• Journal of the Korean Data and Information Science Society
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• v.19 no.4
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• pp.1429-1440
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• 2008

In a meta-analysis combining the results from different clinical trials, it is important to consider the possible heterogeneity in outcomes between trials. Such variations can be regarded as random effects. Thus, random-effect models such as HGLMs (hierarchical generalized linear models) are very useful. In this paper, we propose a HGLM framework for analyzing the binominal response data which may have variations in the odds-ratios between clinical trials. We also present the prediction intervals for random effects which are in practice useful to investigate the heterogeneity of the trial effects. The proposed method is illustrated with a real-data set on 22 trials about respiratory tract infections. We further demonstrate that an appropriate HGLM can be confirmed via model-selection criteria.

• Applied Biological Chemistry
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• v.35 no.2
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• pp.87-91
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• 1992

Twenty-six N-substituted-5-chloro-1,3-dimethylpyrazole-4-carboxamide were synthesized and their antifungal activity against Rhizoctonia solani, Pyricularia oryzae, Botrytis cinerea and Colletotricum gleosporiodes was compared. N-phenyl-5-chloro-l,3-dimethylpyrazole-4-carboxamides having electron releasing group at the meta position of phenyl ring demonstrated good fugicidal activity against R. solani.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.1
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• pp.203-217
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• 2021

Purpose: The purpose of this meta-analysis was to examine the high-level evidence of the effects of manual therapy on musculoskeletal diseases. Methods: Domestic databases were searched for studies that conducted clinical trials associated with manual therapy on chronic musculoskeletal diseases. A total of 591 studies published between 2005 and 2018 were identified, with 18 studies satisfying the inclusion data. The studies were classified according to patient, intervention, comparison, and outcome (PICO). The search outcomes were items associated with pain and physical function. The 18 studies included in the study were evaluated by using the R meta-analysis (version 4.0). The quality of 18 randomized control trials was evaluated by using the Cochrane risk of bias (ROB). The effect sizes were computed as the corrected standardized mean difference (SMD). Subgroup and meta-regression analyses were also used. Egger's regression test was carried out in order to analyze the publication bias. Cumulative meta-analysis and sensitivity analysis were also conducted in order to analyze the data error. Results: The following factors showed the large effect size of manual therapy on chronic musculoskeletal diseases: pain (Hedges's g = 2.66; 95% CI = 1.47 ~ 3.85), and physical function (Hedges's g = 2.15; 95% CI: 1.22 ~ 3.08). The subgroup analysis only showed a statistical difference in the type of manual therapy (pain) and outcome (physical function). No statistically significant difference was found in the meta-regression analysis. Publication bias was found in the data, but the results of the trim-and-fill method showed that such bias did not largely affect the obtained data. Furthermore, there were no data errors in the cumulative meta-analysis and sensitivity analysis. Conclusion: This study provides evidence for the effectiveness of manual therapy on chronic musculoskeletal diseases in pain and physical function. Subgroup analysis suggests that only the type of manual therapy for pain and the type of outcome for physical function differed in effect size.

• Journal of the Korea Safety Management & Science
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• v.11 no.4
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• pp.213-220
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• 2009

The minimum latency problem, also known as the traveling repairman problem and the deliveryman problem is to minimize the overall waiting times of customers, not to minimize their routing times. In this research, a genetic algorithm, a clonal selection algorithm and a population management genetic algorithm are introduced. The computational experiment shows the objective value of the clonal selection algorithm is the best among the three algorithms and the calculating time of the population management genetic algorithm is the best among the three algorithms.

• Journal of Korean Academy of Nursing
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• v.37 no.4
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• pp.529-539
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• 2007

Purpose: This quantitative meta analysis sought to determine the effectiveness of SMIs. Method: Forty-six experimental studies with a randomized or nonequivalent control group pre-post test design were included in the analysis. The selected studies were classified according to the sample characteristics, the types and methods of the interventions, and the types of outcome variables. Six intervention types were distinguished: cognitive-behavioral intervention(CBT), relaxation techniques(RT), exercise(EX), multimodal programs 1 and 2(MT1, 2), and organization-focused interventions(OTs). Effect sizes were calculated for the 4 outcome categories across intervention types: psycho-social outcome, behavioral-personal resources, physiologic, and organizational outcome. Results : Individual worker-focused interventions(ITs) were more effective than OTs. A small but significant overall effect was found A moderate effect was found for RT, and small effects were found for other ITs, The effect size for OTs was the smallest. The interventions involving CBT and RT appeared to be the preferred means of reducing worker's psycho-social and organizational outcomes. With regard to physiologic outcomes, RT appeared to be most effective. CBT appeared to be most effective in reducing psycho-social outcomes. The effects of OT were non-significant, except for the psycho-social outcomes. Conclusions: SMIs are effective. Interventions involving RT and CBT are more effective than other types.

• Journal of Environmental Health Sciences
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• v.37 no.6
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• pp.397-405
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• 2011

Objectives: The impact of climate change on the health has been of increasing concern due to a recent temperature increase and weather abnormality, and the research results of the impact varied depending on regions. We synthesized risk estimates of the overall health effects of low and high temperature taking account of the heterogeneity. Methods: A comprehensive literature search was conducted using PUBMED to identify journal articles of low and/or high temperature effects on mortality. The search was limited to the English language and epidemiological studies using time-series analysis and/or case-crossover design. Random-effect models in meta analysis were used to estimate the percent increase in mortality with $1^{\circ}C$ temperature decrease or increase with 95% confidence intervals (CI) in cold or hot days. Results: Twenty three studies were presented in two tables: 1) low temperature effects; 2) high temperature effects on mortality. The combined effects of low and high temperatures on total mortality were 2% (95% CI, 1-4%) per $1^{\circ}C$ decrease and 4% (95% CI, 2-5%) per $1^{\circ}C$ increase of temperature, respectively. Conclusions: This meta analysis found that both low and high temperatures affected mortality, and the magnitude of high temperature appeared to be stronger than that of low temperature.

• Journal of Korean Clinical Health Science
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• v.4 no.1
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• pp.504-509
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• 2016

Purpose. This study aims to present basic data to develop programs suitable to the characteristics of elderly people through a meta-analysis of effectiveness of variables related to psychological effects of programs of elderly people conducted in past 15 years. Methods. The analysis subjects are total 229 articles related to the psychological effects of programs for elderly people and submitted for master or doctor degrees or published in academic journals. CMA2 is used for the analysis. Results. The results of this study shows lower variables of the psychological effect promoting factor group that are highly effective for Life Satisfaction, Self-Efficacy, Self-Respect and Self-Integration and lower variables of suppressing factor group that are highly effective for Loneliness, Tension, Weakness, Anger and Depression. For the effect scale of psychological effect promoting factors, Arts is shown to be the highest followed by Exercise, Consultation, Recollection, Others and Recreation in order. For the effect scale of suppressing factors, Consultation is shown to be the highest followed by Recollection, Arts, Exercise, Others and Recreation) in order. Conclusions. This study has its own meaning for establishing integrated factors of psychological effects of programs for elderly people and presenting realistic data for planing programs suitable for various desires of elderly people.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.4
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• pp.614-621
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• 2012

Although there is a broad dispute over genetically modified foods on safety, the worldwide adoption of transgenic crops is rapidly increasing. The objectives of this study were to identify trends in the effects of transgenic on crop yields and examine the effect of agricultural variables including crop type, biotech trait, tillage system, and yield environment on corn and soybean yield. A meta-analysis from the 34 peer-reviewed scientific literatures was conducted to compare the crop yield between transgenic crops and conventional varieties. Results showed that the yield of transgenic corn and soybean was strongly dependent on growing conditions. Transgenic hybrids had higher yield potential in the low crop yield environments such as high weeds and/or insect infestation, low soil water, and cool temperature conditions, while transgenic crops did not have yield advantages in high yield environments. The results from this study suggest that producers should consider the potential yield environmental conditions and possible yield reductions when producers choose crop hybrids in their fields.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.11
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• pp.4665-4669
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• 2015

The aim of this study was to assess the diagnostic value of RASSF1A methylation in renal cell carcinoma. Systematically search were performed using the Pubmed, ProQest and Web of Science for all articles on the association between RASSF1A methylation and renal cell carcinoma before 15 April 2015. After the filtration, 13 studies involving 677 cases and 497 controls met our criteria. Our meta-analysis suggested that hypermethylation of RASSF1A gene was associated with the increased risk of RCC(OR:4.14, 95%CI:1.06-16.1). Stratified analyses showed a similar risk in qualitative detection method(OR:28.4, 95%CI:10.2-79.6), body fluid sample(OR:12.8, 95%CI:5.35-30.8), and American(OR:10.5, 95%CI:1.97-55.9). Our result identified that RASSF1A methylation had a strong potential in prediction the risk of Renal cell carcinoma.

• Journal of Korean Medicine Rehabilitation
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• v.26 no.4
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• pp.37-44
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• 2016

Objectives To determine the effectiveness of Chuna manual therapy combined acupuncture for trigeminal neuralgia. Methods We searched 6 electronic databases (Pubmed, CAJ, Oasis, RISS, DBPIA, KoreanTK) and 2 journals up to August 2016. We included randomized controlled trials (RCTs) using Chuna manual therapy combined acupuncture for trigeminal neuralgia. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results 3 RCT studies were eligible in our review. The meta-analysis of 3 studies showed favorable results for the use of Chuna manual therapy combined acupuncture. High risk of bias were observed in all studies. Conclusions Although there are favorable results with meta-analysis, our systematic review are highly dependent on the single source of Chinese electrical database, CAJ. Now limited evidence is available to support Chuna manual therapy combined acupuncture for trigeminal neuralgia and further well-designed RCTs should be encouraged.