• YAKHAK HOEJI
• /
• v.38 no.2
• /
• pp.140-148
• /
• 1994

${\beta}-Lactamase$ stability, chemotherapeutic activity, and pharmacokinetics of 7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazinyl]thiocarbonylthiomethyl-3-cephem-4-carboxylic acid(CEN1), 7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyrimidyl)piperazinyl]thiocarbonylthiomethyl-3-cephem-4-carboxylic acid(CEN2), pivaloyloxymethyl-7-[(Z)-2-(2-aminothizaole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazinyl]thiocarbonyl-thiomethyl-3-cephem-4-carboxylate(CEN1P), and pivaloyloxymethyl-7-{(Z)--2-(2-aminothizaole-4-yl)-2-methoxyiminoacetamido]-3-[4-(2-pyridyl)piperazinyl]thiocarbonyl-thiomethyl-3-cephem-4-carboxylate(CEN2P) were examined. CEN1, CEN2, CEN1P, and CEN2P were very stable to the ${\beta}-lactamase$ obtained from three strains(Enterobacter cloacae P99, Escherichia coli TEM, and Citrobacter freundii). Chemotherapeutic activities$(ED_{50})$ of CEN2 and CEN2P against experimental systemic infections due to Streptococcus pyogenes 77A and Escherichia coli 078 were superior to those of CEN1 and CEN1P, respectively. The $ED_{50}$ values of CEN1, CEN2 were 5.82 mg/kg, 0.89 mg/kg(s.c., S. pyogenes 77A) while those of CEN1P, CEN2P were 14.56mg/kg, 6.40mg/kg(p.o., S. pyogenes 77A), respectively. The pharmacokinetics of CEN1, CEN2, CEN1P, and CEN2P were investigated in mice and rats. In mice, peak blood levels of $1.25\;{\mu}g/ml$ were recorded within 20 min after oral administration of a single dose equivalent to 40 mg/kg CEN1P. Cmax of CEN1P was much higher than that of CEN1 in mice and rats. Oral absorption of CEN2P was much higher than that of CEN2.

• Journal of the Korean Geotechnical Society
• /
• v.17 no.4
• /
• pp.153-160
• /
• 2001

딜라토메터를 이용한 현장 수평압밀계수 추정법의 국내 점토지반 및 실트질 지반에의 적용성을 평가하기 위해 국내 점토지반과 실트지반에 대하여 각각 딜라토메터 관입시험 및 소산시험을 수행하였다. 소산시험 결과로부터 DMT-C법 [p$_2$-log t법과 C-√t법]과 DMT-A법을 이용하여 수평압밀계수를 추정하여 상호 비교하였으며 다른 실험방법에서 얻어진 결과들과도 함께 비교하고 평가하였다. 비교대상으로는 동일지반의 현장 피에조콘 소산시험으로 얻어진 수평압밀계수 및 불교란시료에 대하여 수행된 로셀압밀실험 및 일차원 실내압밀실험 결과가 함께 이용되었다. 연구결과 C-√t법을 제외한 p$_2$-log t법과 DMT-A법은 국내 점토지반에 대하여 상호일치하는 결과를 줄 뿐 아니라 피에조콘 결과와도 비교적 잘 일치하는 수평 압밀계수를 측정하였으며 다른 결과와 비교할 때 신뢰성 있는 결과를 주었다. 그러나 실트질 지반에 대하여는 p$_2$-log t법만이 적용 가능할 것으로 판단된다.

• Journal of the Korean Wood Science and Technology
• /
• v.38 no.1
• /
• pp.56-65
• /
• 2010

The purpose of this study was finding out proper wall assembly to reduce moisture accumulation in light frame wall under outdoor air conditions. For the purpose, moisture transfer and accumulation in a wall were evaluated for five types of wall assembly; typical wall (T), addition of a vapor retarder (P1), addition of two vapor retarders (P2), addition of an open air gap for ventilation behind the siding (P3), and shift of vapor retarder with proposed wall 'P3' (P4). The moisture transfer and accumulation in the all walls were evaluated after applying the typical and proposed walls to the field test house. Performances of the typical and proposed walls were compared according to the season. Rank for effective wall on reducing moisture accumulation in wall was 1) shift of vapor ratarder and addition of open air gap (P4), 2) addition of vapor retarder (P1), 3) typical wall (T), 4) addition of open air gap (P3), and 5) the other (P2).

• The Journal of the Korea Contents Association
• /
• v.12 no.4
• /
• pp.367-372
• /
• 2012

The aim of this study was to assess the effect of exposure factors such as kVp and mA applied by BMI on the image quality and patients absorbed dose of Coronary angiography in CT. Each data sets were into 4groups with different exposure values : Group A at 100kVp, 240mAs, Group B at 120kVp, 240mAs, Group C at 100kVp, 270mAs and Group D at 120kVp, 270mAs, and the mean of the scores of 4 groups was calculated for image quality as 4grades that is, 1(poor), 2(fair), 3(good) and 4(very good). Patient absorbed dose was calculated as DLP on the monitor. In case of absorbed dose, deviation in 2groups at 100kVp was 5.6 $mGy{\cdot}cm$, 11 $mGy{\cdot}cm$, was at 120kVp(DLP) with p<0.05. There was rather difference between groups with 100kVp or 120kVp respectively but the gaps were very little. No significant correlation was found between exposure factors and image quality in any images assessed(p>0.05), and the image quality was sufficient for diagnosis. As we applying coronary angiography, the selection of adequate exposure factors considering BMI identified might be effective for reduction of patient absorbed dose, improvement of image quality and diagnostic accuracy.

• Korean Journal of Psychosomatic Medicine
• /
• v.28 no.2
• /
• pp.126-134
• /
• 2020

Objectives : The purpose of this study was to investigate the needs for return-to-work support of cancer survivors and related factors in patients with cancer and their caregivers. Methods : 182 patients and 114 caregivers were recruited. Distress Thermometer and Problem List and scale ranging 0~10 measuring the degree of needs for return-to-work support were utilized. The needs for return-to-work support between the patient group and caregiver group (patient's needs evaluated by the caregiver) were compared, and related factors were investigated using logistic regression analysis. Results : 34.6% and 28.1% of patients and caregivers reported return-to-work support of cancer survivors is "very necessary". The degree of needs was 6.60±3.365 points in the patient group and 6.17±3.454 points in the caregiver group, with no significant difference (p=0.282). The needs for return-to-work support evaluated by patients was high when they underwent surgery (OR=2.592, p=0.007), has fertility problems (OR=6.137, p=0.025), has appearance problems (OR=2.081, p=0.041), or has fatigue (OR=2.330, p=0.020). The needs for return-to-work support of patients evaluated by caregivers was high when patients treated with breast cancer (vs respiratory cancer, OR=13.038, p=0.022 ; vs leukemia/lymphoma, OR=4.517, p=0.025 ; vs other cancer, OR=13.102, p=0.019), has work/school problems (OR=4.578, p=0.005), or has depression (OR=3.213, p=0.022). Conclusions : The degree of needs for return-to-work support of cancer survivors was high, and factors related to the needs were different between the two groups. This suggests that return-to-work support of cancer survivors is required, and clinical characteristics, the distress of patients, and differences between patients and their caregivers should be considered in establishing a support plan.

• Journal of Digital Convergence
• /
• v.10 no.2
• /
• pp.249-254
• /
• 2012

Assessing the exposure dose and the obtained image during the abdominal radiography with 128-slice MDCT scanner and 4-slice MDCT scanner which are recently being used in clinics using the body tissue-equivalent phantom and the glass dosimeter, the results were as follows. During the CT test for the abdomen, the absorbed dose was $35.8{\pm}0.46mGy$ in 4-MDCT, and $19.03{\pm}0.25mGy$ in 128-MDCT, which indicated that the radiation dose necessary to obtain the image meaningful to diagnosis was required less by 128-MDCT(P<0.05). As a result of analyzing the image obtained from the abdominal test using MDCT with a 5-point Likert scale, 4-MDCT showed the result of 3.52 points, and 128-MDCT showed the result of 4.01 points, that is, the image quality of 128-MDCT was evaluated high, and there was a statistically significant difference. In the results above, it is considered that 128 slice MDCT scanner will be much used later as it can reduce the radiation exposure, and make us obtain the high quality of image.

• Journal of the Korean Geotechnical Society
• /
• v.34 no.7
• /
• pp.51-58
• /
• 2018

In this study a series of centrifuge tests were carried out in dry sand to analyze the comparison of lateral pile behavior for static loading and dynamic loading condition. In case of static loading condition, the lateral displacement was applied up to 50% of pile diameter by deflection control method. And the input sine wave of 0.1 g~0.4 g amplitude and 1 Hz frequency was applied at the base of the soil box using shaking table for dynamic loading condition. From comparison of experimental static p-y curve obtained from static loading tests with API p-y curves, API p-y curves can predict well within 20% error the ultimate subgrade reaction force of static loading condition. The ultimate subgrade reaction force of experimental dynamic p-y curve is 5 times larger than that of API p-y curves and experimental static p-y curves. Therefore, pseudo-static analysis applied to existing p-y curve for seismic design could greatly underestimate the soil resistance at non-linear domain and cause overly conservative design.

• Journal of the Korean Society of Food Culture
• /
• v.11 no.2
• /
• pp.207-215
• /
• 1996

This study was carried out to find the effects of salt and other materials on the taste and fermentation of kimchi. Several parameters such as pH, acidity, salt concentration and sensory evaluation during fermentation at $20^{\circ}C\;and\;5^{\circ}C$ (after keeping at $20^{\circ}C$ for 24 hours) were used. The results are as follows: As the fermentation period increases the pH of kimchi decreases. The pH of all samples rapidly decreases to 4.2. During fermentation, the acidity at 3 hours was higher than at 5, 8 and 12 hours. For in the sensory evaluation during fermentation, kimchi salted for 5 hours showed a higher score than those salted for 3, 8 and 12 hours. During the storage period, the pH of kimchi with salted oysters rapidly decreased. A sensory evaluation done during the storage period, showed that earlier on in the storage, kimchi with salted oysters was scored higher than kimchi with other Jeotkals. The leek-added kimchi was also highly scored.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2016.05a
• /
• pp.510-510
• /
• 2016

농업 비점오염원의 영향을 분석하고 여러 가지 대안(관리정책)이 수계의 수질에 미치는 영향을 평가하기 위해서 유역모형의 적용이 필요하다. 이러한 유역모형에는 모형의 복합성, 계산시간 등에 따라 simple method, mid-range model, detail model로 나눌 수 있다. Simple methods는 요구되는 자료가 작으나 그 결과의 정확성은 떨어진다. 반면에 detail model는 정확한 결과를 획득할 수 있으나 그만큼 방대한 자료와 모니터링을 요구하며, 보정 및 검증에 많은 시간과 노력을 필요로 한다. 특히, 복잡한 유역특성 및 축산오염원을 포함한 복잡한 특성들을 고려해서 모델링하기 위해서는 detail model이 필요하며 본 연구에서는 HSPF모델을 이용해서 그 영향을 분석하고자 하였다. 따라서 본 연구에서는 농업에 미치는 영향을 평가하기 위해서 청미천 유역 및 덕천천 유역을 대상유역으로 선정하여 그 영향을 분석하였다. 농업에 미치는 영향을 평가하기 위해서 유역내 투입된 비료사용량을 통계청 자료를 활용하여 산정후 적용하였으며, 축산 부산물중 자원화되는 축산 액비 및 퇴비량을 산정하여 그 영향에 대해 분석하였다. 또한 기존에 광범위하게 활용되고 있는 수질오염총량관리제도에서 산정되는 배출부하량에 유달율을 고려하여 점오염으로 입력하였으며, 직접방류되는 하수처리장도 함게 고려하여 구축하였다. 청미천 유역의 청미천1 지점의 BOD, T-N, T-P에 대한 보정기간의 평균 관측값은 4.205mg/L, 3.844mg/L, 0.137mg/L이며 검정기간의 관측값은 2.741mg/L, 4.638mg/L, 0.144mg/L로 나타났다. BOD, T-N, T-P에 대한 보정기간의 NSE는 -0.58, -0.20, -0.33이며, 검정기간의 NSE는 -0.26, -1.35, -3.54로 분석되었다. BOD, T-N, T-P에 대한 보정기간의 RMSE는 2.65, 1.63, 0.12이며, 검정기간의 RMSE는 1.36, 1.64, 0.07로 나타났다. 덕천천 유역의 경우 국가관측망이 없어 동진강의 제일 말단 지점인 동진강3 지점의 BOD, T-N, T-P에 대한 보정기간 평균관측값은 2.891mg/L, 3.455mg/L, 0.096mg/L이며, 검정기간의 관측값은 2.293mg/L, 3.223mg/L, 0.104mg/L로 나타났다. BOD, T-N, T-P에 대한 보정기간의 NSE는 -0.20, -0.56, -0.49이며, 검정기간의 NSE는 0.24, -0.06, -0.19으로 분석되었다. BOD, T-N, T-P에 대한 보정기간의 RMSE는 1.53, 2.12, 0.05이며, 검정기간의 RMSE는 1.05, 0.98, 0.06으로 나타났다. 본 연구의 분석결과는 점오염원, 축산계비점오염, 토지계비점오염, 시비량, 배경부하로 구분하여 분석을 실시하였으며 분석결과 청미천 유역의 비점오염 기여율이 약 65%를 차지하고 있는 것으로 평가되었으며, 덕천천 말단에서는 약 37.7%의 비점오염물질이 하천수질에 영향을 미치는 것으로 나타났다. 또한, 기존 수질오염 총량관리제도에서 점오염의 감소에 의한 비점오염비중이 커지는 것으로 평가되었으며, 그 중 축산이 차지하는 비중이 상대적으로 높은 것으로 평가되고 있지만, 본 연구의 결과에서는 그보다 적은 수준이 수계에 영향을 미치는 것으로 분석되었다.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.19 no.3
• /
• pp.207-214
• /
• 1990

Amish 집단(미국 오하이오주 홈스카운터 거주)의 vitamin E 영양상태를 24시간 회상법, 영양보충제의 사용량 조사 colorimetric법에 의한 혈장 vitamin E의 분석으로 평가하였다 평균식이 섭취 vitamin E는 7.4mg a-tocopherol equivalent였으며 평균 181.4 IU는 영양보충제로 섭취했다 전체 vitamin E의 67.7% 는 식이를 통해 섭취했으며 32.4%는 영양보충제를 복용함으로 섭취했다 평균 혈장 vitamin E 농도는 13.4mg/ml였다 혈장 vitamin E와 영양제로 복용한 vitamin E 사이에는 유의적인 상관과계가(r=0.489 p=0.0001)를 보여주었고 혈장 vitamin E와 연령과도 상관관계(r-0.216, p=0.0017)가 있었다 Amish 집단의 vitamin E 영양상태는 충분했으며 이집단 중의 어떤 자들은 고단위의 다량의 vitamin E 영양제를 복용하고 있어 vitamin E에 대한 올바른 정보를 알려주고 효율적인 영양교육을 시킬 필요성이 요청되었다.