• The Korean Journal of Physiology and Pharmacology
• /
• v.6 no.2
• /
• pp.109-112
• /
• 2002

The signal pathways involved in the regulation of AP-1 DNA binding activity in long-term nicotine stimulated bovine adrenal medullary chromaffin (BAMC) cells have not been well characterized. To understand the involvement of second messengers in the regulation of AP-1 DNA binding activity, the present study was designed to define the time-course for inhibition of nicotine-induced responses by cholinergic antagonists, $Ca^{2+}$ and calmodulin (CaM) antagonists, and calcium/calmodulin-dependent protein kinase (CaMK) II inhibitor using electrophoretic mobility shift assay. Nicotine $(10{\mu}M)$ stimulation increased AP-1 DNA binding activity at 24 hr after treatment. Posttreatment with hexamethonium (1 mM) plus atropine $(1{\mu}M)$ (HA), nimodipine $(1{\mu}M),$ or calmidazolium $(1{\mu}M)$ at 0.5, 3, and 6 hr after the nicotine treatment significantly inhibited the AP-1 DNA binding activity increased by long-term nicotine stimulation. However, posttreatment with HA, nimodipine, or calmidazolium at 9 or 12 hr after the nicotine treatment did not affect the nicotine-induced increase of AP-1 DNA binding activity. The pretreatment of BAMC cells with various concentrations of KN-62 inhibited the increase of AP-1 DNA binding activity induced by nicotine in a concentration-dependent manner. KN-62 $(10{\mu}M)$ posttreatment beginning at 0.5, 3, or 6 hr after the nicotine treatment significantly inhibited the increase of AP-1 DNA binding activity. However, KN-62 posttreatment beginning at 9 or 12 hr after the nicotine treatment did not affect the increase of AP-1 DNA binding activity. This study suggested that stimulation (for at least 6 hr) of nicotinic receptors on BAMC cells was necessary for increase of AP-1 DNA binding activity, and activation of $Ca^{2+},$ CaM, and CaMK II up to 6 hr at least seemed to be required for the increase of nicotine-induced AP-1 DNA binding activity.

• The Journal of Korean Association of Computer Education
• /
• v.15 no.5
• /
• pp.55-62
• /
• 2012

With the development of mobile communications and Internet technology, there is a strong need to provide seamless and fast connectivity for roaming devices. Generally, the mobile host (MH) may have several available networks when entering a new wireless area. However, the standard of decision for user's internet connection is provided only the subsystem identification (SSID) and signal strength of access point (AP). These two standards could not enough to decide optimal AP to the MH. Therefore, to decide the optimal AP, more information is needed. In this paper, we present additional information such as status of MH, capacity, current load, and depth of network hierarchy, by router advertisement message at layer 3. Also, we proposed decision engine (DE) on the MH that analyzes APs and decides the optimal AP automatically by AP's status information. For the MH, wireless connection period is increased, the power consumption is decreased, and the signaling overhead is reduced. For AP and router, the load balancing is provided and the network topology can also be more efficient.

• Korean Journal of Computational Design and Engineering
• /
• v.11 no.6
• /
• pp.429-439
• /
• 2006

The purpose of this study is to support the integration from current 2D drawing-based design to future 3D model-based design. In this paper, an important theme is the combination between the STEP-based 2D drawing standards (i.e., AP202) and the IFC-based 3D building model standards. To achieve the purpose, two methodologies are proposed as follows: the development of IFC extension model for the 2D shape data representation by harmonizing ISO/STEP AP202; and the development of mapping solution between IFC 2D extension model and KOSDIC by constructing the exchange scenario for 2D shape data representation. It is expected that the proposed IFC2X2 2D extension model and mapping solution will offer the basis of development of the integrated standards model in AEC industry.

• Korean Journal of Food Science and Technology
• /
• v.40 no.5
• /
• pp.516-521
• /
• 2008

This study was conducted to optimize the analysis condition and quantify the 2-acetyl-1-pyrroline (2AP) in the brown aroma rice. Extraction effect of the solvent for 2AP was the order of ethanol>acetonitrile>methanol in the range from 30 to $90^{\circ}C$. In the extraction time of 15, 30, 60, and 90 min, the 30 min had the highest 2AP concentration, and it was decreased according to lapse of time. At grinding time, 5 sec resulted in highest 2AP concentration. It was recommended that five sec grinding time, using ethanol, at $90^{\circ}C$ for 30 min was the optimization conditions to quantify the 2AP. Hyangmibyeo2ho and Aranghyangchalbyeo were mild aroma. In the foreign aroma rice, 11 of 19 accessions of Indica types and 2 of 6 accessions of Japonica types were more than mild aroma. Finally, 30 accessions of aroma rice were selected based on their 2AP concentration and agronomic traits.

• Journal of the Chungcheong Mathematical Society
• /
• v.31 no.3
• /
• pp.333-341
• /
• 2018

In this paper we introduce the concept of equi-integrability of sequence of the fuzzy number-valued AP-Henstock-Stieltjes integrable functions. Under this concept, we prove two convergence theorems for sequences of the fuzzy number-valued AP-Henstock-Stieltjes integrable functions.

• Journal of Soil and Groundwater Environment
• /
• v.23 no.3
• /
• pp.1-9
• /
• 2018

This study is aimed to quantitatively evaluate the effects of drought on groundwater system in rural areas. For this purpose, the standardized groundwater level index (SGI) was used for 68 groundwater monitoring wells. To determine accumulation period (AP) which represents the month with the highest correlation coefficient between SGI and SPI, correlation analysis between the two for 68 wells were peformed. The results indicated the AP values ranged in 1~3 months for most of the well, but it was 7~10 months in some wells. These results can be interpreted such that the total amount of groundwater will not decrease significantly in long-term drought situations unlikely the reservoirs with the high AP values. The nationwide maximum AP values were 4.1 and 4.0 in Chungbuk-do and Gyeongnam-do, while the minimum AP values were 1.8 and 2.0 in Gangwon-do and Chungnam-do, respectively. The maximum and minimum values of correlation coefficient were 0.623 and 0.459 in Gyeongnam-do and Chungnam-do/Chungbuk-do, respectively. Consequently, it could be concluded that the wells with low AP value tend to respond to short-term drought, but it has little effect on groundwater system when the long drought occurs.

• Korean Journal of Pharmacognosy
• /
• v.52 no.2
• /
• pp.77-83
• /
• 2021

The number of people suffering from diabetes have been increased around the world. In this study, we investigated the antidiabetic and antioxidant effects of Anthriscus sylvestris(L.) Hoffm and its main compounds. It was divided into root(R) and aerial part(AP) for comparative analysis. Total polyphenol, total flavonoid content was higher in AP extract, but nodakenin content was higher in R(1169.13 ± 6.00 mg/g) extract. Antioxidant activity was also higher in AP extract. To compare antidiabetic efficacy, we analyzed the effects of R and AP extracts on ɑ-glucosidase inhibition(AGI), dipeptidyl peptidase-4(DPP-4) and protein tyrosine phosphatase(PTP)1B activity. R and AP extracts showed similar effects on AGI and DPP-4 activity in a concentration dependent manner, and there was no effect on PTP1B activation. Glucose uptake(139.51 ± 3.19%) in 3T3-L1 cells was more effective in the AP extract-treated group than the positive control, rosiglitazone, group. Both R and AP extracts were effective in protecting against pancreatic beta cell damage caused by hyperglycemia. These results suggest that Anthriscus sylvestris(L.) Hoffm. could be used as a candidate for diabetes treatment.

• Journal of The Korean Society of Grassland and Forage Science
• /
• v.44 no.2
• /
• pp.133-139
• /
• 2024

This study aimed to evaluate the efficiency of combining acidification with adsorbents (zeolite and biochar) to mitigate the environmental impacts of pig slurry, focusing on ammonia (NH₃) emission and nitrate (NO₃^-) leaching. The four treatments were applied: 1) pig slurry (PS) alone as a control, 2) acidified PS (AP), 3) acidified pig slurry with zeolite (APZ), and 4) acidified pig slurry with biochar (APB). The AP mitigates NH₃ emission and NO₃^- leaching compared to PS alone. Acidification reduced the cumulative NH₃ emission and its emission factor by 35.9% and 12.5%, respectively. The APZ and APB increased NH₄⁺-N concentration, with the highest level in APB, compared to AP. The NH₄⁺ adsorption capacity of APB (0.90 mg g^-1) was higher than that of APZ (0.63 mg g^-1). The APB and APZ treatments induced less NH₃ emission compared to AP. The cumulative NH₃ emission was reduced by 12.2% and 27.6% in APZ and APB, respectively, compared to AP treatment. NO₃^- leaching began to appear on days 12 and 13, and its peak reached on days 16 and 17, which were later than AP. The cumulative NO₃^- leaching decreased by 17.7% and 25.0% in APZ and APB, respectively, compared to AP treatment. These results suggest that combining biochar or zeolite with acidified pig slurry is an effective method to mitigate NH₃ emission and NO₃^- leaching, with biochar being particularly effective.

• Research in Plant Disease
• /
• v.23 no.4
• /
• pp.355-362
• /
• 2017

The 4 viruses, the Apple chlorotic leaf spot virus (ACLSV), Apple stem pitting virus (ASPV), Apple stem grooving virus (ASGV), and Apple mosaic virus (ApMV) and 1 viroid, Apple scar skin viroid (ASSVd) are known major viral pathogens of apple trees in Korea. Infection degree of the 5 viral pathogens in the commercial nursery trees of major apple cultivars, 'Hongro', 'Fuji' and bud mutation of 'Fuji' was investigated. Infection ratio of the ACLSV, ASPV and ASGV for scion of an apple cultivar 'Hongro' were 100%, 81.3% and 100%, respectively. On the other hand, no infection for either ApMV and ASSVd detected. For the root stock of the cultivar, infection ratio of ACLSV, ASPV and ASGV showed 87.5%, 81.3% and 100% as well as ApMV and ASSVd were 12.5% and 6.3%, respectively. From the scion of apple cultivars 'Fuji' and bud mutation of 'Fuji', infection ratio of ACLSV, ASPV and ASGV showed 86.7%, 86.7% and 100%, respectively. Whereas, no infection for either ApMV or ASSVd detected. From the root stock of the cultivars, infection ratio of ACLSV, ASPV and ASGV showed 86.7%, 93.3% and 93.3% as well as ApMV and ASSVd were 12.5% and 6.3%, respectively. Result of our study indicates that most of commercial nursery apple trees were supplied with multiple infections by apple viruses causing potential losses for apple growers and, henceforth, agricultural policy for supply of the virus-free trees should be employed as soon as possible.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• v.y2005m4
• /
• pp.75-78
• /
• 2005

The present work has been studied to investigate the effect of formulation on friability of HTPB/AP propellants including Butacene and $Cr_{2}O_3$. The mechanical properties and burning rate of the propellants were measured using Inston tensile tester and strand burner, respectively. Friability was calculated by shot-gun and closed bomb test. The result showed that friability was higher, as the content of Butacene or AP $6{\mu}m$ in the propellant formulations was increased.