• Journal of the Korean Ceramic Society
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• v.39 no.5
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• pp.511-516
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• 2002

Hexagonal $YMnO_3$ thin films were prepared from $Y(NO_3)_3{\cdot}5H_2O$ and $Mn(CH_3CO_2)_2{\cdot}4H_2O$ as starting materials on the Si(100) substrates by the sol-gel method. The crystal structure and the electrical properties of the $YMnO_3$ thin films were investigated as a function of heat treatment temperature, the amount of water(Rw) of hydrolysis and the addition of catalysis. The crystallization of the $YMnO_3$ thin film began at 700${\circ}C$ and completed at 800${\circ}C$ for 1 h. The c-axis (0001) preferred orientation of hexagonal $YMnO_3$ was detected for the $YMnO_3$ thin films with Rw=6 and that was decreased for the $YMnO_3$ thin films with Rw=1 and Rw=12. The crystallinity and preferred orientation of the $YMnO_3$ thin films were depended on the addition of acid and/or alkali catalysis, which, in turn, the preferred orientation of c-axis was decreased and the orthorhombic phase of $YMnO_3$ was detected to the specimens with the addition of catalysis. The $YMnO_3$ thin film with Rw=6 showed good leakage current density of $1.2{\times}10-8 A/cm^2$ at the applied voltage of 0.2V and the leakage current density was not changed drastically with applied voltage.

• Journal of Nutrition and Health
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• v.56 no.6
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• pp.602-614
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• 2023

Purpose: The balance between synthesis and degradation of proteins plays a critical role in the maintenance of skeletal muscle mass. Mitochondrial dysfunction has been closely associated with skeletal muscle atrophy caused by aging, cancer, and chemotherapy. Polygalacin D is a saponin derivative isolated from Platycodon grandiflorum (Jacq.) A. DC. This study aimed to investigate the effects of polygalacin D on myoblast differentiation and muscle atrophy in association with mitochondrial function in in vitro and in zebrafish models in vivo. Methods: C2C12 myoblasts were cultured in differentiation media containing different concentrations of polygalacin D, followed by the immunostaining of the myotubes with myosin heavy chain (MHC). The mRNA expression of markers related to myogenesis, muscle atrophy, and mitochondrial function was determined by real-time quantitative reverse transcription polymerase chain reaction. Wild type AB^* zebrafish (Danio rerio) embryos were treated with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) with or without polygalacin D, and immunostained to detect slow and fast types of muscle fibers. The Tg(Xla.Eef1a1:mitoEGFP) zebrafish expressing mitochondria-targeted green fluorescent protein was used to monitor mitochondrial morphology. Results: The exposure of C2C12 myotubes to 0.1 ng/mL of polygalacin D increased the formation of MHC-positive multinucleated myotubes (≥ 8 nuclei) compared with the control. Polygalacin D significantly increased the expression of MHC isoforms (Myh1, Myh2, Myh4, and Myh7) involved in myoblast differentiation while it decreased the expression of atrophic markers including muscle RING-finger protein-1 (MuRF1), mothers against decapentaplegic homolog (Smad)2, and Smad3. In addition, polygalacin D promoted peroxisome proliferator-activated receptor-gamma coactivator (Pgc1α) expression and reduced the level of mitochondrial fission regulators such as dynamin-1-like protein (Drp1) and mitochondrial fission 1 (Fis1). In a zebrafish model of FOLFIRI-induced muscle atrophy, polygalacin D improved not only mitochondrial dysfunction but also slow and fast muscle fiber atrophy. Conclusion: These results demonstrated that polygalacin D promotes myogenesis and alleviates chemotherapy-induced muscle atrophy by improving mitochondrial function. Thus, polygalacin D could be useful as nutrition support to prevent and ameliorate muscle wasting and weakness.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.6
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• pp.2581-2587
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• 2013

This paper aims at the design of wheel and axle with cap. The cap is conceptually designed by using TRIZ/CAE. Wheel axle is used at railway vehicle to safety and it is always investigated to reduce the railway vehicle weight. The cap has hollow shaft with the material of SM45C. Cap is located in the bearing seat of wheel and axle. The cap becomes durable within the allowable stress of EN13103, 13104 standard. In this study, the strength of wheel and axle with cap becomes higher than that of hollow shaft. The weight of wheel and axle with cap becomes lower by about 6.75 percent than that of solid shaft. The confidence of wheel and axle with cap can be improved by comparing with solid and hollow shafts.

• Journal of Life Science
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• v.33 no.3
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• pp.277-286
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• 2023

Sarcopenia is the age-related loss of muscle mass and function. It is a natural part of aging and can lead to decreased mobility and increased frailty. The ubiquitin-proteasome pathway, which is involved in muscle protein degradation, is closely linked to sarcopenia. Germinated Rhynchosia nulubilis hydrolysate (GRH) has been reported to have anti-inflammatory and antioxidant properties, but there have been no reports on its inhibitory effect on muscle reduction. However, no study has yet explored the relationship between GRH and muscle loss inhibition. In this study, we evaluated the effects of GRH on muscle atrophy inhibitory activity in dexamethasone (Dexa)-induced muscle atrophy C2C12 myotubes and mouse models. Moreover, we identified a molecular pathway underlying the effects of GRH on skeletal muscle. May Grunwald-Giemsa staining showed that the length and area of myotubes increased in the groups treated with GRH. In addition, the GRH-treated group significantly reduced the expression of muscle ring finger protein 1 and muscular atrophy F-box (MAFbx) in the Dexa-induced muscular atrophy C2C12 model. GRH also improved muscle strength in C57BL/6 mice with Dexa-induced muscle atrophy, resulting in prolonged running exhaustive time and increased grip strength. We found that muscle strengthening by GRH was correlated with a decreased expression of the MAFbx gene in mouse muscle tissue. In conclusion, GRH can attenuate Dexa-induced muscle atrophy by inhibiting the ubiquitin-proteasome pathway via downregulation of the MAFbx gene expression.

• Journal of the Korean Chemical Society
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• v.63 no.6
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• pp.473-485
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• 2019

In this study, we investigated the differences of graph constructed by middle school students in daily-life and scientific contexts according to the views on the nature of scientific measurement. A test consisting of three similar data sets regarding daily-life and scientific contexts was developed, and administered to 151 ninth graders. They were expected to construct proportional, inverse-proportional, and increasing and become constant form of graphs for each data set. Graphs constructed were analyzed in the aspects of constructing a trend line (types of a trend line, interpolation/extrapolation), selecting axes variables, scaling axes, and plotting points. Analyses of the results revealed that the students with set paradigm tended to construct a curved trend line, while those with point paradigm constructed a broken trend line in inverse-proportional graph questions. In the aspects of interpolation/extrapolation, most students with set paradigm performed both interpolation and extrapolation better than those with point paradigm in scientific context. Most students with set paradigm performed both interpolation and extrapolation regardless of contexts, while the proportion of interpolation of those with point paradigm was higher in scientific context than in daily-life context. In selecting axes variables, scaling axes, and plotting dots, there were no statistically significant differences between set and point paradigms. On the bases of the results, educational implications for improving graph construction skills of middle school students are discussed.

• Journal of the Earthquake Engineering Society of Korea
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• v.13 no.6
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• pp.87-98
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• 2009

It is well known that reinforcement details in the plastic hinge region of bridge piers give the most important effects on the seismic performance of bridges, from investigations of bridge failures in many earthquake events and in laboratory tests. Longitudinal reinforcement details give larger effects than lateral reinforcement details do. The lap-spliced longitudinal steel shows slip during earthquake events, which results in low ductility and inadequate seismic performance. However, before the issue of the earthquake design code, a considerable number of bridge piers were constructed with lap-spliced longitudinal steel in the plastic hinge region. Therefore, a large amount of research has been conducted on the seismic performance and retrofit of circular and rectangular shaped bridge columns with lap-spliced longitudinal steel. However, research on wall type piers is very limited. This paper investigates the seismic performance of a pier wall by a quasi-static test in the weak axis direction and proposes a retrofit method. From the test with variables being the longitudinal steel detail and the transverse steel amount, it is shown that the currently used definition of yield displacement is not adequate. Therefore a new definition of yield displacement for the ductility investigation for a pier wall is proposed. In addition, a retrofit method by steel plates and bolts is proposed to improve ductility, and test results show that slip of the longitudinal steel is prevented by up to a considerably large displacement.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.6
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• pp.655-662
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• 2014

This study conducted tensile tests on an Alloy 690TT tube at room temperature (RT) and at $343^{\circ}C$ using tube- and ring-type specimens to investigate the stress-strain behavior and tensile properties of a steam generator (SG) tube in the axial and circumferential directions at RT and at the design temperature of a nuclear power plant (NPP). The results of the axial tensile test showed that yield point phenomena appeared at both RT and $343^{\circ}C$, and serrated flow in the stress-strain curve appeared at $343^{\circ}C$. Yield and tensile strengths for both directions were clearly lower at $343^{\circ}C$ compared to RT; however, the elongations were approximately the same at both test temperatures. Regardless of the test temperature, the strengths in the circumferential direction were lower by approximately 5~10 % than those in the axial direction. In addition, the test data revealed that the reduction in the yield and tensile strengths of the Alloy 690TT SG tube with the test temperature was more significant than that estimated by the temperature correction factor of ASME Sec.II.

• Journal of Korean Ophthalmic Optics Society
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• v.8 no.2
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• pp.71-76
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• 2003

This study was performed to survey dioptric differences between the refractive states of both eyes from 1,100 patients who were given their prescriptions in spectacles. The differences were obtained by using dioptric power matrix. The prevalence of anisometropia was 96.9% for isoanisometropia, 2.9% for simple anisometropia, 0.2% for antimetropia. Spherical anisometropia was 22.1%, cylindrical anisometropia was 10.9%, spherocylindrical anisometropia was 46.5%, and no anisometropia was 20.5%. Anisometropia was more in thirties and forties than in other groups. In distribution of only spherical diopter differences, 76.1% were less than 0.50D, 91.7% were under 1.00D, only 2.5% were over 2.00D. In cylindrical diopter differences alone, 93.3% had under 0.50D, 1.7% had more than 1.00D. In spherocylindrical anisometropia, 52.8% were less than 0.50D, 78.6% were under 1.00D, 5.1% were more than 2.00D. In axis differences, with-the-rule type was 29.9%, against-the-rule type was 29.8%, oblique type was 40.3%.

• Journal of the Korean Applied Science and Technology
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• v.35 no.3
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• pp.948-955
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• 2018

The purpose of this study was to compare plantar pressure and COP parameters in three types of arch support insole during stair descent in elderly with flatfoot. A total of 14 women elderly were recruited for this study. Pedar-X was used to obtain plantar pressure(peak pressure, mean pressure, and contact area) and COP(distance, displacement, excursion) parameters. One-way ANOVAs were used to compare peak pressure, mean pressure, and contact area, distance of COP, displacement of COP, and excursion of COP. Among the plantar pressure parameters, significant(p<0.05) differences were observed in M3 for the peak pressure, M2, M3, and M4 for the mean pressure, and M2, M3, and M6 for the contact area. Among the COP parameters, distances of COP both in the mediolateral and anteroposterior axes revealed significant(p<0.05) differences. The larger peak pressure values of type A and B insoles were observed as compared to normal insole. The larger peak pressure and shorter COP distance values of type A and B insoles were observed as compared to normal insole.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.1-7
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• 2020

Although the temperature load is an important load among the various loads affecting the behaviors of general rahmen-type temporary bridges (GRTB), no study of the thermal load has been carried out. In the case of GRTB, horizontal displacement should be free, and the generated internal force should be minimized to reduce stress due to a temperature load. Sliding girder type bridge (SGTB) allows the axial deformation due to thermal load, and decreases the axial stress and delivers bending stress. This study examined the temperature behavior of an SGTB. Structural analysis was carried out for four types of spans (eq, 10, 20, 30, and 40m) and three types of pier heights (eq, 2, 4, and 6m) along with the GRTB. The applied loads were a fixed vertical load and an axial temperature load. The friction coefficient was 0.4, which is a representative value of a steel girder. Consequently, the stress of the SGTB increased with increasing span length, regardless of the temperature load. The stress of the GRTB increased with increasing temperature and span length. Compared to the GRTB, the stress of the SGTB decreased by 20% to 50% at the center of the girder and by 50% to 90% at the bottom of the pier. This could secure the structural efficiency compared to the GRTB with the same specifications.