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Antimycobacterial Activity and Cytotoxicity of Flavonoids from the Flowers of Chromolaena odorata  

Suksamrarn, Apichart (Department of Chemistry, Faculty of Science, Ramkhamhaeng University)
Chotipong, Apinya (Department of Chemistry, Faculty of Science, Ramkhamhaeng University)
Suavansri, Tananit (Department of Chemistry, Faculty of Science, Ramkhamhaeng University)
Boongird, Somnuk (Department of Agricultural Science, Faculty of Science, Ramkhamhaeng University)
Timsuksai, Puntip (Department of Chemistry, Faculty of Science and Technology, Rajabhat Institute Nakhonratchasi)
Vimuttipong, Saovaluk (National Center for Genetic Engineering and Biotechology, National Science and Technology, Development Agenc)
Chuaynugul, Aporn (Department of Chemistry, Faulty of Science, Ramkhamhaeng University)
Publication Information
Archives of Pharmacal Research / v.27, no.5, 2004 , pp. 507-511 More about this Journal
Abstract
From the flowers of Chromolaena odorata (Eupatorium odoratum) four flavanones, isosakuranetin (5,7-dihydroxy-4'-methoxyflavanone) (1), persicogenin (5,3'-dihydroxy-7,4'-dimethoxyflavanone) (2), 5,6,7,4'-tetramethoxyflavanone (3) and 4'-hydroxy-5,6,7-trimethoxyfla-vanone (4), two chalcones, 2'-hydroxy-4,4',5',6'-tetramethoxychalcone (5) and 4,2'-dihydroxy-4',5',6'-trimethoxychalcone (6), and two flavones, acacetin (5,7-dihydroxy-4'-methoxyflavone) (7) and luteolin (5,7,3',4'-tetrahydroxyflavone) (8) were isolated and identified. Compound 1 exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis with the MIC value of 174.8 $\mu$M, whereas compounds 4,7, and 8 exhibited weak activity with the MIC values of 606.0, 704.2 and 699.3 $\mu$M respectively. Compound 7 showed moderate cytotoxicity against human small cell lung cancer (NCI-H187) cells with the MIC value of 24.6 $\mu$M, whereas compound 8 exhibited moderate toxicity against NCI-H187 cells and week toxicity against human breast cancer (BC) cells with the MIC values of 19.2 and 38.4 $\mu$M respectively.
Keywords
Chromolaena odorata; Asteraceae; Flavonoids; Antimycobacterial activity; Cytotoxicity; Struture-activity relationship;
Citations & Related Records

Times Cited By Web Of Science : 23  (Related Records In Web of Science)
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