• Title/Summary/Keyword: 36-membered marcrolide

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Isolation of Scopafungin, a Potent Inhibitor of Phospholipase C from Actinomycetes isolate No. 2511-5 (방선균 분리주 No. 2511-5로부터 포스포리파제 C 저해물질 스코파훈진의 분리)

  • 오원근;이현선;안순철;김보연;박문수;민태익;안종석
    • YAKHAK HOEJI
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    • v.39 no.5
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    • pp.554-559
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    • 1995

  • MT 2511-5 was purified as a inhibitor of phospholipase C(PLC) from culture broth of a Streptmyces sp. NO. 2511-5. It was identified as scopafungin, 36-membered marcrolide by physico-chemical and spectroscopic data. Its $IC_{50}$ was 30.mu.M against phospholipase C and it also showed inhibitory activity against some fungi.

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