• 한국식품조리과학회지
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• 제19권4호
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• pp.504-510
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• 2003

동충하초를 이용하여 증편의 영양성과 기호성을 개선하기 위하여 동충하초의 첨가량, 2차발효시간, 탁주량을 달리한 후 반응표면분석법으로 최적화하여 최적조건을 얻고자 하였다. 동충하초의 양과 발효시간을 증가시킬수록 b값과 2차 발효후 부피는 증가하는 경향을 나타내었고 동충하초양과 발효시간을 증가시킬수록 색은 더 짙어지는 경향을 나타내었으며 탁주는 30% 첨가했을 때 색이 가장 짙게 나타났다. 2차 발효후 PH의 변화는 발효시간을 증가시킬수록 증가하는 경향을 나타내었고 3%이상 첨가한 처리구에서는 발효시간 증가에 따른 pH가 급격히 증가하는 경향을 나타내었다. b값은 34이상, 색의 강도는 3점이상, 2차발효 후 부피는 40$m\ell$이상, 그리고 2차발효 후 pH는 4.02∼4.04을 제한조건으로 하는 증편의 최적제조 조건은 2차발효 시간을 중심점 45분으로 고정시켰을 때 동충하초의 함량은 3.7%∼4.0%, 탁주의 함량은 19∼22%였다.

• 대한치과교정학회지
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• 제25권3호
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• pp.299-310
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• 1995

이 연구의 목적은 교정치료시 제2대구치의 위치변화를 알아보기 위함이다. 이를 위하여 제1대구치까지 banding하여 교정치료를 완료한 성인환자 64명을 Class I 발치군 15명, Class I 비발치군 12명, Class II 13명, Class III 14명으로 4개의 군으로 분류하고 치료전후의 두부방사선 계측사진을 분석하였다. 이 연구로부터 얻어진 결과는 다음과 같다. 1. Class I 발치군에서 하악 제2대구치는 제1대구치보다 적은 정출과 더 많은 원심경사를 보였고, 상악 제2대구치는 제1대구치와 유사한 정출과 근심경사를 보였다. 2. Class I 발치군에서 하악 제2대구치는 제1대구치에 비해 함입되고 유사한 원심경사를 보였으며, 상악 제2대구치는 제1대구치와 비슷하게 정출되었다. 3. Class II군에서 하악 제2대구치는 제1대구치에 비해 적은 정출을 보였고, 상악 제2대구치는 제1대구치보다 많은 정출을 보였다. 4. Class III군에서 하악 제2대구치는 제1대구치와 유사한 정출과 더 많은 원심경사를 보였으며, 상악 제2대구치는 제1대구치에 비해 적은 정출을 보였다. 5. 제2대구치 위치변화에 대한 각 군간의 비교시 FH plane에서 상악 제2대구치 치근 분기점까지 거리 변화는 Class I 발치군과 Class II, Class I 발치군과 Class III군에서 차이를 보였으며, 구개평면과 교합평면에 대한 상악 제2대구치의 각도 변화는 Class I 발치군과 Class III군에서 차이를 보였으며, 하악평면에 하악 제2대구치 치근분기점까지 거리변화는 Class I 발치군과 비발치군, Class I 비발치군과 Class II군, Class I 비발치군과 Class III군에서 차이를 보였으며, 하악 평면과 교합평면에 대한 하악 제2대구치의 각도 변화는 각 군간에 차이를 보이지 않았다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1699-1702
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• 2014

Objective: To evaluate clinical efficacy of a dose escalating schedule of paclitaxel concurrent with radiotherapy in treating patients with locally advanced non-small cell lung (NSCLC). Methods: Patients with locally advanced NSCLC were treated with conventional fractionated radiotherapy or three dimensional conformal radiotherapy (3 DCRT), concurrently with a dose escalating schedule of paclitaxel. All patients were divided into three groups, A with paclitaxel $30mg/m^2$, B with paclitaxel $60mg/m^2$ and C with paclitaxel $90mg/m^2$. Paclitaxel was repeated every week for a total of 4 or 6 weeks. Results: Among 109 patients, response rates were 68.8%, 71.1% and 71.8% (p>0.05) for group A (n=32), B (n=38), and C (n=39) respectively. Accordingly, disease control rates were 81.3%, 81.6% and 82.1% (p>0.05). Progression-free survival time was $8.0{\pm}5.0$ months, $11.6{\pm}6.1$ months, and $14.8{\pm}7.9$ months (p<0.05), respectively. Overall survival time was $15.4{\pm}7.6$ months, $18.2{\pm}8.0$ months, and $22.0{\pm}7.6$ months (p<0.05), one-year survival rates were 62.5%, 73.1% and 90.0% (p>0.05) and two-year survival rates were 31.3%, 38.5% and 50.0% (p<0.05). Main side-effects were bone marrow suppression, radiation related esophagitis and gastrointestinal reaction. Conclusion: In treating patients with NSCLC, concurrent chemoradiotherapy with paclitaxel improves early response compared with conventional fractionated radiotherapy or 3 DCRT. The survival rate was improved with the addition of paclitaxel, but there was an increase in adverse reactions when the dose of paclitaxel was increased.

• 수산해양기술연구
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• 제32권3호
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• pp.217-222
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• 1996

대형정치망의 원통내에 있어서 멸치어군의 이동행동은 1992년 12월 1일부터 12월 4일까지 일본국 석천현 칠미시 연안에 있는 안단 정치망 어장 3호망에서 스케닝 소나를 이용하여 실시하였는데, 그 결과를 요약하면 다음과 같다. 1. 2개의 원통시아에 어군의 이동행동은 주야간에 차이가 있었고, 밤보다는 낮에 더 많이 이동하였다. 2. 제2 원통에 멸치어군이 존재하였을 때, 제1원통에 있는 멸치어군이 제2 원통으로의 입망 비율은 78%였고, 제2 원통에 멸치어군의 존재는 제2원통에의 입망 비율에 영향을 미쳤다는 것을 시사하고 있다. 그러나, 제2원통에 조밀하게 멸치어군이 존재하였을 때, 제 2원통에 입망한 어군의 체류시간은 매우 짧았고, 제2 원통에서 어군의 밀도 상승은 어군의 도피 비율을 증가시킨다는 것을 시사하고 있다. 3. 멸치어군은 원통에 입망할 때, 대부분이 망의 중앙에서 먼바다 쪽으로 방향을 바꾸어 이동하였다.

• 한국자기공명학회논문지
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• 제11권1호
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• pp.24-29
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• 2007

[ ${\beta}ig-h3$ ] is an extracellular matrix protein that mediates cell adhesion through interaction with integrins. The 18 residue YH motifs within each fas-1 domain are known to be responsible for the interaction with the ${\alpha}_v{\beta}_5$ integrin, and the synthetic YH motif peptides are known to inhibit endothelial tube formation and reduces the number of blood vessels, and so expected to be an effective inhibitor of angiogenesis. In this study, we solved the 3D structure of the 18 residue YH motif peptide (EALRDLLNNHILKSAMCA; D2 peptide) within the second fas-1 domain of ${\beta}ig-h3$ using NMR. The Peptide has ${\alpha}-helix$ structure at the C terminal region but the N terminal region is flexible. The present structural information may be helpful for developing more effective peptide drug candidate for the treatment of diseases dependent on angiogenesis.

• Nutritional Sciences
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• 제8권3호
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• pp.196-199
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• 2005

A study during second trimester of pregnancy was conducted among 100 women from a population with mild to moderate deficient iodine intake (median 7 ${\mu}g$/L)to monitor the changes in serum free thyroxin ($FT_4$), triiodothyionine ($T_3$) and thyrtropin (TSH). Thyroid related hormones were assessed using radioimmunoassay (RIA) and immunoradiometricassay (IRMA). As compared with non pregnant women, mean $FT_4$ levels decreased, $T_3$ levels increased and TSH levels were slightly depressed in pregnant women. Mean $FT_4$ concentration reached its highest level in the $4^{th}$ month and linearly decreased until the $6^{th}$ month. Mean $T_3$ level remained almost constant during $2^{nd}$ trimester of pregnancy. Mean TSH level remained unaltered during the $4^{th}$ and $5^{th}$ months and was slightly lower than that for the control group. However, these differences were statistically insignificant At the end of the second trimester, hypothyroxinemia and $T_3$ levels greater than the upper limit of the laboratory reference range were found in $34\%$ and $38\%$ of women, respectively. These changes in thyroid hormones reflect typical adaptations of the thyroid gland during pregnancy to the limited availability of iodine.

• Archives of Plastic Surgery
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• 제35권5호
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• pp.527-532
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• 2008

Purpose: Transverse type or volar oblique type of defect of thumb tip can be covered by Moberg flap or second toe pulp free flap. We compared these two methods in functional result, patients' satisfaction, and sensation, etc. to find a better way to cover the defect of the thumb tip. Methods: From 2003 to 2006, we chose the patients randomly with preoperative pictures. The patients had the defect of the thumb tip which is either transverse or volar oblique type. The 6 patients were treated with Moberg flap and other 6 patients were treated with second toe pulp free flap. We have analyzed the results by 2 point discrimination, side pinching power test, pulp to pulp pinching power test, pain scales (visual analogue scale), satisfaction scales of the patients (functional and aesthetic), the degree of the range of motion, etc. Results: All flaps survived without any complications. In the cases of Moberg flaps, the value of static 2 point discrimination test was 5.6 mm, and the value of moving 2 point discrimination test was 4.8 mm. In the cases of second toe pulp free flaps, the values were 9.6 mm and 9.3 mm. In the cases of Moberg flaps, the value of the Side pinch power test was 6.6 kg, 4.4 kg. In the case of second toe pulp free flaps, the values were 4.8 kg and 2.5 kg. The value of aesthetic satisfaction scale of the patients in Moberg flaps was 5.6, the value of functional satisfaction scale of the patients was 3.6. In cases of second toe pulp free flaps, the values were 5.6 and 3.6. The active range of motion of Interphalangeal joint in the cases of Moberg flaps was 46.6 degree, and the active range of motion of metacarpophalangeal joint was 55 degree, in the cases of second toe pulp free flaps, the values were 36.6 degree and 59 degree. Conclusion: As a result, when the defect of the thumb tip is transverse or volar oblique type, we suggest that the operators choose Moberg flap to cover the defect of the thumb tip.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6799-6804
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• 2014

Background: Chemotherapy is the mainstay of treatment for the majority of patients with advanced non-small cell lung cancer (NSCLC) without driver mutations and many receive therapies beyond first-line. Second-line chemotherapy has been disappointing both in terms of response rate and survival and we know relatively little about the prognostic factors. Materials and Methods: One thousand and eight patients with advanced NSCLC who received second-line chemotherapy after progression were reviewed in Shanghai Pulmonary Hospital, China, from September 2005 to July 2010. We analyzed the effects of potential prognostic factors on the outcomes of second-line chemotherapy (overall response rate, ORR; progression free survival, PFS; overall survival, OS). Results: The response and progression free survival of first-line chemotherapy affects the ORR, PFS and OS of second-line chemotherapy (ORR: CR/PR 15.4%, SD 10.1%, PD2.3%, p<0.001; PFS: CR/PR 3.80 months, SD 2.77 months, PD 2.03 months, p<0.001; OS: CR/PR 11.60 months, SD 10.33 months, PD 6.57 months, p=0.578, p<0.001, p<0.001, respectively). On multivariate analysis, better response to first-line therapy (CR/PR: HR=0.751, p=0.002; SD: HR=0.781, p=0.021) and progression within 3-6 months (HR=0.626, p<0.001), together with adenocarcinoma (HR=0.815, p=0.017), without liver metastasis (HR=0.541, p=0.001), never-smoker (HR=0.772, p=0.001), and ECOG PS 0-1 (HR=0.745, p=0.021) were predictors for good OS following second-line chemotherapy. Conclusions: Patients who responded to first-line chemotherapy had a better outcome after second-line therapy for advanced NSCLC, and the efficacy of first-line chemotherapy, period of progression, histology, liver metastasis, smoking status and ECOG PS were independent prognostic factors for OS.

• Molecules and Cells
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• 제40권2호
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• pp.123-132
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• 2017

Insulin signaling is coordinated by insulin receptor substrates (IRSs). Many insulin responses, especially for blood glucose metabolism, are mediated primarily through Irs-1 and Irs-2. Irs-1 knockout mice show growth retardation and insulin signaling defects, which can be compensated by other IRSs in vivo; however, the underlying mechanism is not clear. Here, we presented an Irs-1 truncated mutated mouse ($Irs-1^{-/-}$) with growth retardation and subcutaneous adipocyte atrophy. $Irs-1^{-/-}$ mice exhibited mild insulin resistance, as demonstrated by the insulin tolerance test. Phosphatidylinositol 3-kinase (PI3K) activity and phosphorylated Protein Kinase B (PKB/AKT) expression were elevated in liver, skeletal muscle, and subcutaneous adipocytes in Irs-1 deficiency. In addition, the expression of IRS-2 and its phosphorylated version were clearly elevated in liver and skeletal muscle. With miRNA microarray analysis, we found miR-33 was down-regulated in bone marrow stromal cells (BMSCs) of $Irs-1^{-/-}$ mice, while its target gene Irs-2 was up-regulated in vitro studies. In addition, miR-33 was down-regulated in the presence of Irs-1 and which was up-regulated in fasting status. What's more, miR-33 restored its expression in re-feeding status. Meanwhile, miR-33 levels decreased and Irs-2 levels increased in liver, skeletal muscle, and subcutaneous adipocytes of $Irs-1^{-/-}$ mice. In primary cultured liver cells transfected with an miR-33 inhibitor, the expression of IRS-2, PI3K, and phosphorylated-AKT (p-AKT) increased while the opposite results were observed in the presence of an miR-33 mimic. Therefore, decreased miR-33 levels can up-regulate IRS-2 expression, which appears to compensate for the defects of the insulin signaling pathway in Irs-1 deficient mice.

• Journal of Periodontal and Implant Science
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• 제34권3호
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• pp.523-533
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• 2004

The purpose of this study was to evaluate the alveolar bone surface following root separation angle in the mandibular second molars. The fifty mandibular second molars(which were extracted) were selected, and the alveolar bone surface following root separation angle of the selected teeth were evaluated. The results were obtained as follows; 1. The root separation angle of fifty mandibular second molars were divided into three groups. The first $group(10-20^{\circ})$ was made up of ten teeth, the second $group(20-30^{\circ})$ was made up of fifteen teeth, and the third group(30-40$^{\circ}$) was made up of twenty-five teeth. 2. The mean root separation angle was $28.1^{\circ}$. The mean alveolar bone rate on the mesial surface of the mesial root was 44.27%, on the distal surface of the mesial root was 36.52%, on the mesial surface of the distal root was 33.45%, and on the distal surface of the distal root was 25.28%. 3. The mean alveolar bone rate on the distal surface of the mesial root, which composed the root separation area, was 32.95% in the first group, 36.06% in the second group, and 38.22% in the third group. The mean alveolar bone rate in the mesial surface of the distal root was 31.40% in the first group, 31.93% in the second group, and 35.18% in the third group. 4. The positive correlation was found between the root separation angle and the alveolar bone rate in the root separation area.(P<0.05) Although the mandibular second molar is a very important tooth in the oral cavity, its treatment and diagnosis is very difficult due to the variation of its root form. When periodontal disease involves the mandibular second molar, the result of this study assists in its treatment and diagnosis.