• Journal of the Korea Society of Computer and Information
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• v.21 no.12
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• pp.11-18
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• 2016

Magnetic resonance image (MRI) is widely used in brain research field and medical image. Especially, non-invasive brain activation acquired image technique, which is functional magnetic resonance image (fMRI) is used in brain study. In this study, we investigate brain activation occurred by LED light stimulation. For investigate of brain activation in experimental small animal, we used high magnetic field 9.4T MRI. Experimental small animal is Balb/c mouse, method of fMRI is using echo planar image (EPI). EPI method spend more less time than any other MRI method. For this reason, however, EPI data has low contrast. Due to the low contrast, image pre-processing is very hard and inaccuracy. In this study, we planned the study protocol, which is called block design in fMRI research field. The block designed has 8 LED light stimulation session and 8 rest session. All block is consist of 6 EPI images and acquired 1 slice of EPI image is 16 second. During the light session, we occurred LED light stimulation for 1 minutes 36 seconds. During the rest session, we do not occurred light stimulation and remain the light off state for 1 minutes 36 seconds. This session repeat the all over the EPI scan time, so the total spend time of EPI scan has almost 26 minutes. After acquired EPI data, we performed the analysis of this image data. In this study, we analysis of EPI data using statistical parametric map (SPM) software and performed image pre-processing such as realignment, co-registration, normalization, smoothing of EPI data. The pre-processing of fMRI data have to segmented using this software. However this method has 3 different method which is Gaussian nonparametric, warped modulate, and tissue probability map. In this study we performed the this 3 different method and compared how they can change the result of fMRI analysis results. The result of this study show that LED light stimulation was activate superior colliculus region in mouse brain. And the most higher activated value of segmentation method was using tissue probability map. this study may help to improve brain activation study using EPI and SPM analysis.

• Journal of the Korean earth science society
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• v.28 no.6
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• pp.720-732
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• 2007

For the Seoul metropolitan area and the eastern Kyeongsang Basin, we simultaneously calculated $Q_P^{-1}$ and $Q_S^{-1}$ by applying the extended coda-normalization method for 98 seismograms of local Earthquakes. As frequency increases from 1.5 Hz to 24 Hz, the result decreased from $(4.0{\pm}9.2){\times}10^{-3}$ to $(4.1{\pm}4.2){\times}10^{-4}$ for $Q_P^{-1}$ and $(5.5{\pm}5.6){\times}10^{-3}$ to $(3.4{\pm}1.3){\times}10^{-4}$ for $Q_S^{-1}$ in Seoul Metropolitan Area. The result of eastern Kyeongsang basin also decreased from $(5.4{\pm}8.8){\times}10^{-3}$ to $(3.7{\pm}3.4){\times}10^{-4}$ for $Q_P^{-1}$ and $(5.7{\pm}4.2){\times}10^{-3}$ to $(3.5{\pm}1.6){\times}10^{-4}$ for $Q_S^{-1}$. If we fit a frequency-dependent power law to the data, the best fits of $Q_P^{-1}$ and $Q_S^{-1}$ are $0.005f^{-0.89}$ and $0.004f^{-0.88}$ in Seoul metropolitan Area, respectively. The value of $Q_P^{-1}$ and $Q_S^{-1}$ in the eastern Kyeongsang basin are $0.007f^{-1.02}$ and $0.006f^{-0.99}$, respectively. The $Q_S^{-1}$ value of the eastern Kyeongsang basin is almost similar to Seoul metropolitan area. But the $Q_P^{-1}$ value of the eastern Kyeongsang basin is a little higher than that of Seoul metropolitan area. This may be that the crustal characteristics of the eastern Kyeongsang basin is seismologically more heterogeneous. However, these $Q_P^{-1}$ values in Korea belong to the range of seismically stable regions all over the world.

• 한국균학회소식:학술대회논문집
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• 2014.10a
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• pp.25-25
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• 2014

Three species of Fusarium, F. fujikuroi, F. verticillioides and F. proliferatum, are known to be associated with bakanae disease of rice [1, 2]. F. fujikuroi infects rice flowers and survive in endosperm and embryo of the seeds. Infected seed is an important source of primary inoculum of pathogens [3]. Seeds of rice (Oryza sativa cv. Boramchan) collected from bakanae-infected field were found to be 96% infected with Fusarium sp., 52% with F. fujikuroi, 42% with F. verticillioides, and 12% with F. proliferatum as determined by incubation method and species-specific PCR assays. F. fujikuroi was detected at lemma/palea, endosperm and embryo whereas F. verticillioides and F. proliferatum were recovered only from lemma/palea by means of component plating test. Seed disinfection methods have been developed to control bakanae disease and prochloraz has been most widely used for rice seeds. Two chemicals formulated with prochloraz (PC 1) and prochloraz + hexaconazole (PC 2) that inhibit biosynthesis of ergosterol strongly reduced the incidence of Fusarium spp. on selective media to 4.7% and 2.0%, respectively. Disease symptoms of rice seedlings in nursery soil were alleviated by chemical treatment; seedlings with elongated leaves or wide angle between leaf and stem were strikingly reduced from 15.6 to 3.2% (PC 1) and 0 (PC 2), stem rots were reduced from 56.9 to 26.2% (PC 1) and 32.1% (PC 2), and normal seedling increased from 0.4 to 13.3% (PC 2). Prochloraz has some disadvantages and risks such as the occurrence of tolerant pathogens [4] and effects on the sterol synthesis in animals and humans [5]. For these reasons, it is necessary to develop new disinfection method that do not induce fungal tolerance and are safe to humans and animals. Chlorine dioxide ($ClO_2$), that is less toxic, produces no harmful byproducts, and has high oxidizing power, has been reported to be effective at disinfection of several phytopathogenic fungi including Colletotrichum spp. and Alternaria spp. [6]. Gaseous $ClO_2$ applied to rice seeds at a concentration of 20 ppm strongly suppressed mycelial growth of Fusarium fujikuroi, F. verticillioides and F. proliferatum. The incidence of Fusarium spp. in dry seed with 8.7% seed moisture content (SMC) tended to decrease as the concentration of $ClO_2$ increased from 20 to 40 ppm. Applying 40 ppm $ClO_2$ at 90% relative humidity, incidence was reduced to 5.3% and resulted in significant reduction of disease symptoms on MS media. In nursery soil, stem rot was reduced from 56.9 to 15.4% and the number of normal seedlings increased from 0.4 to 25.5%. With water-soaked seeds (33.1% SMC) holding moisture in the endosperm and embryo, the effectiveness of disinfection using $ClO_2$ increased, even when treated with only 20 ppm for four hours. This suggests that moisture was a key element for action of $ClO_2$. Removal of the palea and lemma from seeds significantly decreased the incidence of Fusarium spp. to 3.0%. Seed germination appeared to decrease slightly by water-soaking at $30^{\circ}C$ because of increased SMC and by physical damage of embryos from hulling. These results indicate that the use of gaseous $ClO_2$ was effective as a means to disinfect rice seeds infected with Fusarium spp. and that moisture around the pathogens in the seed was an important factor for the action of $ClO_2$. Further investigations should be conducted to ascertain the best conditions for complete disinfection of Fusarium spp. that infect deep site of rice seeds.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2021.06a
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• pp.327-330
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• 2021

본 논문은 RGB 영상 데이터셋의 일부만을 지도학습하여(Sparsely-supervised learning) Annotation 되지 않은 영상에 대해 손-객체의 3D 포즈를 복원하기 위한 방법을 제안한다. 기존의 연구에서는 손-객체의 포즈에 해당하는 6DoF 만을 학습 데이터로 활용한다. 이와 달리, 본 논문에서는 정확도 향상을 위해 복원된 결과를 동일한 입력 영상 내에서 비교 가능하도록 3D 모델로 복원한 결과를 입력 영상의 마스크로 만들어 학습에 반영하였다. 구체적으로 추정된 포즈로 만들어낸 마스크를 입력 영상에 적용한 결과와 Ground-truth 포즈를 적용한 영상을 학습 시에 손실 함수에 반영하였다. 비교 실험을 통해 제안된 방법이 해당 방법을 적용하지 않은 경우 보다 3D 매쉬 오차가 적었음을 확인할 수 있었다.

• Applied Chemistry for Engineering
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• v.33 no.6
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• pp.563-573
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• 2022

This work aimed to develop a new equation for turbidity (Turb) simulation and prediction using statistical methods based on principal component analysis (PCA) and multiple linear regression (MLR). For this purpose, water samples were collected monthly over a five year period from Cheurfa dam, an important reservoir in Northwestern Algeria, and analyzed for 12 parameters, including temperature (T°), pH, electrical conductivity (EC), turbidity (Turb), dissolved oxygen (DO), ammonium (NH₄⁺), nitrate (NO₃^-), nitrite (NO₂^-), phosphate (PO₄^3-), total suspended solids (TSS), biochemical oxygen demand (BOD₅) and chemical oxygen demand (COD). The results revealed a strong mineralization of the water and low dissolved oxygen (DO) content during the summer period. High levels of TSS and Turb were recorded during rainy periods. In addition, water was charged with phosphate (PO₄^3-) in the whole period of study. The PCA results revealed ten factors, three of which were significant (eigenvalues >1) and explained 75.5% of the total variance. The F1 and F2 factors explained 36.5% and 26.7% of the total variance, respectively and indicated anthropogenic pollution of domestic agricultural and industrial origin. The MLR turbidity simulation model exhibited a high coefficient of determination (R² = 92.20%), indicating that 92.20% of the data variability can be explained by the model. TSS, DO, EC, NO₃^-, NO₂^-, and COD were the most significant contributing parameters (p values << 0.05) in turbidity prediction. The present study can help with decision-making on the management and monitoring of the water quality of the dam, which is the primary source of drinking water in this region.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.10
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• pp.1452-1460
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• 2014

The objective of this work was to evaluate the nutritional parameters of young bulls supplemented with different ratios of protein: carbohydrate on tropical pastures from 4 until 18 months old. Fifty-five non-castrated beef calves ($138.3{\pm}3.4kg$, 90 to 150 d of age) were used. The calves (young bulls) were subjected to a 430-d experimental period encompassing 4 seasons. The treatments were as follows: control, only mineral mixture; HPHC, high protein and high carbohydrate supplement; HPLC, high protein and low carbohydrate supplement; LPHC, low protein and high carbohydrate supplement; and LPLC, low protein and low carbohydrate supplement. The amount of supplement was adjusted every 28 d. Dry matter (DM) intake was higher in the dry-to-rainy transition and rainy seasons for all nutritional plans. Non-supplemented animals had lower intakes of DM and total digestible nutrients (TDN) than supplemented young bulls in all seasons. Although differences in DM intake were not observed between supplemented animals, the supplements with high carbohydrate (HPHC and LPHC) had lower forage intake during suckling (rainy-to-dry transition season) and in the rainy season. However, the HPHC treatment animals had higher intake and digestibility of neutral detergent fiber. It can be concluded that supplementation with high protein levels (supplying 50% of the crude protein requirement) provide the best nutritional parameters for grazing young bulls in most seasons, increasing intake and digestibility of diet, and these effects are more intense when associated with high carbohydrate levels level (supplying 30% TDN requirement).

• Biomolecules & Therapeutics
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• v.29 no.3
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• pp.311-320
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• 2021

Accumulation of reactive oxygen species (ROS) is associated with the development of various diseases. However, the molecular mechanisms underlying oxidative stress that lead to such diseases like autosomal dominant polycystic kidney disease (ADPKD) remain unclear. Here, we observed that oxidative stress markers were increased in Pkd1f/f:HoxB7-Cre mice. Forkhead transcription factors of the O class (FOXOs) are known key regulators of the oxidative stress response, which have been observed with the expression of FoxO3a in an ADPKD mouse model in the present study. An integrated analysis of two datasets for differentially expressed miRNA, such as miRNA sequencing analysis of Pkd1 conditional knockout mice and microarray analysis of samples from ADPKD patients, showed that miR-132-3p was a key regulator of FOXO3a in ADPKD. miR-132-3p was significantly upregulated in ADPKD which directly targeted FOXO3 in both mouse and human cell lines. Interestingly, the mitochondrial gene Gatm was downregulated in ADPKD which led to a decreased inhibition of Foxo3. Overexpression of miR-132-3p coupled with knockdown of Foxo3 and Gatm increased ROS and accelerated cyst formation in 3D culture. This study reveals a novel mechanism involving miR-132-3p, Foxo3, and Gatm that is associated with the oxidative stress that occurs during cystogenesis in ADPKD.

• Korean Journal of Applied Biomechanics
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• v.14 no.3
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• pp.99-118
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• 2004

The aim of this study is to evaluate tennis shoes's plantar pressure distribution in tennis prayers and to determine the influence of the shoe on various tennis movements. When investigating the biomechanics of movement in tennis, one of the first things to do is to understand the movement patterns of the sport, specifically how these patterns relate to different tennis shoes. Once these patterns are understood, footwear company can design tennis shoes that match the individual needs of tennis players. Plantar pressure measurement is widely employed to study foot function, the mechanical pathogenesis for foot disease and as a diagnostic and outcome measurement tool for many performance. Measurements were taken of plantar pressure distribution across the foot and using F-Scan(Tekscan Inc.) systems respectively. The F-Scan system for dynamic in-shoe foot pressure measurements has enabled us to assess quantitatively the efficacy of different types of footwear in reducing foot pressures. The Tekscan F-Scan system consists of a flexible, 0.18mm thick sole-shape having 1260 pressure sensors, the sensor insole was trimmed to fit the subjects' right, left shoes. For this study 4 university male, high level tennis players were instructed to hit alternated forehand stroke, backhand stroke, forehand volley, backhand volley, smash, service movement in 4 different tennis shoes. 1. When impact in tennis movement, peak pressure distribution of landing foot displayed D>C>B>A, A displayed the best low pressure distribution. A style's tennis shoes will suggest prayer with high impact. If prayer with high impact feeling during pray in tennis wear A style, it will decrease injury, will have performance improvement. 2. When impact in tennis movement, plantar pattern of pressure distribution in landing foot displayed B>A>C>D in stability performance. During tennis, prayer want to stability movement suggest B style tennis shoes when tennis movement impact keep stability of human body. B style tennis shoes give performance improvement 3. When impact in tennis movement, plantar pattern of center of force(C.O.F.)trajectory in landing foot analyzed this : 1) When stroke movement and volley movement in tennis, prayer better to rearfoot movement. 2) when service movement, prayer midfoot strike movement. 3) when smash movement, prayer have forefoot strike movement.

• Tuberculosis and Respiratory Diseases
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• v.68 no.1
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• pp.1-5
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• 2010

Background: To analyze the result of $^{18}F-FDG$ positron emission tomography (PET) in patients with a concomitant malignancy and tuberculoma in a tuberculosis (TB)-endemic area. Methods: Twelve patients with a concomitant malignancy and tuberculoma, who underwent whole-body $^{18}F-FDG$ PET, were evaluated retrospectively. The maximal standardized uptake values (SUVmax) of the malignancy and tuberculoma were compared. In 6 patients, $^{18}F-FDG$ PET was repeated during the anti-TB treatment and the changes in SUVmax were analyzed. Results: Of the 12 patients, 10 were male. The mean age was $67.2{\pm}7.9$ years. Tuberculomas were located in the lung (n=10) and lymph nodes (n=2), and tumors were located in the lung (n=6), colon (n=3), stomach (n=1), ovary (n=1) and liver (n=1). Although the mean SUVmax of malignant lesions was higher than that of tuberculomas ($5.2{\pm}3.2$ vs $3.5{\pm}2.0$), the difference was not significant. In 4 patients, the SUVmax was higher in the tuberculoma than the tumor. After anti-TB treatment in 6 patients, the mean SUVmax of the tuberculomas decreased significantly, from $3.5{\pm}2.0$ to $1.6{\pm}0.9$ (p=0.028). Conclusion: In patients with a concomitant malignancy and tuberculoma, SUVmax alone could not differentiate between them. However, $^{18}F-FDG$ PET may be useful in monitoring the response to anti-TB treatment.

• Journal of the Korean Chemical Society
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• v.41 no.11
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• pp.581-585
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• 1997

The luminescence spectra of Tb(Ⅲ) complexes have been investigated as a function of molar metal-to-ligand ratio and pH. The ligands used in this study are iminodiacetate (IDA) and methyliminodiacetate (MIDA). The 549 nm emission band, most sensitive to the coordination environment among the observed bands, is monitored to reveal the optimum condition for $TbL^{3-}_3$ complex formation in aqueous state.