• Journal of the Korean Geotechnical Society
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• v.33 no.1
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• pp.5-15
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• 2017

Skin friction may be one of the most critical factors in designing the prebored and precast pile. Special attention was given to the interface behavior of cement milk-surrounding soil during the installation of prebored and precast pile. Small-scale field model pile test was conducted for the case of single pile. The size and geometry of the small-scale field model piles were designed with pile length 1.3m, boring diameter 0.067 m. Quick maintain-load test was conducted for the cases of boring diameter 150, 125, 90, 86, 74 mm and water-cement ratio 90, 70, 60%. It was shown that the bearing capacity of the pile increased as the cement-water ratio and cement milk thickness increased. Considering the scale effect between the small-scale model test and the actual construction site, it was found that cement milk thickness of 0.1~0.4D (50~200 mm) was reasonable for the stability of the structure. Also, the proper cement paste water / cement ratio was about 70% when considering the results of this study and quality control.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.113-117
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• 2003

The recent development of methods for culturing hair follicles in vitro has proved an important tool to investigate many aspects of drug screening. Hair follicles develop as a result of epithelial-mesenchymal interactions between epidermal keratinocytes and dermal cells. We isolated some follicle cells using explantation and enzymatic digestion method from human scalp hair follicles. So we could culture some follicular cells, such as outer root sheath (ORS) cells, dermal papilla (DP) cells, dermal sheath (DS) cells, matrix cells and melanocytes. To induce hair morphogenesis in vitro the cells were 3-D cultured as skin structures. Moreover, to develop hair follicel organ culture model, we applied dermal equivalent (DE) to culturing hair follicles to expand hair growth period.

• Korean Journal of Food Science and Technology
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• v.40 no.4
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• pp.436-442
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• 2008

Hydroxyproline and Pro-Hyp dipeptide are the digestive products of collagen hydrolysate called collagen peptide. Some suggested that collagen peptides could improve aged or damaged skins, however, the effects of collagen peptides on the skin have not been known. In this study, we investigated the effects of digestive products of collagen peptides, hydroxyproline and Pro-Hyp dipeptide on skin quality using the UV-damaged dorsal skin of hairless mouse as a model system. Female SKH hairless mice were pre-irradiated with UV for 7 weeks, and then hydroxyproline, Pro-Hyp dipeptide were orally administered for 7 weeks with UV irradiation. Wrinkle formation (by replica image), skin elasticity, barrier status (by TEWL, transepidermal water loss), epidermis thickness, and biophysical changes in the stratum comeum (by hematoxylin & eosin staining) were examined. With the oral peptide treatment, effects such as skin barrier maintenance, anti-skin thickening, and recovery of the stratum corneum were observed. These results indicate that oral intake of collagen peptides may have beneficial effects on damaged skin cells.

• Korean Journal of Cognitive Science
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• v.11 no.2
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• pp.1-10
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• 2000

Realistic facial animation research field which communicates with human and computer using face has increased recently. The human face is the part of the body we use to recognize individuals and the important communication channel that understand the inner states like emotion. To provide the intelligent interface. computer facial animation looks like human in talking and expressing himself. Facial modeling and animation research is focused on realistic facial animation recently. In this article, we suggest the method of facial modeling and animation for realistic facial synthesis. We can make a 3D facial model for arbitrary face by using generic facial model. For more correct and real face, we make the Korean Generic Facial Model. We can also manipulate facial synthesis based on the physical characteristics of real facial muscle and skin. Many application will be developed such as teleconferencing, education, movies etc.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.2
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• pp.227-233
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• 2004

Chronic exposure to solar radiation, particularly ultraviolet (UV) light, causes a variety of adverse reactions on human skin, such as sunburn, photoaging and photocarcinogenesis. Free radicals and reactive oxygen species (ROS) caused by UV exposure or other environmental facts play critical roles in cellular damage. And, repeated-UV irradiation activated the expression of the matrix metalloproteinase (MMP) and induced skin irritation. Therefore, the development of effective and safe photoprotectants that can reduce and improve the skin damage has been required. The purpose of this study was to investigate the photo-protective effect of several chinese medical plants (Juniperus chinensis) on the UV -induced skin cell damages. We tested free radical and superoxide scavenging effect in vitro. Fluorometric assays of the proteolytic activities of MMP-1 (collagenase) were performed using fluorescent collagen substrates. UVA induced MMP-1 synthesis and activity were analyzed by enzyme-linked immunosorbent assay (ELISA) and gelatin-based zymography in skin fibroblasts. We also examined anti-inflammatory effects by the determination test of proinflammatory cytokine, interleukin 6 in HaCaT keratinocytes. Expression of prostaglandin E$_2$ (PGE$_2$) after UVB irradiation was measured by competitive enzyme immunoassay(EIA) using PGE$_2$ monoclonal antibody. In the human skin we tested anti-irritation effect on the SLS-induced damage skin after appling the extract containing emulsion. We found that Juniperus chinensis extract had potent radical scavenging effect by 98% at 100$\mu\textrm{g}$/mL. The extract of Juniperus chinensis showed strong inhibitory effect on MMP-1 activities by 97% at 100 $\mu\textrm{g}$/mL and suppressed the UVA induced expression of MMP-1 by 79% at 25$\mu\textrm{g}$/mL. This extract also showed strong inhibition on MMP-2 activity in UVA irradiated fibroblast by zymography. In the test of proinflammatory cytokines of human keratinocytes Juniperus chinensis extract decreased expression of interleukin 6 about 30%. The amount of PGE$_2$ by HaCaT keratinocytes was significantly increased at the doses of above 10 mJ/$\textrm{cm}^2$ of UVB (p < 0.05). At the concentrations of 3.2-25$\mu\textrm{g}$/mL of this extract, the production of PGE$_2$ by HaCaT keratinocytes (24 h after 10mJ/$\textrm{cm}^2$ UVB irradiation) was significantly inhibited in culture supernatants (p < 0.05). In SLS-induced skin irritation model in vivo, we found to reduce skin erythema and improve barrier recovery after appling Juniperus chinensis extract containing emulsion when compared to irritated non-treated and placebo-treated skin. Our results suggest that Juniperus chinensis extract can be effectively used for the prevention of UV and SLS-induced adverse skin reactions and applied as anti-aging and anti-irritation cosmetics.

• Toxicological Research
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• v.31 no.2
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• pp.97-104
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• 2015

The skin exposure to solar irradiation and photoreactive xenobiotics may produce abnormal skin reaction, phototoxicity. Phototoxicity is an acute light-induced response, which occurs when photoreacive chemicals are activated by solar lights and transformed into products cytotoxic against the skin cells. Multifarious symptoms of phototoxicity are identified, skin irritation, erythema, pruritis, and edema that are similar to those of the exaggerated sunburn. Diverse organic chemicals, especially drugs, are known to induce phototoxicity, which is probably from the common possession of UV-absorbing benzene or heterocyclic rings in their molecular structures. Both UVB (290~320 nm) and UVA (320~400 nm) are responsible for the manifestation of phototoxicity. Absorption of photons and absorbed energy (hv) by photoactive chemicals results in molecular changes or generates reactive oxygen species and depending on the way how endogenous molecules are affected by phototoxicants, mechanisms of phototoxcity is categorized into two modes of action: Direct when unstable species from excited state directly react with the endogenous molecules, and indirect when endogeneous molecules react with secondary photoproducts. In order to identify phototoxic potential of a chemical, various test methods have been introduced. Focus is given to animal alternative test methods, i.e., in vitro, and in chemico assays as well as in vivo. 3T3 neutral red uptake assay, erythrocyte photohemolysis test, and phototoxicity test using human 3-dimensional (3D) epidermis model are examples of in vitro assays. In chemico methods evaluate the generation of reactive oxygen species or DNA strand break activity employing plasmid for chemicals, or drugs with phototoxic potential.

• Journal of Ginseng Research
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• v.16 no.2
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• pp.111-123
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• 1992

Drying characteristic data for peeled ginseng were obtained to determine dominant drying factors and fitted with five selected drying models and an empirical model. Among air temperature, relative humidity and diameter of ginseng root, drying air temperature was found to be the most influencing factor on drying rate. Drying velocity appeared faster as the drying temperature increased but its effect was less at high temperature than at low temperature. Quality change during the drying process did not occur except when relative humidity was 75fb. At high relative humidity, skin color of ginseng was turned to light brown. Approximate-Diffusion and the Empirical model for drying were in a good agreement with experimental data. The models are as follows; $.$ Approximate-Diffusion model MR = A$.$exe(-k$.$1) A = 1.72 + 0.407 In(D) - 0.0000963T3 - 0.358 In(RH) + 0.0000945 RH2 B= 1.01 + 0.0195RH - 0.O0518D2 + 0.0708 In(T) - 0.492 In(RHI-D.0000933RH2$.$Empirical model MR= Cl + Cs$.$In(t) Cl= 1.14+0.382 In(D)-0.00008477a-0.139 In(RH)+0.0000664RH2 Cs=0.440-0.0224 In(D)-0.193 In(T)+0.0000464T2-0.00000771RH2

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1958-1962
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• 2005

A driver's emotion is a very important factor of safe driving. This paper classified a driver's emotion into 3 major emotions, can be occur when driving a car: Surprise, Joy, Tired. And It evaluated the classifier using Hidden Markov Models, which have observation sequence as bio-signals. It used the 2-D emotional plane to classfiy a human's general emotion state. The 2-D emotional plane has 2 axes of pleasure-displeasure and arsual-relaxztion. The used bio-signals are Galvanic Skin Response(GSR) and Heart Rate Variability(HRV), which are easy to acquire and reliable. We classified several moving pictures into 3 major emotions to evaluate our HMM system. As a result of driving simulations for each emotional situations, we can get recognition rates of 67% for surprise, 58% for joy and 52% for tired.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.1
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• pp.96-104
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• 2009

An anatomically detailed elderly human body model is under development. Using the anthropometric database of domestic nation-wide size survey, SizeKorea, a standard size and shape of 50th %tile elderly was constructed. Through the local recruitment process, a male volunteer with 71 years of age, 163cm of height and 63kg of weight has been selected. The exterior (skin) and interior (skeleton and organ) geometries were acquired from whole body 3D laser scan and various medical images such as CT, X-ray, and Ultrasonic of the volunteer. A particular attention has been paid into the combining process of exterior and interior geometries especially for joint articulation positions since they were measured at different postures (sitting vs. supine). A whole ribcage of PMHS which possessed similar anthropometry and age of standard 50th %tile elderly was prepared and dissected for the precise gauge of cortical rib bone thickness distributions. After completing the morphological construction of elderly human body, the finite element modeling will be processed by meshing elements and assigning mechanical properties to various biological tissues which reflect the aging effect.

• Fashion & Textile Research Journal
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• v.11 no.5
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• pp.779-787
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• 2009

The purpose of this study was to classify the head shape for the apparel industry and to suggest standard head model for korean women. The 23 measurement items of 891 females, aged more than 18 years were used to analysis by statistical methods. Factor analysis, cluster analysis and duncan test were performed using these data. Through factor analysis, 5 factors were extracted upon factor scores and those factors comprised 68.76% for the total variances. 5 clusters as their head and face shape were categorized. We decided for the type 3 to standard head shape. 24 participants were measured using computed tomography(CT). The measured data of skin and skeleton and the standard head shapes were illustrated.