• Title/Summary/Keyword: 40 principles

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Nuclear Bodies Built on Architectural Long Noncoding RNAs: Unifying Principles of Their Construction and Function

  • Chujo, Takeshi;Hirose, Tetsuro
    • Molecules and Cells
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    • v.40 no.12
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    • pp.889-896
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    • 2017
  • Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis, storage, and sequestration of specific RNAs, proteins, or ribonucleoprotein complexes. Recent studies reveal that a subset of nuclear bodies in various eukaryotic organisms is constructed using architectural long noncoding RNAs (arcRNAs). Here, we describe the unifying mechanistic principles of the construction and function of these bodies, especially focusing on liquid-liquid phase separation induced by architectural molecules that form multiple weakly adhesive interactions. We also discuss three possible advantages of using arcRNAs rather than architectural proteins to build the bodies: position-specificity, rapidity, and economy in sequestering nucleic acid-binding proteins. Moreover, we introduce two recently devised methods to discover novel arcRNA-constructed bodies; one that focuses on the RNase-sensitivity of these bodies, and another that focuses on "semi-extractability" of arcRNAs.

A Work Improvement Study by Motion-Time Analysis (동작시간분석에 의한 작업개선연구 -PCB조립작업을 사례로-)

  • 박성학
    • Journal of the Korean Professional Engineers Association
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    • v.16 no.3
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    • pp.33-40
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    • 1983
  • This paper is one of the case studies to improve the labor productivity of PCB assembly through Work Factor motion-time analysis and the application of the motion economy principles and the human factors engineering theory. In result, we can improve 129% of the labor productivity by using a rotary table for the parts delivery. Therefore, it is expected that this result can be used for a lot of the manual works of the small and medium-sized industries especially.

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Design For Manufacture and Assembly(DFMA) (생산공정 및 조립을 고려한 설계)

  • 이건상
    • CDE review
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    • v.8 no.3
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    • pp.40-51
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    • 2002
  • Design and manufacturing (or production) must be closely interrelated. They should never be viewed as separate disciplines or activities. Each part or component of a product must be designed so that it not only meets design requirements and specifications, but also can be manufactured and assembled economically, ecologically and with relative ease. This approach improves productivity and allows a manufacturer to remain competitive. This broad view has become recognized as the area of design for manufacture and assembly(DFMA). Here the principles of the DFMA and their some examples are reviewed.

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The principles of posionous mushrooms, their unexpected utilitie

  • Shirahama, Hirushisa
    • Plant Resources
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    • v.3 no.1
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    • pp.100-104
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    • 2000
  • Lampteromyces japonicus is the most popular source of mushroom poisoning in Japan. We isolated poisonous substance, illudin S, 40 years ago, which shower strong anti-tumoric activity. Its analogs are now the most hopeful anti-cancer agent. Clitocybe acromelalgia gives unique poisoning which exhibits symptoms similar to acromelalgia and erythromelalgia. We intended to isolate the toxin causing these poisoning but neuroexciatory compounds, acromelic acids A and B, were isolated. They are now known as the most potent glutamate agonists and good reagents for the study of the glutamate receptor of a neurocell.

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A Comparative Study on International Convention and National Legislation Relating to the Liability of the Air Carrier

  • Lee, Kang-Bin
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.40
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    • pp.97-144
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    • 2008
  • The purpose of this paper is to review the text of national legislation relating to the carrier's liability in respect of the carriage of passengers, baggage and cargo by air in major states such as United Kingdom, Germany, France, Canada, Russia and China, and to compare the air carrier's liability under the national legislations of above states with them under the Warsaw System relating to the international carriage by air. Also this paper reviews the text of the draft legislation relating to the carrier's liability in respect of the carriage by air in Korea. The Warsaw Convention for the Unification of Certain Rules Relating to International Carriage was adopted in 1929. In 1999, the ICAO adopted the Montreal Convention for the Unification of Certain Rules for International Carriage by Air vastly modernizing the unification of private air law. The Montreal Convention replaced the instruments of the “Warsaw System”, and came into force on 4 November 2003. The Montreal Convention is not only an international convention. It has also exercised a considerable influence on national legislation. A the Convention, or certain of its principles, with the object of regulating their national air transport. The main feature of the liability regime of the air carrier under the Montreal Convention is the two-tier liability system for death or injury of the passenger with strict liability up to 100,000 SDR and presumptive liability with a reversed burden of proof without any limit above that threshold. The principles of the liability of the air carrier under the Montreal Convention have been adopted into national legislations by the United Kingdom, Germany, France, Canada, Russia and China. Now the Ministry of Justice of Korea is proceeding to make a new national legislation relating to the liability of the air carrier in respect of the carriage by air. The draft legislation of the Part VI the Carriage by Air of the Commercial Code of Korea has adopted the main principles of the liability of the air carrier under the Montreal Convention. In conclusion, the national legislation relating to the liability of the air carrier in Korea will contribute to settle efficiently the dispute on the carrier's liability in respect of the carriage of passengers, baggage and cargo by air.

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A Study on Policy Instrument for the Development of Ethical AI-based Services for Enterprises: An Exploratory Analysis Using AHP (기업의 윤리적 인공지능 기반 서비스 개발을 위한 정책수단 연구: AHP를 활용한 탐색적 분석)

  • Changki Jang;MinSang Yi;WookJoon Sung
    • Journal of Information Technology Services
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    • v.22 no.2
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    • pp.23-40
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    • 2023
  • Despite the growing interest and normative discussions on AI ethics, there is a lack of discussion on policy instruments that are necessary for companies to develop AI-based services in compliance with ethical principles. Thus, the purpose of this study is to explore policy instruments that can encourage companies to voluntarily comply with and adopt AI ethical standards and self-checklists. The study reviews previous research and similar cases on AI ethics, conducts interviews with AI-related companies, and analyzes the data using AHP to derive action plans. In terms of desirability and feasibility, Research findings show that policy instruments that induce companies to ethically develop AI-based services should be prioritized, while regulatory instruments require a cautious approach. It was also found that a consulting support policy consisting of experts in various fields who can support the use of AI ethics, and support for the development of solutions that adhere to AI ethical standards are necessary as incentive policies. Additionally, the participation and agreement of various stakeholders in the process of establishing AI ethical standards are crucial, and policy instruments need to be continuously supplemented through implementation and feedback. This study is significant as it presents the necessary policy instruments for companies to develop ethical AI-based services through an analytical methodology, moving beyond discursive discussions on AI ethical principles. Further analysis on the effectiveness of policy instruments linked to AI ethical principles is necessary for establishing ethical AI-based service development.

DEVELOPMENT OF NUCLEAR ENERGY AND RADIATION TEXTBOOKS FOR ELEMENTARY, MIDDLE, AND HIGH SCHOOL STUDENTS

  • Han, Eun Ok;Kim, Jae Rok;Choi, Yoon Seok;Lochhead, James
    • Journal of Radiation Protection and Research
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    • v.40 no.3
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    • pp.132-146
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    • 2015
  • To develop tailored elementary, middle, and high school textbooks suitable for understanding the nuclear energy and radiation, quantitative and qualitative research was carried out in parallel, which included nine steps to ensure the validity of content and structure. The elementary, middle, and high school students wanted to acquire information used in their daily lives, including the definition of nuclear energy and radiation, principles and status of nuclear power generation, and information about irradiated food, medical radiation, and radiation in life. In the evaluation of the effects of textbook contents according to the educational requirements of each school level, high suitability frequencies (>80%) were shown for the human character, education goals, curriculum goals, evaluation method, and education time. At some levels, the high suitability frequencies (>70%) were shown for the education grade, education type, and textbook type.

Uncertainty Quantification of Thermophysical Property Measurement in Space and on Earth: A Study of Liquid Platinum Using Electrostatic Levitation

  • Jannatun Nawer;Takehiko Ishikawa;Hirohisa Oda;Chihiro Koyama;Douglas M. Matson
    • Journal of Astronomy and Space Sciences
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    • v.40 no.3
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    • pp.93-100
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    • 2023
  • A study of uncertainty analysis was conducted on four key thermophysical properties of molten Platinum using a noncontacting levitation technique. More specifically, this work demonstrates a detailed reporting of the uncertainties associated with the density, volumetric thermal expansion coefficient, surface tension and viscosity measurements at higher temperatures for a widely used refractory metal, Platinum using electrostatic levitation (ESL). The microgravity experiments were conducted using JAXA's Electrostatic Levitation Furnace (ELF) facility on the International Space Station and the terrestrial experiments were conducted using NASA's Marshal Space Flight Center's ESL facility. The performance of these two facilities were then quantified based on the measurement precision and accuracy using the metrological International Standards Organization's Guide to the Expression of Uncertainty Measurement (GUM) principles.

Managerial Strategies for Records Reappraisal and Deaccessioning at Archives (기록물 재평가 및 처분을 통한 보존관리 전략에 관한 연구 - 사기록관을 중심으로 -)

  • Seo Eun-Gyoung
    • Journal of the Korean Society for Library and Information Science
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    • v.40 no.3
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    • pp.35-51
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    • 2006
  • Prior to the 1980's, reappraisal and deaccessioning were considered as an 'anti-archival' activity. Recently. however, many archivists have come to realize that a reappraisal and deaccessioning is essential to providing better access to more important records and to strengthen and refine holdings. To develop a program with strong and well-focused holding appropriate to the Purpose and environments of archives. archives have to carry out systematic and continuing Procedure to reevaluate past appraisal. This study explores the various main issues and opinions with regard to reappraisal and deaccessioning and then. suggests the reappraisal principles and deaccessioning procedures such as return of the materials to donor. transfer to more appropriate depository, destruction of the material.

A Survey on Head Nurses' Perceptions and Performances on Staff Evaluation (수간호사가 활용하는 근무성적 평정에 관한 조사연구)

  • Kim, So-In
    • Journal of Korean Academy of Nursing Administration
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    • v.1 no.1
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    • pp.35-45
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    • 1995
  • This study was designed and carried out to identify the methodologies of the staff evaluation used by the headnurses and their perception on the purpose of the evaluations, and to measure the degree and type of perceived purpose and the degree of implementation of staff evaluation principles into preactice. A hundred and eleven from four general hospitals with 600 beds and over were conveniently sampled. Data were gathered from August 20, through September 10, 1994 ; demographic data of respondents and 'methodologies used for staff evaluation' by questionaires, level of 'perceived purposes of staff evaluation' and level of implementation of the 'principles of staff evaluation into practice' by Likert-type rating scales developed by the researcher. Raw and percentile scores and means were calculated and data were processed further by t-tests and ANOVA. Results are as follows ; 1. Traditional methodlogies : checklists(90.1%) and ranking methods(45.9%) revealed to be the two mostly prefered and used methods. 2. Of the 20 item-descriptions of the 'purpose of staff evaluation': 10 'control, evaluative' and 10 'non-control, developmental' the first(mean=3.19) to the ninth(mean=2.74) in rank order revealed to be the 'control, evaluative purpose', while the tenth in rank order revealed to be the first among the 'non-control, evaluative' item(mean-1.57). 3. Level of purpose of staff evaluation perceived as 'control ; evaluative'(mean=43.76, S.D.=5.01) revealed to be significantly(t=-3.86, p<.05) highter than 'non-control ; developmental'(mean=40.65, S.D.=3.41). 4. Level of implementation of 'staff evaluation principle into practice' revealed to be moderately high(mean=2.40).

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