• 한국식품영양과학회지
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• 제24권1호
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• pp.1-9
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• 1995

1, 25(OH)2-23ene-D3 is a novel vitamine D3 analog which has a double bond between C-23 and C-24. We describe the effects of this analog on cell differentiation and cell proliferation in vitro using the human histiocytic lymphoma cell line U937, and on calcium metabolism in rats in vivo. In the present investigation 1, 25(OH)2-23ene-D3 was compared to the natural metabolite of vitamin D3, 1$\alpha$, 25-dihydroxycholecalciferol[1, 25(OH)2-23ene-D3 was more potent than 1, 25(OH)2-23ene-D3 for inhibition of proliferation and induction of differentiation of U937 cells. Especially, its effect on induction of differentiation, as measured by superoxide production and nonspecific esterase(NSE) activity, was about 20-fold more potent that 1, 25(OH)2-23ene-D3. This analog morphologically and functionally differentiated U937 cells to monocyte-macrophage phenotype showing a decrease of N/C ratio in Giemsa staining and the increase of adherence ability to surface. Intraperitoneal administration of 1, 25(OH)2-23ene-D3 to rats showed that the compound had at least 50 times less activity than 1, 25(OH)2-23ene-D3 in causing hypercalcemia and hypercalciuria. The strong direct effects of 1, 25(OH)2-23ene-D3 on cell proliferation and cell differentiation, coupled with its decreased activity of calcium metabolism make this compound an interesting candidate for clinical studies including patients with leukemia, as well as several skin disorders, such as psoriasis.

• 한국시뮬레이션학회논문지
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• 제4권1호
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• pp.113-119
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• 1995

In 3D computer graphics, fractal techniques have been applied to terrain models. Even though fractal models have become popular for recreating a wide variety of the shapes found in nature, a specific 3D terrain model such as Uleung Island could not be formulated by statistical fractals easily owing to the random effects. However, by locating the midpoints on the edges and the surface of a specific terrain such as Uleung Island, a similar shape of the terrain model can be simulated. This paper shows the way of simulating 3D Uleung Island terrain model by the statistical fractals wherein the subdivision algorithm is used.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2004년도 추계학술대회 논문집
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• pp.40-43
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• 2004

The effects of free surface on wake behind a rotating propeller were investigated experimentally in a circulating water channel with the variation of water depth. Instantaneous velocity fields were measured using two-frame PIV technique at tow different blade phases and ensemble-averaged to investigate the phase-averaged flow structure in the wake region. For an isolated propeller, the flow behind the propeller is influenced by the propeller rotation and the free surface. The phase-averaged mean velocity fields show that the potential wake and the viscous wake are formed by the boundary layers developed on the blade surfaces. The interaction between the tip vortices and the slipstream causes the oscillating trajectory of tip vortices. Tip vortices are generated periodically and the slipstream contracts in the near-wake region. The presence of free surface affects the wake structure largely, when the water depth is less than 0.6D. The free surface modifies the vortex structure, especially the tip and trailing vortices and flow structure in slipstreams of the propeller wake behind X/D = 0.3.

• 대한조선학회논문집
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• 제42권5호
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• pp.427-434
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• 2005

The free surface influenced the wake behind a rotating propeller and its effects were investigated experimentally in a circulating water channel with the variation of water depth. Instantaneous velocity fields were measured using two-frame PIV technique and ensemble-averaged to study the phase-averaged flow structure in the wake region. For an isolated propeller, the flow behind the propeller is affected only by the propeller rotation speed, the leading on the blades and the proximity of the propeller to the free surface. The phase-averaged mean velocity fields show that the potential wake and the viscous wake developed on the blade surfaces. The interaction between the tip vortices and the slipstream causes the oscillating trajectory of tip vortices. The presence of the free surface greatly affected the wake structure, especially for propeller immersion depth of 0.6D. At small immersion depths, the free surface modified the tip and trailing vortices and the slipstream flow structure downstream of X/D = 0.3 in the propeller wake.

• 대한토목학회논문집
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• 제42권2호
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• pp.257-261
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• 2022

건축물의 디자인 자유도 향상, 작업자 안전 향상, 비교적 쉬운 납기예측 등의 이점으로 건설 산업에 적용된 3D 프린팅 기술(Additive manufacturing, AM)은 각종 효과성의 검증과 산업적용이 진행되고 있다. 다만, 기존기술대비 낮은 성숙도로 인해, 건축AM기술의 전주기에 발생하는 새로운 문제들을 해소하기 위한 연구들이 진행 중이다. 본 논문에서는 이러한 문제점 중에서도 현장 환경에 건축물을 적층 시공하는 과정에서, 낮은 시공표면평탄이 적층 제조 형상물에 미치는 영향을 확인한다. 특히 레이저 스캐닝을 통한 3차원 재구성 및 정량 분석을 통해, 낮은 평탄도로 인한 불균일한 적층형상물을 분석하고, 이를 해소하기 위한 적층시공전략을 제안한다.

• 대한한방내과학회지
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• 제27권4호
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• pp.895-904
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• 2006

Objectives : In the present study, the author intended to investigate whether two oriental medical prescriptions named Socheongryongtang-ga-seoggo (SCTS) and Prescription D (P-D) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Materials and Methods : Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of SCTS or P-D to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of SCTS and P-D on contractility of isolated tracheal smooth muscle were investigated. Results : SCTS did not affect mucin release from cultured HTSE cells, without cytotoxicity. However, P-D significantly increased mucin release from cultured HTSE cells. with significant cytotoxicity. SCTS inhibited Ach-induced contraction of isolated tracheal smooth muscle. P-D also inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusions : The author suggests that the effects of SCTS and P-D with their components should be further investigated and it is valuable to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.246.2-247
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• 2002

In this study. we tried to investigate whether polymerized basic amino acid e.g. poly-L-lysine(PLL) which has the molecular weight under 10 kD significantly affects the physiological and stimulated mucin release from cultured hamster tracheal surface epithelial cells. Confluent primary hamster tracheal surface epithelial(HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of either PLLs or adenosine triphosphate(ATP) and PLL to assess the effects on basic or ATP-stimulated 3H-mucin release. (omitted)

• Journal of Electrochemical Science and Technology
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• 제13권3호
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• pp.347-353
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• 2022

Agarose hydrogel, a solid electrolyte, was investigated voltammetrically in terms of transport properties and natural convection effects using a ferrocenyl compound as a redox probe. To confirm the diffusion properties of solute on the agarose interface, the diffusion coefficients (D) of ferrocenemethanol in agarose hydrogel were determined by cyclic voltammetry (CV) according to the concentration of agarose hydrogel. While the value of D on the agarose interface is smaller than that in the bulk solution, the square root of the scan rate-dependent peak current reveals that the mass transport behavior of the solute on the agarose surface shows negligible convection or migration effects. In order to confirm the reduced natural convection on the gel interface, scan rate-dependent CV was performed in the solution phase and on the agarose surface, respectively. Slow scan voltammetry at the gel interface can determine a conventional and reproducible diffusion-controlled current down to a scan rate of 0.3 mV/s without any complicated equipment.

• Journal of Electrochemical Science and Technology
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• 제10권4호
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• pp.408-415
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• 2019

Electroplating is a widely used surface treatment method in the manufacturing process of electronic parts and uniformity of the electrodeposition thickness is very crucial for these applications. Since many variables including fluid flow influence the uniformity of the film, it is difficult to conduct efficient research only by experiments. So many studies using simulation have been carried out. However, the most popular simulation technique, which calculates secondary current distribution, has a limitation on the considering the effects of fluid flow on the deposition behavior. And modified method, which is calculating a tertiary current distribution, is limited to a two-dimensional study of simple shapes because of the massive computational load. In the present study, we propose a new electroplating simulation method that can be applied to complex shapes considering the effect of flow. This new model calculates the electroplating process with three steps. First, the thickness of boundary layers on the surface of the cathode plane and velocity magnitudes at the positions are calculated from the simulation of fluid flow. Next, polarization curves of different velocities are obtained by calculations or experiments. Finally, both results are incorporated into the electroplating simulation program as boundary conditions at the cathode plane. The results of the model showed good agreements with the experimental results, and the effects of fluid flow of electrolytes on the uniformity of deposition thickness was quantitatively predicted.

• 한국표면공학회지
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• 제41권5호
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• pp.205-213
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• 2008

A 3D particle code is developed to analyze electron behavior in a planar magnetron sputtering cathode either in balanced or unbalanced configuration. Three types of collisions are included; electron - neutral elastic, excitation to a metastable state and ionization. Flight path is calculated by a 4-th order Runge-Kutta method with a time step of 10 ps. Effects of electron starting position, magnetic field intensity and configuration were analyzed. For a more efficient and accurate modeling, multithreading technique is considered for multicore CPU computers. Under an assumption of cold ion approach, target erosion profiles are predicted for a flat target surface.