• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.5
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• pp.437-450
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• 2014

In this study, we developed a methodology to determine the reference parameter for an aircraft impact induced risk assessment of nuclear power plant (NPP) using finite element impact analysis of containment building. The target structure used to develop the method of reference parameter selection is one of the typical Korean PWR type containment buildings. We composed a three-dimensional finite element model of the containment building. The concrete damaged plasticity model was used for the concrete material model. The steels in the tendon, rebar, and liner were modeled using the piecewise-linear stress-strain curves. To evaluate the correlations between structural response and each candidate parameter, we developed Riera's aircraft impact force-time history function with respect to the variation of the loading parameters, i.e., impact velocity and mass of the remaining fuel. For each force-time history, the type of aircraft is assumed to be a Boeing 767 model. The variation ranges of the impact velocity and remaining fuel percentage are 50 to 200m/s, and 30 to 90%, respectively. Four parameters, i.e., kinetic energy, total impulse, maximum impulse, and maximum force are proposed for candidates of the reference parameter. The wellness of the correlation between the reference parameter and structural responses was formulated using the coefficient of determination ($R^2$). From the results, we found that the maximum force showed the highest $R^2$ value in most responses in the materials. The simplicity and intuitiveness of the maximum force parameter are also remarkable compared to the other candidate parameters. Therefore, it can be concluded that the maximum force is the most proper candidate for the reference parameter to assess the aircraft impact induced risk of NPPs.

• Journal of the Korean Association of Geographic Information Studies
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• v.11 no.4
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• pp.139-149
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• 2008

A load effect by vehicles running on a road and an increase of traffic is distinguished as a serious issue in the level of bridges' maintenance and management since it causes a quick damage of bridges. The expansion joint is the most important since it makes vehicles' traveling amicable and stress or additional load harmful to molding patterns minimized. However, it is very difficult to measure its expansion length since vehicles continue to pass on the expansion joint. Therefore, the study could see that it was possible to carry out a qualitative and quantitative maintenance and management if its expansion length is extracted with images. The study could acquire three dimensional coordinates of expansion joints with images. As the results of calculating RMSE of check point residual at 32 points in A area and at 28 points in B area, both A and B areas had very good results of RMSEsms 0.829mm~1.680mm. As the results of analyzing expansion length and immediate value extracted by images, the study analyzed that RMSE of A area was 0.64mm and RMSE of B area was 0.28. The average residual of A area was 0.60% and the average rresidual of B area was 0.27%. Therefore, it is judged that it is more scientific and efficient than the past to measure expansion length with images at the time of repairing and managing bridges in the future.

• Tunnel and Underground Space
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• v.27 no.4
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• pp.243-252
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• 2017

Since the failure behavior of transversely isotropic rocks is significantly different from that of isotropic rocks, it is necessary to develop a transversely isotropic rock failure function in order to evaluate the stability of rock structures constructed in transversely isotropic rock masses. In this study, a spatial distribution function for strength parameters of transversely isotropic rocks is proposed, which is based on the Cassini oval curve proposed by 17th century astronomer Giovanni Domenico Cassini to model the orbit of the Sun around the Earth. The proposed distribution function consists of two model parameters which could be identified through triaxial compression tests on transversely isotropic rock samples. The original Mohr-Coulomb (M-C) failure function is extended to a three-dimensional transversely isotropic M-C failure function by employing the proposed strength parameter distribution function for the spatial distributions of the friction angle and cohesion. In order to verify the suitability of the transversely isotropic M-C failure function, both the conventional triaxial compression and true triaxial compression tests of transversely isotropic rock samples are simulated. The predicted results from the numerical experiments are consistent with the failure behavior of transversely isotropic rocks observed in the actual laboratory tests. In addition, the simulated result of true triaxial compression tests hints that the dependence of rock strength on intermediate principal stress may be closely related to the distribution of the microstructures included in the rock samples.

• International Journal of Highway Engineering
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• v.6 no.1 s.19
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• pp.47-56
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• 2004

To determine the pure bond strength between substrate and its overlayed concrete material, a direct pull-off test method was introduced by using a bi-material cylinder with which a penny-shaped crack was mountained at its interface. First, to evaluate the stress magnification or concentration at the interface, the energy release rates of a penny-shaped interface crack in remote tension loading on a bi-material cylinder were determined in terms of different modulus ratios and undonded area ratios(crack ratios) using a commercial finite element program. Then the energy release rates were calibrated as non-dimensional values in consideration of structural dimensions and applied forces. And to evaluate whether this new pull-off test method gives sound test results, three different sizes of unbended area ratios were incorporated along their interface in bi-material cylinders(sulphur polymer concrete + old concrete). Test results showed that all specimens were broken off at their interfaces as intended. Also the FEM analyses and test results indicated that a bi-material specimen with unbended area ratio of 0.4$\sim$0.6 is suitable for best accurate testing.

• Structural Engineering and Mechanics
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• v.57 no.1
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• pp.1-20
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• 2016

On the basis of the geological conditions of high and steep mountainous slope on which an exit portal of an express railway tunnel with a bridge-tunnel combination is to be built, the composite structure of the exit portal with a bridge abutment of the bridge-tunnel combination is presented and the stability of the slope on which the express railway portal is to be built is analyzed using three dimensional (3D) numerical simulation in the paper. Comparison of the practicability for the reinforcement of slope with in-situ bored piles and diaphragm walls are performed so as to enhance the stability of the high and steep slope. The safety factor of the slope due to rockmass excavation both inside the exit portal and beneath the bridge abutment of the bridge-tunnel combination has been also derived using strength reduction technique. The obtained results show that post tunnel portal is a preferred structure to fit high and steep slope, and the surrounding rock around the exit portal of the tunnel on the high and steep mountainous slope remains stable when rockmass is excavated both from the inside of the exit portal and underneath the bridge abutment after the slope is reinforced with both bored piles and diaphragm walls. The stability of the high and steep slope is principally dominated by the shear stress state of the rockmass at the toe of the slope; the procedure of excavating rockmass in the foundation pit of the bridge abutment does not obviously affect the slope stability. In-situ bored piles are more effective in controlling the deformation of the abutment foundation pit in comparison with diaphragm walls and are used as a preferred retaining structure to uphold the stability of slope in respect of the lesser time, easier procedure and lower cost in the construction of the exit portal with bridge-tunnel combination on the high and steep mountainous slope. The results obtained from the numerical analysis in the paper can be used to guide the structural design and construction of express railway tunnel portal with bridge-tunnel combination on high and abrupt mountainous slope under similar situations.

• The Journal of the Convergence on Culture Technology
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• v.8 no.5
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• pp.515-524
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• 2022

The turnout system of the sleeper floating tracks (STEDEF) on urban transit is a Anti-vibration track composed of a wooden sleeper embedded in a concrete bed and a sleeper resilience pad under the sleeper. Therefore, deterioration and changes in spring stiffness of the sleeper resilience pad could be cause changes in sleeper support conditions. The damage amount of manganese crossings that occurred during the current service period of about 21 years was investigated to be about 17% of the total amount of crossings, and it was analyzed that the damage amount increased after 15 years of use (accumulated passing tonnage of about 550 million tons). In this study, parameter analysis (wheel position, sleeper support condition, and dynamic wheel load) was performed using a three-dimensional numerical model that simulated real manganese crossing and wheel profile, to analyze the damage type and cause of manganese crossing that occurred in the actual field. As a result of this study, when the voided sleeper occurred in the sleeper around the nose, the stress generated in the crossing nose exceeded the yield strength according to the dynamic wheel load considering the design track impact factor. In addition, the analysis results were evaluated to be in good agreement with the location of damage that occurred in the actual field. Therefore, in order to minimize the damage of the manganese crossing, it is necessary to keep the sleeper support condition around the nose part constant. In addition, by considering the uniformity of the boundary conditions under the sleepers, it was analyzed that it would be advantageous to to replace the sleeper resilience pad together when replacing the damaged manganese crossing.

• Tuberculosis and Respiratory Diseases
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• v.58 no.1
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• pp.31-42
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• 2005

Background : Peroxiredoxins (Prxs) are a relatively newly recognized, novel family of peroxidases that reduce $H_2O_2$ and alkylhydroperoxide into water and alcohol, respectively. There are 6 known isoforms of Prxs present in human cells. Normally, Prxs exist in a head-to-tail homodimeric state in a reduced form. However, in the presence of excess $H_2O_2$, it can be oxidized on its catalytically active cysteine site into inactive oxidized forms. This study surveyed the types of the Prx isoforms present in the pulmonary epithelial, macrophage, endothelial, and other cell lines and observed their response to oxidative stress. Methods : This study examined the effect of exogenous, excess $H_2O_2$ on the Prxs of established cell lines originating from the pulmonary epithelium, macrophages, and other cell lines, which are known to be exposed to high oxygen partial pressures or are believed to be subject to frequent oxidative stress, using non-reducing SDS polyacrylamide electrophoresis (PAGE) and 2 dimensional electrophoresis. Result : The addition of excess $H_2O_2$ to the culture media of the various cell-lines caused the immediate inactivation of Prxs, as evidenced by their inability to form dimers by a disulfide cross linkage. This was detected as a subsequent shift to its monomeric forms on the non-reducing SDS PAGE. These findings were further confirmed by 2 dimensional electrophoresis and immunoblot analysis by a shift toward a more acidic isoelectric point (pI). However, the subsequent reappearance of the dimeric Prxs with a comparable, corresponding decrease in the monomeric bands was noted on the non-reducing SDS PAGE as early as 30 minutes after the $H_2O_2$ treatment suggesting regeneration after oxidation. The regenerated dimers can again be converted to the inactivated form by a repeated $H_2O_2$ treatment, indicating that the protein is still catalytically active. The recovery of Prxs to the original dimeric state was not inhibited by a pre-treatment with cycloheximide, nor by a pretreatment with inhibitors of protein synthesis, which suggests that the reappearance of dimers occurs via a regeneration process rather than via the de novo synthesis of the active protein. Conclusion : The cells, in general, appeared to be equipped with an established system for regenerating inactivated Prxs, and this system may function as a molecular "on-off switch" in various oxidative signal transduction processes. The same mechanisms might applicable other proteins associated with signal transduction where the active catalytic site cysteines exist.

• The korean journal of orthodontics
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• v.36 no.6
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• pp.412-421
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• 2006

Objective: The result of finite element analysis depends on material properties, structural expression, density of element, and boundar or loading conditions. To represent proper elastic behavior, a finite element model was made using Hounsfield unit (HU) values in CT images. Methods: A 13 year 6 month old male was used as the subject. A 3 dimensional visualizing program, Mimics, was used to build a 3D object from the DICOM file which was acquired from the CT images. Model 1 was established by giving 24 material properties according to HU. Model 2 was constructed by the conventional method which provides 2 material properties. Protraction force of 500g was applied at a 45 degree downward angle from Frankfort horizontal (FH) plane. Results: Model 1 showed a more flexible response on the first premolar region which had more forward and downward movement of the maxillary anterior segment. Maxilla was bent on the sagittal plane and frontal plane. Model 2 revealed less movement in all directions. It moved downward on the anterior part and upward on the posterior part, which is clockwise rotation of the maxilla. Conclusion: These results signify that different outcomes of finite element analysis can occur according to the given material properties and it is recommended to use HU values for more accurate results.

• Journal of Life Science
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• v.28 no.3
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• pp.307-313
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• 2018

Alopecia cause psychological stress due to their effect on appearance. Thus, the global market size of the alopecia treatment products are growing quickly. Timosaponin A III is the well known active ingredient of Anemarrhenae Rhizoma. In this study, we investigated and compared the binding affinity of timosaponin A III with finasteride (5-beta reductase antagonist) and minoxidil (androgen receptor antagonist) on the target protein active site by in silico computational docking studies. The three dimensional crystallographic structure of 5-beta reductase (PDB ID : 3G1R) and androgen receptor (PDB ID: 4K7A) was obtained from PDB database. In silico computational autodocking analysis was performed using PyRx, Autodock Vina, Discovery Studio Version 4.5, and NX-QuickPharm option based on scoring functions. The timosaponin A III showed optimum binding affinity (docking energy) with 5-beta reductase as -12.20 kcal/mol as compared to the finasteride (-11.70 kcal/mol) and with androgen receptor as -9.00 kcal/mol as compared to the minoxidil (-7.40 kcal/mol). The centroid X, Y, Z grid position of the timosaponin A III on the 5-beta reductase was similar (overlap) to the finasteride, but the X, Y, Z centroid grid of the timosaponin A III on the androgen receptor was significantly far from the minoxidil centroid position. These results significantly indicated that timosaponin A III could be more potent antagonist to the 5-beta reductase and androgen receptor. Therefore, the extract of Anemarrhenae Rhizoma or timosaponin A III containing biomaterials can substitute the finasteride and minoxidil and can be applied to the alopecia protecting product and related industrial fields.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.2
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• pp.63-75
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• 2013

The Inner Port Phase 2 area of the Pyeongtaek-Dangjin Port is enclosed by a total of three permeable sea-walls, and the disposal site to the east of the Inner Port Phase 2 is also enclosed by two permeable sea-walls. The maximum tidal range measured in the Inner Port Phase 2 and in the disposal site in May 2010 is 4.70 and 2.32 m, respectively. It reaches up to 54 and 27%, respectively of 8.74 m measured simultaneously in the exterior. Regression formulas between the difference of hydraulic head and the rate of interior water volume change, are induced. A three-dimensional numerical hydrodynamic model for the Asan Bay is constructed incorporating a module to compute water discharge through the permeable sea-walls at each computation time step by employing the formulas. Hydrodynamics for the period from 13th to 27th May, 2010 is simulated by driving forces of real-time reconstructed tide with major five constituents($M_2$, $S_2$, $K_1$, $O_1$ and $N_2$) and freshwater discharges from Asan, Sapkyo, Namyang and Seokmoon Sea dikes. The skill scores of modeled mean high waters, mean sea levels and mean low waters are excellent to be 96 to 100% in the interior of permeable sea-walls. Compared with the results of simulation to obstruct the flow through the permeable sea-walls, the maximum current speed increases by 0.05 to 0.10 m/s along the main channel and by 0.1 to 0.2 m/s locally in the exterior of the Outer Sea-wall of Inner Port. The maximum bottom shear stress is also intensified by 0.1 to 0.4 $N/m^2$ in the main channel and by more than 0.4 $N/m^2$ locally around the arched Outer Sea-wall. The module developed to compute the flow through impermeable seawalls can be practically applied to simulate and predict the advection and dispersion of materials, the erosion or deposion of sediments, and the local scouring around coastal structures where large-scale permeable sea-walls are maintained.