• 한국물환경학회지
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• 제25권6호
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• pp.964-971
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• 2009

In this paper, activated sludge settling was characterized based on field trip and zone settling tests. Plants used for this study include 5 conventional activated sludge processes and 3 A2O type treatment processes. The treatment capacities are in the range from 12,000 to $250,000m^3$/day. Total number of zone settling tests were 188 set and SVI values representing settling characteristics were from 100 to 300 mL/g. It was found out that zone settling velocity of these examined plant sludges can be approximated by mean values calculated by Keinath and Daigger/Roper models. Based on these three models, solid flux analysis were carried out in order to compare design criteria ($3.96{\sim}6.04kg/m^2-hr$) recommended by Korea Sewage Facility Design Guideline with two models used in USA. The results show that design criteria are only applicable for normal condition in settling characteristics (below SVI 100 mL/g). Solid flux analysis of surveyed plants indicates that most of the plants are operated underload conditions except several plants experiencing poor sludge settling problem. Most of the plants are operated under high sludge blanket depths (SBD).

• 한국농공학회논문집
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• 제56권6호
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• pp.139-147
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• 2014

Forecasting salinity in an estuary reservoir is essential to promise irrigation water for the reclaimed land. The objective of the research was to assess salinity balance and its temporal and spatial variations in the Iwon estuary reservoir which has been issued by its high contents of salinity in spite of desalination process for four years. Seepage flows through the see dikes which could be one of possible reason of high salinity level of the reservoir was calculated based on the salinity balance in the reservoir, and used as input data for salinity modeling. A three-dimensional hydrodynamic model, Environmental Fluid Dynamics Code (EFDC), was used to simulate salinity level in the reservoir. The model was calibrated and validated based on weekly or biweekly observed salinity data from 2006 to 2010 in four different locations in the reservoir. The values of $R^2$, RMSE and RMAE between simulated and observed salinity were calculated as 0.70, 2.16 dS/m, and 1.72 dS/m for calibration period, and 0.89, 1.15 dS/m, and 0.89 dS/m for validation period, respectively, showing that simulation results was generally consistent with the observation data.

• 생약학회지
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• 제44권3호
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• pp.275-280
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• 2013

This study was carried out to investigate the effect of Origanum vulgare extracts on cell proliferation of human hair dermal papilla cell (HHDPC) using sulforhodamine B (SRB) assay, antioxidant activity by 1,1-diphenyl-2-picryl hydrazyl (DPPH) method, expression of insulin-like growth factor-1 (IGF-1) by analyzing reverse transcriptase polymerase chain reaction (RT-PCR) and hair growth in a shaving animal model of C57BL/6 mice topically applying with an amount of 0.1 mL once a day for 3 weeks. The mice were divided into 4 groups including normal group (saline, N), negative control group (dimethyl sulfoxide, NC), positive control group (5 mg/mL minoxidil, PC), and experimental group (Origanum vulgare extracts, OV). Treatment of OV didn't show cytotoxicity in HHDPC up to 10 ${\mu}g/mL$ and exhibited antioxidant activity with $IC_{50}$ of 31.0 ${\mu}g/mL$. IGF-1 expression in the skin was significantly (p<0.05) increased in the PC and OV compared to the N or NC. PC and OV also showed a prominently promoted hair regrowth compared to the N or NC in hair growth observation. The hair regrowth of OV was significantly higher than that of PC (p<0.05). Therefore, these results indicate that O. vulgare extracts effectively stimulated hair growth in an animal model.

• Biomolecules & Therapeutics
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• 제6권4호
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• pp.383-388
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• 1998

The present study was aimed to investigate the preventive effects of rebamipide on the multiple organ dysfunction in a rat model of circulatory shock induced by bacterial endotoxin (E. coli lipopolysaccharide; LPS) in comparison with that of methotrexate. Endotoxemia for 6 hours resulted in little change in the levels of hemoglobin and neutrophils. However, treatment with methotrexate decreased significantly the numbers of circulating neutrophils. Significant increases in serum alanine aminotransferase (ALT,958 $\pm$ 250 lU/L, p<0.001) and aspartate aminotransferase (AST, 1350 $\pm$ 295 lU/L, p<0.001) levels induced by endotoxemia were significantly decreased by rebamipide and methotrexate. The increased level of lactic acid dehydrogenase (LDH) by LPS (2850 $\pm$ 467 lU/L, p<0.05) was significantly inhibited by rebamipide, but not by methot.elate. The elevated serum creatinine (1.2$\pm$0.1, p.0.05) and urea levels (55.3$\pm$6.5 mg/dL, p.0.01) by LPS were also decreased by rebamipide, but not by methotrexate. In line with these results, the plasma concentration of tumor necrosis factor-$\alpha$ (TNF-7,167 $\pm$ 20 pg/mL) was significantly increased upon injection of endotoxin at 1 hour by 1570$\pm$100 pg/mL, and declined to 312$\pm$35 pg/mL at 6 hours. The TNF-$\alpha$ level at 6 hours was significantly decreased by rebamipide to 207$\pm$8 pg/mL (P<0.05). Taken together, it is summarized that rebamipide inhibits the development of multiple ogran dysfunction by inhibition of neutrophil activation in association with inhibition of TNF-$\alpha$ formation in a murine model of endotoxemia.

• 한국정보전자통신기술학회논문지
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• 제11권6호
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• pp.800-806
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• 2018

소프트웨어 효율성은 운용 환경에서 사용시간에 따라 고장없이 사용할 수 있는 확률이며, 소프트웨어 시스템 안정성에 영향을 미치는 가장 근본적인 요인이다. 정보기술 분야에서 활용되고 있는 컴퓨터 시스템의 오작동은 관련 산업분야에 중요한 손실을 야기할 수도 있다. 따라서, 본 연구에서는 소프트웨어 고장시간 자료를 가지고 유한고장 NHPP 모형에 기반하여 다양한 위험함수에 의존한 소프트웨어 신뢰성 모형의 속성을 분석 하였다. 제안한 모형의 위험함수 패턴은 Goel-Okumoto모형은 상수가 되고, Minimax 모형과 Rayleigh모형은 증가패턴을 따르지만, 위험함수의 증가폭은 Minimax 모형이 Rayleigh모형과 Goel-Okumoto모형 보다 작은 것으로 나타났다. 또한, 평균값 함수m(t)의 참값 오차와 평균제곱오차(MSE)는 Minimax 모형이 모두 Rayleigh 모형과 Goel-Okumoto모형 보다 작아서 상대적으로 효율적이였다. 본 연구의 결과는 소프트웨어 개발자에게 위험함수에 관한 기본정보로 활용될 수 있을 것으로 기대한다.

• 대한한방내과학회지
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• 제22권3호
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• pp.415-422
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• 2001

Objectives: We aimed to identify the dose-dependent inhibitory effects of Yukmijihwang-tang-Hap-Sabaek-san(YMHSB) and Root cortex of Morus alba L.(RCM) on the mRNA expression of Interieukin(IL)-6, IL-S, granulocyte macrophage colony stimulating factor(GM-CSF) involved in the asthma model. Methods: In this study BEAS-2B cell lines, human epithelial cells, were used. These cells were stimulated by tumor necrosis $factor(TNF)-{\alpha},\;IL-1{\beta}$ and histamine for artificial inflammatory expression. ${\beta}-actin$ messenger RNA(mRNA) was used for the internal standard. After each 24 hours of the YMHSB and RCM treatment, total cellular RNAs were collected by treating RNA zol directly on the living cells. Then the transcriptional activities of IL-6, 8 and GM-CSF were measured by RT-PCR with electrophoresis. Results: In the YMHSB study, the mRNA expression of GM-CSF and IL-8 is significantly inhibited compared to that of control group. But the mRNA expression of IL-6 is not significantly inhibited. In the RCM study, the mRNA expression of GM-CSF and IL-S is significantly inhibited compared to that of control group. But the mRNA expression of IL-6 is not significantly inhibited. Conclusions: This study shows that YMHSB and RCM have dose-dependent inhibitory effects on the mRNA expression of IL-S and GMCSF in human epithelial cells. So these herbal medicines may inhibit the inflammatory process of asthma. Advanced studies are required to investigate the mechanisms of inhibition by herbal medicine in the asthma model.

• 수산해양기술연구
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• 제18권2호
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• pp.101-108
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• 1982

유한요소법에 의한 고체내부 사각열원 주위 열전도특성은 실험에서 구한 결과와 거의 일치하였으며 열전도특성을 요약하면 다음과 같다. 1. 사각열원의 중심거리 이동에 따른 열전도에 미치는 중심방향의 영향은 열원 사이의 거리가 가까울수록 낮은 온도분포를 보이며 x=16cm 일 때 model 4에서 $\theta$=0.698 model 3에서는 $\theta$=0.401이다. 그리고 내부로 감에 따라 그 차는 감소한다. x=40cm에서 model 4은 $\theta$=0.907이고 model 6은 $\theta$=0.895이다. 2. 높이방향의 영향은 공기와 접하므로 대류현상이 일어나므로 열원의 크기를 벗어나는 구역은 model 1~3에서는 y=8~12cm model 4~6에서는 y=4~8cm이다. 그리고 두 곳의 온도의 차는 $\theta$≒0.009이다. 3. 열전도도의 변화에 따른 열전도의 영향은 그 값이 클수록 강하게 나타나며 model 2에 대해서 높이 방향의 전 경계에 대한 무차원온도의 변동은 k=7 일 때 $\theta$=0.079~0.054 k=0.3일 때 $\theta$=0.0036~0.0025의 값을 나타낸다

• 한국식품위생안전성학회지
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• 제38권6호
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• pp.449-456
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• 2023

본 논문은 적은 농도로 존재하는 Vibrio parahaemolyticus를 6시간이내에 10⁶ CFU/mL까지 신속하게 배양가능한 배지인 Rapid Enrichment Broth for V. parahaemolyticus(REB-V)를 개발하여 V. parahaemolyticus를 신속하게 검출할 수 있도록 하였다. Modified Gompertz model과 RSM를 활용하여 V. parahaemolyticus를 신속하게 증균할 수 있도록 첨가 성분을 최적화하였다. 그 결과 2%(w/v) NaCl BPW에 D-(+)-mannose 0.3 g/L, L-valine 0.2 g/L, magnesium sulfate 0.2 g/L를 첨가하였을 때 V. parahaemolyticus의 증균량이 최대였다. REB-V의 배양조건을 pH 7.84와 37℃으로 최적화하였으며, 2%(w/v) NaCl BPW와 비교하여 REB-V의 증균 효율을 확인하기 위해 7시간 증균을 통해 증균량을 평가하였다. 또한 매시간마다 배양액에서 DNA를 추출하였고, 추출한 DNA로 real-time PCR을 수행하여 REB-V의 분자진단법 적용가능성을 확인하였다. 그 결과 7시간 동안 2%(w/v) NaCl BPW에서 V. parahaemolyticus는 5.452±0.151 Log CFU/mL까지 증균되었고, REB-V에서는 7.831±0.323 Log CFU/mL의 V. parahaemolyticus가 증균되었다. 최종적으로 REB-V에서 6시간 이내에 10⁶ CFU/mL 이상으로 증균된 것을 확인하였고, REB-V의 증균속도가 2%(w/v) NaCl BPW보다 빠르고 같은 시간 내의 증균량이 2%(w/v) NaCl BPW보다 많았음을 통해 REB-V의 증균효율이 우수한 것으로 확인되었다.

• Biomolecules & Therapeutics
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• 제28권4호
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• pp.344-353
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• 2020

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives, and their pharmacological activities against lung inflammation were, for the first time, examined in vivo using lipopolysaccharide (LPS)-induced acute lung injury model. In addition, the metabolism of KW02 was also investigated using microsomal stability test and pharmacokinetic study in rats. When orally administered, some of these compounds (30 mg/kg) showed higher inhibitory action against LPS-induced lung inflammation in mice compared to moracin M. Of them, 2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)benzofuran-6-yl acetate (KW02) showed potent and dose-dependent inhibitory effect on the same animal model of lung inflammation at 1, 3, and 10 mg/kg. This compound at 10 mg/kg also significantly reduced IL-1β concentration in the bronchoalveolar lavage fluid of the inflamed-lungs. KW02 was rapidly metabolized to 5-(6-hydroxybenzofuran-2-yl)-1,3-phenylene bis(dimethylcarbamate) (KW06) and moracin M when it was incubated with rat serum and liver microsome as expected. When KW02 was administered to rats via intravenous or oral route, KW06 was detected in the serum as a metabolite. Thus, it is concluded that KW02 has potent inhibitory action against LPS-induced lung inflammation. It could behave as a potential prodrug of moracin M to effectively treat lung inflammatory disorders.

• 한국수처리학회지
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• 제26권6호
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• pp.3-12
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• 2018

The objective of this study was to evaluate the radius of influence of effluent of water treatment system developed for the purpose of improvement of reservoir water quality using fluorescent dye (Rhodamine-WT) tracer experiment and 3-D numerical model. The tracer experiment was carried out in a medium-sized agricultural reservoir with a storage capacity of $227,000m^3$ and an average depth of 1.6 m. A guideline with a total length of 160 m was installed at intervals of 10 m in the horizontal direction from the discharge part, and a Rhodamine measurement sensor (YSI 6130, measurement range $0-200{\mu}g/L$) was used to measure concentration changes in time, distance, and depth. Experimental design was established in advance through Jet theory and the diffusion process was simulated using ELCOM, a three dimensional hydraulic dynamics model. As a result of the study, the direct effect radius of the jet emitted from the applied water treatment system was about 50-70 m, and the radius of physical effect by the advection diffusion was judged to be 100-120 m. The numerical simulations of effluent advection-diffusion of the water treatment system using ELCOM showed very similar results to those of the impact radius analysis using the tracer experiment and jet flow empirical equations. The results provide valuable information on the spatial extent of the water quality improvement devices installed in the reservoir and the facility layout design.