• Journal of the Microelectronics and Packaging Society
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• v.23 no.3
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• pp.1-6
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• 2016

The Internet of Things (IoT) is a new technology paradigm demanding one packaged system of various semiconductor and MEMS devices. Therefore, the development of electronic packaging technology with very high connectivity is essential for successful IoT applications. This paper discusses both fan-out wafer level packaging (FOWLP) and 3D stacking technologies to achieve the integrattion of heterogeneous devices for IoT. FOWLP has great advantages of high I/O density, high integration, and design flexibility, but ultra-fine pitch redistribution layer (RDL) and molding processes still remain as main challenges to resolve. 3D stacking is an emerging technology solving conventional packaging limits such as size, performance, cost, and scalability. Among various 3D stacking sequences wafer level via after bonding method will provide the highest connectivity with low cost. In addition substrates with ultra-thin thickness, ultra-fine pitch line/space, and low cost are required to improve system performance. The key substrate technologies are embedded trace, passive, and active substrates or ultra-thin coreless substrates.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.3
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• pp.313-318
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• 2012

Application of composite structures on naval ships strongly depends on the mechanical strength and collapse behavior of the T-joints of the whole structure. Because of the weight advantages over single skin composite and bolt fastening joining, three types of T-joints using both honeycomb sandwich composite and adhesive bonding were suggested to determine the effect of T-joint configuration. It was found that joining with a urethane foam block and overlaminates using the secondary co-bonding technique improves T-joint strength.

• Clinical and Experimental Pediatrics
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• v.52 no.2
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• pp.234-241
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• 2009

Purpose : We investigated the relationship between thyroid hormone and serum tumor necrosis factor (TNF-${\alpha}$), interleukin (IL-6) and N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) in patients with Kawasaki disease (KD). Methods : Serum levels of thyroid hormone, TNF-${\alpha}$, IL-6, and NT-proBNP were measured in 52 KD patients in the acute and subacute phase and 10 patients with acute febrile illness (control group). TNF-${\alpha}$ and IL-6 were determined by sandwich enzyme-linked immunosorbent assay (ELISA). Echocardiography was performed to detect coronary artery lesions (CAL) in KD patients. Results : Low $T_3$ syndrome occurred in 63.5% of KD patients. $T_3$ in the acute phase of KD was lower than that in the control. In KD patients, $T_3$ was lowered in the acute phase and elevated in the subacute phase, whereas TNF-${\alpha}$, IL-6 and NT-proBNP were elevated in the acute phase and decreased in the subacute phase. NT-proBNP, and IL-6 were higher in patients with low $T_3$ than in those with normal $T_3$. In addition, $T_3$ inversely correlated with IL-6 and NT-proBNP. Of the 4 patients with CAL, 3 had very low $T_3$. Compared with intravenous immunoglobulin (IVIG)-responsive patients, IVIG-resistant patients had lower $T_3$ and higher IL-6 and NT-proBNP. Conclusion : $T_3$ decreases in the acute phase of KD and normalizes in the subacute phase without thyroid hormone replacement. Low $T_3$ may be partially induced by IL-6 rather than TNF-${\alpha}$, and is strongly associated with high NT-proBNP. $T_3$ in KD may be used for the differential diagnosis, monitoring the activity of the disease, and predicting the severity of inflammation.

• 한국정보디스플레이학회:학술대회논문집
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• 2005.07a
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• pp.31-35
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• 2005

A prerequisite for a wide market acceptance of 3D displays is the ability to switch between 3D and full resolution 2D. In this paper we present a robust and cost effective concept for an auto-stereoscopic switchable 2D/3D display. The display is based on an LCD panel, equipped with switchable LC-filled lenticular lenses. A demonstrator of this concept is made. We will discuss measurements and numerical simulations of the key optical characteristics of this display. The switching characteristics of LC-filled lenticular lenses are discussed and the overlap of the view distributions is introduced as a figure of merit for crosstalk. The 0.62 overlap in our present demonstrator design, gives an excellent 3D image quality, combined with a good depth impression.

• Environmental Mutagens and Carcinogens
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• v.24 no.1
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• pp.1-9
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• 2004

Three D-type cyelins (D1, D2, and D3) are expressed in G1 phase of the cell cyele and have been implicated in cell transformation and neoplasia in human and mouse. Cyclin D1 overexpression or amplification was described in various human cancers. However, there is controversy about the role of cyclin D2 in cell cyele progression and human carcinogenesis. Specially, loss of cyelin D2 is involved in a vital tumor suppressor function in normal breast tissue, and that its loss may be related to tumorigenesis. The author examined to effect over-expression of cyclin D2 on the cell proliferation, apoptosis, and cell cycle using cyclin D2 transfected stable T47D breast cancer cells to investigate whether cyclinD2 functions as a positive regulator or negative regulator in cell proliferation. Overexpression of cyclin D2 led to the suppression of cell growth in cyclin D2 transfected T47D in both in its expression level and a time dependent manner with up to 50% reduction of cell growth at 72 hours. Therefore, the authors performed the cell cycle phase analysis using the flow cytometry to investigate the effect of cyclin D2 on the cell cycle phase in cyclin D2 transfected stable T47D cells. The flow cytometry analysis revealed increased sub G0 phase in cyclin D2 transfeted cells up to 23% at 72 hours. To confirm these results induced by overexpression of cyclinD2, the apoptotic bodies were counted in control and cyclin D2 transfected T47 cells. There are markedly increases of apoptotic bodies in cyclin D2-transfected cells up to 18%. These results suggested that Cyclin D2 suppresses the cell proliferation in breast cancers cells via the induction of apotosis.

• Earthquakes and Structures
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• v.8 no.3
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• pp.555-572
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• 2015

This paper presents an experimental study of three two-dimensional (2D/planar) steel reinforced concrete (SRC) T-shaped column-RC beam hybrid joints and six 3D SRC T-shaped column-steel beam hybrid joints under low cyclic reversed loads. Considering different categories of steel configuration types in column cross section and horizontal loading angles for the specimens were selected, and a reliable structural testing system for the spatial loading was employed in the tests. The load-displacement curves, carrying capacity, energy dissipation capacity, ductility and deformation characteristics of the test subassemblies were analyzed. Especially, the seismic performance discrepancies between planar hybrid joints and 3D hybrid joints were intensively compared. The failure modes for planar loading and spatial loading observed in the tests showed that the shear-diagonal compressive failure was the dominating failure mode for all the specimens. In addition, the 3D hybrid joints illustrated plumper hysteretic loops for the columns configured with solid-web steel, but a little more pinched hysteretic loops for the columns configured with T-shaped steel or channel-shaped steel, better energy dissipation capacity & ductility, and larger interlayer deformation capacity than those of the planar hybrid joints. Furthermore, it was revealed that the hysteretic loops for the specimens under $45^{\circ}$ loading angle are generally plumper than those for the specimens under $30^{\circ}$ loading angle. Finally, the effects of steel configuration type and loading angle on the seismic damage for the specimens were analyzed by means of the Park-Ang model.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.14 no.9
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• pp.720-725
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• 2001

In this study, Pb(La,Ce)Ti $O_3$ ceramics were manufactured for 20 MHz resonator application. Electromechanical coupling factor( $k_{t}$, $k_{t3}$, mechanical quality factor( $Q_{mt}$ , $Q_{mt3}$ and dydnamic range (D.R) of thickness vibration mode were measured as the variations of $\ell$/t(length/thickness) ratio of ceramic substrates. Mechanical quality factor( $Q_{mt3}$) and dynamic range of third overtone thickness vibration mode showed the highest value of 2,773 and 52.22dB at specimen S4($\ell$/t=12), respectively. The excellent temperature stability of resonant frequency suitable for resonator application was shown, regardless of thermal shock.k.ock.k.

• Journal of Periodontal and Implant Science
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• v.30 no.1
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• pp.39-52
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• 2000

Polypeptide growth factor belong to a class of potent biologic mediator which regulate cell differentiation, proliferation, migration and metabolism. 1,25-dihydroxyvitamin $D_3$ decrease cell proliferation, and stimulate alkaline phosphatase activity which express in osteoblast during cell differentiation period. IGF-I is known to stimulate cell proliferation and differentiation too. 1,25-dihydroxyvitamin $D_3$ is known to increase IGF-I binding sites and IGF binding protein which inhibite the effect of IGF. The purpose of this study is to evaluate potential role of IGF-I as mediator that control the action of 1,25-dihydroxyvitamin $D_3$. MC3T3-E1 cell were seeded $5{\times}10^5/ml$ at 100mm culture plate in ${\alpha}-MEM$ containing 10% fetal bovine serum. After 48 hour incubation period, medium were changed ${\alpha}-MEM$ containing 5% fetal bovine serum. After 24 hours, $10^{-9}M$ 1,25-dihydroxyvitamin $D_3$ added. Total mRNA was extracted at 0, 6, 24, 48, 72 hour. PRPCR method was programed for the detection of IGF-I mRNA. In the both groups of 1,25-dihydroxy vitamin $D_3$ treated and control, alternative splicing form of IGF-I, IGF-IA and IGF-IB were expressed. In the 1,25-dihydroxyvitamin $D_3$ treated group, IGF-I mRNA expression was matained until 24 hour, there after expression was decresed. MC3T3-E1 cell were seeded $2.5{\times}10^4/ml$ at 24well plate in ${\alpha}-MEM$ containing 10% fetal bovine serum. After 48 hour incubation period, medium were changed ${\alpha}-MEM$ containing 3% fetal bovine serum. After 24 hours, $10^{-9}M$ 1,25-dihydroxyvitamin $D_3$ and 10 ng/ml IGF-I were added separately or together. Cell were cultured for 1 and 3 days, $2{\mu}Ci/ml\;[^3H]$ -thymidine was added for the last 24h of culture of each days. ${[^3H]}$-thymidine incorporation in to DNA was measured and expressed counter per minute(CPM). DNA synthetic activity was significantly decreased by 1,25-dihydroxyvitamin $D_3$ both at 1 day and 3 day, and in the combination group of 1,25-dihydroxyvitamin $D_3$ and IGF-I, DNA synthetic activity was also decreased both at 1 day and 3 days. IGF-I did not affect the DNA synthetic activity compared to control group both at 1 day and 3 day. From the above results, 1,25-dihydroxyvitamin $D_3$ was potent inhibitor of cell proliferaton in MC3T3-E1 cells. It assumed that the effect of 1,25-dihydroxyvitamin $D_3$ on osteoblast proliferation may be mediated in part by decreased level of IGF-I.

• Journal of the Microelectronics and Packaging Society
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• v.8 no.4
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• pp.17-23
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• 2001

The 3-D Hall sensor has two horizontal magnetic field sensing parts ($\chi$, y components) and one vertical magnetic field sensing part (z component). For conventional, 3-D Hall sensor it is general that the sensitivity for $B_{z}$ is about 1/10 compared with those for $B_\chi$ or $B_y$. Therefore, in this work, we proposed 3-D Hall sensor with new structure. We have increased the sensitivity about 6 times to form the trench using anisotropic etching. And we have increased the sensitivity for the $B_z$ by 80% compared with those of $B_\chi$ and$B_y$ using deposition of the ferromagnetic thin films on the bottom surface of the wafer to concentrate the magnetic fluxes. When the input current was 3 mA, sensitivities of the fabricated sensor with Ni/Fe film for $B_\chi, B_y$ and $B_{z}$ were measured as 120.1 mV/T, 111.7 mV/T, 95.3 mV/T, respectively. The measured linearity of the sensor was within $\pm$3% of error.

• Korean Journal of Organic Agriculture
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• v.9 no.4
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• pp.113-121
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• 2001

This study was conducted to evaluate the effects of functional ingredients with supplementation as a bulking agent in composting of swine manure. Treatments were T1 & T5 ; Swine mature+Vermiculite, T2 & T6 ; Swine manure+Perlite, T3 & T7 ; Swine manure+Vermiculite+Perlite, T4 & T8 ; Swine manure+Bark. T1, T2, T3 and T4 were supplemented with functional ingredients on d 0 of composting, T5, T6, T7 and T8 were supplemented with functional ingredients on d 3 of composting. Functional ingredients were Fermkito and Yucca. During the composting period, changes of temperature were showed traditionally composting trend. Volatile fatty acids were decreased regardless of treatments in functional ingredients supplementation. Organic matter, T-N and C/N ratio were showed higher bark treatments than other treatments. pH and EC were net differences among the treatments. P$_2$O$_{5}$ and $K_2$O were showed level of 1-3%. In heavy metal, Cr were showed higher in vermiculite treatment than other treatments. In conclusion, vermiculite and perlite treatments were greater composting effects than bark.