• 제목/요약/키워드: 4P Analysis

검색결과 17,684건 처리시간 0.052초

다시마밥 제조조건의 최적화 (Optimizing Cooking Condition of Short Grain Rice Containing Sea-tangle Patch)

  • 신은수;이진화;박경태;류홍수;장대흥
    • 한국식품영양과학회지
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    • 제33권10호
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    • pp.1726-1734
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    • 2004
  • 백미밥에 비하여 기능성과 기호성이 향상된 다시마밥의 최적조건을 구하기 위하여, 관능검사를 실시하였고, 그 결과를 반응표면 분석하여 다시마편 첨가비율, 가수량과 침지시간 등의 최적 수준을 정하고, 최적수준으로 제조한 다시마밥과 백미밥의 물성검사와 영양적 품질평가를 비교하였다. 40대 이상을 대상으로 한 결과로부터 얻어진 2차 회귀 방정식에서 맛, 찰기, 색상, 전반적기호도의 관능적 특성에서 유의성이 인정되었고(p<0.03), 예측되는 최적조건은 다시마편 첨가비율 14%, 가수량 1.67배, 침지시간 47분이었다. 이 최적조건으로 지은 다시마밥의 경도는 압력솥으로 지었음에도 불구하고 경도는 상압에서 지은 백미밥과 비슷하였다. 부착성은 상온에서 지은 백미밥보다는 낮았고 압력솥에서 지은 백미밥과는 큰 차이 없었다. 씹힘성은 상온에서 지은 백미밥에 비해 2배 높았으나 압력솥에서 지은 백미밥보다는 약간 낮았다. 밥을 지은 뒤 30분 경과 후의 물성의 변화는 백미밥보다 다시마밥의 변화가 더 적었다. 다시마밥의 식이섬유소 함량은 5.4%이었고, 백미밥에 비해 식이성 섬유소, 회분, 단백질의 보강효과는 현저하였다. 다시마밥의 단백질 소화율(in vitro), 단백질 효율비 (C-PER)과 전분호화도는 백미밥에 비해 낮게 나타났다. 따라서 다시마밥은 열량섭취량이 높고, 섬유소 섭취량이 낮은 현대인의 식생활에 이을 보완해주는 저열량 고섬유소의 기능적 식품으로 권장할 수 있을 것으로 판단된다.

부산·울산·경남 작업치료사의 지역사회중심재활에 대한 인식도 조사 및 활성화 방안 (A Study on Recognition and Activation Plan of Occupational Therapists for Community Based Rehabilitation in Pusan·Ulsan·Gyeongnam Province)

  • 김성례;한승협;김지영;박용광;임애진;한윤희;감경윤
    • 대한지역사회작업치료학회지
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    • 제2권1호
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    • pp.1-11
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    • 2012
  • 목적 : 부산 울산 경남 지역의 장애인복지관과 병원에서 근무하는 작업치료사를 대상으로 지역사회중심재활에 대한 인식도와 필요성을 조사하여 향후 지역사회중심재활에서 작업치료사의 역할을 구축하고, 지역사회중심재활 참여에 대한 활성화 방안을 모색하고자 한다. 연구방법 : 2010년 12월 1일부터 2011년 5월 4일까지 한국장애인복지관협회에 등록된 부산 울산 경남 지역에 소재한 장애인복지관에 근무하는 작업치료사 23명과 부산 지역에 소재한 병원에서 근무하는 작업치료사 49명을 대상으로 설문을 실시하였다. 통계분석은 SPSS12.0 통계 패키지 프로그램을 이용하였다. 결과 : 지역사회중심재활에 대한 작업치료사의 인식도와 필요도는 두 집단 모두 높은 것으로 나타났고 두 집단 간 유의한 차이는 없었다(p>.05). 또한 지역사회중심재활 중 작업치료사가 필요하다고 생각되는 영역에 대해 재활상담 및 정보제공, 가정방문재활치료, 직업재활, 재활기구대여, 장애예방교육으로 조사되었으며, 지역사회중심재활에서 작업치료사의 활성화를 위해서는 인력 수급과 국가적 차원의 법적/제도적 장치 마련과 관련 전문가와의 팀웍 조성 등이 필요한 것으로 나타났다. 결론 : 본 연구는 지역사회중심재활에 대한 작업치료사들의 인식도와 작업치료사들의 필요성은 높은 것으로 나타났으나, 현재 시행되는 기관은 부족한 것으로 나타났다. 따라서 지역사회중심재활에 있어 작업치료의 활성화를 위한 법적/제도적 장치 마련이 시급하다.

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급성 피부장벽파괴 동물모델에 대한 스트론튬의 피부보습효과 (Skin Humidity Effects of Strontium on Acute Skin Barrier Damage in Hairless Mice)

  • 민대기;김윤범
    • 대한한의학회지
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    • 제29권1호
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    • pp.117-133
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    • 2008
  • Objectives : Since ancient times, Koreans have applied medicinal spabaths for treatment of various diseases. The objective of this study was to investigate the effect of strontium, one of the common ingredients of such baths, experimentally on acute skin barrier damage. Materials and Methods : Male hairless mice, average weight 20g, were divided into six groups. Each group consisted of five mice. The first was the normal, non-treated group. The second was the control group with acute skin barrier damage intentionally induced by TS. The third was the Ba-Sr1 group bathed in 1mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fourth was the Ba-Sr7 group bathed in 7mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fifth was the Sr1 group bathed in 1mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. The sixth was the Sr7 group bathed in 7mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. External changes of skin, skin erythema level, transepidermal water loss level, and GOT and GPT level of each group were checked immediately before and after TS, 3 hrs, 5 hrs and 24 hrs after inducing acute skin barrier damage. Then, tissue samples were made and examined for damage to epithelial cells, stratum corneum, change of mucous polysaccharide in dermis and amount of mast cells. Statistical analysis was performed by one way-ANOVA, Scheffe and Duncan for a post hoc test and pairwise comparison for comparing for difference between each time. Statistical significance was achieved if the probability was less than 5% (p<0.05) Results : 1. From skin erythema and TEWL level indicating the function of the skin barrier, we can know that it is helpful to the skin barrier to bathe in a water solution including a low concentration of strontium. 2. In the control group with acute skin barrier damage induced by TS, skin barrier damage persisted until 3-5 hrs and recovered after 5-24 hrs. Differently from the control group, in the case of taking a bath in a water solution including strontium, skin barrier damage recovered after only 3-5 hrs. Therefore, the bath with a water solution including strontium can promote recovery of the skin barrier. 3. Bathing in water solution including a higher concentration of strontium was more beneficial to recovery of skin barrier damage. 4. There was no influence on serum GOT and GPT from bathing in a water solution including strontium. Conclusions : The strontium was effective for recovery and mitigation of acute skin barrier damage induced by tape stripping. I suggest that strontium (Sr) can be used as an external treatment medicine, addedinto bath water to treat acute skin barrier damage.

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Comparison of conservative therapy and steroid therapy for Bell's palsy in children

  • Yoo, Hye Won;Yoon, Lira;Kim, Hye Young;Kwak, Min Jung;Park, Kyung Hee;Bae, Mi Hye;Lee, Yunjin;Nam, Sang Ook;Kim, Young Mi
    • Clinical and Experimental Pediatrics
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    • 제61권10호
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    • pp.332-337
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    • 2018
  • Purpose: Bell's palsy is characterized by sudden onset of unilateral facial weakness. The use of corticosteroids for childhood Bell's palsy is controversial. This study aimed to identify clinical characteristics, etiology, and laboratory findings in childhood Bell's palsy, and to evaluate the efficacy of corticosteroid treatment. Methods: We conducted a retrospective analysis of children under 19 years of age treated for Bell's palsy between January 2009 and June 2017, and followed up for over 1 month. Clinical characteristics, neuroimaging data, laboratory findings, treatments, and outcomes were reviewed. Patients with Bell's palsy were divided into groups with (group 1) and without (group 2) corticosteroid treatment. Differences in onset age, sex, laterality, infection and vaccination history, degree of facial nerve palsy, and prognosis after treatment between the groups were analyzed. Results: One hundred patients were included. Mean age at presentation was $7.4{\pm}5.62years$. A total of 73 patients (73%) received corticosteroids with or without intravenous antiviral agents, and 27 (27%) received only supportive treatment. There was no significant difference in the severity, laboratory findings, or neuroimaging findings between the groups. Significant improvement was observed in 68 (93.2%) and 26 patients (96.3%) in groups 1 and 2, respectively; this rate was not significantly different between the groups (P=0.48). Conclusion: Childhood Bell's palsy showed good prognosis with or without corticosteroid treatment; there was no difference in prognosis between treated and untreated groups. Steroid therapy in childhood Bell's palsy may not significantly improve outcomes.

Effect of Chlorella on Metallothionein Synthesis and Binding Capacity of Cadmium in Cadmium Poisoned Rat Liver and Kidney

  • Hwang Yoo-Kyeong;Choi Hyun-Jin;Nan Meng;Yoo Jai-Du;Kim Yong-Ho
    • 대한의생명과학회지
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    • 제12권1호
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    • pp.23-27
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    • 2006
  • The rate of metallothionein synthesis on cadmium-poisoned rats reflects the level of toxicity, and also it reduces the toxicity which is caused by the uptake of cadmium. Chlorella supplementation in the diets of the cadmium-poisoned rats decreased the concentration of cadmium in blood and urine compared with the control group. Although the liver and kidneys of rats are major target organs of cadmium and coherence of metallothionein and cadmium, no previous study has determined the correlation between the rate of metallothionein synthesis in the liver and kidneys of rats and dietary supplementation of chlorella with cadmium uptake. This study analyzed total metallothionein level on the tissue of the liver and kidneys, the concentration of cadmium bound to the metallothionein, and the total concentration of cadmium on the tissue of the liver and kidneys after dietary supplementation with 1%, 5%, and 10% dried chlorella and 40 ppm of cadmium to 46 male SD rats (mean weight: $150\pm20\;g$) for 4 weeks. According to the data analysis of the total rate of metallothionein synthesis in the liver and kidneys, the group of SD rats on the supplementation with 1% chlorella and 40 ppm of cadmium showed a rate of $93.2\pm8.9\;ng/g$, a significant decrease of 58.8% compared to that of the control group of SD rats on the supplementation with cadmium only, which showed a rate of $227.3\pm32.5 ng/g$ (P=0.0001). In contrast, no significant difference was observed through the changing of chlorella concentrations between 5% and 10% chlorella supplementation with cadmium. The group supplemented with 1% or greater chlorella levels represented a greater decrease in the total cadmium concentration of the kidney and liver tissues, the amount of total metallothionein synthesis, the amount of metallothionein with binding to cadmium, and the concentration of free cadmium without binding to metallothionein. Consequently, the supplementation of 1% and 5% chlorella was effective in reducing the synthesis of metallothionein for cadmium uptake, but increased the rate of binding of cadmium to metallothionein.

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24주 추적 조사를 통한 한국인 알코올 의존 환자의 재발 예측 인자 규명 연구 (A Study on Relapse Predictors in Korean Alcohol-Dependent Patients - A 24 Weeks Follow up Study -)

  • 김철민;김성곤;남궁기;조동환;이병욱;최인근;김민정
    • 생물정신의학
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    • 제14권4호
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    • pp.249-255
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    • 2007
  • 목 적: 본 연구에서는 알코올 의존의 재발 예측 인자로 중요하다고 알려진 사회 인구학적 변인, 음주력, 음주갈망, 치료 동기, 병식과 같은 요인들 중에 어떤 요인들이 한국인 알코올 의존의 재발을 예측하는지를 전향적으로 조사하였다. 방 법: 알코올 의존 환자 48명을 대상으로 사회 인구학적 특성, 음주력, Timeline Follow-Back(TLFB), Obsessive-Compulsive Drinking Scale(OCDS), Alcohol Urge Questionnaire(AUQ), Pennsylvania Alcohol Craving Scale(PACS), University of Rhode Island Change Assessment(URICA), Hanil Alcohol Insight Scale(HAIS)등을 조사한 후, 24주간 총 11회에 걸쳐 외래를 방문하도록 하였다. 24주 동안 조사한 TLFB자료에 근거하여 대상자 중에서 과음(일일 5standard drinking 이상)일이 나타난 경우 혹은 더 이상 추적 방문이 되지 않은 경우 모두 재발한 것으로 하여 재발군으로 분류하였으며, 그렇지 않은 경우를 비재발군으로 분류하였다. 알코올 의존의 재발을 예측할 수 있는 요인을 찾는 방법으로 SPSS PC+11.5 프로그램의 로지스틱 회귀분석을 이용하였다. 결 과: 음주를 시작한 연령, 음주로 인한 문제가 발생된 연령, 최근 1년간 1일 음주량, 최근 1년간 월 음주일수, PACS, AUQ, OCDS, URICA, HAIS와 같은 요인들 중 최근 1년간 1일 음주량과 HAIS 점수가 알코올 의존의 재발에 영향을 주는 것으로 나타났다(p<.05). 결 론: 알코올 의존 환자의 치료에서 1일 음주량이 많은 경우와 병식이 낮은 경우가 재발 가능성이 높으므로 앞으로의 치료에서 이러한 요인을 고려해야 할 것이다.

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Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?

  • Jeong, Ji Seong;Nam, Ki Taek;Lee, Buhyun;Pamungkas, Aryo Dimas;Song, Daeun;Kim, Minjeong;Yu, Wook-Joon;Lee, Jinsoo;Jee, Sunha;Park, Youngja H.;Lim, Kyung-Min
    • Biomolecules & Therapeutics
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    • 제25권5호
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    • pp.545-552
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    • 2017
  • Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects of repeated oral treatment of low to high dose BPA in juvenile Sprague-Dawley rats. Exposing juvenile rats to BPA (0, 0.5, 5, 50, and 250 mg/kg oral gavage) from post-natal day 9 for 90 days resulted in higher food intakes and increased body weights in biphasic dose-effect relationship. Male mammary glands were atrophied at high dose, which coincided with sexual pre-maturation of females. Notably, proliferative changes with altered cell foci and focal inflammation were observed around bile ducts in the liver of all BPA-dosed groups in males, which achieved statistical significance from 0.5 mg/kg (ANOVA, Dunnett's test, p<0.05). Toxicokinetic analysis revealed that systemic exposure to BPA was greater at early age (e.g., 210-fold in $C_{max}$, and 26-fold in AUC at 50 mg/kg in male on day 1 over day 90) and in females (e.g., 4-fold in $C_{max}$ and 1.6-fold in AUC at 50 mg/kg vs. male on day 1), which might have stemmed from either age- or gender-dependent differences in metabolic capacity. These results may serve as evidence for the association between risk of cancer and exposure to low-dose BPA, especially in young children, as well as for varying toxicity of xenobiotics in different age and gender groups.

만성질환자들의 한의약의료서비스 이용과 결정요인 -제주도 보건소이용 환자를 중심으로- (The Use of Traditional Korean Medicine and its Affecting Factors among Patients with Chronic Disease in Jeju Province, Korea)

  • 오종수;한동운;임문혁;홍용석;이영호;노홍인
    • 대한예방한의학회지
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    • 제13권3호
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    • pp.55-71
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    • 2009
  • Background : Traditional Korean medicine(TKM) has gained in popularity among chronic patients in recent years. The use of TKM among patients with chronic diseases is common, with about two thirds of patients using some form of TKM in Korea. Objectives : The purpose of this study is to analyze the use of TKM and determine what factors affect to use TKM among patients with chronic diseases. The study also aims to provide information on TKM therapies and assist therapy selection among various TKM therapies for patients with chronic diseases. Methods : The design of the study was descriptive cross-sectional, and data were collected using a 21-item questionnaire. This study was conducted with subjects with confirmed diagnosis of chronic diseases, who live in Jeju Province, Korea. Results : Among the participants, past or current TKM use was 66.7%, with a statistically significant difference in gender and level of health status groups(p<0.05), but no difference in age, marital status, education, occupation, and income groups. The most common therapies of TKM used by the patients included acupuncture(51.1%), physiotherapy(16.8%), cupping(13.5%), and herbal medicine(4.8%). The main benefits from TKM perceived by the patients were chronic diseases management and health promotion. In a logistic regression analysis, significant influencing factors related to TKM use were gender, family income level, the extent of recognition of efficacy, heath status, and health security program. Conclusions : In this study the socio-demographic and health status, recognition of TKM efficacy factors associated with TKM use among patients with chronic diseases were similar to those found in the general population. The findings suggest that due to the relatively high use of TKM among patients with chronic diseases in Korea, this topic should be taken into account in the development of a holistic approach for patients with chronic diseases and an efficient chronic disease management system. Additionally proactive and consistent management of TKM is necessary in the health care system in Korea.

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외상성 췌장 손상의 임상 결과 및 예후인자 (Clinical Outcomes and Risk Factors of Traumatic Pancreatic Injuries)

  • 이홍태;김재일;최평화;박제훈;허태길;이명수;김철남;장석효
    • Journal of Trauma and Injury
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    • 제24권1호
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    • pp.1-6
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    • 2011
  • Purpose: Even though traumatic pancreatic injuries occur in only 0.2% to 4% of all abdominal injuries, the morbidity and the mortality rates associated with pancreatic injuries remain high. The aim of this study was to evaluate the clinical outcomes of traumatic pancreatic injuries and to identify predictors of mortality and morbidity. Methods: We retrospectively reviewed the medical records of 26 consecutive patients with a pancreatic injury who underwent a laparotomy from January 2000 to December 2010. The data collected included demographic data, the mechanism of injury, the initial vital signs, the grade of pancreatic injury, the injury severity score (ISS), the revised trauma score (RTS), the Glasgow Coma Scale (GCS), the number of abbreviated injury scales (AIS), the number of associated injuries, the initial laboratory findings, the amount of blood transfusion, the type of operation, the mortality, the morbidity, and others. Results: The overall mortality rate in our series was 23.0%, and the morbidity rate was 76.9%. Twenty patients (76.9%) had associated injuries to either intra-abdominal organs or extra-abdominal organs. Two patients (7.7%) underwent external drainage, and 18 patients (69.3%) underwent a distal pancreatectomy. Pancreaticoduodenectomies were performed in 6 patients (23.0%). Three patients underwent a re-laparotomy due to anastomosis leakage or postoperative bleeding, and all patients died. The univariate analysis revealed 11 factors (amount of transfusion, AAST grade, re-laparotomy, associated duodenal injury, base excess, APACHE 11 score, type of operation, operation time, RTS, associated colon injury, GCS) to be significantly associated with mortality (p<0.05). Conclusion: Whenever a surgeon manages a patient with traumatic pancreatic injury, the surgeon needs to consider the predictive risk factors. And, if possible, the patient should undergo a proper and meticulous, less invasive surgical procedure.

The Anti-calcification Effect of Dithiobispropionimidate, Carbodiimide and Ultraviolet Irradiation Cross-linking Compared to Glutaraldehyde in Rabbit Implantation Models

  • Park, Samina;Kim, Soo Hwan;Lim, Hong-Gook;Lim, Cheong;Kim, Yong Jin
    • Journal of Chest Surgery
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    • 제46권1호
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    • pp.1-13
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    • 2013
  • Background: Glutaraldehyde (GA) is a widely used cross-linking agent for improving mechanical properties and resistance to enzymatic degradation of collagenous tissue, but it has several drawbacks such as calcification and cytotoxicity. The aim of this study was to find the alternative effective cross-linking methods to GA. Materials and Methods: Bovine pericardium was processed with GA with ethanol+octanol and glycine detoxification, and polyethylene glycol (PG) space filler, dimethyl 3,3'-dithiobispropionimidate (DTBP), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) treatment, and the physical fixation of ultraviolet irradiation were done. The biologic material properties of variously treated pericardial tissues were assessed by biochemical, mechanical and histological tests. Treated pericardial tissues were also implanted subcutaneously or intramuscularly into the rabbit for 10 weeks to assess the xenoreactive antibody response of immunoglobulin G and M, their anti-calcification effect. Results: The biochemical and mechanical properties of EDC fixed pericardial tissues were comparable to the GA fixed tissue. The cytotoxicity was lowest in space filler treated GA fixed group. In rabbit subcutaneous or intramuscular implantation models, decellularization, space filler, EDC treatment group showed significantly lower calcium content than GA only and DTBP treatment group (p<0.05, analysis of variance). The titer of anti $Gal{\alpha}1-3Gal{\beta}1$-4GlcNAc-R antibodies did not change in the postimplantation serial enzyme-linked immunosorbent assay. Hematoxylin and eosin and von Kossa staining showed that decellularization, space filler, EDC, and ultraviolet treatment had less inflammatory cell infiltration and calcium deposits. Conclusion: The decellularization process, PG filler, and EDC treatments are good alternative cross-linking methods compared to GA only fixation and primary amine of DTBP treatment for cardiovascular xenograft preservation in terms of the collagen cross-linking stability and in vivo anti-calcification effects.