YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Isolation of Scopafungin, a Potent Inhibitor of Phospholipase C from Actinomycetes isolate No. 2511-5

방선균 분리주 No. 2511-5로부터 포스포리파제 C 저해물질 스코파훈진의 분리

  • 오원근 (한국과학기술연구원 생명공학연구소) ;
  • 이현선 (한국과학기술연구원 생명공학연구소) ;
  • 안순철 (한국과학기술연구원 생명공학연구소) ;
  • 김보연 (한국과학기술연구원 생명공학연구소) ;
  • 박문수 (한국과학기술연구원 생명공학연구소) ;
  • 민태익 (한국과학기술연구원 생명공학연구소) ;
  • 안종석 (한국과학기술연구원 생명공학연구소)
  • Published : 1995.10.01
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Abstract

MT 2511-5 was purified as a inhibitor of phospholipase C(PLC) from culture broth of a Streptmyces sp. NO. 2511-5. It was identified as scopafungin, 36-membered marcrolide by physico-chemical and spectroscopic data. Its $IC_{50}$ was 30.mu.M against phospholipase C and it also showed inhibitory activity against some fungi.

Keywords

References

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