• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.5.1-5.14
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• 2018

Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has remained elusive. Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under oxidative stress. We subsequently activated SIRT3 using honokiol to evaluate its therapeutic potential for IVDD. We assessed SIRT3 expression in degenerative nucleus pulposus (NP) tissues and oxidative stress-induced nucleus pulposus cells (NPCs). SIRT3 was knocked down by lentivirus and activated by honokiol to determine its role in oxidative stress-induced NPCs. The mechanism by which honokiol affected SIRT3 regulation was investigated in vitro, and the therapeutic potential of honokiol was assessed in vitro and in vivo. We found that the expression of SIRT3 decreased with IVDD, and SIRT3 knockdown reduced the tolerance of NPCs to oxidative stress. Honokiol ($10{\mu}M$) improved the viability of NPCs under oxidative stress and promoted their properties of anti-oxidation, mitochondrial dynamics and mitophagy in a SIRT3-dependent manner. Furthermore, honokiol activated SIRT3 through the AMPK-PGC-$1{\alpha}$ signaling pathway. Moreover, honokiol treatment ameliorated IVDD in rats. Our study indicated that SIRT3 is involved in IVDD and showed the potential of the SIRT3 agonist honokiol for the treatment of IVDD.

• Journal of Korean Foot and Ankle Society
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• v.16 no.2
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• pp.101-107
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• 2012

Purpose: The aim of this study was to investigate the radiological characteristics of the osteoarthritis of the second metatarsophalangeal (MTP) and tarsometatarsal (TMT) joint. Materials and Methods: Between January 2002 and August 2010, 27 patients (33 feet) who had second metatarsal osteoarthritis (OA) were reviewed retrospectively. Group 1 was 14 patients (17 feet) with second MTP joint OA. Group 2 was 13 patients (16 feet) with second TMT joint OA. Group 3 was 24 patients (25 feet) had hallux valgus without second metatarsal (MT) OA as control. Weight bearing foot anteroposterior (AP) and lateral view were checked, and measured hallux valgus angle, metatarsus adductus angle (MAA), second MT functional length, first and second MT length by Hardy & Clapham method on AP view, angle of second MT with horizontal plane, calcaneal pitch, talo-first MT on lateral view. Results: On weight bearing foot AP view, second MT functional length of group 1, 2, 3 was 2.4 mm, -0.1 mm, 0.7 mm and MAA of group 1, 2, 3 was $17.7^{\circ}$, $17.7^{\circ}$, $14.5^{\circ}$. Second MT functional length of group 1 was longer than control group and it was statistically significant. MAA was significant different between group 1-3 and group 2-3. Angle of second MT with horizontal plane of group 2 was smaller than control group and it was statistically significant. Other radiographic parameters have no statistical significance. Conclusion: Group 1 has long functional length of second MT and group 2 has small angle of second MT with horizontal plane.

• Journal of Environmental Science International
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• v.28 no.4
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• pp.441-454
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• 2019

The present study analyzes the characteristics of 43 typhoons that affected the Korean Peninsula between 2002 and 2015. The analysis was based on 3-second gust measurements, which is the maximum wind speed relevant for typhoon disaster prevention, using a typhoon disaster prevention model. And the distribution and characteristics of the 3-second gusts of four typhoons, RUSA, MAEMI, KOMPASU, and BOLAVEN that caused great damage, were also analyzed. The analysis show that between May and October during which typhoons affected the Korean Peninsula, the month with the highest frequency was August(13 times), followed by July and September with 12 occurrences each. Furthermore, the 3-second gust was strongest at 21.2 m/s in September, followed by 19.6 m/s in August. These results show that the Korean Peninsula was most frequently affected by typhoons in August and September, and the 3-second gusts were also the strongest during these two months. Typhoons MAEMI and KOMPASU showed distribution of strong 3-second gusts in the right area of the typhoon path, whereas typhoons RUSA and BOLAVEN showed strong 3-second gusts over the entire Korean Peninsula. Moreover, 3-second gusts amount of the ratio of 0.7 % in case of RUSA, 0.8 % at MAEMI, 3.3 % at KOMPASU, and 21.8 % at BOLAVEN showed as "very strong", based on the typhoon intensity classification criteria of the Korea Meteorological Administration. Based on the results of this study, a database was built with the frequencies of the monthly typhoons and 3-second gust data for all typhoons that affected the Korean Peninsula, which could be used as the basic data for developing a typhoon disaster prevention system.

• Honam Mathematical Journal
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• v.38 no.3
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• pp.593-611
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• 2016

This paper is concerned with the classifications of quadric surfaces of first and second kinds in Euclidean 3-space satisfying the Jacobi condition with respect to their curvatures, the Gaussian curvature K, the mean curvature H, second mean curvature $H_{II}$ and second Gaussian curvature $K_{II}$. Also, we study the zero and non-zero constant curvatures of these surfaces. Furthermore, we investigated the (A, B)-Weingarten, (A, B)-linear Weingarten as well as some special ($C^2$, K) and $(C^2,\;K{\sqrt{K}})$-nonlinear Weingarten quadric surfaces in $E^3$, where $A{\neq}B$, A, $B{\in}{K,H,H_{II},K_{II}}$ and $C{\in}{H,H_{II},K_{II}}$. Finally, some important new lemmas are presented.

• 한국방재학회:학술대회논문집
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• 2010.02a
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• pp.114.1-114.1
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• 2010

본 연구에서는 우리나라에 적합한 재해예측모형을 구축하기 위하여 중해상도(10km)의 입력 자료를 이용하여 태풍에 의해 지상에 발생 가능한 3-second gust를 추정하였다. 중해상도 입력자료의 구축은 경상남도(부산광역시 포함) 시 군 구 단위의 행정구역으로 구분하였으며, 추정된 3-second gust를 이용하여 건물의 주요구성 요소별로 피해 확률을 구한 뒤, 발생 가능한 최대피해액을 산정하였다. 태풍 Maemi에 의한 최대강풍 피해액은 여러 주택유형 중에서도 '대표주택' 유형의 경우 약 6천억 원으로 분석되었다. 비교적 내륙에 위치한 지역에서는 적은 피해액을, 해안가에 위치한 지역에서는 많은 피해액을 나타내며, 부산광역시에서 피해액이 높은 구 군의 경우 경상남도 시 군의 평균적인 피해액과 비슷한 것으로 보아 부산이 경상남도와 비교하여 면적으로는 작지만 태풍에 의한 강풍에 매우 취약함을 알 수 있다.

• Journal of the Korean Ceramic Society
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• v.26 no.3
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• pp.297-304
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• 1989

The dielectric properties of SrTiO3 GBL Capacitor have been investigaetd as a function of the second heat treatment time and the amount of Ta. The grain size of semiconductive SrTiO3 after sintering at 1,46$0^{\circ}C$ for 4 hours in N2/H2 atmosphere increased as the amount of Ta increased, and then decreased as the amount of Ta exceed 0.01 mole. Also, the dielectric constant after the second heat treatment showed the same tendency. When the semiconductive SrTiO2 was second heat treated at 1,10$0^{\circ}C$ in air with varying time, the dielectric constant increased as the second heat treatment time increased up to 60 minutes, and then decreased as the time became longer than 60 minutes.

• Kyungpook Mathematical Journal
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• v.61 no.3
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• pp.671-677
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• 2021

For a distance-regular graph with valency k, second largest eigenvalue r and diameter D, it is known that r ≥ $min\{\frac{{\lambda}+\sqrt{{\lambda}^2+4k}}{2},\;a_3\}$ if D = 3 and r ≥ $\frac{{\lambda}+\sqrt{{\lambda}^2+4k}}{2}$ if D ≥ 4, where λ = a₁. This result can be generalized to the class of edge-regular graphs. For an edge-regular graph with parameters (v, k, λ) and diameter D ≥ 4, we compare $\frac{{\lambda}+\sqrt{{\lambda}^2+4k}}{2}$ with the local valency λ to find a relationship between the second largest eigenvalue and the local valency. For an edge-regular graph with diameter 3, we look at the number $\frac{{\lambda}-\bar{\mu}+\sqrt{({\lambda}-\bar{\mu})^2+4(k-\bar{\mu})}}{2}$, where $\bar{\mu}=\frac{k(k-1-{\lambda})}{v-k-1}$, and compare this number with the local valency λ to give a relationship between the second largest eigenvalue and the local valency. Also, we apply these relationships to distance-regular graphs.

• Korean Journal of Mathematics
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• v.28 no.3
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• pp.439-447
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• 2020

Let M be a lattice module over a C-lattice L. Let Spec^s(M) be the collection of all second elements of M. In this paper, we consider a topology on Spec^s(M), called the second classical Zariski topology as a generalization of concepts in modules and investigate the interplay between the algebraic properties of a lattice module M and the topological properties of Spec^s(M). We investigate this topological space from the point of view of spectral spaces. We show that Spec^s(M) is always T₀-space and each finite irreducible closed subset of Spec^s(M) has a generic point.

• International Journal of Highway Engineering
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• v.18 no.3
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• pp.115-125
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• 2016

PURPOSES : This study proposes a methodology to collect data necessary for microlevel emission estimation, such as second-by-second speeds and road grades, and to accordingly estimate emissions. METHODS : To ease data collection for microlevel emission estimation, a vehicle equipped with speed- and location-recording instruments as well as equipment for measuring road geometry was used. As a case study, this vehicle and the proposed methodology were used on a 10-km-long highway in Yongin City, Korea. Emissions from the vehicle during driving were estimated in various microscale driving conditions. RESULTS : Differences in the estimated emission under different microscale driving conditions cannot be ignored. Compared with the estimations obtained when second-by-second data were not considered, CO and NOx emissions were more than threefold higher when considering second-by-second speed; similarly, CO and NOx emission estimations were higher by approximately 10% and 3%, respectively, when considering second-by-second road grade. CONCLUSIONS : The proposed method can estimate vehicle emissions under real-world driving conditions in such applications as road design and traffic policy assessments.

• Journal of Information Processing Systems
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• v.12 no.2
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• pp.310-321
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• 2016

TCS_SHA-3 is a family of four cryptographic hash functions that are covered by a United States patent (US 2009/0262925). The digest sizes are 224, 256, 384 and 512 bits. The hash functions use bijective functions in place of the standard compression functions. In this paper we describe first and second preimage attacks on the full hash functions. The second preimage attack requires negligible time and the first preimage attack requires $O(2^{36})$ time. In addition to these attacks, we also present a negligible time second preimage attack on a strengthened variant of the TCS_SHA-3. All the attacks have negligible memory requirements. To the best of our knowledge, there is no prior cryptanalysis of any member of the TCS_SHA-3 family in the literature.