• Bulletin of the Korean Chemical Society
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• 제28권10호
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• pp.1797-1802
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• 2007

The kinetics and mechanism of the nucleophilic substitution reactions of diphenyl phosphinic (1) and thiophosphinic (2) chlorides with substituted X-pyridines are investigated kinetically in acetonitrile at 35.0 and 55.0 oC, respectively. A concerted mechanism with backside nucleophilic attack is proposed for the pyridinolysis of 1, on the basis of the linear Bronsted plot with the βX value of 0.68. In the case of the pyridinolysis of 2, the Hammett and Bronsted plots are biphasic concave upwards with the break point at 3- phenyl pyridine. These results indicate a change in mechanism from a concerted SN2(P) process with direct backside nucleophilic attack for less basic nucleophiles (X = 3-CN-3-Ph) to a stepwise process with frontside attack for more basic nucleophiles (X = 4-MeO-3-Ph). Apparent secondary inverse kinetic isotope effects with deuterated pyridine (C5D5N), kH/kD < 1, are observed for the pyridinolysis of 1 and 2.

• 자원환경지질
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• 제24권3호
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• pp.287-299
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• 1991

The study area is mainly composed of metasedimentary rocks which are included in Ogchon, Choson and Pyongan Groups. Because of thrust faults which are developed in this area, a coal bearing formation is repeatedly distributed two times, and Choson Group is thrusted over Pyongan Group. Deformation in this area was taken place in a series of three phases ($D_1$, $D_2$ and $D_3$) ; $D_1$ was most intense whereas $D_3$ was weakest. Thrust faults developed in the upper curst duringD2 produced cataclastic rocks and fault breccia,truncating regional slaty cleavage and earlier folds which were formed during $D_1$ stage. The quartz microstructures of metapsammitic rocks in Choson and Pyongan Groups suggest that dislocation creep mechanism predominated early in fabric development, afterwards deformation mechanism was transfered to pressure solution which intensified the earlier fabrics. According to strain analysis using quartz grains and quartz aggregate grains, the strain magnitude(Es) of Pyongan Group represents larger values than that of Choson Group due to the contrast of constituent minerals, the size of original quartz grains and matrix content. Apparent flattening type in strain pattern appears in the whole area. It is suggested that the relationship between Ogchon Group and Choson Group may be thrust contact.

• The Korean Journal of Physiology and Pharmacology
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• 제23권2호
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• pp.113-120
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• 2019

Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the water homeostasis of the epidermis, and decreased AQP3 expression following ultraviolet (UV)-irradiation of the skin is associated with reduced skin moisture. No previous study has examined whether the skin-moisturizing effect of MELs might act through the modulation of AQP3 expression. Here, we report for the first time that MELs ameliorate the UVA-induced downregulation of AQP3 in cultured human epidermal keratinocytes (HaCaT keratinocytes). Our results revealed that UVA irradiation decreases AQP3 expression at the protein and messenger RNA (mRNA) levels, but that MEL treatment significantly ameliorated these effects. Our mitogen-activated protein kinase inhibitor analysis revealed that phosphorylation of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase or p38, mediates UVA-induced AQP3 downregulation, and that MEL treatment significantly suppressed the UVA-induced phosphorylation of JNK. To explore a possible mechanism, we tested whether MELs could regulate the expression of peroxidase proliferator-activated receptor gamma ($PPAR-{\gamma}$), which acts as a potent transcription factor for AQP3 expression. Interestingly, UVA irradiation significantly inhibited the mRNA expression of $PPAR-{\gamma}$ in HaCaT keratinocytes, whereas a JNK inhibitor and MELs significantly rescued this effect. Taken together, these findings suggest that MELs ameliorate UVA-induced AQP3 downregulation in HaCaT keratinocytes by suppressing JNK activation to block the decrease of $PPAR-{\gamma}$. Collectively, our findings suggest that MELs can be used as a potential ingredient that modulates AQP3 expression to improve skin moisturization following UVA irradiation-induced damage.

• 전기전자학회논문지
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• 제7권2호
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• pp.253-259
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• 2003

좋은 3D 엔진이란 객체들의 상호 작용을 실세계와 유사하게 표현하는 물리학 엔진을 말한다. 충돌은 이런 상호작용 중의 하나이며, 충돌 유무 검사와, 충돌 지점, 충돌후의 반응을 다룬다. 대부분의 물리학 엔진과 같이 충돌 검사도 정확하게 검출하려면 많은 시간이 소요된다. 그러나 요구되는 정밀도만 만족하는 모델 사용으로 검출시간을 조절 할 수 있다. 그러므로 요구되는 정밀도와 시간에 따라 충돌 검출 모델을 선정하여야 한다. 본 논문에서는 충돌 검출 모델들을 정확도에 따라 7단계로 구분하여 구현하고 실험했다. 이를 통해 시간과 정확도의 연관 관계를 분석하고, 이에 따른 충돌 검출 모델을 선택하기 위한 기준을 제시하고자 한다.

• 기술혁신학회지
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• 제3권2호
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• pp.94-110
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• 2000

This article prospects the patterns of technological innovation in the steel industry and suggests the directions of technological innovation in Korean steel industry. Technological innovation patterns can be analysed through technological trends, innovation-inducing mechanism, and innovators' relationships. In the technological trends, direct coupling of manufacturing processes, lasting growth of mini-mill, and the importance of technological integration are prospected. In the innovation-inducing mechanism, while production system will be specialized, the development of new steel materials and environment-friendly technological innovation will be accelerated. In the innovators' relationships, steel industry faces more complex competition and new forms of inter-firm cooperation including M&A, joint venture, and joint R&D. In order to cope with such changes in the technological innovation patterns, Korean steel industry need to establish core competence based on technological innovation through a great leap in R&D investment, the production of high value-added products, the development of new generation steel technologies, strategic joint R&D, comprehensive technological cooperation, and government's active support.

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.243.3-244
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• 2001

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.276-277
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• 2006

In order to accelerate the sintering of Al-Bronze powder covered with passive oxide film, we focused on the way to add Al-Ca fluoride consisting of $AlF_3$ and $CaF_2$, examined the effect of the $CaF_2$ mixing rate in Al-Ca fluoride, the amount of the added Al-Ca fluoride and the sintering temperature on sintering properties of Al-Bronze powder and considered the mechanism of the sintering acceleration. Al-Bronze powder was sintered most effectively by adding Al-Ca fluoride with the $CaF_2$ mixing rate of 20mass%. If the amount of added fluoride was over 0.05mass% and the sintering temperature was over 1123K, the sintering acceleration of the Al-Bronze powder appears. Regarding the mechanism of the sintering acceleration, it was presumed that $Al_2O_3$ film on the surface of the Al-Bronze particles was removed in the process of the formation of gaseous AlOF by the reaction with $AlF_3$, and the reaction was accelerated further by the presence of the liquid phase which is formed in Al-Ca fluoride.

• Geomechanics and Engineering
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• 제31권4호
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• pp.375-384
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• 2022

The variation of the undrained shear strength (c_u) is an important consideration for assessing slope stability in engineering practice. Previous studies focused on the three-dimensional (3D) stability of slopes in normally consolidated clays generally assume the undrained shear strength increases linearly with depth but does not vary in the horizontal direction. To assess the 3D stability of slopes with spatially varying undrained shear strength, the kinematic approach of limit analysis was adopted to obtain the upper bound solution to the stability number based on a modified failure mechanism. Three types failure mechanism: the toe failure, face failure and below-toe failure were considered. A serious of charts was then presented to illustrate the effect of key parameters on the slope stability and failure geometry. It was found that the stability and failure geometry of slopes are significantly influenced by the gradient of c_u in the depth direction. The influence of c_u profile inclination on the slope stability was found to be pronounced when the increasing gradient of c_u in the depth direction is large. Slopes with larger width-to-height ratio B/H are more sensitive to the variation of c_u profile inclination.

• Bulletin of the Korean Chemical Society
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• 제32권11호
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• pp.3880-3886
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• 2011

The nucleophilic substitution reactions of diisopropyl thiophophinic chloride (3) with substituted anilines ($XC_6H_4NH_2$) and deuterated anilines ($XC_6H_4ND_2$) are investigated kinetically in acetonitrile at $65.0^{\circ}C$. The anilinolysis rate of 3 is rather slow to be rationalized by the conventional stereoelectronic effects. The obtained deuterium kinetic isotope effects (DKIEs; $k_H/k_D$) are secondary inverse ($k_H/k_D$ = 0.80-0.96). The anilinolyses of ten P=S systems in MeCN are reviewed on the basis of DKIEs and selectivity parameters to obtain systematic information on the DKIEs and mechanism for thiophosphoryl transfer reactions. The steric effects of the two ligands on reactivity, DKIEs, mechanism, and substituent effects of the nucleophile (X) on the DKIEs are discussed.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.532-543
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• 2004

The present work have been developed the interpretation processor including the behavior of material failure and the separation phenomena under transient dynamic loading (the operation of explosive bolt) using AUTODYN V4.3, SoildWork 2003 and TrueGrid V2.1 programs. It has been demonstrated that the interpretation in ridge-cut explosive bolt under dynamic loading condition should be necessary to the appropriate failure model and the basic stress of bolt failure is the principal stress. The use of this interpretation processor developing the present work could be extensively helped to design the shape and the amount of explosives in the explosive bolt having a complex geometry. It is also proved that the interpretation processor approach is an accurate and effective analysis technique to evaluate the separation mechanism in explosive bolts.