• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2010년도 춘계학술발표논문집 2부
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• pp.766-768
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• 2010

폴리리듬 7 against 3 는 "기존의 3개의 동일한 길이의 음표가 진행하는 시간동안 7개의 동일한 길이의 음표가 동시에 연주되는 폴리리듬 이다"라고 간단히 설명할 수 있다. 이러한 폴리리듬 7 against 3를 실제로 연주하는 것은 쉽지 않다. 그러나 그 느낌이 어떠한 지는 본 연구에서 다루려고 하는 가상리듬을 통하여 알 수 있다. 본 연구에서는 7 against 3 에 대한 몇 가지 가상 리듬을 단계별로 제시하고 그 새로운 가능성에 대하여 생각해 보았다.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2012년도 춘계학술논문집 1부
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• pp.10-13
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• 2012

본 연구에서는 그 동안의 '7 시리즈 폴리리듬' 연구의 연장선상에서 폴리리듬 7 against 5를 다루려고 한다. 폴리리듬 7 against 5는 "기존의 5개의 동일한 길이의 음표가 진행하는 시간동안 7개의 동일한 길이의 음표(혹은 7개의 동일한 일련의 음표집합)가 동시에 연주되는 폴리리듬 이다"라고 간단히 설명할 수 있을 것이다. 이러한 폴리리듬 7 against 5 를 실제로 연주하는 것은 그 동안의 7 against 3나 7 against 4의 연구에서 살펴보았듯이 결코 쉽지 않다. 그러나 그 대략의 느낌이 어떠한 지는 본 연구에서 다루려고 하는 가상리듬을 통하여 알 수 있다. 본 연구에서는 7 against 5에 대한 간단한 가상리듬을 제시하고 그 의미와 새로운 가능성을 살펴보았다.

• 대한수의학회지
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• 제23권2호
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• pp.199-203
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• 1983

The anthelmintic efficiency of nitroxynil(Trodax) at a dose rate of 10mg/kg was tested in naturally infected Korean native goat (Black goat) against Fasciola hepatica, Eurythrema pancreaticum, and Paramphistomum sp. The drug was administered with injection subcutaneouslly and the efficiency was measured by faecal examination microscopically. The results obtained were summarized as follows: 1. The anthelmintic efficiency of nitroxynil against Fasciola hepatica was shown 33.3% on day 7, 88.9% on day 14 and 94.4% on day 28 after the administration of the drug, respectively. The reduction rates of egg per gram of faeces (E. P. G.) against Fasciola hepatica in faecal examination were shown 86.8% on day 7, 97.7% on day 14, and 99.7% on day 28 postmedication. 2. The anthelmintic efficiency of nitroxynil against Paramphistomum sp. was shown 0% on day 7, 10.5% on day 14, and 36.8% on day 28 after the administration of drug. The reduction rates of E. P. G. against the parasite were shown 13.2% on day 14, and 39.4% on day 28 postmedication. 3. The anthelmintic efficiency of nitroxynil against Eurythrema pancreaticum was shown 0% on day 7, 16.6% on day 14, and 25% on day 28 after the administration of the drug.

• Archives of Pharmacal Research
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• 제27권5호
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• pp.507-511
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• 2004

From the flowers of Chromolaena odorata (Eupatorium odoratum) four flavanones, isosakuranetin (5,7-dihydroxy-4'-methoxyflavanone) (1), persicogenin (5,3'-dihydroxy-7,4'-dimethoxyflavanone) (2), 5,6,7,4'-tetramethoxyflavanone (3) and 4'-hydroxy-5,6,7-trimethoxyfla-vanone (4), two chalcones, 2'-hydroxy-4,4',5',6'-tetramethoxychalcone (5) and 4,2'-dihydroxy-4',5',6'-trimethoxychalcone (6), and two flavones, acacetin (5,7-dihydroxy-4'-methoxyflavone) (7) and luteolin (5,7,3',4'-tetrahydroxyflavone) (8) were isolated and identified. Compound 1 exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis with the MIC value of 174.8 $\mu$M, whereas compounds 4,7, and 8 exhibited weak activity with the MIC values of 606.0, 704.2 and 699.3 $\mu$M respectively. Compound 7 showed moderate cytotoxicity against human small cell lung cancer (NCI-H187) cells with the MIC value of 24.6 $\mu$M, whereas compound 8 exhibited moderate toxicity against NCI-H187 cells and week toxicity against human breast cancer (BC) cells with the MIC values of 19.2 and 38.4 $\mu$M respectively.

• 약학회지
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• 제38권6호
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• pp.677-682
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• 1994

A number of 7-[3-hydroxy-(4-methylthio or 3-methylthiomethyl)pyrrolidinyl]quinoline-3-carboxylic acids were synthesized by condensation of 7-fluoro substituted quinoline-3-carboxylic acid with 3-hydroxy-4-methylthiopyrrolidine or 3-hydroxy-4-methylthiomethylpyrrolidine. The in vitro antimicrobial activity of them were tested against twenty species of Gram-positive or Gram-negative microorganisms. It showed remarkable antibacterial activity, particularly against Gram-positive microorganisms. Among those 1-cyclopropyl-5-amino-6,8-difluoro 7-(3-hydroxy-4-methylthiomethylpyrrolidinyl)-1,4-dihyd ro-4-oxo-3-quinolinecarboxylic acid(12d) and 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-hydroxy-4-methylthiometby1pyrrolinyl)-1,4-dihydro-4-oxo-3-quinolinocarboxylic acid(12g) showed the most potent in vitro antibacterial activity, and 12d showed better antibacterial activity against MRSA compared to ciprofloxacin and sparfloxacin.

• 약학회지
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• 제37권2호
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• pp.136-142
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• 1993

To a suspension of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-{3,7-diazabicyclo[3.3.0]oct-1(5)-en-3-yl}-4-oxo-3-quinoline carboxylic acid(C1) in sodium hydroxide solution and water is added dropwise with stirring carbon disulfide. [6R-[6$\alpha$, 7$\beta$(Z)]]-7-[[[2-Amino-4-thiazoly)methoxyimino]-acetyl]amino]-3-[[[[7-( 3-carboxy-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-guinolonyl)-3,7-diazabicyclo[3.3.0]oct-1(5)-en-3-yl]thioxomethyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (DACD) was synthesized from 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[7-(mercapto) thioxomethyl-[3,7-dia zabicyclo[3.3.0]oct-1(5)-en-3-yl}]-4-oxo-3-quinoline carboxylic acid disodium salt(C2) and cefotaxime. The invitro activity of novel dual-action cephalosporin, DACD, was compared with the in vitro activities of CENO(cefotaxime 3'-norfloxacin dithiocarbamate), cefotaxime, and norfloxacin against a variety of bacterial species. In vitro activity of DACD was superior to that of norfloxacin against Streptococcus pyogenes. Against Gram-positive and Gram-negative bacteria, its activity was almost equal to that of CENO.

• Bulletin of the Korean Chemical Society
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• 제30권2호
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• pp.435-440
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• 2009

19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a~2l, 3a~3g were synthesized and preliminarily evaluated in vitro against influenza virus $A_3$,B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus $A_3\;(TC_{50}\;=\;120.6\;{\mu}mol/L,\;IC_{50}=\;19.2\;{\mu}$mol/L, SI = 6.3) and B (T$C_{50}\;=\;120.6\;{\mu}mol/L,\;IC_{50}=\;29.9\;{\mu}$mol/L, SI = 4.0); 2g was more active against influenza $A_3$ virus at very low cytotoxicity ($TC_{50}\;>\;2092.1\;{\mu}mol/L,\;IC_{50}=\;143.7\;{\mu}mol/L,$ SI > 14.6) than the parent compound; Compounds 2b, 2c, 2f showed higher activities both against HSV-1 and HSV-2 than that of the parent compound, and 2f was the most potent inhibitor of HSV-1 ($TC_{50}\;=\;200.0\;{\mu}mol/L,\;IC_{50}\;=\;11.3\;{\mu}mol$/L, SI = 17.7 ) and HSV-2 ($TC_{50}\;=\;200.0\;{\mu}mol/L,\;IC_{50}\;=\;20.7\;{\mu}mol$/L , SI = 9.7).

• 동아시아식생활학회지
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• 제14권3호
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• pp.288-293
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• 2004

This study was carried out to determine the antimutagenic and anticancer effects of fermented soybean using Ames test and cytotoxicity, respectively. The ethyl acetate fraction (200 g/plate) of fermented soybean in the Salmonella typhimurium TA100 strain showed 86.6% of inhibition rate against the mutagenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG). In addition, the suppression of ethyl acetate fraction with same concentration of fermented soybean in the Salmonella typhimurium TA98 and TAI00 strains showed 82.4% and 90.8% inhibition against 3-amino-l,4-dimethyl-5H-pyrido-(4,3-b)indol (Trp-P-l), respectively. The cytotoxicity effects of fermented soybean against the cell lines with human lung carcinoma (A549), human gastric carcinoma (AGS) and human breast adenocarcinoma (MCF-7) were inhibited with the increase of the extract concentration. The treatment of 1.0 mg/mL ethyl acetate fraction of fermented soybean showed strong cytotoxicities of 71.6%, 91.5% and 80.7% against A549, AGS and MCF-7, respectively.

• Journal of Applied Biological Chemistry
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• 제61권3호
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• pp.239-243
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• 2018

쌀바구미 및 어리쌀바구미에 대한 고수 종자에서 추출한 정유의 살충활성을 비교하기 위하여 3가지 추출법(수증기증류, 용매 및 초임계 추출법)을 통해 정유를 추출하였다. 용매 및 초임계 추출법으로 추출한 정유는 쌀바구미 및 어리쌀바구미에 대해 살충효과를 나타내지 않은 반면에 수증기증류 추출법으로 추출한 정유는 쌀바구미 및 어리쌀바구미에 대하여 살충효과를 나타내었다. 고수종자의 수증기증류 추출법으로 추출한 정유를 GC-MS를 통해 분석한 결과 linalool (59.92%)이 가장 많은 함량을 나타내었으며, 그 다음으로 camphor (7.94%), linalool oxide (7.70%), p-cymene (7.44%), ${\alpha}-pinene$ (6.44%), limonene (3.29%), geranyl acetate (3.19%)의 순으로 함량 차이를 나타내었다. 이들 중 camphor와 linalool은 쌀바구미 및 어리쌀바구미에 대해 가장 우수한 살충활성을 나타내었으며, 나머지 성분들은 살충활성을 나타내지 않았다. 본 연구결과는 고수종자의 수증기증류 추출법에 의한 정유와 구성성분인 camphor 및 linalool이 저곡해충에 대한 살충제로서의 잠재력을 지니고 있는 것을 보여준다.

• 공업화학
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• 제35권3호
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• pp.248-254
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• 2024

본 연구에서는 전나무와 잣나무 잎으로부터 항균특성을 갖는 기능성 물질을 추출한 후 반응표면분석법 중 중심합성 계획법(CCD-RSM)을 이용하여 최적화하였다. 최적 추출 조건은 전나무의 경우 추출온도(59.5 ℃)와 주정/초순수 부피비(69.5 vol.%)이었으며, 이때 반응치는 추출수율(13.5%), 대장균 억제직경(11.6 mm), 황색포도상구균 억제직경(9.3 mm)로 산출되었다. 또한 잣나무의 경우에는 최적 추출조건인 추출온도(59.2 ℃)와 주정/초순수 부피비(67.8 vol.%)에 서 추출수율(4.8%), 대장균 억제직경(7.9 mm), 황색포도상구균 억제직경(12.5 mm)로 산출되었다. 각 천연물의 최적조건에서 실제 실험 결과 전나무 잎의 추출수율은 13.0%, 대장균 억제직경은 11.7 mm, 황색포도상구균 억제직경은 9.2 mm로 약 ± 2.30% 오차율을 나타내며, 잣나무 잎의 추출수율은 5.1%, 대장균 억제직경은 7.5 mm, 황색포도상구균 억제직경은 12.3 mm로 ± 4.23% 오차율을 나타내었다.