• Korean Journal of Veterinary Research
• /
• v.40 no.3
• /
• pp.471-478
• /
• 2000

The pharmacokinetic properties of KR-V compounds, recently developed as new anti-HIV agents, were studied after i.v. and p.o. administration in rats. The concentrations of the KR-V series were determined in rat plasma using an high-performance liquid chromatography (HPLC)-UV detection system. Of the 19 KR-V compounds investigated in the present study, only KR-V 3, 10, 14, 16 and 18-1 showed oral bioavailability. The plasma concentration-time data could be adequately described by an one-compartment open model. In the i.v. kinetic study (10mg/kg), the CLt of KR-V 3, 10, 14 and 16 (>4L/hr/kg) were significantly higher than that of KR-V 18-1 (1.1 L/hr/kg). The AUC of KR-V 18-1 was greater ($8.97{\mu}g{\cdot}hr/ml$) than that of the other compounds, but the Vd (0.58 L/kg) was lower. In the p.o. kinetic study (50mg/kg), although the t-1/2 of KR-V 18-1 was shorter than that of the other compounds, the AUC ($3.659{\mu}g{\cdot}hr/ml)$ and $C_{max}(1.891{\mu}g/ml$) were markedly higher. In a seperated in vitro experiment, only KR-V 18-1, of the 5 compounds with bioavailibility, exhibits potent activity against HIV-1 mutant strains. Therefore, KR-V 18-1 is expected to become a new potent anti-AIDS drug candidate/lead compound.

• 전기산업
• /
• v.8 no.3
• /
• pp.59-67
• /
• 1997

• Proceedings of the Korean Society of Broadcast Engineers Conference
• /
• 2022.06a
• /
• pp.836-838
• /
• 2022

3D Point Cloud는 3D 콘텐츠를 더욱 실감 나게 표현하기 위한 데이터 포맷이다. Point Cloud 데이터는 3차원 공간상에 존재하는 데이터로 기존의 2D 영상에 비해 거대한 용량을 가지고 있다. 최근 대용량 Point Cloud의 3D 데이터를 압축하기 위해 V-PCC(Video-based Point Cloud Compression)와 같은 다양한 방법이 제시되고 있다. 따라서 Point Cloud 데이터의 원활한 전송 및 저장을 위해서는 V-PCC와 같은 압축 기술이 요구된다. V-PCC는 Point Cloud의 데이터들을 Patch로써 뜯어내고 2D에 Projection 시켜 3D의 영상을 2D 형식으로 변환하고 2D로 변환된 Point Cloud 영상을 기존의 2D 압축 코덱을 활용하여 압축하는 기술이다. 이 V-PCC로 변환된 2D 영상은 기존 2D 영상을 전송하는 방식을 활용하여 네트워크 기반 전송이 가능하다. 본 논문에서는 V-PCC 방식으로 압축한 V3C 데이터를 방송망으로 전송 및 소비하기 위해 MPEG Media Transport(MMT) Packet을 만드는 패킷화 방안을 제안한다. 또한 Server와 Client에서 주고받은 V3C(Visual Volumetric Video Coding) 데이터의 비트스트림을 비교하여 검증한다.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.16 no.1
• /
• pp.627-633
• /
• 2015

We designed of a LDO regulator with a OVP and UVLO protection function for a PMIC. Proposed LDO regulator circuit consists of a BGR reference circuit, an error amplifier and a power transistor and so on. The proposed LDO regulator is designed for low voltage input power protection. Proposed LDO circuit generated fixed 2.5 V from a supply of 3.3V. It was designed with 3.3 V power supply using a $0.35{\mu}m$ CMOS technology. SPICE simulation results showed that the proposed circuit provides 0.713 mV/V line regulation with output 2.5 V ~ 3.9 V and $8.35{\mu}V/mA$ load regulation with load current 0 mA to 40 mA.

• Journal of Sericultural and Entomological Science
• /
• v.9
• /
• pp.21-25
• /
• 1969

Various formulae for estimation of leaf production in mulberry trees were investigated and obtained. Four varieties of mulberry trees were used as the materials, and four characters. namely branch length (X, 1). branch diameter (X, 2). leaf number per branch (X, 3), and leaf area per branch (X, 4). were studies. The formulae to eatimate the leaf yield of mulberry trees are as follows: 1. Y$_1$v$_1$＝-115.760＋0.068X$_1$＋165.756X$_2$ Y$_1$v$_2$＝-221.500＋1.768X$_1$＋38.152X$_2$ Y$_1$v$_3$＝-253.826-0.116X$_1$＋289.507X$_2$ Y$_1$v$_4$＝ -157.559＋1.063X$_1$＋106.088X$_2$ where Y$_1$v$_1$, Y$_1$v$_2$, Y$_1$v$_3$, Y$_1$v$_4$, are showed the estimated yield of the each variety, namely Gaeryang souban, Ilchirye, Nosang. and Suwon Sang No. 4, respectively. X$_1$ and X$_2$ denote the measured values of branch length and branch diameter, respectively. 2. Y$\sub$7/v$_1$＝-118.478-0.665X$_1$＋184.445X$_2$＋2.346X$_3$ Y$\sub$7/v$_2$＝-217.432＋2.062X$_1$＋35.668X$_2$-1.058X$_3$ Y$\sub$7/v$_3$＝-206. 249-0.739X$_1$＋268.08X$_2$＋2.770X$_3$ Y$\sub$7/v$_4$＝-153.383＋0.009X$_1$＋2.024X$_2$＋0.171X$_3$where Y$\sub$7/v$_1$, Y$\sub$7/v$_2$, Y$\sub$7/v$_3$, Y$\sub$7/v$_4$, are the estimated yield of the each variety, namely Gaeryang. Souban, Ilichirye, Nosang, and Suwon Sang No. 4, respectively. X$_1$, X$_2$, X$_3$, denote the measured values of each character. branch length, branch diameter and leaf number per branch, respectively. 3. Y$\sub$11/v$_1$＝82. 567-1.283X$_1$＋15.501X$_2$＋0.640X$_3$＋3.511X$_4$ Y$\sub$11/v$_2$＝136.411＋0.311X$_1$＋1.921X$_2$-0. 217X$_3$＋0.214X$_4$ Y$\sub$11/v$_3$＝150.2Z7-0.139X$_1$＋11.788X$_2$＋0.143X$_3$＋0.381X$_4$ Y$\sub$11/v$_4$＝160.850＋0.323X$_1$＋66.076X$_2$-0.794X$_3$＋2..614X$_4$ where Y$\sub$11/v$_1$, Y$\sub$11/v$_2$, Y$\sub$11/v$_3$, Y$\sub$11/v$_4$, are the estimated yield values of four varieties, and X$_1$, X$_2$, X$_3$, X$_4$ denote the measured values of four characters. namely branch length, branch diameter. leaf number per branch and leaf area per branch. respectively. The estimation method of mulberry leaf yield by measurement of some characters, branch length. branch diameter. leaf number per branch and leaf area per branch. could be the better method to determine the leaf yield of mulberry trees without destroying the leaves and without weighting the leaves of mulberry trees than the other methods.

• The Bulletin of The Korean Astronomical Society
• /
• v.39 no.1
• /
• pp.66.1-66.1
• /
• 2014

Radiative transfer programs to simulate the 3-micron auroral $CH_4$ emissions of Jupiter have been developed. The formalism of the radiative transfer calculations including the thermal, fluorescent, and auroral emissions of the $CH_4$ bands for an atmospheric layer having an optical depth of ${\tau}_v$ is given by: ${\mu}dI_v/d{\tau}_v=I_v-{\varpi}_v{^*}J_v(1-{\varpi}_v{^*})B_v-{\varpi}{^*}F_{ov}{e}{x}{p}(-{\tau}_v/{\mu}_o)4{\pi}-hv{\varpi}{^*}V/4{\pi}$ where ${\varpi}_v{^*}$ is the single scattering albedo of $CH_4$ consisting of Einstein A coefficient and collisional deexcitation rate. Other terms are usual radiative transfer parameters appearing in textbooks including the terms for scattered ${\varpi}_v{^*}J_v$, thermal $(1-{\varpi}_v{^*})B_v$, and attenuated solar radiations $F_{ov}$ at the certain atmospheric layer. For auroral excitations, we include V, which is the number of excited states per $cm^3$ persec by auroral particle bombardments. We apply this formalism to the high-resolution spectra of the auroral regions observed with GNIRS/Gemini North, and will present preliminary results for the 3 micron auroral processes of Jupiter.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.10
• /
• pp.3030-3034
• /
• 2014

Bis-chloroethylnitrosourea (BCNU) is currently used as an anti-cancer drug for glioblastoma therapy. In this study, BCNU was loaded into the hydrophobic cores of R3V6 amphiphilic peptide micelles for efficient delivery into brain tumors. The scanning electron microscope (SEM) study showed that the BCNU-loaded R3V6 peptide micelles (R3V6-BCNU) formed spherical micelles. MTT assay showed that R3V6-BCNU more efficiently induced cell death in C6 glioblastoma cells than did BCNU. In the Annexin V assay, R3V6-BCNU more efficiently induced apoptosis than did BCNU alone. Furthermore, the results showed that R3V6 was not toxic to cells. The positive charges of the R3V6 peptide micelles may facilitate the interaction between R3V6-BCNU and the cellular membrane, resulting in an increase in cellular uptake of BCNU. In vivo evaluation with an intracranial glioblastoma rat model showed that R3V6-BCNU more effectively reduced tumor size than BCNU alone. The results suggest that R3V6 peptide micelles may be an efficient carrier of BCNU for glioblastoma therapy.

• Analytical Science and Technology
• /
• v.16 no.3
• /
• pp.206-211
• /
• 2003

The DC polarograms of some rare earth elements have been investigated in various pH solution and electrolytes. Samarium ion has two well-defined reduction waves at -1.75 V and -1.95 V in 0.1 M NaCl solution and those are a diffusion controlled in nature. Europium and ytterbium ions give also two step reduction waves at -0.75 V and -1.95 V for europium and -1.45 V and -2.00 V for ytterium in $(C_2H_5)_4NCl$ solution. On the other hand, lantanium and neodium ions show a single reduction wave at -1.75 V. The differences of half wave potentials between europium, ytterium and samarium ions make it possible to determine each ions in the mixed solution sponteniously. In case of europium ion, the stability constants for the complexs of $Eu^{3+}$-EDTA and $Eu^{3+}$-DTPA are evaluated.

• Review of KIISC
• /
• v.17 no.6
• /
• pp.9-19
• /
• 2007

미국, 독일 등 선진국을 중심으로 개발된 공통평가기준(Common Criteria, CC) 3.1이 공식 문서로 등재되어 2009년 9월부터는 기존의 CC v2.3을 완전히 대체할 것으로 예상됨에 따라 현재 우리나라 평가 완료된 CC v2.3 기반 보호프로파일은 CC 3.1 기반 보호프로파일로 개정이 필요하다. 따라서 본 논문은 CC v2.3과 v3.1에서의 보호프로파일 요구사항을 비교 및 분석하고, 보안기능 및 보증요구사항의 평가업무량 및 제출물 작성수준을 분석한다. 이러한 미국, 영국, 캐나다, 프랑스, 네덜란드 등 선진국의 주도하에 개발되고 있는 CC v3.1에 대한 분석을 통하여 국제적으로 새롭게 정립되고 있는 평가기준 및 평가방법에 대한 기술을 확보할 수 있으며, 향후 CC v3.1에 의한 평가 기반을 마련하는데 기여 할 것이다.

• The Journal of Korean Society for Radiation Therapy
• /
• v.31 no.1
• /
• pp.51-56
• /
• 2019

Purpose: The usefulness of using single-electron radiation for secondary radiotherapy of breast cancer patients after surgery is assessed and the use of a combine of different energy. Methods and materials : In this study, 40 patients (group A) using energy 6 MeV and 9 MeV, and 19 patients (group B) using a combine of 9 MeV and 12 MeV were studied among 59 patients who performed secondary care using combine electronic radiation. Each patient in each group, 6 MeV, 9 MeV, Combine(6 MeV / 9 MeV) and 9 MeV, 12 MeV, Combine (9 MeV / 12 MeV) were developed in different ways, and the maximum doses delivered to the original hospital, D95, D5, and $V_3$, $V_5$, $V_{10}$ were compared. Result: The D95 mean value of Group A treatment plan was $785.33{\pm}225.37cGy$, $1121.79{\pm}87.02cGy$ at 9 MeV, and $1010.98{\pm}111.17cGy$ at 6 MeV / 9 MeV, and the mean value at 6 MeV / 9 MeV was most appropriate for the dose. The mean values of the low dose area $V_3$ and $V_5$ in the lung of the breast direction being treated were $3.24{\pm}3.49%$ and $0.72{\pm}1.55%$ at 6 MeV, the highest 9 MeV at $7.25{\pm}4.59%$, $3.07{\pm}2.64%$, the lowest at 6 MeV. Maximum and average lung dose was $727.78{\pm}137.27cGy$ at 6 MeV / 9 MeV, $49.16{\pm}24.44cGy$, highest 9 MeV at $998.97{\pm}114.35cGy$, $85.33{\pm}41.18cGy$, and lowest 6 MeV at $387.78{\pm}208.88cGy$, $9.27{\pm}6.60cGy$. The value of $V_{10}$ was all close to zero. Group B appeared in the pattern of Group A. Conclusion: Relative differences in low-dose areas of the lungs $V_3$ and $V_5$ were seen and were most effective in the dose transfer of tumor bed in the application of combined energy. It is thought that the method of using electronic energy in further radiation treatments for breast cancer is a more effective way to use the energy effect of limiting energy resources, and that if you think about it again, it could be a little more beneficial radiation treatment for patients.