• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7859-7863
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• 2015

Purpose: To compare the efficacy and toxicity of gemcitabine versus docetaxel in a second-line setting of nonsmall cell lung cancer (NSCLC) patients previously treated with platin-based combination chemotherapy. Materials and Methods: We retrospectively evaluated the medical records of 57 patients treated with single agent gemcitabine or docetaxel in second-line setting of advanced NSCLC who received one prior platinum-based therapy. Results: The mean age was $56.7{\pm}8.39$ years with 55 (96.5%) males and two (3.5%) females. Forty of them received docetaxel and 17 gemcitabine. The mean number of chemotherapy cycles was $6.8{\pm}4.0$ in the gemcitabine group, while it was $4.6{\pm}3.0$ in the docetaxel group. Overall response rates were 8% and 12% (P=0.02) for gemcitabine and docetaxel, respectively. The median survival time was 22 versus 21 months for gemcitabine and docetaxel, respectively. The median times to progression were 8 and 5 months. There was no difference between the two groups in terms of incidence of adverse affects (40% vs 47.1%). All of the hematological side effects were grade 1/2. No major toxicity was encountered necessitating stopping the drug for either group. Conclusions: Treatment with gemcitabine demonstrated clinically equivalent efficacy with a significantly improved safety profile compared with those receiving docetaxel in the second-line setting for advanced NSCLC in this study. Based on these results, treatment with gemcitabine should be considered a standard treatment option for second-line NSCLC.

• 대한두경부종양학회지
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• 제14권1호
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• pp.35-39
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• 1998

Objectives: Minimal improvement in the long-term survival of head and neck cancer(HNC) patients has occurred despite a multitude of advances in the control of loco regional disease and a second primary malignancy(SPM) contribute to the continued poor prognosis for the HNC patients. This study was performed in order to identify the clinical characteristics of SPM in the HNC patients. Materials and Methods: The medical records of 354 patients of head and neck squamous cell carcinoma that were followed up after initial treatment during the period of 1987 through 1994 were reviewed. This study examines the medical records of 354 patients with squamous cell carcinoma of the head and neck, of whom 26 subsequently developed a second neoplasm. Results: The actuarial SPM rate was 7.3%, and median time to presentation for the SPM was 26.8 months. The SPM were more likely to occur in male patients who had oral cavity index tumors. Patient whose index tumor was small at diagnosis had a greater chance of developing a second tumor as did those with no cervical lymph node metastases to the neck. Initial treatment modality was not associated with an increased risk of developing a second tumor. The commonest sites for the SPM were the lung and other head and neck area. The 3-year survival for patients who developed a secondary tumor from the time of its diagnosis was 27.8%. Conclusion: The SPM in the head and neck cancer patients are not uncommon and early detection of the SPM will contribute to increase the long-term survival of HNC patients.

• 한국강구조학회 논문집
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• 제21권6호
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• pp.627-636
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• 2009

본 연구는 강구조 설계기준에서 제시하고 있는 하중증폭계수를 적용한 2차 해석법의 타당성을 해석적 방법을 통해 평가하는데 그 목적이 있다. 이를 위해 KBC 2005에서 제안하고 있는 B1 및 B2 계수를 적용한 2차 해석과 KBC 2009(안)에서 제안하고 있는 하중증폭계수를 적용한 직접해석을 3층 1스팬 및 5층 3스팬 비가새 강구조 골조에 대해 실시하고, 그 해석 결과를 2차 비선형 해석 결과와 비교하여 기준에서 제안된 2차 해석법들을 평가하였다. 해석의 주요 변수로는 골조의 규모, 기둥의 축력비, 해석방법 등이 적용되었다. 연구 결과 고축력 조건시 KBC 2005에서 제안된 하중증폭계수를 적용한 2차 해석은 2차 효과의 영향을 적절하게 고려하지 못하나 KBC 2009(안)에서 제안된 직접해석법의 경우 적절한 수준에서 2차 효과를 고려하고 있는 것으로 나타났다.

• 한국전산구조공학회논문집
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• 제21권4호
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• pp.391-399
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• 2008

본 논문에서는 다중 균열 구조물에서의 균열 진전에 따른 에너지 해방을 및 고차 미분값을 구할 수 있는 가상균열 진전법을 제시한다. 이 방법은 다중 균열 체계의 에너지 해방율과 고차 미분값이 단 한번의 해석으로 수행될 수 있는 장점이 있다. 예제에서 얻어진 해의 최대 오차는 에너지 해방율 0.2%, 일차 미분값 $2\sim3%$, 이차 미분값 $5\sim10%$이다 이 방법으로 구한 에너지 해방률의 미분값들은 파괴 확률을 구하거나, sire effect law에 적용될 수 있다.

• 한국자원식물학회지
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• 제18권1호
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• pp.8-14
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• 2005

중부지방에서 비닐하우스를 이용한 비가림으로 홍화 2기작 재배 가능성을 검토하고자, 1기작 직파재배후 2기작 정식 방법을 직파, 육묘이식 재배로 구분하여 실시한 결과를 요약하면 아래와 같다. 1. 1기작이 2기작에 비하여 출현 소요일수는 길었으나 생존율과 생육이 높거나 양호하였다. 2. 2기작 정식방법에 따른 입모율 및 활착율은 육묘이식 재배보다 직파 재배에서 높았으나, 생육 차이는 미미 하였다. 3. 종실 수량은 1기작 135 kg/10a에 비하여 2기작에 서 $30\~74\%$감수되었다. 춘기 1기작 재배후 2기작 직파 재배시 입모율 $89.3\%$, 총종실 수량 229 kg/10a로 가장 높아 중부지방에서 적합한 2기작 재배 형태로 나타났다.

• Radiation Oncology Journal
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• 제13권3호
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• pp.267-275
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• 1995

방사선치료와 항암화학요법 등 암의 치료법이 점차 발전해감에 따라 치료후 장기간 생존하는 환자들이 많아지고 특히 소아암 치료후 장기 생존자가 증가하면서 여러가지 치료로 인한 합병증 및 문제점들이 발생하고 있다. 그중 중요한 하나가 이차암의 발생인데 본과에서 이차 악성 고형 종양 발생 환자 2예를 경험하였기에 보고하고자 한다. 한 예는 우측 슬와부에 발생한 rhab-domyosarcoma group II로 수술후 방사선치료 및 항암화학요법을 시행받았는데 3년7개월 후 방사선치료부위에서 osteosarcoma가 발생하였고 또 다른 한 예는 우측 하복부에 소장 악성 림프종이 발생하여 방사선치료 및 항암화학요법을 시행받았고 18년후에 방사선치료부위에 leimyosarcoma가 발생하였다. 문헌 고찰을 통해 소아암 치료후 이차암 발생의 위험 요인들을 고찰하였고 이차암에 대한 인식 및 세밀한 추적 조사가 필요함을 확인하였다.

• 수산해양기술연구
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• 제53권3호
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• pp.256-265
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• 2017

Seafood is attracting attention as a future food industry. In recent years, the demand for fishery equipment of mechanization, automation, and unmanned was increased due to the environment affected by seafood processing, stricter regulations on safety, decline and aging of fishery worker. Ark shell (Scapharca subcrenata) was being produced in many steps in the production process. The process has been made such as collection-landing-washing-first sort (goods/non-goods)-transports-second sort (size). It was undergone first and second steps by delivering to the consumer. Here, the first step is to sort goods to collection and the second step is to sort by size. The fishery workers need ten people in first step and six people in second step. The workload of one hour per kg is 4,247 kg/h in first step and 2,213 kg/h in second step. In addition, the goods ratio by work process was 79% in first step and 98% in the second step. In this process, a lot of fishery worker and working time is needed. Therefore, this study developed elemental techniques for an automated size sorting system considering the working process problem, time and situation for washing and sorting of ark shell.

• Restorative Dentistry and Endodontics
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• 제34권4호
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• pp.346-349
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• 2009

하악 제2대구치는 근관형태의 다양한 변이를 가지고 있어 근관치료시 여러가지 어려움을 야기한다. 본 연구에서는 하악 제2대구치의 여러가지 근관형태를 비율별로 분석해보고자 2005년에서 2008년까지 보라매병원에서 하악 제2대구치 근관치료를 받은 86개의 치아에서 치수강 개방 후 육안으로 근관입구의 형태를 확인하고 근관장 측정용 파일 삽입 후 방사선 사진을 촬영하여 근관형태를 기록, 분석하였다. 그 결과 C형 근관은 31.4%(27개)의 발현빈도를 보였으며 3근관 50%(43개), 4근관 12.7%(11개), 2근관 5.8%(5개)로 나타났다. C형 근관의 성별에 따른 발현빈도는 남성에서 31.7%, 여성에서 31.1%였다. 좌측 하악 제2대구치는 30.9%, 우측 하악 제2대구치는 31.8%의 C형 근관 발현빈도를 보였다.

• 대한소아치과학회지
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• 제49권3호
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• pp.340-347
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• 2022

하악 제2소구치 치배의 원심 변위는 해당 치아의 매복 뿐만 아니라 하악 제1대구치의 맹출 경로를 방해하여 추가적인 맹출 지연을 야기할 수 있다. 이 증례 보고는 원심으로 변위된 하악 제2소구치로 인해 하악 제1대구치의 맹출 지연이 나타난 두 증례를 소개하고 있다. 원심으로 변위된 하악 제2소구치 치배의 근심 이동을 위해 선행 유치의 의도적 발거술을 시행할 수 있다. 하지만 제2유구치의 조기 상실 시 바람직하지 않은 하악 제1소구치의 원심 이소맹출이 나타날 수 있다. 하악 제1소구치의 바람직하지 않은 원심 이소맹출을 방지하면서 원심으로 변위된 하악 제2소구치 치배를 근심으로 이동시키기 위해 하악 제2유구치의 편측치아절제술 및 순차적 발거를 수행하였다.

• 한국문헌정보학회지
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• 제17권
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• pp.11-47
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• 1989

This study intends to examine the background and the procedure of the carving of the tablets of the second edition of Dae-Jang-Mock­Lock(재조대장목록). the time and the route of the moving of the tablets. into Haein-sa, and the contents and the system of it. This study is mainly based on the second edition of Dae-Jang-Mock-Lock. But the other closely related materials such as restored first. edition of the Dae- Jang-Mock-Lock, Koryo Sin-Jo-Dae-Jang-Byeol-Lock (고려신조대장교정별록). Kae-Won-Seok-Kyo-Lock (개원석교록). Sok-Kae­Won-Seok-Kyo-Lock (속개원석교록). Jeong-Won-Sin-Jeong-Seok-Kyo­Lock(정원신정석교록), Sok-Jeong-Won-Seok-Kyo-Lock(속정원석교록), Dea-Jung-Sang-Bu-Beob-Bo-Lock(대중상부법보록), and Kyeong-Woo-Sin-Su-Beob-Bo-Lock(경우신수법보록), are also analysed and closely examined. The results of this study can be summarized as follows: 1. The second edition of Tripitaka Koreana(고려대장경) was carved for the purpose of defending the country from Mongolia with the power of Buddhism, after the tablets of the first edition in Buin-sa(부이사) was destroyed by fire. 2. In 1236. Dae-Jang-Do-Gam(대장도감) was established, and the preparation for the recarving of the tablets such as comparison between the content, of the first edition of Tripitalk Koreana, Gal-Bo-Chik-Pan-Dae­Jang-Kyeong and Kitan Dae- Jang-Kyeong, transcription of the original copy and the preparation of the wood, etc. was started. 3. In 1237 after the announcement of Dae-Jang-Gyeong-Gak-Pan-Gun­Sin-Gi-Go-Mun(대장경핵판군신석고문), the carving was started on a full scale. And seven years later (1243), Bun-Sa-Dae-Jang-Do-Gam(분사대장도감) was established in the area of the South to expand and hasten the work. And a large number of the tablets were carved in there. 4. It took 16 years to carve the main text and the supplements of the second edition of Tripitaka Koreana, the main text being carved from 1237 to 1248 and the supplement from 1244 to 1251. 5. It can be supposed that the tablets of the second edition of Tripitaka Koreana, stored in Seon-Won-Sa(선원사), Kang-Wha(강화), for about 140 years, was moved to Ji-Cheon-Sa(지천사), Yong-San(용산), and to Hae-In-Sa(해인사) again, through the west and the south sea and Jang-Gyeong-Po(장경포), Go-Ryeong(고령), in the autumn of the same year. 6. The second edition of Tripitaka Koreana was carved mainly based on the first edition, comparing with Gae-Bo-Chik-Pan-Dae-Jang-Kyeong(개보판대장경) and Kitan Dae-Jang-Kyeong(계단대장경). And the second edition of Dae-Jang-Mock-Lock also compiled mainly based on the first edition with the reference to Kae-Won-Seok-Kyo-Lock and Sok-Jeong-Won-Seok-Kyo-Lock. 7. Comparing with the first edition of Dae-Jang-Mock-Lock, in the second edition 7 items of 9 volumes of Kitan text such as Weol-Deung­Sam-Mae-Gyeong-Ron(월증삼매경론) are added and 3 items of 60 volumes such as Dae-Jong-Ji-Hyeon-Mun-Ron(대종지현문논) are substituted into others from Cheon chest(천함) to Kaeng chest(경함), and 92 items of 601 volumes such as Beob-Won-Ju-Rim-Jeon(법원주임전) are added after Kaeng chest. And 4 items of 50 volumes such as Yuk-Ja-Sin-Ju-Wang-Kyeong(육자신주왕경) are ommitted in the second edition. 8. Comparing with Kae-Won-Seok-Kyo-Lock, Cheon chest to Young chest (영함) of the second edition is compiled according to Ib-Jang-Lock(입장록) of Kae-Won-Seok-Kyo-Lock. But 15 items of 43 vol­umes such as Bul-Seol-Ban-Ju-Sam-Mae-Kyeong(불설반주삼매경) are ;added and 7 items of 35 volumes such as Dae-Bang-Deung-Dae-Jib-Il­Jang-Kyeong(대방등대집일장경) are ommitted. 9. Comparing with Sok-Jeong-Won-Seok-Kyo-Lock, 3 items of the 47 volumes (or 49 volumes) are ommitted and 4 items of 96 volumes are ;added in Caek chest(책함) to Mil chest(밀함) of the second edition. But the items are arranged in the same order. 10. Comparing with Dae- Jung-Sang-Bo-Beob-Bo-Lock, the arrangement of the second edition is entirely different from it. But 170 items of 329 volumes are also included in Doo chest(두함) to Kyeong chest(경함) of the second edition, and 53 items of 125 volumes in Jun chest(존함) to Jeong chest(정함). And 10 items of 108 volumes in the last part of Dae-Jung-Sang-Bo-Beob-Bo-Lock are ommitted and 3 items of 131 volumes such as Beob-Won-Ju-Rim-Jeon(법원주임전) are added in the second edition. 11. Comparing with Kyeong-Woo-Sin-Su-Beob-Bo-Lock, all of the items (21 items of 161 volumes) are included in the second edition without ;any classificatory system. And 22 items of 172 volumes in the Seong­Hyeon-Jib-Jeon(성현집전) part such as Myo-Gak-Bi-Cheon(묘각비전) are ommitted. 12. The last part of the second edition, Joo chest(주함) to Dong chest (동함), includes 14 items of 237 volumes. But these items cannot be found in any other former Buddhist catalog. So it might be supposed as the Kitan texts. 13. Besides including almost all items in Kae-Won-Seok-Kyo-Lock and all items in Sok-Jeong-Won-Seok-Kyo-Lock, Dae-Jung-Sang-Bo­Beob-Bo-Lock, and Kyeong-Woo-Sin-Su-Beob-Bo-Lock, the second edition of Dae-Jang-Mock-Lock includes more items, at least 20 items of about 300 volumes of Kitan Tripitaka and 15 items of 43 volumes of traditional Korean Tripitake that cannot be found any others. Therefore, Tripitaka Koreana can be said as a comprehensive Tripitaka covering all items of Tripitakas translated in Chinese character.