• 통합자연과학논문집
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• 제10권1호
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• pp.20-26
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• 2017

Chemerin receptor, which predominantly expressed in immune cells as well as adipose tissue, was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Recent studies suggest chemerin may play an important role in the pathogenesis of obesity and insulin resistance and it becomes a potential therapeutic target for treating type II diabetes. The crystal structure of chemerin receptor has not yet been resolved. Therefore, in the present study, homology modelling of CMKLR1 was done utilizing the crystal structure of human angiotension receptor in complex with inverse agonist olmesartan as the template. Since the template has low sequence identity, we have incorporated both threading and comparative modelling approach to generate the three dimensional structure. 3D models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of CMKLR1.

• 한국기계가공학회지
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• 제21권9호
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• pp.56-62
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• 2022

This study analyzed the output precision of 3D printing methods. The inner impeller of the centrifugal compressor was printed in as a sheet with 100% packing density using two methods: field deposition modelling and stereolithography. Dimensional differences between the initial CAD and printed models were evaluated using a 3D scanner. To investigate the dimensional characteristics of the 3D printed impeller, 3D dimension analysis and point dimension analysis were performed. The point dimension analysis was divided into 3D and 2D for comparative analysis.

• 통합자연과학논문집
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• 제10권3호
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• pp.119-124
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• 2017

Glucagon-like peptide 2 receptor, a GPCR, binds with the glucagon-like peptide, GLP-2 and regulates various metabolic functions in the gastrointestinal tract. It plays an important role in the nutrient homeostasis related to nutrient assimilation by regulating mucosal epithelium. GLP-2 receptor affects the cellular response to external injury, by controlling the intestinal crypt cell proliferation. As they are therapeutically attractive towards diseases related with the gastrointestinal tract, it becomes essential to analyse their structural features to study the pathophysiology of the diseases. As the three dimensional structure of the protein is not available, in this study, we have performed the homology modelling of the receptor based on single- and multiple template modeling. The models were subjected to model validation and a reliable model based on the validation statistics was identified. The predicted model could be useful in studying the structural features of GLP-2 receptor and their role in various diseases related to them.

• 한국지반공학회논문집
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• 제18권1호
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• pp.17-28
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• 2002

터널의 막장부근에서는 하중전이가 복잡한 3차원적 거동특성을 나타낸다. 일반적으로 3차원 해석은 입력자료의 준비 및 결과 해석에 많은 노력을 요하며, 비선형 압밀해석을 수행하는 경우 컴퓨터 계산수요가 커지는 문제 때문에 실제설계는 2차원 해석법을 주로 사용하게 된다. 3차원적인 터널거동을 2차원적으로 모델링하기 위하여는 터널 굴진과정을 수치해석적으로 표현하기 위한 경험 파라미터가 요구되며, 해석결과는 이 파라미터 값에 따라 크게 변화하는 특성을 나타낸다. 특히 이 값의 평가는 주로 주관적이고 경험적인 판단에 의존하게 되므로 임의성이 커 해석의 신뢰성 문제를 야기할 수 있다. 특히 지반거동이 간극수 등 시간의존성 요인에 의해 영향을 받는 경우 이 파라미터를 평가하기는 더욱 어려워진다. 본 논문에서는 이러한 문제점을 개선하기 위하여 제안된 Time-based 2-D Modeling Method를 사용하여 지하수위가 높은 풍화화강토내 터널굴착 문제에 적용하였고 이를 분할 굴착에도 적용 가능하도록 확장하였다. 해석결과는 실측결과와 잘 일치하는 거동을 보였다. 이 방법을 이용하여 복합막장터널의 거동특성을 조사한 결과, 마제형 터널단면의 역학적 유익성이 확인되었다.

• International Journal of Internet, Broadcasting and Communication
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• 제12권3호
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• pp.9-17
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• 2020

In this paper, as part of the research for the infrastructure of very high flexible and reconfigurable data center using very high speed crossbar switches, we developed a simulator that can model two and three dimensional connection structure of switches with an efficient control algorithm using software defined network and verified the functions and analyzed the performance accordingly. The simulator consists of a control module and a switch module that was coded using Python language based on the Mininet and Ryu Openflow frameworks. The control module dynamically controls the operation of switching cells using a shortest multipath algorithm to calculate efficient paths adaptively between configurable computing resources. Performance analysis by using the simulator shows that the three-dimensional switch architecture can accommodate more hosts per port and has about 1.5 times more successful 1:n connections per port with the same number of switches than the two-dimensional architecture. Also simulation results show that connection length in a 3-dimensional way is shorter than that of 2-dimensional way and the unused switch ratio in a 3-dimensional case is lower than that of 2-dimensional cases.

• 감성과학
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• 제20권2호
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• pp.87-102
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• 2017

3D프린팅에 대한 관심이 증가함에 따라, 3D프린팅에 선행되어야 할 3D모델링 교육에 대한 관심으로 증가하고 있다. 그러나 현존하는 3D모델링 소프트웨어들은 대부분 외국 브랜드에서 개발하였고, 이에 따라 인터페이스가 모두 영어되어 있기에 이러한 용어에 익숙하지 않은 한국인 입문자들을 대상으로 3D모델링 소프트웨어 교육을 수행하기에는 제약이 있다. 본 연구는 이러한 현실을 반영하면서 3D프린팅을 위한 한국형 3D모델링 교육용 소프트웨어를 개발할 때 고려해야할 사항이 무엇인지 탐색하기 위해 이루어졌다. 이를 위해 3D모델링 경험이 없는 사람들로 하여금 입문자들의 접근이 용이하다고 알려진 대표적인 무료공개 3D모델링 소프트웨어 123D Design나 Tinker CAD 중 하나로 집만들기 과제를 수행하게 한 후, 이에 대한 설문을 진행하였다. 결과적으로 Tinker CAD에 대한 사용자 경험이 123D Design에 대한 것보다 호의적이고, 전자를 경험하면서 발생한 오류가 후자를 경험하면서 발생한 오류보다 적으며, 전자에서 과업을 완료한 사람의 비율이 후자에서 과업을 완료한 사람의 비율보다 높음을 확인할 수 있었다. 종합논의에서는 Tinker CAD의 특성(입체도형을 통해 쉽게 모델링 가능)과 웹 기반 구동방식을 적용한 입문자 교육용 3D모델링 소프트웨어 개발 및 123D Design의 특성(세밀한 치수조작과 도형정렬 가능)과 윈도우 기반 구동방식을 적용한 초?중급자 교육용 3D모델링 소프트웨어 개발을 제안하였다.

• 해양환경안전학회지
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• 제3권1호
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• pp.73-83
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• 1997

To predict the oil-spill dispersion in marine waters, the oil-spill dispersion model based on Lagrangian particle-tracking method was developed and applied to Kwangyang and Jinju Bay. The tidal current movements to be required as input data of the oil-spill dispersion model were obtained by a two-dimensional numerical tidal model. Evaluation of tidal current movements using mean tide was successful. Modelling results were compared with the field data obtained at spill site. There were some descrepancies between modeling results and field data. However, the general pattern of modelling results was similar to that of field data. Provided the real-time tidal currents and more accurate wind data are supported, more favorable results can be obtained.

• Journal of the Korean Data and Information Science Society
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• 제21권3호
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• pp.555-560
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• 2010

One-dimensional approach to two-dimensional warranty data involves modeling us- age as a function of time. Iskandar (1993) suggests a simple linear model for usage. However, simple linear form of intensity function is of limited value to model the situa-tion where the intensity varies over time. In this study Weibull intensity is considered where the scale parameter is expressed in terms of different models. We will nd out how each parameter in the model a ects the warranty cost and which model gives a bigger number of failures within the two-dimensional warranty region.

• Wind and Structures
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• 제25권6호
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• pp.537-549
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• 2017

In this study, the turbulent flow around a bluff body for different wind velocities was investigated numerically by using its two- and three-dimensional models. These models were tested to verify the validity of the simulation by being compared with experimental results which were taken from the literature. Variations of non-dimensional velocities in different positions according to the bluff body height were analysed and illustrated graphically. When the velocity distributions were examined, it was seen that the results of both two- and three-dimensional models agree with the experimental data. It was also seen that the velocities obtained from two-dimensional model matched up with the experimental data from the ground to the top of the bluff body. Particularly, compared to the front part of the bluff body, results of the upper and back part of the bluff body are better. Moreover, after comparing the results from calculations by using different models with experimental data, the effect of multidimensional models on the obtained results have been analysed for different inlet velocities. The calculation results from the two-dimensional (2D) model are in satisfactory agreement with the calculation results of the three-dimensional model (3D) for various flow situations when comparing with the experimental data from the literature even though the 3D model gives better solutions.

• 한국항해항만학회지
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• 제26권5호
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• pp.563-569
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• 2002

오염물질 확산모델링시 기존의 유한차분모델의 단점을 보완하기 위해 입자추적법이 사용되고 있다. 본 연구에서는 Princeton Ocean Model에 결합하여 사용할 수 있는 3차원 입자추적모델을 개발하였으며 이를 다양한 수치실험을 통해 검증하였다. 또한 미국 플로리다 주 템파만의 해양방류구 모델링에 적용하므로써 모델의 유용성을 확인하였다. 예상대로 입자추적모델은 기존의 유한차분모델에 비해 적은 확산범위를 나타내었으며, 이는 기존의 유한차분모델이 안고 있는 수치확산에 따른 오차로 추정된다. 새로이 개발된 모델은 다양한 해양확산모델링에 유용하게 응용될 것으로 기대된다.