• 품질경영학회지
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• 제45권4호
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• pp.697-708
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• 2017

Purpose: The purpose of this study is to investigate the characteristics and limitations of various R&D processes. And to propose new R&D processes by analyzing the characteristics of the era of the fourth industrial revolution that will lead to innovative changes throughout the industry. Methods: Research method is to analyze the previous research on existing R&D process and draw out implications, and develop a new R&D process model that reflects characteristics of the fourth industrial revolution era. Results: This study analyzes the characteristics and situation of existing R&D process and derives the features of parallel structure and modularity suitable for the 4th industrial revolution era, characterized by super connectivity, super intelligence, super fusion. And propose a R&D process model that can respond flexibly and promptly to various market and customer needs. Conclusion: Suggestions for the development of R&D processes suitable for the fourth industrial revolution era will present new strategies and measures and provide diverse & innovative opportunities.

• Journal of Microbiology and Biotechnology
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• 제21권4호
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• pp.379-386
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• 2011

The objective of this work was to investigate the ability of the plant growth-promoting rhizobacterium Pseudomonas aureofaciens 63-28 to induce plant defense systems, including defense-related enzyme levels and expression of defense-related isoenzymes, and isoflavone production, leading to improved resistance to the phytopathogen Rhizoctonia solani AG-4 in soybean seedlings. Seven-day-old soybean seedlings were inoculated with P. aureofaciens 63-28, R. solani AG-4, or P. aureofaciens 63-28 plus R. solani AG-4 (P+R), or not inoculated (control). After 7 days of incubation, roots treated with R. solani AG-4 had obvious damping-off symptoms, but P+R-treated soybean plants had less disease development, indicating suppression of R. solani AG-4 in soybean seedlings. Superoxide dismutase (SOD) and catalase (CAT) activities of R. solani AG-4-treated roots increased by 24.6% and 54.0%, respectively, compared with control roots. Ascorbate peroxidase (APX) and phenylalanine ammonia lyase (PAL) activities of R. solani AG-4-treated roots were increased by 75.1% and 23.6%, respectively. Polyphenol oxidase (PPO) activity in soybean roots challenged with P. aureofaciens 63-28 and P+R increased by 25.0% and 11.6%, respectively. Mn-SOD (S1 band on gel) and Fe-SOD (S2) were strongly induced in P+R-treated roots, whereas one CAT (C1) and one APX (A3) were strongly induced in R. solani AG-4- treated roots. The total isoflavone concentration in P+Rtreated shoots was 27.2% greater than the control treatment. The isoflavone yield of R. solani AG-4-treated shoots was 60.9% less than the control.

• 대한화장품학회지
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• 제39권4호
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• pp.329-335
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• 2013

본 연구에서는 기질 화합물로써 일련의 4-hydroxybenzyl alchol (4-HBA) 유도체들의 치환기($R_1$ 및 $R_2$) 변화에 따른 tyrosinase 활성저해에 관한 3차원적인 구조-활성 상관관계(3D-QSARs) 모델을 유도하고 정량적으로 검토하였다. 그 결과, 입체장(S), 정전기장(E), 소수성장(Hy), 수소결합 받게장(HA) 및 수소결합 주게장(HD)의 조합조건에서 통계적으로 양호한 CoMSIA FF 모델(상관성; $r^2$ = 0.858 및 예측성; $q^2$ = 0.951)을 유도하였다. 등고도 분석결과에 의하면 기질분자의 $R_2$-치환기는 입체적으로 작고 음전하를 띄며, 소수성이면서 수소결합 주게장을 선호하지 않는 치환기가 올수록 tyrosinase 활성저해 작용이 용이하다. 그리고 $R_1$-치환기는 수소결합 주게장을 선호하는 치환기 이어서 $R_1$-치환체가 용이하게 탈 양성자화가 일어나야 tyrosinase 활성저해 작용을 용이하게 할 것이라고 예상되며, 이를 위해서는 $R_1$-치환기가 비 치환체(H)이어야 될 것으로 예상되었다.

• Journal of Chest Surgery
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• 제36권4호
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• pp.297-299
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• 2003

흉강내시경을 이용한 교감신경 절단술은 수장부 다한증뿐만 아니라 액와부 다한증에 대해서도 효과가 좋다고 알려져 있다. 이전에 R2, 3, 4교감신경 절단술의 여러 가지 조합 방법들과 다르게 R4, 5절단 방법 효과를 알아보고자 한다. 액와부 액취증 없이 과다한 땀이 나는 환자들을 대상으로 2002년 2월부터 8월까지 2mm 흉강내시경 이용하여 5예의 흉강경 교감신경절단술 시행하였다. 모든 환자들 수술 결과에 만족하였고 과다한 땀은 더 이상 없었다. 총 5예 중, 3예에서(60%) 보상성 다한증을 경험하였는데, 그중 1예만(20%) 의미 있게(불편한 정도는 아니지만) 보상성 다한증을 허리 및 허벅지에 보였다. 액와부 다한증에 대한 치료로 R4, 5 교감신경절단술은 효과적인 치료 방법으로 생각한다.

• 약학회지
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• 제10권2_3호
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• pp.5-7
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• 1966

A variety plant in Polygonatum sibirieum R$_{EDOUTE}$, P. sibiricum R$_{EDOUTE}$ var. multiverticillatum R$_{IM}$ named by author, was discovered in Kang Won-Do, Korea. It was found that this plant has 4-7 whorled leaves, while the ordinary P. sibiricum R$_{EDOUTE}$ has 4 ones. De verticillato 4 vel plura usque ad 7 fo lium; Recenter invento: Haec noviter inventa varietas habet 4 vel plura usque ad folia latiora et altiora quam antea.a.

• Archives of Pharmacal Research
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• 제23권4호
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• pp.332-337
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• 2000

This study describes the synthesis, in vitro evaluation and molecular modeling study of novel compounds for the inhibition of TNF-$\alpha$production, Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone (9) was selected as a lead compound and its pyridine derivative 10 was more potent in activity and safer than rolipram.

• 약학회지
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• 제49권6호
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• pp.443-448
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• 2005

Diosgenin (25 (R) - spirost-5-en-3$\beta$ -ol) was oxidized with 2,3-dichloro -5,6-dicyano-1,4-benzoquinone to form 25(R)-1,4,6-spirostatrien-3-one (1) as rigid cyclic $\alpha$,$\beta$-unsaturated carbonyl compound. This compound was reacted with $H_{2}O_{2}$, m-chloroperoxybenzoic acid (mCPBA), NaOCl in the presence with (R,R)- or (S,S)-Jacobsen catalyst, tert-butyl-hydroperoxide (TBHP) in Mo$(CO)_{6}$, and in VO $(acac)_{2}$ catalyst, respectively, 25(R) -1,4,6-spirostatrien -3-one (1) was reduced with $NaBH_{4}$ L-Selectride, $LiAIH_{4}$,$BH_{3}$ $\cdot$$(CH_{3})_{2}S$, Superhydride, Red-Al, and lithium tri-tert-butoxyaluminium hydride. And 25(R)-4,6-spirostadien-3$\beta$-ol (4) was treated with $H_{2}O_{2}$, mCPBA, TBHP in D - (-) - and L-(+)-diisopropyltar-trate and $Ti(OiPr)_{4}$ condition (Sharpless asymmetric epoxidation), TBHP in $Mo(CO)_{6}$, and in $VO(acac)_{2}$ catalyst, respectively.

• Journal of Chest Surgery
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• 제41권3호
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• pp.343-346
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• 2008

배경: 다한증 환자에서 흉부교감신경절단술은 효과적인 치료방법으로, 수술직후에는 만족도가 높으나 시간이 지남에 따라 재발 및 보상성 발한으로 인해 만족도가 떨어지는 경향이 있다. 재발 및 보상성 발한을 최소화하기 위해 신경절제를 위한 다양한 방법이 제시되고 있다. 이에 흉부교감신경의 절단범위에 따른 증상 및 만족도, 재발, 보상성 발한을 비교 평가하였다. 대상 및 방법: 1999년 1월부터 2007년 7월까지 수부 다한증으로 흉부 교감신경절단술을 시행한 180명의 환자 중 술 후 추적이 가능했던 111명을 대상으로 하였다 제3번 늑골 상연에서 교감신경절을 절단한 39예(R3)와 제4번 늑골상연에서 교감신경절을 절단한 72예(R4)로 나누어서 술 후 초기 및 중기 만족도, 보상성 발한, 재발의 정도를 비교하였다. 결과: 두 군간의 연령에 있어서는 차이가 있었으나 성별에 있어서는 차이가 없었다. 초기의 만족도(R3, R4)는 각각 94.9%, 98.7%로 차이가 없었고, 중기 만족도 또한 84.6%, 87.5%로 차이가 없었다. 일상 생활에 불편함을 초래하는 중증도 이상의 보상성 발한은 R3에서 23.1%, R4에서 9.7%로 유의한 차이를 보였다(p=0.020). 재발되어 재수슬한 경우는 각각 5.1%, 4.2%로 유의한 차이를 보이지는 않았다. 결론: 수부다한증의 치료에 있어 교감신경절단술 시 R4가 R3에 비해 초기 및 중기 만족도 및 재발에 있어서는 차이가 없으나, 술 후 보상성 발한이 보다 적은 것으로 보인다.

• 대한기계학회논문집B
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• 제24권1호
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• pp.124-131
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• 2000

In this study, pool boiling performance of Turbo/B-type metal-formed tubes was investigated. Tubes with three different cavity gap width(0.04 mm, 0.07 mm, 0.1 mm) were manufactured and tested using R-11, R-123 and R-134a. Tests were conducted at two different saturation temperatures $4.4^{\circ}C$ and $26.7^{\circ}C.$ Heat flux was varied from 10 kW/m2 to 50 kW/m2. It was found that optimum gap width varied for different refrigerants. For low-pressure refrigerants such as R-11 or R-123, optimum gap width was 0.07 mm. For high-pressure refrigerant R-134a, however, the optimum value was 0.1 mm. Compared with the heat transfer performance of the smooth tube, the metal-formed tubes enhanced the heat transfer coefficients significantly - 6.5 times for R-11, 6.0 times for R-123 and 5.0 times for R-134a (at $4.4^{\circ}C$ saturation temperature and 40 kW/m2 heat flux), which are comparable with the performance of foreign products. The heat transfer coefficients of R-134a were larger than those of R-11 or R-123, and they increased as the saturation temperature increased.

• 동력기계공학회지
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• 제12권4호
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• pp.26-31
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• 2008

The evaporation heat transfer coefficient and pressure drop of R-22 and R-407C in a small diameter copper tube were investigated experimentally. The main components of the refrigerant loop are a receiver, a compressor, a mass flow mete, a condense and a double pipe type evaporate (test section). The test section consists of a smooth copper tube of 4.3 mm inner diameter. The refrigerant mass fluxes were varied from 100 to $300[kg/m^{2}s]$ and the saturation temperature of evaporator were $5[^{\circ}C]$. The evaporation heat transfer coefficients of R-22 and R-407C increase with the Increase in mass flux and vapor quality. The evaporation heat transfer coefficient of R-22 is about $7.3\sim47.1%$ higher than that of R-407C. The evaporation pressure drop of R-22 and R-407C increase with the increase of mass flux. The pressure drop of R-22 is about $8\sim20%$ higher than that of R-407C.