• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.2
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• pp.154-163
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• 2021

Purpose: In children overlap of autoimmune hepatitis (AIH) and primary sclerosing cholangitis is labelled as autoimmune sclerosing cholangitis (ASC). The only prospective pediatric study showed a high prevalence of ASC by using endoscopic retrograde cholangiopancreatography. Aims of our study were to find the prevalence of ASC by using magnetic resonance cholangiography (MRC) in AIH and in non-AIH cirrhosis and to compare clinical presentation and outcome of AIH and ASC. Methods: Prospectively we did MRC in 38 children with AIH (cases) and 19 disease controls (Wilson disease). Multiple biliary strictures with proximal dilatation on MRC were taken as definitive changes of ASC. Detail clinical, laboratory parameters, liver histopathology and treatment outcome were recorded. Results: The median age of cases was 11.5 (3-18) years, 22 (57.9%) were girls and 28 (73.7%) were diagnosed as type 1 AIH. MRC was done in 11 children (28.9%) at the time of diagnosis and in 27 (71.1%) after a median follow-up of 2.5 (0.3-10) years. Abnormal MRC changes were seen in 14/38 (36.8%) of AIH and 8/19 (42.1%) of controls. However, definite changes of ASC were present in four (10.5%) children in AIH and none in controls. None of the clinical, laboratory, histological parameters and treatment response were significantly different between ASC and AIH groups. Conclusion: The prevalence of ASC in children with AIH was just 10.5%. We suggest MRC in select group with cholestatic features, inflammatory bowel disease and in those who showed poor response to immunosuppression instead of all children with AIH.

• Proceedings of the KIEE Conference
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• 1999.07f
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• pp.2691-2694
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• 1999

The multi-resonant converter(MRC) can reduce the switching losses exiting in a converter, so it is capable of operating at a high frequency. Such a few MHz high frequency application provides a high power density [$W/inch^{3}$]. But the high voltage stress across a switch of the resonant circuit is about 4$\sim$5 times the input voltage, it causes increasing of the conduction loss in MRC. In this paper, the mode analysis for the suggested AT Forward MRC with low voltage stress is discussed. The operational modes of the AT Forward MRC are divided to 8 equivalent modes according to the two switching sequences, Each mode is analyzed over all of the paper.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.4
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• pp.645-652
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• 2001

In this paper is adopted the One-Ray Rician channel model for AVHS's platoon to short-range IVC (Inter-Vehicle Communication System) and analyzed packet probability characteristics in 60㎓ millimeter wave with very powerful to MP(multipath-wave). Both Convolution coding and MRC diversity is adopted that Multimedia service is satisfied following user's desire increase in the next and analyzed packet probability characteristics of DS-CDMA/QPSK systems.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.3
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• pp.323-328
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• 2001

Multicarrier modulation is a promising technique for mobile communications system, since it has a strong immunity to multipath fading and increasing bandwidth efficiency. In this paper, the performance of MC DS-CDMA/MPSK has been analyzed with that of DS-CDMA/MPSK system using MRC diversity in the same frequency bandwidth. The results show that with no diversity we can see that the BER of about $10^{-5}$ is achieved at $E_b/N_o$ = 25 dB, with diversity is reachable up to 12 dB.

• Biomolecules & Therapeutics
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• v.20 no.5
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• pp.470-476
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• 2012

Resveratrol, a chemopreventive agent, is rapidly metabolized in the intestine and liver via glucuronidation. Thus, the pharmacokinetics of resveratrol limits its efficacy. To improve efficacy, the activity of resveratrol was investigated in the context of sphingolipid metabolism in human gastric cancer cells. Diverse sphingolipid metabolites, including dihydroceramides (DHCer), were tested for their ability to induce resveratrol cytotoxicity. Exposure to resveratrol ($100{\mu}M$) for 24 hr induced cell death and cell cycle arrest in gastric cancer cells. Exposure to the combination of resveratrol and dimethylsphingosine (DMS) increased cytotoxicity, demonstrating that sphingolipid metabolites intensify resveratrol activity. Specifically, DHCer accumulated in a resveratrol concentration-dependent manner in SNU-1 and HT-29 cells, but not in SNU-668 cells. LC-MS/MS analysis showed that specific DHCer species containing C24:0, C16:0, C24:1, and C22:0 fatty acids chain were increased by up to 30-fold by resveratrol, indicating that resveratrol may partially inhibit DHCer desaturase. Indeed, resveratrol mildly inhibited DHCer desaturase activity compared to the specific inhibitor GT-11 or to retinamide (4-HPR); however, in SNU-1 cells resveratrol alone exhibited a typical cell cycle arrest pattern, which GT-11 did not alter, indicating that inhibition of DHCer desaturase is not essential to the cytotoxicity induced by the combination of resveratrol and sphingolipid metabolites. Resveratrol-induced p53 expression strongly correlated with the enhancement of cytotoxicity observed upon combination of resveratrol with DMS or 4-HPR. Taken together, these results show that DHCer accumulation is a novel lipid biomarker of resveratrol-induced cytotoxicity in human gastric cancer cells.

• Journal of Broadcast Engineering
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• v.11 no.2 s.31
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• pp.222-228
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• 2006

In this paper, we propose a receive diversity method for orthogonal frequency division multiplexing (OFDM) systems with cochannel interference. In the method, combining is done in the frequency domain by using the subcarrier based maximum ratio combining (MRC) method. For MRC, we exploit the power of cochannel interference as well as the power of channel noise. The accuracy of the power estimate of interference plus noise is enhanced by averaging the initial estimates over the correlated subchannels where the coherency between the subchannel gains comes from the limited delay spread of the channel. Simulation results show that the proposed method yields 2-3.5dB gain of signal to noise ratio compared to the conventional MRC method and less than 1 dB difference to the ideal case.

• Clinical and Experimental Reproductive Medicine
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• v.38 no.4
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• pp.186-192
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• 2011

Objective: Since IVF program was first established, various types of media and culture systems have been developed either in-house or commercially. The aim of this study was to compare the efficacy of in-house Maria Research Center (MRC) media to that of commercially available Sydney IVF media in human day 3 embryo transfer cycles. Methods: Three hundred sixty nine couples were included in this prospective, randomized, and comparative study. All couples undergoing IVF treatment at the Maria Fertility Hospital were randomly assigned to either Sydney IVF (n=178) or MRC (n=191) media. Results: No difference was observed between the MRC media and Sydney IVF media groups with respect to fertilization rate (74.4% vs. 75.5%). The clinical pregnancy and implantation rates of MRC media (47.1% and 20.0%, respectively) were also similar to those of Sydney IVF media (44.4% and 19.4%, respectively). However, the proportion of embryos with good quality on day 3 was significantly higher in the MRC media group than the Sydney IVF media group (50.2% vs. 43.2%) ($p$ <0.05). Conclusion: MRC media were as effective as Sydney IVF media for sustaining embryo development and pregnancy rates. The present study implies that MRC media can be a suitable alternative to commercially available media for human IVF-ET program.

• Proceedings of the KIPE Conference
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• 1998.07a
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• pp.1-4
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• 1998

In this paper, we proposed the alternated forward zero voltage switching multi-resonant Converter (AT Forward ZVS MRC). The AT forward ZVS MRC has similar characteristics with clamp mode forward ZVS MRC. So it can reduce the voltage stress to tow or three times a input density [W/inch2]. The proposed converter type is verified through the experimental converter with 48V input voltage, 5V/50W output voltage/power. The measured maximum voltage stress is 170V of 2.9 times the input voltage and the maximum efficiency of 81.66% is measured.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.14 no.3
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• pp.6-14
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• 2000

The high efficiency multi-resonant converter(MRC) is capable of operating at a high frequency because the losses are decreased due to the resonant tank circuit. Such a few MHz high frequency applications provide high power density[W/inch3] of the converter. However, the resonant voltage stress across the switch of the resonant tank circuit is 4∼5 times input voltage. This high voltage stress increases the conduction losses because of on-resistance of a MOSFET with higher rating. In this paper, the modeling analysis for the AT Forward MRC suggested to solve the these problems is discusses. The operational modes of the AT Forward MRC are divided to 8 equivalent modes according to the two switching sequences. Each mode analysis is covered using the equivalent circuits modeled over all of the paper. The operational principle of the resonant converter was verified through the experimental converter with 48[V] input voltage, 5[V]/50[W] output voltage/power and PSpice simulation. The measured maximum voltage, 5[V]/50[W] output voltage/power and PSpice simulation. The measure maximum voltage stress is 170[V] of 2.9 times the input voltage and the maximum efficiency is measured to 81.66%.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.4 no.5
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• pp.1005-1015
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• 2000

In this paper, the performance of Hybrid CDU MFSK system has been analyzed in the environment that narrowband Class-A impulsive noise include Gaussian noise in wireless communication channel and Nakagami fading. The performance of system improved to adopting both of technique MRC diversity and BCH channel coding. The results show that there is substantial degraded in Hybrid CDMA system performance by impulse index is stronger and the fading index is smaller. But also improvement can be obtained when BCH coding techniques are adopted. Additional MRC diversity techniques is more improvement than BCH coding techniques when degraded environment with the low fading index. But BCH coding techniques is more improvement than MRC diversity techniques when fading index has been increased. The Hybrid CDMA MFSK system is incomplete to voice communication standard BER$(10^{-3})$ in Rayleigh fading by independent each adopting techniques BCH coding and MRC diversity. But it's satisfy(improvement can be obtained) to voice communication standard BER in strong impulse noise(24dB over) by adopting techniques BCH coding and MRC diversity at a time. Additional it's a substantial enhancement $(10^{-3})$satisfaction) in fading index (m=3, 22dB) in addition to strong impulse noise and 24dB over with data service standard $(10^{-5})$ BER satisfaction. This result show that there is error performance improved by diversity branch and coding advantage.