• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.1078-1083
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• 2009

HEC-HMS(Hydrologic Modeling System)은 강우-유출 모의를 위한 차세대 소프트웨어이며 HEC-1에 포함되어 있는 단위도 및 수문학적 홍수추적 이외에도 격자형 강우자료(레이더 데이터)를 이용하여 적용할 수있는 유사분포 유출변화와 장기 연속모의에 적용할 수 있는 간단한 수분감소 등을 추가적으로 포함하고 있다. 또한 GUI(Graphical User Interface)환경, 통합 수문분석 성분, 자료 저장 및 관리 능력, 그래�d 처리 및리포트 출력기능으로 구성되어 있으며 여러 가지 프로그램 언어(C, C++, Fortran)를 이용하여 개발되었다. 본 연구에서는 낙동강 수계의 금호강에 위치한 동촌 지점을 유출구로 선정하고 5개의 소유역과 두 개의 하도로 구성하여 유출모의를 실시하였으며 수문자료 선정은 2007년$^{\sim}$2008년에 발생한 홍수사상과 유량조사 사업단에서 개발한 수위-유량관계곡선식을 활용하였다. 또한, HEC-GeoHMS 모형을 GIS와 연계하여 지형인자를 추출하고 추출된 지형인자를 이용하여 매개변수를 산정하였다. HEC-HMS 모형의 계산 조건에서 손실 우량은 SCS CN, 유출변환은 Clark 단위도법을 적용하였다. 또한 관측치와 계산치의 적합도 검증은 평균제곱 근오차(root mean squar error; RMSE)와 모형 효율성 계수(model efficiency; ME)를 산정하여 분석하였다

• Elastomers and Composites
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• v.39 no.3
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• pp.217-227
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• 2004

A new thermotropic liquid crystalline polymer(TLCP) containing a triad aromatic ester type mesogenic unit and butylene terephthalate unit(BT) in the main chain was synthesized by polycondensation reaction. The TLCP synthesized showed nematic mesophasic behavior and its transition temperature from solid to mesophase was $260^{\circ}C$. The TLCP/PBT blends were prepared by in-situ polymerization in PBT solution and characterized by differential scanning calorimeter(DSC), thermogavimetric analyzer(TGA), scanning electron microscope(SEM), x-ray diffractometer(XRD), and dynamic mechanical thermal analyze, (DMTA). The blends showed well dispersed TLCP phases with domain sizes $0.05{\sim}0.2{\mu}m$ in the PBT matrix. As the increasing TLCP content from 5 to 20 wt%, ${\Delta}Hm$ values of pure PBT in the blend were increased because TLCP acts as a nucleating agent in the PBT matrix. The mechanical properties of the blends depended on the TLCP contents because the TLCP acted effectively as a reinforcing material in the PBT matrix. The blends showed good interfacial adhesion between the TLCP phase and PBT matrix.The blends prepared by in-situ polymerization showed higher mechanical properties and well dispersed TLCP domains than those of the blends prepared by melt blending.

• Journal of Life Science
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• v.32 no.5
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• pp.355-361
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• 2022

Melanin pigments are the main cause of skin color. They are produced in melanocytes and then transferred to keratinocytes, which eventually gives the skin surface a variety of colors. Although many skin-lightening or depigmenting agents have been developed, the demand for materials to reduce pig- mentation is still increasing. Here, we tried to find materials for skin-lightening or depigmentation using natural compounds and found that mistletoe (Viscum album var. coloratum) extracts (ME) had an inhibitory effect on tyrosinase activity. As a result, ME significantly reduced pigmentation in human primary melanocytes. In addition, a promoter reporter assay revealed that ME inhibited the transcription of microphthalmia-associated transcription factor (MITF), melanophilin (MLPH), tyrosinase-related protein-2 (TRP-2), and tyrosinase (TYR) genes in HM3KO melanoma cells. In addition, ME decreased the protein level for pigmentation-related molecules, such as TYR and TRP-1. Furthermore, it markedly inhibited the melanogenesis of zebrafish embryos, an in vivo evaluation model for pigmentation. To elucidate the action mechanism of ME, we investigated its effects on intracellular signaling. Eventually, the ME dramatically decreased the phosphorylation of the cAMP responsive element binding protein (CREB), AKT, and ERK. The data suggest that ME may inhibit the melanogenesis pathway by regulating the signaling pathway related to pigmentation. Taken together, these data propose that ME can be developed as a depigmenting or skin-lightening agent.

• Journal of Dental Rehabilitation and Applied Science
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• v.21 no.1
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• pp.15-23
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• 2005

The purpose of this study was to evaluate effect of aging and thermocycling on the tensile strength of restorative composite resins. Eight commercially available light-cured restorative composites (Heliomolar: HM, Palfique Estelite: PE, Spectrum: ST, UniFil-F: UF, Z100: ZH, Clearfil AP-X: CA, P60: PS, and Palfique Toughwell: PT) were selected as experimental materials. Rectangular-shaped tensile test specimens were fabricated in a teflon mold giving 5 mm in gauge length and 2 mm in thickness. All samples were stored in distilled water at $37^{\circ}C$ for 100 days. Every 10 days, specimens were thermocycled for 1,000 cycles with 15 seconds of dwelling time in each $5^{\circ}C$ and $55^{\circ}C$ water baths. Tensile testing was carried out at a crosshead speed of 0.5 mm/min and fracture surfaces were observed with a scanning electron microscope. The results obtained were summarized as follows; 1. The strength degradation of thermocycled group was severer than that of the aged group (P<0.01). 2. The tensile strength of the CA and ST groups were significantly higher than that of other groups after thermocycling treatment (P<0.05). 3. Fracture surfaces showed that the composite resin failure developed along the matrix and the filler/resin interface region.

• Korean Journal of Food Science and Technology
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• v.20 no.1
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• pp.6-12
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• 1988

To improve the individual packaging method and extend the shelf life of mackerel (Scomber japonicus), salted and unsalted mackerel fillets were packaged in laminated plastic film bag (Nylon/PE: $20{\mu}m/40{\mu}m,\;12{\times}15$ cm) filled with $CO_2$ gas, in vacuum, and stored at O and/or $5^{\circ}C$. The other samples were packaged in plastic foam trays, overwrapped with oxygen permeable film (control), and stored at same temperature. Volatile basic nitrogen (VBN), trimethylamine (TMA), histamine (HM) and viable cell counts (VCC) were progressed with the increasing of storage time, but thiobarbituric acid (TBA) values decreased gradually after reaching at a maximum peak in 5-9 days. Judging from 4 chemical components, VBN was the most available component in quality judgement of mackerel fillets and its upper limiting content was 25 mg%. Regression equation for shelf life prediction of mackerel fillets with sensory evaluation and VBN component was determined.

• Toxicological Research
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• v.17 no.4
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• pp.297-301
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• 2001

The acute toxicity of CJ-50005, an inactivated whole virus vaccine derived from hepatitis A virus (HM175) grown in human MRC-5 diploid fibroblast culture, was tested in Sprague Dawley (SD) rats and beagle dogs. CJ-50005 was orally and intramuscularly administered up to the maximum dose of 81$\mu\textrm{g}$/kg. as much as 3,000 times of the expected clinical dose, in SD rats and was intramuscularly administered up to 27 $\mu\textrm{g}$/kg, as much as 1,000 times of the expected clinical dose, in beagle dogs. In these experiments, there were no death and clinical changes which were related to CJ-50005 administration. In addition, there were no significant changes between control and treated groups in body weights and autopsy findings. In conclusion, the administration of CJ-50005 over 81$\mu\textrm{g}$/kg in SD rats and over 27$\mu\textrm{g}$/kg in beagle dogs was proved to be safe, and it is thought that CJ-50005 may not show any toxicity in its clinical use.

• Parasites, Hosts and Diseases
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• v.52 no.4
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• pp.429-433
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• 2014

To identify sequences of Entamoeba histolytica associated with the development of amebic liver abscess (ALA) in hamsters, subtractive hybridization of cDNA from E. histolytica HM-1:IMSS under 2 growth conditions was performed: 1) cultured in axenic medium and 2) isolated from experimental ALA in hamsters. For this procedure, 6 sequences were obtained. Of these sequences, the mak16 gene was selected for amplification in 29 cultures of E. histolytica isolated from the feces of 10 patients with intestinal symptoms and 19 asymptomatic patients. Only 5 of the 10 isolates obtained from symptomatic patients developed ALA and amplified the mak16 gene, whereas the 19 isolates from asymptomatic patients did not amplify the mak16 gene nor did they develop ALA. Based on the results of Fisher's exact test (P<0.001), an association was inferred between the presence of the mak16 gene of E. histolytica and the ability to develop ALA in hamsters and with the patient's symptoms (P=0.02). The amplification of the mak16 gene suggests that it is an important gene in E. histolytica because it was present in the isolates from hamsters that developed liver damage.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2007.11a
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• pp.305-306
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• 2007

ACP(Advanced Spent Fuel Conditioning Process)의 금속전환로에 $U_3O_8$을 공급하기 위하여 20 kgHM/batch의 $UO_2$ 펠릿(pellets)을 처리할 수 있는 건식분말화 장치가 개발되고있다. 건식분말화 장치는 500 $^{\circ}C$온도에서 공기를 공급하여 일정한 입도범위의 균질한 $U_3O_8$을 만든다. 이런 건식 분말화 장치의 효율을 높이기 위해서는 반웅로에 불어 넣어주는 공기의 유량을 증가시킬 필요가 있다. 하지만 공기와 반응하여 생성되는 $U_3O_8$ 입자는 그 크기가 최소 3 ${\mu}$m 정도로 매우 미세하여，반응로 출구를 통해 외부로 빠져나갈 가능성 이있다. 이를 방지하기 위해 분말화 장치 출구 바깥에는 필터가 설치되어 있으나 공기와 함께 $U_3O_8$ 입자가 계속해서 빠져 나갈 경우 입자로 인해 필터가 막혀 제 기능을 할 수 없게 된다. 따라서 건식 분말화 장치는 미세한 $U_3O_8$ 입자가 반응로 밖으로 빠져나가지 않도록 입구에서의 공기 유량을 일정 수준 이하로 조절해주는 것이 필요하다. 이 연구의 목적은 초기 유량으로부터 유량을 점점 증가시키면서 시간변화에 따른 입자 거동 특성을 해석하며， 결과로부터 주어진 크기의 타원입자에 대해 최대 허용 공기 유량을 결정하고자한다. 이 해석을 위해 유동과 입자를 동시에 해석할 수 있는 ANSYS-CFX 5.7.1과 ANSYS-CFX 10.0 두 가지의 소프트웨어가 사용되었다. 해석 결과를 바탕으로 좀더 정확한 유량 한계치 계산을 위해 추가로 수행되어야 할 해석에 대해 제안하였다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.5
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• pp.775-781
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• 2002

The T-type amino acid transporter 1 (TATI) is a Na$^{+}$-independent amino acid transporter which selectively trans- ports aromatic amino acids subserving the amino acid transport system T. To understand the transport properties of aromatic amino acids by human TAT1 (hTATl ), we have examined the hTATl -mediated aromatic amino acid transports using a Xenopus laeuis oocyte expression system. When expressed in Xenopin laeuis oocytes, hTATl induced L- [$^{14}$ C]tryptophan transport which was not dependent on Na$^{+}$ or Cl$^{[-10]}$ in the medium. Uptake was time-dependent and exhibited a linear dependence on incubation time up to 30 min. The L- ($^{14}$ C)tryptophan uptake was highly inhibited by L-isomers of tryptophan, tyrosine and phenylalanine, whereas other L-amino acids did not inhibit hTATl -mediated L- ($^{14}$ C)tryptophan uptake. The hTATl induced the relatively low-affinity transport of aromatic amino acids such as L- ($^{14}$ C)tryptophan, L- ($^{14}$ C)tyrosine and L- ($^{14}$ C)phenylalanine (Km values: 450～750 $\mu$M), consistent with the properties of classical amino acid transport system T. The L- ($^{14}$ C)tryptophan uptake did not show any remarkable pH dependence within the pH range of 5.5 to 8.5. The time-dependent efflux of L- ($^{14}$ C)tryptophan was detected from the oocytes expressing hTATl, which was not affected by the presence or absence of L-tryptophan in the extracellular medium, indicating that hTATl-mediated transport is due to the facilitated diffusion. Expression of hTATl in Xenopu laevis oocytes induced the transport of tryptophan, tyrosine and phenylalanine, indicating that hTATl is a transporter subserving system T These results suggest that hTATl has essential roles in the absorption of aromatic amino acids from epithelial cells to the blood stream. Hecause hTATl is proposed to be crucial to the efficient absorption of aromatic amino acids from intestine and kidney, its defect such as blue diaper syndrome could be involved in the disruption of aromatic amino acid transport.ort.

• Journal of the Korean Society of Hazard Mitigation
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• v.6 no.3 s.22
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• pp.69-76
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• 2006

An hydraulic and hydrologic analysis procedure was proposed to reduce the inundation damage of highway in urban stream, that could contribute the EAP and Traffic control planning of Dongbu highway in the Jungrang stream basin which is one of the representative urban area in Korea. We performed the HEC-HMS runoff analysis, and the UNET unsteady flow modeling to decide the inundation reaches and their characteristics. The high inundation risk areas were of Emoon railway bridge and the Wollueng bridge, which are inundated in the case of 10 year and 20 year frequency flood respectively. We also analyze the inundation characteristics under the various conditions of the accumulation rainfall and the duration. Flood elevation at the Wolgye-1 bridge exceed over Risk Flood Water Level(EL.17.84 m) when the accumulation rainfall is over 250 mm and shorter duration than 7 hr. When neglecting backwater effect from the Han river, inundation risk are highly at the reach C2(Wolgye-1 br. ${\sim}$Jungrang br., left bank), C1(Wolgye-1 br. ${\sim}$Jungrang br., right bank), D(Jungrang br. ${\sim}$Gunja br.) in order, but when consider the effect, the inundation risk are higher than the others at the reach D2(Jungrang br. ${\sim}$Gunja br., left bank) and E(Gunja br. ${\sim}$Yongbi br.), which are located downstream near confluence.