• Clinical and Experimental Reproductive Medicine
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• 제41권2호
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• pp.68-74
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• 2014

Objective: In search of an ideal method of assisted hatching (AH), we compared the effects of conventional micropipette-AH and laser-AH on the blastocyst formation rate (BFR) and blastocyst cell numbers. Methods: Four-to five-week-old ICR female mice were paired with male mice after superovulation using Pregnant mare's serum gonadotropin (PMSG) and hCG. The two-cell embryos were flushed from the oviducts of female mice. The retrieved two-cell embryos underwent one of five AH procedures: single mechanical assisted hatching (sMAH); cross mechanical assisted hatching (cMAH); single laser assisted hatching (sLAH); quarter laser assisted hatching (qLAH); and quarter laser zona thinning assisted hatching (qLZT-AH). After 72 hours incubation, double immunofluorescence staining was performed. Results: Following a 72 hours incubation, a higher hatching BFR was observed in the control, sMAH, cMAH, and sLAH groups, compared to those in the qLAH and qLZT-AH groups (p<0.05). The hatched BFR was significantly higher in the qLAH and qLZT-AH groups than in the others (p<0.05 for each group). The inner cell mass (ICM) was higher in the control and sMAH group (p<0.05). The trophectoderm cell number was higher in the cMAH and qLAH groups (p<0.05). Conclusion: Our results showed that the hatched BFR was higher in groups exposed the the qLAH and qLZT-AH methods compared to groups exposed to other AH methods. In the qLAH group, although the total cell number was significantly higher than in controls, the ICM ratio was significantly lower in than controls.

• 치위생과학회지
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• 제14권4호
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• pp.468-476
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• 2014

본 연구는 국민건강영양조사 제4기 자료를 이용하여 한국 성인에서 비타민 섭취와 치주염과의 관련성을 구명하고자 하였다. 국민건강영양조사 원시자료에서 건강조사와 구강검진 및 식이조사에 모두 참여한 19세 이상 성인 6,245명의 자료를 추출한 후 복합표본설계를 반영하기 위하여 가중치를 고려한 통계분석을 실시하였다. 대상자의 인구사회학적 특성, 전신건강상태와 행태, 구강건강상태와 행태 및 비타민 섭취 5분위에 따른 치주염 유병률의 차이를 ${\chi}^2$-검정을 이용하여 분석하였으며, 로지스틱 회귀분석을 이용하여 인구사회학적 특성, 전신건강상태와 행태 및 구강건강상태와 행태를 보정한 비타민 섭취와 치주염과의 관련성을 분석하였다. 치주염 유병률은 성별, 나이, 결혼상태, 교육, 수입에 따라 통계적으로 유의한 차이가 있었으며(p<0.05), 주관적 건강상태, 심혈관질환 여부, 당뇨 여부, 음주행태, 흡연상태, 및 BMI에 따른 차이도 통계적으로 유의하였고(p<0.05), 칫솔질 횟수, 주관적 구강건강상태, 구강위생용품 사용여부에 따른 차이도 통계적으로 유의하였다(p<0.05). 한편 고려된 비타민 중 비타민 A와 레티놀 및 비타민 B2 섭취가 적을수록 치주염 유병위험이 통계적으로 유의하게 높았고, 인구사회학적 특성과 전신건강상태와 행태 및 구강건강상태와 행태를 보정한 후에는 비타민 B2에서만 통계적으로 유의한 관련성이 있었다(OR: Q1=1.00, Q2=0.72, Q3=0.73, Q4=0.76, Q5=0.84). 따라서 적절한 비타민 B2의 섭취는 치주염 유병위험을 감소시킴으로써 한국 성인 인구의 지속적인 치주건강을 유지하는 데 도움이 될 수 있을 것으로 생각된다.

• 치위생과학회지
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• 제19권4호
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• pp.271-278
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• 2019

Background: This study aimed to examine the factors that influence clinical performance of dental hygiene students to provide useful data for developing strategies to improve clinical competence. Methods: The effects of variables on clinical competence by quantile level were analyzed using quantile regression analysis in 247 dental hygiene students. Quantile regression and multiple regression analyses were conducted using the Stata 11.0 program to analyze predictors of clinical competence. Results: The clinical competence score of dental hygiene students was 42.69±5.90, the satisfaction of clinical practice was 49.90±7.44, the clinical practice stress was 50.62±7.37, and the professional self-concept was 31.68±4.41. Empathy was the highest at 50.87±4.93. Multiple regression analysis showed that school year, stress from clinical training, satisfaction with clinical training, professional self-concept, and empathy had significant impact on clinical competence. Quantile regression analysis showed that the effects varied depending on the clinical competence level. School year and professional self-concept had a significant positive effect, regardless of the clinical competence level, while empathy had a significant positive effect at the top 10% (Q90) of the clinical competence level. Satisfaction with clinical practice affected clinical competence at Q25, Q50, and Q90. Stress from clinical practice had significant effects at Q25, Q50, and Q90 (p<0.05). Conclusion: According to the study results, different factors affected clinical competence according to the quantile of clinical competence. This study provides valuable implications for designing clinical competence enhancement programs and strategies. In addition, objective indicators for considering factors that may affect the clinical competence, such as academic competence and satisfaction of practice hospitals, are expected to require detailed analysis and measures.

• 대한정형도수물리치료학회지
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• 제28권1호
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• pp.19-27
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• 2022

Background: This study investigated the effects of a single-leg hopping test and Q-angle when applying Mulligan taping, flossing bands, and a combination of Mulligan taping and flossing bands to chronic ankle instability (CAI) patients. Methods: The subjects of the study were 68 patients with chronic ankle instability, randomly divided into three groups receiving the following treatments: Mulligan taping (n=22), flossing bands (n=23), and a combination of Mulligan taping and flossing bands (n=23). The immediate effects of the treatments were evaluated using the single-leg hopping test and Q-angle measurement for functional movement before and after the intervention. Results: All three groups showed significant improvements in the single-leg hopping test after the intervention, and there was a significant difference between the performance of the simultaneous application group and the Mulligan taping group (p<.01). As a result of the post-hoc test, there was a significant difference in the simultaneous application group than in the mulligan taping group (p<.01). When measuring the Q-angle change during the activity of descending stairs, there was also a significant effect in all three groups, with no significant differences when comparing the changes between groups (p>.05). Conclusions: In conclusion, Mulligan taping and flossing bands were confirmed as effective interventions for the functional movement of the lower extremities in patients with CAI. This study can provide basic data on the effectiveness of interventions in patients with CAI.

• 한국수학사학회지
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• 제17권4호
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• pp.27-36
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• 2004

이 논문에서는 튜링의 기계주의에 대한 괴델의 비평을 다룬다. 여기에서 튜링의 기계주의란 튜링기계의 기호배열이 인간의 마음의 각 상태에 대응된다는 것을 의미한다. 첫째 부분에서는 계산으로서의 인지과정에 대한 튜링의 분석을 검토한다. 두 번째 부분에서는 튜링기계의 개념을 살펴보고, 세 번째 부분에서는 인지적 체계로서의 튜링기계가 갖는 계산적 한계를 설명한다. 네 번째 부분에서는 괴델이 튜링의 기계주의에 동의하지 않았음을 보이고, 마지막으로 오라클 튜링기계과 그 함의에 대하여 논의한다.

• Journal of Yeungnam Medical Science
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• 제12권1호
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• pp.113-123
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• 1995

성적학대와 관련된 신경증적 경향을 알아보고자 1994년 7월 10일부터 17일까지 M.H.Q의 신경증척도를 대구시내 소재의 여자고등학교 학생 320명을 대상으로 설문 조사하여 다음과 같은 결과를 얻었다. 1) 성적학대를 받은 군에서는 대조군보다 불안(p<0.05), 공포(p<0.01), 강박증(p<0.01), 신체화(p<0.05), 우울(p<0.01) 등의 신경증적 경향의 점수가 통계학적으로 유의하게 높았다. 2) 단일횟수보다 여러번의 성적학대를 받았을때 신체화(p<0.01), 우울(p<0.01), 히스테리(p<0.01) 등의 신경증적 경향의 점수가 통계학적으로 유의하게 높았다. 3) 성적학대를 받은 기간이 1년이하보다 1년이상일 경우 강박증(p<0.05), 신체화(p<0.05), 우울(p<0.05) 등의 신경증적 경향의 점수가 통계학적으로 유의하게 높았다. 4) 성적학대의 강도가 높을수록 공포, 신체화, 우울등의 신경증적 경향의 점수가 통계학적으로 유의하게 높았다(p<0.01). 5) 가해자는 낯선사람이 31명(45%)으로 가장 많았고 친척 10명(14%), 형제 7명(10.3%), 동네 이웃사람 6명(8.8%) 등의 순서였고, 상담이나 치료를 받은 적이 있은 사람은 68명중 34명(50%)이었으며 이 중 상담대상으로 친구가 23명(68%), 부모 7명(11.7%)등의 순서였고 전문가는 2명(5.9%)이었다.

• 한국환경보건학회지
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• 제50권1호
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• pp.25-35
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• 2024

Background: There are concerns about the health effects of various environmental pollution exposures among residents living near coal-fired power plants (CFPP). Objectives: This study attempted to compare the concentrations of heavy metals in blood and urine and those of urinary volatile organic compound (VOC) metabolites according to the residential separation distance. Methods: Participants in the study totaled 334 people who have lived for more than 10 years in areas within 10 km of a CFPP. The separation distance was analyzed in quartiles by dividing it into Q1 (88 people), Q2 (89 people), Q3 (89 people), and Q4 (68 people). We explained the purpose of this study to the participants and collected blood and urine after obtaining signatures on a participation agreement. Results: The study participants were 102 males (30.5%) and 232 females (69.5%), with an average age of 71. The average length of residence and distance were 43.8 years and 4,800 meters. The geometric mean concentrations of Pb, Cd, and Hg in blood and As and Cd in urine were respective 1.35 ㎍/dL, 1.43 ㎍/L, 3.16 ㎍/L. They were 167.88 ㎍/g for creatinine and 1.58 ㎍/g creatinine. The metabolite concentrations of VOCs were 50.67 ㎍/g creatinine in t, t-muconic acid (t, t-MA), 10.73 ㎍/g creatinine in benzyl mercapturic acid, 317.05 ㎍/g creatinine in phenylglyoxylic acid, 123.55 ㎍/g creatinine in methylhippuric acid, and 190.82 ㎍/g creatinine in mandelic acid. The concentration of Pb in the blood and Cd and t, t-MA in the urine of residents within affected area of the CFPP showed statistically significant differences among distance groups. Conclusions: The concentration of urinary VOCs metabolites, especially t, t-MA, differed according to the distance groups of residents within the affected area of CFPP (p<0.05).

• 대한의용생체공학회:의공학회지
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• 제19권3호
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• pp.251-260
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• 1998

홀터 심전계는 심장 이상으로 인한 급사 위험이 있는 환자를 위한 비관혈인 진단 장비이다. 본 연구에서는 일상생활 중에 심전도 데이터를 획득할 수 있도록 원칩 마이크로프로세서와 대용량메모리인 플레쉬 메모리(flash memory) 카드를 이용하여 2채널의 홀터 심전계를 설계하였다. 시스템 하드웨어는 크게 원칩 마이크로프로세서(68HC11E9)의 아날로그 심전도 처리회로, 플레쉬 메모리 카드로 구성하였다. 아날로그 심전도 처리회로는 250,500,1000의 이득을 갖는 증폭기와 0.05-100Hz의 대역폭을 갖는 대역통과 필터, 호흡으로 인한 기저선의 이동을 제거하기 위한 auto-balancing 회로와 포화-보정회로를 사용하였다. 심전도 신호는 240샘플/초 샘플링하여 A/D 변환하였다. 심전도는 필터링 및 전처리 과정을 통하여 특징점인 Q-R-T파를 검출하고, 이를 근거로 템플리트 생성, ST레벨, 심박수, QT간격 측정과 부정맥을 검출하였다. 또한 장시간동안의 심전도 데이터와 측정된 진단파라미터를 저장하기 위해 실시간 압축 알고리즘인 MFan과 delta modulation 방법을 이용하여 데이터를 압축, 저장하였다. 20M 바이트 용량의 플레쉬 메모리 카드에 기록된 데이터는 PC의 DOS나 Windows 환경의 ambulatory monitoring 분석시스템과 쉽게 인터페이스가 가능하도록 FFS(Flash File System)의 호환 가능한 SBF(Symetric Block format)포맷으로 저장하여 분석시스템에서 데이터 처리 및 관리할 수 있게 하였다.

• 한국재료학회지
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• 제22권2호
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• pp.61-65
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• 2012

A $Li_2O-2SiO_2$ ($LS_2$) glass was investigated as a lithium-ion conducting oxide glass, which is applicable to a fast ionic conductor even at low temperature due to its high mechanical strength and chemical stability. The $Li_2O-2SiO_2$ glass is likely to be broken into small pieces when quenched; thus, it is difficult to fabricate a specifically sized sample. The production of properly sized glass samples is necessary for device applications. In this study, we applied spark plasma sintering (SPS) to fabricate $LS_2$ glass samples which have a particular size as well as high transparency. The sintered samples, $15mm\phi{\times}2mmT$ in size, ($LS_2$-s) were produced by SPS between $480^{\circ}C$ and $500^{\circ}C$ at 45MPa for 3~5mim, after which the thermal and dielectric properties of the $LS_2$-s samples were compared with those of quenched glass ($LS_2$-q) samples. Thermal behavior, crystalline structure, and electrical conductivity of both samples were analyzed by differential scanning calorimetry (DSC), X-ray diffraction (XRD) and an impedance/gain-phase analyzer, respectively. The results showed that the $LS_2$-s had an amorphous structure, like the $LS_2$-q sample, and that both samples took on the lithium disilicate structure after the heat treatment at $800^{\circ}C$. We observed similar dielectric peaks in both of the samples between room temperature and $700^{\circ}C$. The DC activation energies of the $LS_2$-q and $LS_2$-s samples were $0.48{\pm}0.05eV$ and $0.66{\pm}0.04eV$, while the AC activation energies were $0.48{\pm}0.05eV$ and $0.68{\pm}0.04eV$, respectively.

• Asian-Australasian Journal of Animal Sciences
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• 제23권11호
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• pp.1496-1502
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• 2010

Two experiments were conducted to evaluate the effects of diet complexity and fermented soy protein on growth performance and amino acid digestibility. In Exp. 1, a total of 120 crossbred weanling pigs ($5.68{\pm}0.80\;kg$ BW) were randomly allocated into 4 treatments. Each treatment had 6 replicate pens comprising 5 pigs in each replicate. Experimental diets consisted of simple (soybean meal as protein source) and complex (soybean meal, rice protein concentrate, potato protein concentrate and fish meal as protein sources) diets; each diet contained 0 or 5% fermented soy protein (FSP), respectively. Dietary treatments included: i) simple diet; ii) simple diet with 5% FSP; iii) complex diet; iv) complex diet with 5% FSP. Pigs were provided each experimental diet for 20 d (phase 1) and then fed the same common diet for 10 d (phase 2). During days 0-10, pigs fed FSP diets had greater ADG than those fed non-FSP diets (p<0.05). G/F in FSP treatments was significantly higher than that in non-FSP treatments (p<0.05) from days 0 to 10. Throughout the overall period, G/F was greater in FSP treatments compared with non-FSP treatments (p<0.05). On d 10, N digestibility was higher in pigs fed FSP diets than in those fed non-FSP diets (p<0.05). Diet complexity did not affect growth performance and nutrient digestibility (p>0.05) in this experiment. In Exp 2, 12 ileal-cannulated, weanling barrows were housed in individual metabolism crates and randomly assigned to 1 of 4 treatments (same as Exp. 1) by using a $4{\times}4$ Latin square design. Among the essential amino acids, apparent ileal digestibility (AID) of Met and Val were increased in pigs fed FSP diets compared with those fed non-FSP diets (p<0.05). AID of Met, Phe and total essential amino acids were higher in pigs fed complex diets than in those fed simple diets (p<0.05). Among the non-essential amino acids, AID of Ala in FSP treatments was greater than that in non-FSP treatments (p<0.05). In addition, Asp, Cys, Glu, Pro, Ser and total non-essential amino acid digestibilities in pigs fed complex diets were higher compared with those fed simple diets (p<0.05). Interaction was observed in AID of Met, Asp and Pro. In conclusion, these results indicated that feeding of 5% FSP to nursery pigs improved feed efficiency and AID of amino acids, and diet complexity did not maximize the growth performance of pigs in the subsequent phase.