• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.5
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• pp.1463-1476
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• 2014

In order to understand hydrodynamic and morphodynamic characteristics under wave-current interactions in an estuary, a coupled model for two-way analysis between existing 3-d numerical wave tank and newly-developed 3-d morphodynamic model has been suggested. Comparing to existing experimental results it is revealed that computed results of the newly-suggested model are in good agreement with each laboratory test result for wave height distribution, vertical flow profile and topographical change around ocean floor pipeline in wave-current coexisting field. Also the numerical result for suspended sediment concentration is verified in comparison with experimental result in solitary wave field. Finally, it is shown that the 3-D coupled Hydro-Morphodynamic model suggested in this study is applicable to morphological change under wave-current interaction in an estuary.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.517-522
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• 2016

${\beta}$-Arrestins are one of the protein families that interact with G protein-coupled receptors (GPCRs). The roles of ${\beta}$-arrestins are multifaceted, as they mediate different processes including receptor desensitization, endocytosis, and G protein-independent signaling. Thus, determining the GPCR regions involved in the interactions with ${\beta}$-arrestins would be a preliminary step in understanding the molecular mechanisms involved in the selective direction of each function. In the current study, we determined the roles of the N-terminus, intracellular loops, and C-terminal tail of a representative GPCR in the interaction with ${\beta}$-arrestin2. For this, we employed dopamine $D_2$ and $D_3$ receptors ($D_2R$ and $D_3R$, respectively), since they display distinct agonist-induced interactions with ${\beta}$-arrestins. Our results showed that the second and third intracellular loops of $D_2R$ are involved in the agonist-induced translocation of ${\beta}$-arrestins toward plasma membranes. In contrast, the N- and C-termini of $D_2R$ exerted negative effects on the basal interaction with ${\beta}$-arrestins.

• Journal of computational fluids engineering
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• v.5 no.2
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• pp.38-46
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• 2000

It has been indicated that the rotor/stator interaction has distinct causes of unsteadiness, such as the viscous vortex shedding, wake/stator interaction and potential rotor/stator interaction. In this paper, the mechanism of unsteady potential interaction in one stage axial compressor is numerically investigated for blade row ratio 1:1 and 2:3 at design point and for blade row ratio 2:3 at off-design point in two-dimensional view point. The numerical technique used is the upwind scheme of Van-Leer's Flux Vector Splitting(FVS) and Cubic spline interpolation is applied on zonal interface. In this study the flow unsteadiness due to potential interaction are found to be larger in blade row ratio 2:3 than in 1:1. The total pressure rise in blade row ratio 2:3 is closer to the real value in design point than that in 1:1. The change of unsteady pressure amplitude according to the variation of stator exit pressure is very small.

• Journal of Technologic Dentistry
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• v.38 no.3
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• pp.203-208
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• 2016

Purpose: This study introduces the production process of dog's dental prosthesis using an automated dental prosthetics technology. The occlusal interaction of dog's dental prosthesis was observed. Methods: This study was proceeded with dog's the mandibular first molar teeth. The 3D CAD designed to 3D model specimens was observed by CAD software. and The specimens designed to 3D model specimens was observed occlusal interaction by using articulator. Results: Occlusal contact point in prosthetic specimens were observed in buccal surface. and 98% of the size of the crown is the best occlusal relationship. Conclusion: Observation of occlusal relations result to 98% of the size of the crown is the best.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.19 no.8
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• pp.764-772
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• 2009

In this study, fluid/structure coupled analyses have been conducted for 3-D stator and rotor configuration. Advanced computational analysis system based on computational fluid dynamics(CFD) and computational structural dynamics(CSD) has been developed in order to investigate fluid/structure responses of general stator-rotor configurations. To solve the fluid/structure coupled problems, fluid domains are modeled using the structural grid system with dynamic moving and local deforming techniques. Reynolds-averaged Navier-Stokes equations with Spalart-Allmaras(S-A) and SST ${\kappa}-{\omega}$ turbulence models are solved for unsteady flow problems. A fully implicit time marching scheme based on the Newmark direct integration method is used for computing the coupled aeroelastic governing equations of the 3-D turbine blades for fluid-structure interaction(FSI) problems. Detailed fluid/structure analysis responses for stator-rotor interaction flow conditions are presented to show the physical performance and flow characteristics.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08b
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• pp.1729-1732
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• 2007

We introduce a mobile-type 3D display that achieves a full directional motion parallax and the real time interactions between the observer and the 3D image at the same time. These effects can be unique specified to the mobile-type 3D display.

• 한국정보디스플레이학회:학술대회논문집
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• 2008.10a
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• pp.139-142
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• 2008

Developing from stereoscopic to autostereoscopic, researchers on display technology are trying to provide more depth cues to viewer, leading to the advent of true 3D display. Volumetric 3D displays seem to be practical technology at present. Ultimate display will function like human vision system, with characteristics of providing all depth cues and free interaction.

• Structural Engineering and Mechanics
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• v.61 no.3
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• pp.407-417
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• 2017

RC shear walls are considered one of the main lateral resisting members in buildings. In recent years, FRP has been widely utilized in order to strengthen and retrofit concrete structures. A number of experimental studies used CFRP sheets as an external bracing system for retrofitting of RC shear walls. It has been found that the common mode of failure is the debonding of the CFRP-concrete adhesive material. In this study, behavior of RC shear wall was investigated with three different micro models. The analysis included 2D model using plane stress element, 3D model using shell element and 3D model using solid element. To allow for the debonding mode of failure, the adhesive layer was modeled using cohesive surface-to-surface interaction model at 3D analysis model and node-to-node interaction method using Cartesian elastic-plastic connector element at 2D analysis model. The FE model results are validated comparing the experimental results in the literature. It is shown that the proposed FE model can predict the modes of failure due to debonding of CFRP and behavior of CFRP strengthened RC shear wall reasonably well. Additionally, using 2D plane stress model, many parameters on the behavior of the cohesive surfaces are investigated such as fracture energy, interfacial shear stress, partial bonding, proposed CFRP anchor location and using different bracing of CFRP strips. Using two anchors near end of each diagonal CFRP strips delay the end debonding and increase the ductility for RC shear walls.

• Journal of Digital Contents Society
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• v.16 no.2
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• pp.189-196
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• 2015

The proposed cooperative 3D modelling system enables more efficient modeling works by improving current cooperation systems. Current 3D modeling tasks work on off-line and most of works are cooperation systems which communicate by files. These cooperation system cannot be interactive, occurs time delay while feedback and must have some programs which can read the files. This paper solves these problems using web that has the characteristics of network and proposes new cooperation system form. Using WebGL(Web Graphics Library) which is proposing technology in technical realization of Web 3D modeling, we make 3D objects in web browser and these objects can be manipulated by server-client communication. Therefore, if people use this system, they can use real time interaction and feedback. Also this system lowers a software installation necessity and can access everytime if web browser is installed.

• Korean Journal of Clinical Pharmacy
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• v.25 no.3
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• pp.138-144
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• 2015

Objective: It is to evaluate the drug interaction monitoring program as a pilot project to develop a pharmaceutical care model in a medical intensive care unit and to analyze the influencing factors of drug interactions. Method: Electronic medical records were retrospectively investigated for 116 patients who had been hospitalized in a medical intensive care unit from October to December in 2014. The prevalence of adverse reaction with risk rating higher than 'D' was investigated by Lexi-$Comp^{(R)}$ Online database. The factors related with potential drug interaction and with treatment outcomes were analyzed. Results: The number of patients with a potential interaction of drug combination was 92 (79.3%). Average ages, the length of stay in the intensive care unit and the numbers of prescription drugs showed significant differences between drug interaction group and non-drug interaction group. Opioids (14.4%), antibiotics (7.2%), and diuretics (7.2%) were most responsible drug classes for drug interactions and the individual medications included furosemide (6.4%), tramadol (4.9%), and remifentanil (4.5%). There were 950 cases with a risk rating of 'C' (84.6%), 142 cases with a risk rating of 'D' (12.6%), and 31 cases with a risk rating of 'X' (avoid combination) (2.8%). The factors affecting drug interactions were the number of drugs prescribed (p < 0.0001) and the length of stay at intensive care unit (p < 0.01). The patients in intensive care unit showed a high incidence of adverse reactions related to potential drug interaction. Therefore, drug interaction monitoring program as a one of pharmaceutical care services was successfully piloted and it showed to prevent adverse reaction and to improve therapeutic outcomes. Conclusion: Active participation of a pharmacist in the drug management at the intensive care unit should be considered.