• Proceedings of the Korea Multimedia Society Conference
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• 2000.11a
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• pp.571-574
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• 2000

오늘날 단백질 정보 분석은 HGP(Human Genome Project)이후 Post-genome 시대를 맞이하면서 매우 중요한 분야로 인식되고 있다. 이 단백질 정보를 이용하는 응용은 Discovery of Protein Structure/Function Relationships, Evolutionary Relationships, 3D Modeling 등 많은 분야에서 활용되어진다. 여러 가지 분야들 중에서 특히 단백질 구조 분석을 위한 많은 다양한 소프트웨어들이 출현되고 있다. 하지만 복잡하게 얽혀 있는 단백질들을 검증하기 위해서 Mass Spectrometry에서 발생되는 Peptide Masses의 정보들을 이용할 수 있다. 이에 본 논문에서는 Mass Spectrometry에서 생성된 Peptide Mass Map을 이용하여 기존의 단백질 Database에 있는 단백질들과 비교하는 자동화 단백질 검증 시스템 설계 및 구현에 관한 연구내용을 담고 있다. 이 시스템은 3-계층 중심으로 개발이 이루어지며 이 기종 시스템과의 원활한 통신 다중 계층의 환경에 있는 각 객체들간에 통신을 위해서 RMI 기반의 미들 웨어를 활용하기로 한다.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.4
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• pp.174-182
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• 2003

Recently, medical imaging has taken interest on CAD based solution for anatomical part fabrication or finite element analysis of human body. In principle, contours representing object boundary are obtained through image processing techniques. Surface models are then approximated by a skinning method. For this, various methods should be applied to medical images and contours. The major bottleneck of the reconstruction is to remove shape inconsistency between contours and to generate the branching surface. In order to solve these problems, bi-directional smoothing and the composite contour generation method are proposed. Bi-directional smoothing has advantage of removing the shape inconsistency between contours and minimizing shrinkage effect with a large number of iterations. The composite contour by the proposed method ensures smooth transition in branching region.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.430-436
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• 2018

Special railway vehicles for track maintenance are equipped with a tamping device that adjusts various track trajectories to reduce the vibration of rolling stock and improve ride quality during trains passing over a track. The development of a simulator that can confirm the error of the actual tamping work is important for reducing human error in the linearization of the track misalignment. In this study, to improve the reality and training effect of conventional 2D simulator, 3D simulator modeling was implemented for tamping work of special railway vehicles in virtual space. The problem of buffering during high screen quality of tamping work was solved using the Unwrap UVW mapping technique of a low polygon extracted from high quality polygon modeling. The human error in the training of the tamping work was detected by the principle of circle and square collision when the tamping tyne and the sleeper collided. In addition, vibration of the driving chair was generated at the same time as the collision, and the number of the sleeper strikes is displayed on the simulator exercise screen. Owing to the scattering of railway ballast protruding from the sleepers, which had a serious effect on the safety of the vehicle, the gravel bouncing effect of the tamping unit was applied.

• Korean Journal of Computational Design and Engineering
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• v.20 no.4
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• pp.420-430
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• 2015

Operator Training Simulators (OTSs) provide macroscopic training environment for plant operation. They are equipped with simulation systems for the emulation of remote monitoring and controlling operations. OTSs typically provide 2D block diagram-based graphic user interface (GUI) and connect to process simulation tools. However, process modeling for OTSs is a difficult task. Furthermore, conventional OTSs do not provide real plant field information since they are based on 2D human machine interface (HMI). In order to overcome the limitation of OTSs, we propose a new type of plant training system. This system has the capability required for collaborative training between operators and field workers. In addition, the system provides 3D virtual training environment such that field workers feel like they are in real plant site. For this, we designed system architecture and developed essential functions for the system. For the verification of the proposed system design, we implemented a prototype training system and performed experiments of collaborative training between one operator and two field workers with the prototype system.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.58-64
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• 2011

Objective: The 3-dimensional reconstruction method with resolution recovery modeling has advantages of high spatial resolution and contrast because of its precise modeling of spatial blurring according to the distance from detector plane. The aim of this study was to evaluate one of the resolution recovery reconstruction methods (Astonish, Philips Medical), compare it to other iterative reconstructions, and verify its clinical usefulness. Materials and Methods: NEMA IEC PET body phantom and Flanges Jaszczak ECT phantom (Data Spectrum Corp., USA) studies were performed using Skylight SPECT (Philips) system under four different conditions; short or long (2 times of short) radius, and half or full (40 kcts/frame) acquisition counts. Astonish reconstruction method was compared with two other iterative reconstructions; MLEM and 3D-OSEM which vendor supplied. For quantitative analysis, the contrast ratios obtained from IEC phantom test were compared. Reconstruction parameters were determined by optimization study using graph of contrast ratio versus background variability. The qualitative comparison was performed with Jaszczak ECT phantom and human myocardial data. Results: The overall contrast ratio was higher with Astonish than the others. For the largest hot sphere of 37 mm diameter, Astonish showed about 27.1% and 17.4% higher contrast ratio than MLEM and 3D-OSEM, in short radius study. For long radius, Astonish showed about 40.5% and 32.6% higher contrast ratio than MLEM and 3D-OSEM. The effect of acquired counts was insignificant. In the qualitative studies with Jaszczak phantom and human myocardial data, Astonish showed the best image quality. Conclusion: In this study, we have found out that Astonish can provide more reliable clinical results by better image quality compared to other iterative reconstruction methods. Although further clinical studies are required, Astonish would be used in clinics with confidence for enhancement of images.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1709-1712
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• 2008

The trunk is inclined to the loaded side when carrying an object as one of activities of daily living. As the reaction to this behavior the human body may be inclined to his/her trunk to unloaded side. The present study investigated the biomechanical effects of weight variation for sided load carriage during walking upon joint moments and muscle torques, through the tracker agent and joint driving dynamic analysis. To perform the experiment one male was selected as subject for the study. Gait analysis was performed by using a 3D motion analysis system. Thirty nine 14mm reflective markers, according to the plug-in marker set, were attached to the subject. We used BRG.LifeMOD(Biomechanics Research Group, Inc., USA), for skeletal modeling and inverse and joint driving dynamic simulation during one gait cycle. In walking with a sided load carriage, the subject modeled held the carriage with the right hand, which weighed 0, 5, 10, 15kg, 20kg respectively. The result of this simulation showed that knee and hip in the coronal plane were inclined to the loaded side and loaded side had larger moments as the sided load carriage was increased. On the other hand thoracic and lumbar in the coronal plane had larger negative values as the sided loaded carriage was increased. The thoracic and lumbar in the transverse plane also had larger values as the sided load was increased. And the several muscles of loaded side were increased as increasing sided load. It could be concluded that human body is adopted to side loaded circumstances by showing more biologic force. These results could be very useful in analysis for delivery motion of daily life.

• Archives of Pharmacal Research
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• v.29 no.1
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• pp.50-58
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• 2006

Translationally controlled tumor protein (TCTP), also known as histamine releasing factor (HRF), is found abundantly in different eukaryotic cell types. The sequence homology of TCTP between different species is very high, belonging to the MSS4/DSS4 superfamily of proteins. TCTP is involved in both cell growth and human late allergy reaction, as well as having a calcium binding property; however, its primary biological functions remain to be clearly elucidated. In regard to many possible functions, the TCTP of Plasmodium falciparum (Pf) is known to bind with an antimalarial agent, artemisinin, which is activated by heme. It is assumed that the endoperoxide-bridge of artemisinin is opened up by heme to form a free radical, which then eventually alkylates, probably to the Cys14 of PfTCTP. Study of the docking of artemisinin with heme, and subsequently with PfTCTP, was carried out to verify the above hypothesis on the basis of structural interactions. The three dimensional (3D) structure of PfTCTP was built by homology modeling, using the NMR structure of the TCTP of Schizosaccharomyces pombe as a template. The quality of the model was examined based on its secondary structure and biological function, as well as with the use of structure evaluating programs. The interactions between artemisinin, heme and PfTCTP were then studied using the docking program, FlexiDock. The center of the peroxide bond of artemisinin and the Fe of heme were docked within a short distance of $2.6{\AA}$, implying the strong possibility of an interaction between the two molecules, as proposed. When the activated form of artemisinin was docked on the PfTCTP, the C4-radical of the drug faced towards the sulfur of Cys14 within a distance of $2.48{\AA}$, again suggesting the possibility of alkylation having occurred. These results confirm the proposed mechanism of the antimalarial effect of artemisinin, which will provide a reliable method for establishing the mechanism of its biological activity using a molecular modeling study.

• Archives of design research
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• v.18 no.3 s.61
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• pp.85-94
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• 2005

Most of product designers use 3D CAD system as a inevitable design tool nowadays and many new products are developed through a concurrent engineering process. However, it is very difficult for novice designers to get the sense of reality from modeling objects shown in the computer screens. Such a intangibility problem comes from the lack of haptic interactions and contextual information about the real space because designers tend to do 3D modeling works only in a virtual space of 3D CAD system. To address this problem, this research investigate the possibility of a interactive quantified structure simulation for product design using AR(augmented reality) which can register a 3D CAD modeling object on the real space. We built a quantified structure simulation system based on AR and conducted a series of experiments to measure how accurately human perceive and adjust the size of virtual objects under varied experimental conditions in the AR environment. The experiment participants adjusted a virtual cube to a reference real cube within 1.3% relative error(5.3% relative StDev). The results gave the strong evidence that the participants can perceive the size of a virtual object very accurately. Furthermore, we found that it is easier to perceive the size of a virtual object in the condition of presenting plenty of real reference objects than few reference objects, and using LCD panel than HMD. We tried to apply the simulation system to identify preference characteristics for the appearance design of a home-service robot as a case study which explores the potential application of the system. There were significant variances in participants' preferred characteristics about robot appearance and that was supposed to come from the lack of typicality of robot image. Then, several characteristic groups were segmented by duster analysis. On the other hand, it was interesting finding that participants have significantly different preference characteristics between robot with arm and armless robot and there was a very strong correlation between the height of robot and arm length as a human body.

• Journal of KIISE
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• v.42 no.5
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• pp.609-620
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• 2015

Viewers of videos are likely to absorb more information from the part of the screen that attracts visual attention. This fact has led to the visual attention models that are being used in producing and evaluating videos. In this paper, we investigate the factors that are significant to visual attention and the mathematical form of the visual attention model. We then estimated the visual attention probability using the statistical design of experiments. The analysis of variance (ANOVA) verifies that the motion velocity, distance from the screen, and amount of defocus blur affect human visual attention significantly. Using the response surface modeling (RSM), we created a visual attention score model that concerns the three factors, from which we calculate the visual attention probabilities (VAPs) of image pixels. The VAPs are directly applied to existing gradient based 3D effect perception measurement. By giving weights according to our VAPs, our algorithm achieves more accurate measurement than the existing method. The performance of the proposed measurement is assessed by comparing them with subjective evaluation as well as with existing methods. The comparison verifies that the proposed measurement outperforms the existing ones.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.3D
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• pp.259-267
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• 2012

The development of construction automation systems is proposed as a potent solution to the difficulties encountered by the construction industry and the preparation for the rapidly changing construction environment. A research concerning an intelligent excavation system has taken place since 2006. The intelligent excavation system has several functions for environment sensing, 3D site modeling, work planning, work path generation, unmaned control, and information management. This paper presents a space information model and a work path simulator for work planning and work path generation which is one of key technologies required to apply the earthwork system to the real world. A data structure for an earthwork site is suggested. It overcomes the limitations of previous data structures such as Quadtree and Octree. The work path simulator can generate an effective work path with considering information on work environment, equipment and operator's heuristic. The work path generated by the simulator is compared with that suggested by human operators.