• Archives of Plastic Surgery
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• 제49권3호
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• pp.304-309
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• 2022

Background Laminin 5, which is found in the basement membrane of dermal-epidermal junction (DEJ), is a major adhesive component and associated with proliferating and migrating keratinocytes. In this study, we hypothesized that the topical application of the skin care products containing the novel peptides might restore the DEJ structure by deriving deposition of laminin 5 and promoting the keratinocyte migration. Here, we evaluated the restoration of DEJ by measuring the skin thickness. Methods Single-center retrospective analysis was performed on a total of 13 patients who underwent skin care using Baume L.C.E. (France, Laboratories d' Anjou) between January and March 2021. All patients applied the skin care agent for 2 weeks only on their left hand dorsum. Before the initiation of the application and after 2 weeks, both their hands were evaluated on photography and ultrasound. And the patients were asked to rate their satisfaction with the questionnaire after 2 weeks. Results There was no obvious improvement in photographic assessment and questionnaire. The post-pre difference of skin thickness in ultrasound images was, in left hand, 0.1 ± 0.37 in distal point and 0.1 ± 0.35 in proximal point; and, in right hand, 0 ± 0.17 in distal point and 0 ± 0.15 in proximal point, respectively. The pre-post difference was statistically significant in proximal point (p = 0.035). Conclusion Topical application of novel peptide derivative comprising laminin 5 demonstrated cutaneous changes including skin thickness, as assessed by ultrasound. Further studies using other modalities including dermal density measurement, three-dimensional photography, optical coherence tomography, or skin biopsy would be helpful to determine the skin-improving effects.

• 보존과학회지
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• 제38권4호
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• pp.314-326
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• 2022

Investigation of conservation status, optical survey, infrared thermography, and ultrasonic examination were performed on Avalokitesvara Bodhisattva mural and Buddhist Monk Bodhidharma mural to determine the conservation status and physical properties. As a result of investigation of conservation status, the types of damage are largely divided into the wall and finishing layer damage, painting layer degradation, damage due to restoration materials, stains and contamination, and biological damage. As a result of the optical survey, drawing, stains, and repainted site were confirmed. Result of the infrared thermography, the delamination of the finishing layer was confirmed, and some locations and shapes of the wooden lath inside the wall were identified. The result of the 3D scanning, the deviation, and the separation of the wall was confirmed. As a result of ultrasonic examination, it was confirmed that the physical properties of the mural were identified and the ultrasonic speed was relatively low due to physical damage such as delamination and exfoliation of the finishing layer and cracking. Ultrasonic speed values were also high in some wall cracks or delamination, and it was confirmed by the infrared thermography results that the wooden lath inside the wall was located in those parts. It was possible to understand that the wooden lath inside the walls affects the ultrasonic speed during the ultrasonic examination. Therefore, management through periodic inspection of the relevant elements is necessary, and a countermeasure for damage that may occur in the future should be prepared along with intensive monitoring of the major damage identified in this diagnosis result.

• Restorative Dentistry and Endodontics
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• 제48권1호
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• pp.7.1-7.10
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• 2023

Objectives: This study aimed to evaluate the surrounding and underlying shades' effect on the color adjustment potential (CAP) of a single-shade composite used in a thin layer. Materials and Methods: Cylinder specimens (1.0 mm thick) were built with the Vittra APS Unique composite, surrounded (dual specimens) or not (simple specimens) by a control composite (shade A1, A2, or A3). Simple specimens were also built only with the control composites. Each specimen's color was measured against white and black backgrounds or the simple control specimens with a spectrophotometer (CIELAB system). The whiteness index for dentistry (WI_D) and translucency parameters (TP₀₀) were calculated for simple specimens. Differences (ΔE₀₀) in color between the simple/dual specimens and the controls were calculated. The CAP was calculated based on the ratios between data from simple and dual specimens. Results: The Vittra APS Unique composite showed higher WID and TP₀₀ values than the controls. The highest values of ΔE₀₀ were observed among simple specimens. The color measurements of Vittra APS Unique (simple or dual) against the control specimens presented the lowest color differences. Only surrounding the single-shade composite with a shaded composite barely impacted the ΔE₀₀. The highest CAP values were obtained using a shaded composite under simple or dual specimens. Conclusions: The CAP of Vittra APS Unique was strongly affected by the underlying shade, while surrounding this composite with a shaded one barely affected its color adjustment.

• Hip & pelvis
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• 제35권2호
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• pp.133-141
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• 2023

Purpose: Isolated acetabular fractures can occur as a result of a high energy impact on the hip joint. Surgery is required for most patients with an isolated acetabular fracture in order to alleviate pain, restore joint stability, and regain hip function. This study was conducted in order to examine the course of hip function in patients after surgical treatment of an isolated traumatic acetabular fracture. Materials and Methods: This prospective series of consecutive cases included patients who underwent surgery for treatment of an isolated acetabular fracture in a European level one trauma center between 2016 and 2020. Patients with relevant concomitant injuries were excluded. Scoring of hip function was performed by a trauma surgeon using the Modified Merle d'Aubigné and Postel score at six-week, 12-week, six-month, and one-year follow-up. Scores between 3-11 indicate poor, 12-14 fair, 15-17 good, and 18 excellent hip function. Results: Data on 46 patients were included. The mean score for hip function was 10 (95% confidence interval [CI] 7.09-12.91) at six-week follow-up (23 patients), 13.75 (95% CI 10.74-16.76) at 12-week follow-up (28 patients), 16 (95% CI 13.40-18.60) at six-month follow-up (25 patients), and 15.50 (95% CI 10.55-20.45) at one-year follow-up (17 patients). After one-year follow-up, the scores reflected an excellent outcome in 11 patients, good in five patients, and poor in one patient. Conclusion: This study reports on the course of hip function in patients who have undergone surgical treatment for isolated acetabular fractures. Restoration of excellent hip function takes six months.

• 한국환경생태학회지
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• 제28권3호
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• pp.331-341
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• 2014

본 연구는 고흥, 부산 및 울산지역에 분포하는 거문도닥나무 자생지의 입지 환경, 식생구조 및 토양특성을 조사하여 자생지 보전 및 복원을 위한 기초자료를 제공하고자 한다. 거문도닥나무 자생지는 해발 28~242m에 위치하고, 경사는 $0{\sim}40^{\circ}$로 다양하며, 수관개방율은 57.56%로 나타났다. PC-ORD를 이용한 이단계 군집분석 결과 군집 I(밤나무-소나무군집), 군집 II(떡갈나무-곰솔군집), 군집 III(곰솔군집) 등 세 개의 식물군집으로 분리되었다. 종다양도는 평균 1.3650이며, 균등도와 우점도는 각각 0.8666과 0.1333으로 나타났다. 조사대상지의 토성은 미사질양토와 사양토이며, 토양산도는 pH5.5, 전기전도도는 0.15dS/m, 토양유기물함량은 2.60%, 유효인산함량은 4mg $kg^{-1}$으로 확인되었다. 환경 특성과 식생 및 토양분석 결과에 기초한 상관분석에서는 종다양도와 균등도, 유기물함량과 전질소함량은 정의상관관계를 보였고, 경사와 초본층의 피도, 종다양도와 우점도는 부의관계를 형성하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권3호
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• pp.255-261
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• 2014

Essential fatty acid (EFA) is known to be required for the body to function normally and healthily. However, the effect of EFA on glucose uptake in skeletal muscle has not yet been fully investigated. In this study, we examined the effect of two EFAs, linoleic acid (LA) and ${\alpha}$-linolenic acid (ALA), on glucose uptake of C2C12 skeletal muscle cells and investigated the mechanism underlying the stimulatory effect of polyunsaturated EFAs in comparison with monounsaturated oleic acid (OA). In palmitic acid (PA)-induced insulin resistant cells, the co-treatment of EFAs and OA with PA almost restored the PA-induced decrease in the basal and insulin-stimulated 2-NBDG (fluorescent D-glucose analogue) uptake, respectively. Two EFAs and OA significantly protected PA-induced suppression of insulin signaling, respectively, which was confirmed by the increased levels of Akt phosphorylation and serine/threonine kinases ($PKC{\theta}$ and JNK) dephosphorylation in the western blot analysis. In PA-untreated, control cells, the treatment of $500{\mu}M$ EFA significantly stimulated 2-NBDG uptake, whereas OA did not. Phosphorylation of AMP-activated protein kinase (AMPK) and one of its downstream molecules, acetyl-CoA carboxylase (ACC) was markedly induced by EFA, but not OA. In addition, EFA-stimulated 2-NBDG uptake was significantly inhibited by the pre-treatment of a specific AMPK inhibitor, adenine 9-${\beta}$-D-arabinofuranoside (araA). These data suggest that the restoration of suppressed insulin signaling at PA-induced insulin resistant condition and AMPK activation are involved at least in the stimulatory effect of EFA on glucose uptake in C2C12 skeletal muscle cells.

• 한국컴퓨터정보학회논문지
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• 제29권5호
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• pp.21-29
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• 2024

CT 촬영 시 방사선량을 줄이면 피폭 위험성을 낮출 수 있으나, 영상 해상도가 크게 저하 될 뿐아니라 잡음(noise) 발생으로 인해 진단의 효용성이 떨어진다. 따라서, CT 영상에서의 잡음제거는 영상복원 분야에 있어 매우 중요하고 필수적인 처리 과정이다. 영상 영역에서 잡음과 원래 신호를 분리하여 잡음만을 제거하는 것은 한계가 있다. 본 논문에서는 웨이블릿 변환 기반 GAN 모델 즉, WT-GAN(wavelet transform-based GAN) 모델을 이용하여 CT 영상에서 효과적으로 잡음 제거하고자 한다. 여기서 사용된 GAN 모델은 U-Net 구조의 생성자와 PatchGAN 구조의 판별자를 통해 잡음제거 영상을 생성한다. 본 논문에서 제안된 WT-GAN 모델의 성능 평가를 위해 다양한 잡음, 즉, 가우시안 잡음(Gaussian noise), 포아송 잡음 (Poisson noise) 그리고 스펙클 잡음 (speckle noise)에 의해 훼손된 CT 영상을 대상으로 실험하였다. 성능 실험 결과, WT-GAN 모델은 전통적인 필터 즉, BM3D 필터뿐만 아니라 기존의 딥러닝 모델인 DnCNN, CDAE 모형 그리고 U-Net GAN 모형보다 정성적이고, 정량적인 척도 즉, PSNR (Peak Signal-to-Noise Ratio) 그리고 SSIM (Structural Similarity Index Measure) 면에서 우수한 결과를 보였다.

• Restorative Dentistry and Endodontics
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• 제23권1호
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• pp.424-432
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• 1998

To get a satisfactory result in the composite resin restorations, it is necessary to choose correct shade. At present, most of the commercial composite resins are based on the Vita Lumin shade guide or Bioform shade guide, but color differences might be expected even using the same shade in various materials. In this study, five kinds of light-cured composite resins with A2 and B3 shade were used to measure and compare the color each other while one porcelain served as a control. All composite resins (Spectrum TPH (SP), VeridonFil- Photo (VE), Z100 (Z100), Charisma (CH), Prodigy (PRO)) were filled in to the metal mold (12 mm diameter, 2 mm depth), followed by compression, polymerization and polishing with wet sandpaper. The specimens of porcelain were fabricated by using the refractory mold for porcelain. After 24 hours, the specimens were placed on the spectrocolorimeter and spectral reflectance were measured under CIE illuminant D65. After measuring the values of $L^*$, $a^*$, $b^*$ and ${\Delta}E^*$, following results were obtained; 1. The $L^*$, $a^*$ and $b^*$ values of both shade of porcelain specimens showed significantly higher than those of resin specimens(p<0.05). 2. In comparing the resin specimens of the A2 shade, differences were significant except $L^*$ values of SP-CH and PRO-VE, $a^*$ values of the VE-SP and $b^*$ values of the VE-Z100 and SP-PRO(p<0.05), 3. In comparing the resin specimens of the B3 shade, differences were significant except $L^*$ values of PRO-SP, $a^*$ values of the SP-PRO and Z100-VE and b* values of the PRO-SP(p<0.05). 4. In comparing the resin specimens of the A2 shade, color differences between materials (${\Delta}E^*$) showed the lowest value of 1.66, and the highest was 5.16. ${\Delta}E^*$ values of the materials of VE-PRO, CH-PRO, SP-PRO, SP-Z100 and SP-CH were lower than 3.3. 5. In comparing the resin specimens of the B3 shade, the lowest value of the ${\Delta}E^*$ was 0.57 and the highest was 5.92. ${\Delta}E^*$ values of Z100-CH and SP-PRO were lower than 3.3. The present study revealed there was perceptible color difference between materials even if they have the same designated shade based on Vita shade guide. The results of the present study suggested that it would be necessary to establish the reproducible and constant color specification system for an esthetic restoration.

• 보존과학회지
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• 제38권3호
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• pp.234-242
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• 2022

국립춘천박물관 소장 철조석가불좌상(본관 1971)을 기초로 재현실험을 시행하여 분할 주조법을 연구하였다. 불상의 3D 스캔 데이터를 활용해 1/2 모형으로 축소 제작한 후 기존 연구 결과를 토대로 거푸집제작, 주조 등을 실시하여 불상을 제작하였다. 거푸집의 외부는 친모래와 산청토를 3:4의 비율로, 내부는 친모래와 산청토를 1:3의 비율로 배합하여 제작한 다음 불상을 주조하였다. 주조된 철불을 통해 다양한 주조결함을 관찰할 수 있었으며, 원불상과 유사한 형태적인 모습을 볼 수 있었다. 재현된 철불의 표면 관찰 결과 베이닝, 유동불량, 외부수축공, 피하기공, 표면핀홀, 형 어긋남 등의 주조결함을 지니고 있었으며, 이는 철조석가불좌상에서 보이는 주조결함의 특징과 유사하다. 미세조직은 나뭇가지 모양의 Dendrite 조직과 Pearlite 조직이 확인되었으며, Cementite 조직 사이에서 검은색의 Graphite가 관찰되었다. 본 연구는 철불의 전통주조기술과 제작기법을 위한 실험연구로서 고대 대형 주조기술을 알아볼 수 있는 기초데이터로 활용될 것으로 본다.

• 대한치과보철학회지
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• 제45권2호
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• pp.240-249
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• 2007

Statement of problem: A phenomenon of screw-loosening in implant abutment is frequently occurred in a single and multiple implant restoration. Purpose: This study was performed to evaluate an effect of abutment material on screw-loosening before and after a cyclic loading. In a single-tooth implant, different materials of abutment, Type III Gold alloy and Zirconium composite$(ZrO_2/Al_2O_3)$ were used. Material and method: The Gold alloy(Type III) and Zirconium composite$(ZrO_2/Al_2O_3)$ were used to make a superstructure of implant, the one of types of UCLA, Each group was constituted of 5 sample with a 30-degree offset angulated loading platform. The external hexagonal fixture was rigidly hel d in a special holding zig to ensure solid fixation without rotation during the tightening and a cyclic loading. A Titanium-alloy screw was used to connect and controlled to be tighten in 20Ncm torque by a digital torque gauge. A 20 times of consecutive closing/opening cycle were performed to evaluate the immediate torque loss. In 5 sample of each material group, an initial opening torque was recorded during 3 closing/opening cycle, then 2Hz, 200N, 1,000,000 cyclic loadings were performed, then a opening torque was evaluated. Result & Conclusion: 1. In this limited study, titanium alloy screw tightened in 20Ncm, a cold-welding phenomen on was not observed during the 20 times of closing/opening cycle(p=0.11, p=0.18). 2. In titanium alloy abutment screw, repeated opening and closing of the screw caused to progressive decrease of opening torque(p=0.014). 3. The difference in preload of screw between gold alloy abutment and ceramic$(ZrO_2/Al_2O_3)$ abutment was not significant(p=0.78). 4. The difference in torque loss of screw between gold alloy abutment and ceramic$(ZrO_2/Al_2O_3)$ abutment was not significant after 2Hz,200N, 1,000,000 cyclic loading(p=0.92). 5. In titanium alloy abutment screw tightened by 20Ncm, the screw loosening was not significant on each group after 2Hz, 200Ncm, 1,000,000 cyclic loading(p=0.59).