• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.3
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• pp.824-833
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• 1991

본 연구에서는 차체구조계의 진동모드 변수와 차실음향계의 음향모드변수들이 어떻게 관련되어 차실소음을 결정하는 가를 밝혔다. 그 결과, 수치해석 결과의 효용 성을 높이고 실내소음 평가방법을 체계화 시킬 수 있었으며, 효과적인 소음저감을 위 한 유용한 자료를 얻을 수가 있었다. 한편, 이제까지의 차실소음의 응답해석에서 가 장 큰 오차의 발생요인은 차체의 구조진동 모드데이타인데, 본 연구에서는 유한요소해 석 대신 모드시험 결과를 이용함으써, 유한요소 모델리이 어려운 경우의 소음 해석의 신뢰도를 높일수가 있었다.

• YAKHAK HOEJI
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• v.59 no.3
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• pp.92-97
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• 2015

KIOM-MA128 is a novel Korean herbal medicine with anti-atopic, anti-inflammatory and anti-asthmatic effects. This article presents the first pharmacokinetic study on KIOM-MA128. The purpose of this study was to characterize a pharmacokinetic characteristic of matrine, a potential marker of KIOM-MA128, in rats using population pharmacokinetic model. 1, 2 and 8 g/kg of KIOM-MA128 were administered to rats orally and plasma concentrations of matrine was determined by HPLC-MS/MS. Non-compartmental analysis (NCA) was performed using Phoenix$^{(R)}$ and pharmacokinetic model was built using NONMEM$^{(R)}$. This model was validated with internal validation which is visual predictive check (VPC) and bootstrap. The NCA result of matrine showed that $C_{max}$ was 294.24, 552.22 and 868.65 ng/ml, $AUC_{inf}$ was 1273.05, 2724.76 and $9743.25ng{\cdot}hr/ml$ and $T_{max}$ was 1, 1.3 and 2.3 hr for the doses of 1, 2, and 8 g/kg, respectively. The rat plasma concentrations were described very well with one-compartment model. Pharmacokinetic model for matrine was successfully developed and evaluated. Finally, our model is helpful to understand pharmacokinetic characteristic of KIOM-MA128.

• Journal of Radiation Protection and Research
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• v.43 no.2
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• pp.39-49
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• 2018

Background: A model to assess the activity concentration of agricultural products and the public ingestion dose as result of a nuclear accident is necessarily required to manage the contaminated agricultural systems by the accident, or to estimate the effects of chronic exposure due to food ingestion at a Level 3 PSA. Materials and Methods: A dynamic compartment model, which is composed of three sub-modules, namely, an agricultural plant contamination assessment model, an animal product contamination assessment model, and an ingestion dose assessment model has been developed based on Korean farming characteristics such as the growth characteristics of rice and stockbreeding. Results and Discussion: The application study showed that the present model can predict well the characteristics of the activity concentration for agricultural products and ingestion dose depending on the deposition date. Conclusion: The present model is very useful to predict the radioactivity concentration of agricultural foodstuffs and public ingestion dose as consequence of a nuclear accident. Consequently, it is expected to be used effectively as a module for the ingestion dose calculation of the Korean agricultural contamination management system as well as the Level 3 PSA code, which is currently being developed.

• Nuclear Engineering and Technology
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• v.18 no.3
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• pp.183-193
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• 1986

Full scale HDR containment experiment series pointed out that the previous containment analysis models have a number of shortcomings. One of them is on the calculational model of short term (0~2sec) pressure difference. The pressure differences between subcompartments are dependent on the flow rate, fluid density, head loss coefficient, and flow area ratio. It, however, is not known that any of them is largely attributed to the disagreement of pressure difference between the measured and the calculated values. In this study, the head loss coefficients are expressed with another form to improve the analytic model. The pressure and the pressure difference are evaluated by using COMPARE code with new correlation, and the results show better agreements with experimental values for V.42 test, but overestimate the measured values for V, 43 and underestimate for V.44.

• Proceedings of the Membrane Society of Korea Conference
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• 2004.05a
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• pp.19-24
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• 2004

ED method is employed to effectively remove the organic acid salts in actual PDO fermentation broth. The lower electrical potential is selected to avoid the serious membrane fouling so as to ensure a stable and durative desalination process. Under the selected operation conditions, about 90% of organic acids salts are removed from PDO fermentation broth successfully by ED process. To reduce the loss of PDO product due to the diffusion, the operation time should be considered carefully. And based on mass balance equation and irreversible thermodynamics approach, a mathematical model is developed to describe the desalination process of an aqueous solution containing neutral solute by ED method. While the influence of concentration polarization is reflected by decreasing the conductivity of membrane, the model is verified well to describe the ED processes under varied operation conditions. Through the model, ED process of actual PDO fermentation broth is simulated to get a suitable scope of initial concentration in concentrated compartment.

• Korean Journal of Veterinary Research
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• v.35 no.4
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• pp.691-698
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• 1995

We used rats as the experimental animal for the elucidation of metabolic patterns and pharmacokinetic profiles of SMZ in the rat, by use of the urine and plasma from predetermined intervals, respectively. Information herefrom would give some insight into species differences and sex differences in the metabolism and pharamcokinetics of drugs, at least SMZ in particular. Results would be summarized as follows: 1. There were two hydorxy metabolites(5-hydroxysulfamethazine and 6-hydroxyethylsulfamethazine) and an acetyl derivative($N_4$-acetyl sulfamethazine) in the 24h-collected urine, on confirmation with each standard materials. There were also two unknown metabolites therein. 2. In the viewpoint of quantitative aspect, $N_4$-acetylsulfamethazine was the largest, hence it is assumed that the acetyl pathway is the major one in the metabolism of SMZ in the rat. 3. As regards sex difference in the rat, the male had more metabolic capacity than the female in metabolism of SMZ. 4. The concenteration-time curves of sulfamethazine(20mg/kg, po) in the plasma compartment were fitted to a one-compartment open model by use of a computer program(NONLIN). 5. There were significant differences(P<0.05) in the pharmacokinetics of sulfamethazine between two sexes in the rat, with higher disposition rate in the male. 6. The emergence of $N_4AcSMZ$ metabolized from SMZ was fast in the plasma of the rat. Half-life of $N_4AcSMZ$ was also. significantly different(P<0.05) between two sexes, suggesting differences in the eliminatory capacity of $N_4AcSMZ$.

• Fire Science and Engineering
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• v.17 no.3
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• pp.7-12
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• 2003

A 50 kW polyurethane fire in a compartment of 4 m ${\times}$ 1 m ${\times}$ 1.5m with large openings similar to a subway station was simulated by a large eddy simulation to investigate the fire and smoke control. The NIST FDS, which employed a mixture fraction combustion model and a finite volume method for radiation, was utilized. Distribution of temperature and smoke particles was compared with in the lower and upper corridors for three different smoke control systems, ventilation, purge, and extraction, starting in 5 sec from the ignition of the fire. For the given geometries, the ventilation system showed the best smoke removal rate and lowest temperature distribution in the both corridors. It was confirmed that the purge system is not recommended for a subway station since the smoke removal rate of the purge system was worse than that without a smoke control system.

• Journal of Theoretical and Applied Mechanics
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• v.3 no.1
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• pp.34-44
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• 2002

Theoretical analysis Is carried out to identify the modal coupling effect between some particular acoustic modes of a vehicle compartment cavity and vibration modes of body panels like side doors, roof or floor. A simplified panel-cavity coupled model is investigated on the coupled resonance frequencies, modes and frequency response characteristics. Through parametric study, It Is possible to explain how the acoustic response of a coupled system will be determined by the vibration and acoustic property of the individual panel and cavity system. Full coupled system shows some interesting features different from those of the semi-coupled system In frequency, mode and acoustic response.

• IMMUNE NETWORK
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• v.1 no.3
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• pp.196-202
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• 2001

Backgorund: WEHI-231 B cell line is a representative model for $IgM^+$ mature B cells. To understand the signaling differences between mature and immature B cells, we compared the responsiveness of WEHI-231 and Bal 17 B cell lines to BCR cross-linking. Methods: The extents of tyrosine phosphorylation, ligand-induced internalization, and activation-induced cell death upon BCR cross-linking were compared in two cell lines. Results: Despite a higher expression of BCR, cross-linking of BCR on WEHI-231 cell evoked a weaker level of tyrosine phosphorylation and BCR endocytosis than Bal 17 cells. Furthermore, the endocytosed BCR could not enter the lysosomal compartment and stayed as peripheral spots in WEHI-231 cells. Conclusion: WEHI-231 cell showed preferred BCR-mediated signaling pathways leading to a reduced capability of antigen presentation as well as the enhanced apoptosis in comparision with Bal 17 cells. These results might reflect the signaling differences between mature and immature B cells.

• International Journal of Automotive Technology
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• v.5 no.3
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• pp.209-213
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• 2004

The objective of this paper is to introduce the noise reduction characteristics of a double gap system, which is composed of two air-gaps and two partition sheets. The resonance of acoustic modes of an enclosed cavity can be effectively suppressed by installing the double gap system in the cavity. It is revealed from a simple, one-dimensional model that the double gap system is more effective than the single gap system that consists of one air-gap and one partition sheet, in that the former requires a smaller space than the latter. Finally, these theoretical conclusions are verified by comparison experiments using an actually manufactured enclosed cavity, of which the boundary surfaces are made of thick panels that can be assumed as rigid walls.