• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.243-243
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• 1994

Although active systemic anaphylaxis and passive cutaneous anaphylaxis have been empolyed to study anaphylactic hypersensitivity, it is difficult and time-consuming to induce these reactions in experimental animals. In recent, Jun et al have found a simple method to induced anaphylactic hypersensitivity such as anaphylactic shock(AS) and cutaneous reaction(CR) using compound48/80. Cortex mori (Morus alba L.), the root bark of mulberry tree has been used as an antiphlogistic, diuretic, and expectorant in herbal medicine. The purpose of this study was to determine whether the methanol extract of Cortex mori could inhibit the compound 48/80-induced AS and CR. To induce AS, various doses of compound 48/80 (5, 7.5, 10, 15$\mu\textrm{g}$/gm B.W.) were injected intraperitoneally (i.p.) into ICR mice. The animals were pretreated by three injection(i.p.) of Cortex mori before compound 48/80 administration. Peripheral blood was collected from the right ventricle to estimate the level of serum histamine at 15 minutes after the injctin(i.p.) of various concentration of compound48/80. Mortility rate, mean death time and mesenteric mast cell degranulation rate were evaluated over a 72 hour period. To estimate the effect of Cortex mori on compound 48/80-induced cutaneous reaction, various doses of compound 48/80 with or without Cortex mori were injected intradermally(i.d.) into the shaved flank of Sprague-Dawley rats, and the blue cutaneous patchs induced by Evans'blue injection at the compound 48/80 alone and Cortex mori plus compound 48/80 injection sites were observed. As a Parameter of these reactions, the levels of histamine in the supernatant, calcium uptake and intracellular CAMP of RPMC were measured. supernatant, 1)compound 48/80-induced mortility rate, mean death time, mesenteric mast cell degranulation rate, and serum histamine level in ICR mice were significantly inhibited by pretreatment of Cortex mori, 2) cutaneous reaction inducd by compound48/80 was well developed in Sprague-Dawley rat, but Cortex mori inhibited the compound 48/80-induced blue patch formation remarkably, 3) the compound 48/80-induced degranulation, histamine release and calcium uptake of RPMC pretreated with Cortex mori were significantly inhibited, compared to those of control without Cortex mori pretreatment, and 4)the level of cAMP of RPMC was reduced bythe increased concentration of compound 48/80, pretreatment of Cortex mori not only inhibited the compound 48/80-induced reduction of CAMP but also significantly increased the level of cAMP naturally, from the above results, it is suggested that Cortex mori has an some substances with an ability to inhibits the compound 48/80-induced AS,CR, and mast cell activation.

• Journal of Korean Society for Atmospheric Environment
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• v.22 no.1
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• pp.1-14
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• 2006

Tropospheric aerosols are highly variant in time and space due to non-uniform source distribution and strong influence of meteorological conditions. Backscatter lidar measurement is useful to understand vertical distribution of aerosol. However, the backscatter lidar equation is undetermined due to its dependence on the two unknowns, extinction and backscattering coefficient. This dependence necessitates the exact value of the ratio between two parameters, that is, the lidar ratio. Also, Iidar ratio itself is useful optical parameter to understand properties of aerosols. Tropospheric aerosols were observed to understand variance of lidar ratio at Anmyeon island ($36.32^{/circ}N$, $126.19^{/circ}E$), Korea using a multi-wavelength raman lidar system developed by the Advanced Environmental Monitoring Research Center (ADEMRC), Gwangju Institute Science and Technology (GIST), Korea during measurement periods; March 15$\sim$April $16^{th}$, 2004 and May 24$\sim$ $8^{th}$ 2005. Extinction coefficient, backscattering coefficient, and lidar ratio were measured at 355 and 532 nm by the Raman method. Different types of aerosol layers were distinguished by the differences in the optical properties such as Angstrom exponent, and lidar ratio. The average value of lidar ratio during two observation periods was found to be $50.85\pm4.88$ sr at 355 nm and $52.43\pm15.15$ sr at 532 nm at 2004 and $57.94\pm10.29$ sr at 355 nm and $82.24\pm15.90$ sr at 532 nm at 2005. We conduct hysplit back-trajectory to know the pathway of airmass during the observation periods. We also calculate lidar ratio of different type of aerosol, urban, maritime, dust, continental aerosols using OPAC (Optical Properties of Aerosols and Clouds), Remote sensing of atmospheric aerosol using a multi-wavelengh lidar system with Raman channels is quite and powerful tool to characterize the optical propertises of troposheric aerosols.

• Journal of Korean Society of Transportation
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• v.24 no.6 s.92
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• pp.33-43
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• 2006

This research is to the selection of optimal probability distribution as well as the estimation for design hourly factor in consideration of traffic characteristic, such as road function, lane number and AADT. To accomplish the objectives, we are applied to various probability distribution using traffic data that observed at permanent traffic count points in 2005. The parameters or the selected 14 probability distribution were estimated based on the method of maximum likelihood and the validity condition of the estimated parameter The goodness-of-fit test, such as chi-square test. was performed as well as the estimation of design hourly factor. As a result, An appropriate distributions of each case were selected : Pearson V for two lane of rural roads, LogLogistic for the four lane of rural roads, LogLogistic for the urban roads, Extreme value for recreation roads. And optimal K factor are as following : $0.1{\sim}0.2 $ for two lane of rural roads, $0.09{\sim}0.14$ for the four lane of rural roads. $0.07{\sim}0.13$ for the urban roads, $0.1{\sim}0.2$ for recreation roads.

• Science of Emotion and Sensibility
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• v.14 no.4
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• pp.545-554
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• 2011

In this study, the parameters of Polysomnography (PSG) test, such as total sleep time, snoring time, had been analyzed to evaluate the effectiveness of a developed anti-snore pillow. The developed anti-snore pillow is made up of two polyvinylidene fluoride (PVDF) vibration sensors, pumps, valves, and air bladders. The two PVDF sensors inside the pillow can acquire the sound signals and the algorithm was perfectly designed to extract snoring by removing unwanted noise accurately and automatically. Once the pillow recognizes snore, a pump inside the hardware activates, and a bladder under the neck area inside the pillow will be inflated. The PSG test was used and two volunteers were participated for the study. The parameters of the PSG results were analyzed to evaluate the effectiveness of the anti-snore pillow. The total sleep time of each volunteer was similar on each phase of test, but the snoring time and the longest snoring episode were significantly decreased with the use of anti-snore pillow. The overall results showed excellent possibilities for reducing snoring for the person who snores during sleep by using the anti-snore pillow. The effectiveness of the anti-snore pillow can be evaluated by the PSG test. Moreover, the relationship between each parameter of PSG test and the quality of sleep will be used for further researches.

• Journal of Bio-Environment Control
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• v.6 no.4
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• pp.270-276
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• 1997

This experiment was conducted to develop a practical method to growth in hydroponics conditions. For this purpose, leaf lettuce (Lactuca sativa L., cv. 'Cheongchima') was cultivated under different temperature and light conditions in experimental fields of Sahmyook university from March, 1991 to May, 1996. The visual quality score(VQS), a quantitative parameter to evaluate harvested leaf lettuce quality. The leaf lettuce cultivated at $25^{\circ}C$ solution temperature showed the highest fresh weight pe, plant (59.7g/plant), but lowest visual quality score (5.2), while leaf lettuce cultivated at 15$^{\circ}C$ solution temperature showed lower fresh weight per plant (25.2g/plant) but highest visual quality score (7.2). In general, growth of leaf lettuce was retarded by low solution temperature, but quality was higher than those of other solution temperature. Different day/night temperature of nutrient solutions 20/2$0^{\circ}C$ and 25/2$0^{\circ}C$ was highest in yield, but leaf type was grow longer, and visual quality are inferior to low temperature. Yield was decreased as 10 and 25% at 60 and 80% shading treatment, respectively. Chlorophyll content was decreased by shading. but plant height and root length were increased of leaf lettuce growth with hydroponics.

• Journal of Korean Tunnelling and Underground Space Association
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• v.6 no.4
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• pp.291-302
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• 2004

Blast-induced anisotropic rock damage around a blast-hole was analyzed by a using numerical method with user-defined subroutine based on continuum damage mechanics. Anisotropic blasting pressure was evaluated by applying anisotropic ruck characteristics to analytical solution which is a function of explosive and rock properties. Anisotropic rock damage was evaluated by applying the proposed anisotropic blasting pressure. Blast-induced isotropic rock damage was also analyzed. User-defined subroutines to solve anisotropic and isotropic damage model were coded. Initial rock damages in natural ruck were considered in anisotropic and isotropic damage models. Blasting pressure and elastic modulus of rock were major influential parameters from parametric analysis results of isotropic rock damage. From the results of anisotropic rock damage analysis, blasting pressure was the most influential parameter. Anisotropic rock damage area in horizontal direction was approximately 34% larger and about 12% smaller in vertical direction comparing with isotropic rock damage area. Isotropic rock damage area under fully coupled charge condition was around 30 times larger than that under decoupled charge condition. Blasting pressure under fully coupled charge condition was estimated to be more than 10 times larger than that of decoupled charge condition.

• Korean Journal of Materials Research
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• v.9 no.4
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• pp.349-354
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• 1999

The temperature dependences of the Hall coefficient, carrier mobility, electrical resistivity, Seebeck coefficient, thermal conductivity, and figure-of-merit of the undoped and $CdI_2$-doped 90% $Bi_2Te_3-10% Bi_2Se_3$, single crystals, grown by the Bridgman method, have been characterized at temperatures ranging from 77K to 600K. The saturated carrier concentration and degenerate temperature of the undoped 90% $Bi_2Te_3-10% Bi_2Se_3$ single crystal are $5.85\times10_{18}cm^{-3}$ and 127K, respectively. The scattering parameter of the 90% $Bi_2Te_3-10% Bi_2Se_3$ single crystal is determined to b -0.23, and the electron mobility to hole mobility ratio ($\mu_e/\mu_h)$ is 1.45. The bandgap energy at 0K of the 90% <$Bi_2Te_3-10% Bi_2Se_3$ single crystal is 0.200 eV. Adding $CdI_2$as a donor dopant, a maximum figure-of-merit of $3.2\times10^{-3}/K$$CdI_2$-doped specimen.

• IMMUNE NETWORK
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• v.6 no.4
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• pp.192-198
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• 2006

Background: Investigating strategy to enhance efficiency of gene transfer via adenovirus is critical to sustain gene expression in targeted cells or tissues to regulate immune responses. However, the use of adenovirus as a gene delivery method has been limited by the native tropism of the virus. In this study, the critical parameter is to improve the efficient binding of viral particles to the plasma membrane prior to cellular uptake. Methods: Human immunodeficiency virus (HIV-1) trans-acting activator of transcription (TAT), a protein transduction domain, was fused to the ectodomain of the coxsackie-adenovirus receptor (CAR). The CAR-TAT protein was produced from a Drosophila Schneider 2 cells (S2) transfected with CAR-TAT genes. The function of CARTAT was analyzed the efficiency of adenoviral gene transfer by flow cytometry, and then immunizing AdVGFP with CAR-TAT was transduced on dendritic cells (DCs). Results: S2 transfectants secreting CAR-TAT fusion protein has been stable over a period of 6 months and its expression was verified by western blot. Addition of CAR-TAT induced higher transduction efficiency for AdVGFP at every MOI tested. When mice were vaccinated with DC of which adenoviral transduction was mediated by CAR-TAT, the number of IFN-${\gamma}$ secreting T-cells was increased as compared with those DCs transduced without CAR-TAT. Conclusion: Our data provide evidence that CAR-TAT fusion protein enhances adenoviral transduction and immunogenecity of transgenes on DCs and may influence on the development of adenoviral-mediated anti-tumor immunotherapy.

• Convergence Security Journal
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• v.14 no.6_2
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• pp.73-81
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• 2014

This study has an objective to analyze the causal relationship between the emotional labor of the members in the private security firms and its effect on their job stress and validity of the organization. To carry out the study, I established a population of private security guards working at the security firms in Seoul. Then a total of 700 question naires were sent out for the survey using the random sampling method of clusters. The study was carried out over about four months, from May, 2014 to September, 2014. A total of 676 questionnaires were used for the final data. 24 questionnaires were excluded either because they were not returned or contained extreme value. In this study, a statistical package of SPSSWIN 18.0 and AMOS 18.0 were used in the data analysis and the causal relationship was verified using the covariance structural equation. The analysis showed the emotional labor to have a positive effect on the validity of organization but a negative effect on the job stress at the statistical level of p<.001 and the hypothesis was adopted. The hypothesis regarding the job stress was also adopted because job stress was found to have a negative effect on the validity of organization at the statistical level of p<.001. In addition, job stress was found to have a negative effect on the relationship between the emotional labor and validity of organization at the statistical level of p<.001. As a result, the hypothesis about the job stress would function as the parameter was only partially adopted.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.6
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• pp.458-467
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• 2019

The purpose of this study is the suggestion of optimized parameters in OI (Optimal Interpolation) by experimental study. The observation of applying optimal interpolation is ADCP (Acoustic Doppler Current Profiler) data at the southwestern sea of Korea. FVCOM (Finite Volume Coastal Ocean Model) is used for the barotropic model. OI is to the estimation of the gain matrix by a minimum value between the background error covariance and the observation error covariance using the least square method. The scaling factor and correlation radius are very important parameters for OI. It is used to calculate the weight between observation data and model data in the model domain. The optimized parameters from the experiments were found by the Taylor diagram. Constantly each observation point requires optimizing each parameter for the best assimilation. Also, a high accuracy of numerical model means background error covariance is low and then it can decrease all of the parameters in OI. In conclusion, it is expected to have prepared the foundation for research for the selection of ocean observation points and the construction of ocean prediction systems in the future.