동량 예측은 중요한 의미를 갖는다. 항만 물동량 예측이 항만의 개발정책에 매우 중요하지만 최적의 물동량 예측 모델 개발에는 아직 어려움을 겪고 있다. 이러한 측면에서 본 연구는 중국 컨테이너 물동량 예측모델 제시를 연구의 목적으로 하였다. 중국 컨테이너 물동량 예측은 Clarkson's Shipping Intelligence Network를 통해 수집한 2004년 1월부터 2015년 12월까지 12년간의 월간 데이터를 System Dynamics를 사용하여 2004년부터 2020년까지 변화를 시뮬레이션 하였다. 실제 중국 컨테이너 물동량 데이터와 Stock-flow 다이어그램을 통해 도출된 예측값을 비교하여 모델의 정확도를 검증했다. 검증결과 수 출입 컨테이너 예측모델은 MAPE값이 각각 6.21 %, 7.68 %로 나타나 정확한 예측모델로 확인되었다.

• Journal of Information Science Theory and Practice
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• 제7권4호
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• pp.6-19
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• 2019

The purpose of this article is to problematize the existence of a possible Ibero-American informational thinking. It was initially observed that a relative absence of Ibero-America in the international presentations and mappings of information science exists. Below, the reality of the 22 countries that compose Ibero-America is discussed, a region that can be understood from a sociocultural and geopolitical perspective. Then, a mapping of the information science research in these countries is made. The main research topics found are: epistemological studies, relationships with library science, information literacy, representation and organization, bibliometric studies, information management, user studies, technological dimensions, and relationships with archival science and museum studies. Finally, a general epistemological configuration of information science is presented at a global level, highlighting the great trends of study of information that marked the decades of the 1960s and 1970s (physical model), 1980s and 1990s (cognitive model), and the 21st century (sociocultural model), and which manifested themselves in the different subareas that make up the field. The most recent research in information science, in addition to addressing information transfer (physical dimension) and its relationship with data and knowledge (cognitive dimension), has also incorporated aspects related to the social effects of information, its role in the constitution of identities and culture, and the importance of its material conformations. Such expansion reflects attempts to address the complexity of informational phenomena. Therefore, it is concluded that it is important to place the specific contributions of Ibero-America in this context.

• 대한기계학회논문집A
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• 제20권7호
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• pp.2159-2166
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• 1996

The stochastic properties of variation in fatigue crack growth are important in reliability and stability of structures. In this study,the stochastic model for the variation of fatigue crack growth rate was proposed in consideration of nonhomogeneity of materials. For this model, experiments were ocnducted on 7075-T6 aluminum alloy under the constant stress intensity factor range. The variation of fatigue crack growth rate was expressed by random variables Z and r based on the variation of material coefficients C and m in the paris-Erodogan's equation. The distribution of fatigue life with respect to the stress intensity factor range was evaluated by the stochastic Markov chain model based on the Paris-Erdogan's equation. The merit of proposed model is that only a small number of test are required to determine this this function, and fatigue crack growth life is easily predicted at the given stress intensity factor range.

• The Journal of Asian Finance, Economics and Business
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• 제7권11호
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• pp.83-93
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• 2020

This empirical research aims to modeling and improving the forecasting accuracy of the volatility pattern by employing the Saudi Arabia stock market (Tadawul)by studying daily closed price index data from October 2011 to December 2019 with a number of observations being 2048. In order to achieve significant results, this study employs many mathematical functions which are non-linear spectral model Maximum overlapping Discrete Wavelet Transform (MODWT) based on the best localized function (Bl14), autoregressive integrated moving average (ARIMA) model and generalized autoregressive conditional heteroskedasticity (GARCH) models. Therefore, the major findings of this study show that all the previous events during the mentioned period of time will be explained and a new forecasting model will be suggested by combining the best MODWT function (Bl14 function) and the fitted GARCH model. Therefore, the results show that the ability of MODWT in decomposition the stock market data, highlighting the significant events which have the most highly volatile data and improving the forecasting accuracy will be showed based on some mathematical criteria such as Mean Absolute Percentage Error (MAPE), Mean Absolute Scaled Error (MASE), Root Means Squared Error (RMSE), Akaike information criterion. These results will be implemented using MATLAB software and R- software.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 춘계학술발표회 논문집(I)
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• pp.186-189
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• 2006

Since the columns with flexure-shear failure have lower ductility than those with flexural failure, shear capacity curve models shall be applied as well as flexural capacity curve in order to determine ultimate displacement for seismic design or performance evaluation. In this paper, a proposed modified shear capacity curve model is compared with the other models such as the CALTRANS model, Aschheim et al.'s model, and Priestley et al.'s model. Four shear capacity curve models are applied to the 4 full scale and 7 small scale circular bridge column test results and the accuracy of each model is discussed. It may not be fully adequate to drive a final decision from the application to the limited number of test results, however the proposed model provides the better prediction of failure mode and ultimate displacement than the other models for the selected column test results.