• Title/Summary/Keyword: 2SPA

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A Study on the Affinity of Some Medicinal Herbs to Two Cytochrome P450 Subfamilies, CYP3A4 and CYP2D6 (한약재의 Cytochrome P450 결합관련 안전성에 관한 연구)

  • Yoo, Da-Young;Woo, Hong-Jung;Kim, Young-Chul
    • The Journal of Internal Korean Medicine
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    • v.34 no.4
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    • pp.375-383
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    • 2013
  • Objectives : This study was performed to investigate the metabolic site of some medicinal herbs in the liver associated with CYP (Cytochrome P450). Methods : Cytochrome P450 is the major enzymes involved in drug metabolism and bioactivation. CYP3A4 and CYP2D6, the major CYP isoforms in humans, catalyse the major proportion of drugs available on the market. Scintillation proximity assay (SPA) is often used in studies to identify compounds that inhibit CYP3A4 and CYP2D6. 28 herbal extracts and radioisotopes were attached competitively to SPA beads, and followed by measuring the remaining radioisotopes in the medium. Erythromycin and dexamethasone, inhibitors of CYP3A4 and CYP2D6, were used as controls respectively. Results : Most of the 28 herbal extracts showed dose-dependent affinity to the CYP3A4 while some of the herbs showed affinity to the CYP2D6. Conclusions : These results suggest that most of the 28 herbal extracts are metabolized safely in the liver, combined with CYP3A4 and CYP2D6.

Circularly Rotated Array for Dual Polarized Applicator in Superficial Hyperthermia System

  • Kim, Ki Joon;Choi, Woo Cheol;Yoon, Young Joong
    • Journal of electromagnetic engineering and science
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    • v.15 no.1
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    • pp.20-25
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    • 2015
  • A circularly rotated array for a dual polarized applicator in a superficial hyperthermia system is proposed. The applicator has a wider effective treatment area due to the $180^{\circ}$ phase shift. The dual polarized circularly rotated array (DPCRA) suppresses overheating at the center of the array and helps evenly distribute the heat. This array provides a more effective treatment area than a lattice array when a $2{\times}2$ dual polarized array is fitted to the treatment area. The treatment area is 71.5% of the aperture, whereas the effective treatment areas of the $2{\times}2$ dual polarized lattice array (DPLA) and the single polarized array (SPA) are 57.2% and 38.6% of the same aperture, respectively. The measurement matches the simulation results without blood circulation effects. In a $2{\times}2$ array applicator, the proposed DPCRA has more heat uniformity than the DLA and the SPA.

Ellipsometric Study in Vacuum

  • Kim, Yeong-Dong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.63-63
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    • 2012
  • 편광분석법(ellipsometry)은 대상 물질의 유전율 함수의 실수부와 허수부를 Kramers-Kronig 관계식의 도움 없이 그 물질상수를 정확히 측정할 수 있는 매우 우수한 기술이다. 이 기술의 큰 장점 중 하나는 빛의 편광상태의 변화를 이용한 비파괴적인 방법으로써 실시간 측정이 가능하며, 박막의 두께측정의 오차범위는 0.1 nm 이하로써 매우 정확하다는 것이다. 본 연구자는 이러한 우수한 측정 기술인 편광분석법을 고진공의 분자살박막증착장치(MBE) 와 결합하여 AlSb, AlP의 유전율 함수를 측정하였다. Al 계열을 포함하는 반도체 화합물은 Al의 산소친화력이 강해 대기 중에서 순수한 유전율 함수를 얻기가 불가능하다. 하지만 본 연구실에서 초고진공 상태의 MBE 챔버에서 시료를 성장시키는 동시에 실시간으로 편광분석기를 이용하여 측정하였고, 지금까지 발표된 결과들 중 가장 순수한 상태의 AlSb 유전율 함수를 얻어낼 수 있었다. 또한 순수한 AlP의 유전함수를 측정할 수 있었고, 이는 편광분석기를 이용한 최초의 실험결과로써 이차미분을 이용한 전이점 분석결과 이론적인 전자밴드구조에서 E1, E1+${\Delta}1$, E2에 해당하는 밴드갭들을 확인할 수 있었다. 또한 표면의 원자배열 구조와 실시간으로 일어나는 그들의 역학적인 현상들에 관한 정보를 얻을 수 있는 surface photoabsorption (SPA)를 metalorganic chemical vapor deposition (MOCVD)에 장착하여 실시간 모니터링이 가능하도록 하였다. SPA를 이용하여 GaAs/AlGaAs 양자우물구조의 성장을 원자층 수준으로 실시간 모니터링을 할 수 있었다. 그리고 SPA를 이용하여 MOCVD 안에서 InP에 As가 흡착 및 탈착되는 현상을 분석하여, As의 흡착이 두 단계에 의해 이루어짐을 분석하였다. 그리고 편광분석법의 빠르고 정확한 측정 기술을 규칙적인 구조체에서 전자기파의 회절을 구할 수 있는 Rigorous Coupled-Wave Analysis (RCWA) 계산방법과 결합하여 나노구조의 기하학적인 모양을 정확하고 빠르게 구할 수 있었다. 본 연구를 위해 규칙적인 3차원 Si 구조체 제작하여 편광분석기로 측정하고 $SiO_2$와 표면 거칠기를 고려하여 RCWA로 분석한 결과, 규칙적인 Si 구조와 산화막 층까지 정확하게 분석할 수 있음을 확인하였다. 또한 규칙적인 나노구조분석 연구를 넘어 불규칙적인 나노구조에 대한 분석 가능성을 보이기 위해 InAs 양자점을 증착하여 분석하였고, 이를 통해 편광분석법과 RCWA를 이용하여 불규칙적인 나노구조의 모양과 크기, 분포의 분석이 가능함을 보였다.

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A Study of SPA Vulnerability on 8-bit Implementation of Ring-LWE Cryptosystem (8 비트 구현 Ring-LWE 암호시스템의 SPA 취약점 연구)

  • Park, Aesun;Won, Yoo-Seung;Han, Dong-Guk
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.27 no.3
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    • pp.439-448
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    • 2017
  • It is news from nowhere that post-quantum cryptography has side-channel analysis vulnerability. Side-channel analysis attack method and countermeasures for code-based McEliece cryptosystem and lattice-based NTRU cryptosystem have been investigated. Unfortunately, the investigation of the ring-LWE cryptosystem in terms of side-channel analysis is as yet insufficient. In this paper, we propose a chosen ciphertext simple power analysis attack that can be applied when ring-LWE cryptography operates on 8-bit devices. Our proposed attack can recover the key only with [$log_2q$] traces. q is a parameter related to the security level. It is used 7681 and 12289 to match the common 128 and 256-bit security levels, respectively. We identify the vulnerability through experiment that can reveal the secret key in modular add while the ring-LWE decryption performed on real 8-bit devices. We also discuss the attack that uses a similarity measurement method for two vectors to reduce attack time.

Side channel attack on the Randomized Addition-Subtraction Chains (랜덤한 덧셈-뺄셈 체인에 대한 부채널 공격)

  • 한동국;장남수;장상운;임종인
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.14 no.5
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    • pp.121-133
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    • 2004
  • In [15,16], Okeya and Sakurai showed that the randomized addition-subtraction chains countermeasures [18] are vulnerable to SPA attack. In this paper, we show that Okeya and Sakurai's attack algorithm [15,16] has two latent problems which need to be considered. We further propose new powerful concrete attack algorithms which are different from [15,16,19]. From our implementation results for standard 163-bit keys, the success probability for the simple version with 20 AD sequences is about 94% and with 30 AD sequences is about 99%. Also, the success probability for the complex version with 40 AD sequences is about 94% and with 70 AD sequences is about 99%.

Reuse of the sewage from sea area using the Submerged Moving Media Complete Mixing Activated Sludge (SMMCMAS) (회전매체를 가진 완전혼합활성슬러지 공법을 이용한 온천지구 하수의 재이용)

  • 김홍태;김학석
    • Journal of Environmental Science International
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    • v.11 no.1
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    • pp.69-74
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    • 2002
  • This study was performed to evaluate an applicability of the SMMCMAS system for reuse of the sewage from spa area and was operated to HLR(Hydraulic loading rate) of 211.3 to 126.8 $\ell$/㎥/d. The operating HRT(Hydraulic retention time) ranges were 2.5 to 1.5 hours. Conclusions are as follows; At the optimum HLR of 158.5 $\ell/\m^2$/d (HRT of 2.0 hours), the maximum BOD removal efficiency was 94% and the effluent BOD concentration was 1.1mg/$\ell$ in result. As the HLR was increased to 211.3 $\ell/\m^2$/d, BOD removal efficiency was decreased to 75% and BOD removal efficiency was also reduced to 74% at lower HLR of 126.8 $\ell/\m^2$/d. It shows that the maximum BOD removal efficiency occurs at an optimum HLR value and that the removal efficiency decreases when the HLR is either higher or lower than the optimum value. Sludge production rates were ranged 0.01 to 0.24gVSS/gBODrem/d and accomplished to 0.01gVSS/gBODrem/d at the optimum HLR of 158.5 $\ell/\m^2$/d.

A Study on Characters of Select Behaviors of Tourist - at a spa & resort - (관광객의 선택행동 특성에 관한 연구 - 온천리조트를 중심으로 -)

  • Oh, Jae-kyung
    • Journal of Distribution Science
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    • v.4 no.2
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    • pp.81-106
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    • 2006
  • The value of Its visitors is very important factors on selection of a Spa & Resort. The first detailed purpose of this paper is to analyse the differences of select behaviors of a Spa & Resort according to the types of values of the visitors. The second aim is to conduct a research on the characters of select behaviors of the visitors. The third aim is to analyse the degree of satisfaction of the visitors, re-visitation and the intention of recommendation. The fourth purpose is to provide useful materials on analysis about the values of the visitors at various Spa & Resorts and to trigger dramatic effect of recuperation, relaxation with its visitor's needs met, the maximum of hotel's management profit at Spa & Resort's area and programs to activate the region's economy. Factor Analsis Routine of SPSS Windows Version 10.0 was applied to accomplish the issues of the study. The Applied analysis by research process are as follows; This paper applied Frequency analysis to figure out interviewee's demographic characters and various using types of the visitors, using their experience of visiting, Select influence, Visiting period, Accommodation they use, Accompanyist, Costs, Season, Transportation, The necessary time. This paper showed important correlation between the visitors' select attributes and behaviors after using it, between their personal value and behaviors after using it, between their individual value, motive of use and their select behavior of destinations. In accordance with it, Managers or developer of a Spa & Resort should make a plan after a sufficient review of the visitors' individual value. The visitor's value is changing continuously according to the change of spatial, occasional environment and should be assessed by those changes.

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Studies on High Speed Addressing Driving Scheme using the Priming Effect in Plasma Display Panel (하전 입자 효과를 이용한 Plasma Display Panel의 고속 구동 파형에 관한 연구)

  • Shin, Bhum-Jae;Park, Sang-Sik
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.23 no.2
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    • pp.45-52
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    • 2009
  • This study is related to the realization of high speed address driving method for Full-HD PDP. The new self-priming addressing(SPA) driving scheme was proposed to improve an address discharge time lag, which utilizes the priming effect maintaining the priming discharge during an address period. In this study, the basic characteristics of the priming ramp discharge were investigated and optimize the reset pulse and priming pulse. It is noted that the address discharge time lag is significantly improved from 1.2[${\mu}s$] to 0.8[${\mu}s$] when the slope of the priming ramp pulse is below 0.1[$V/{\mu}s$].

Case Study of Using Facebook of Each Type of Internal and External Sports and SPA Fashion Brands (소비자 활동 지표를 통한 국내외 스포츠, SPA 패션 브랜드의 페이스북 활용 사례연구)

  • Kim, Sang A;Lee, Seunghee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.39 no.3
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    • pp.337-352
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    • 2015
  • This study selected a case study method conforming to qualitative research in order to analyzed how each type of fashion enterprises uses SNS in-side of fashion marketing based on content the researcher monitored and selected from the Facebook website for each enterprise. The standard to select fashion brands in this study is a graded list made based on ranking 5 analysis sites on social media (Socialbakers, socialDigm, Pulse K, BigFoot9, L2). The researcher sorted and then analyzed 2 brands that have many fan joiners and followers among fashion brands that were ranked top of the graded list, work in Facebook animatedly, and had representativeness in each type (SPA, Sports Brands). The study was conducted from January 2013 to March 2013, and the index of Facebook consisted of 3 kinds of elements (comment, like, and share). Each numerical value was counted to decide the monthly ranking. Content analysis was divided into public relations about brand, public relations about products, and customer participation and activities; consequently, the researcher investigated which content was post conforming to the ranking. The study analyzed the analysis results of each brand derived through the method of study compared to other brands. The results are as follows. In case of SPA brands, the category accounting for high rank in index analysis are public relation events to attract customer attention and products and offering information. The results of the monthly trend about whole post category were also similarly analyzed so the promotion goal that the brand wants to seek in priority coincides with the customer compliance rate. Next, in the case of sports brand, public relations for products offering information, event for arousing customer concern, and participation activities accounted for a high rank in the index analysis and posted the most in the analysis of the monthly trend for whole post category. The researcher came to understand that the direction of content for brands shown through Facebook coincides with customer sympathy.

The prevalence of pullorum disease-fowl typhoid in grand parent stock and parent stock in Korea, 2003 (2003년 국내 원종계 및 종계의 추백리-가금티푸스 감염실태)

  • Kim, Ae Ran;Kim, Jae Hong;Lee, Young Ju;Cho, Young Mi;Kwon, Jun Hun;Kwon, Yong Kuk;Lee, Youn Jeong;Choi, Jun Gu;Joh, Sung Jun;Kim, Min Chul;Lee, Eun Kyoung;Kim, Chang Seub;Yang, Hung Gu;Kwag, Sang Ick;Sung, Haan Woo;Moo, In Pil
    • Korean Journal of Veterinary Research
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    • v.46 no.4
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    • pp.347-353
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    • 2006
  • Serum samples of 30 chickens per flock from 6 grand parent stock (GPS) farms and 70 parent stock (PS) farms were collected for seroprevalent study of pullorum disease-fowl typhoid (PD-FT) infection by serum plate agglutination test (SPA). The incidence of PD-FT infection in GPS flocks and PS flocks were 0% and 15.7%, respectively. Especially PS flocks infected with PD-FT showed age dependent patterns that 22.2% of flocks between 20 to 30 weeks of age and 38.9% of flocks between 30 to 40 weeks of age were positive. The incidence of GPS flocks and PS flocks using Salmonella (S.) gallinarum 9R (SG9R) live vaccine were 33.3% and 58.6%, respectively. The sero-positive rate of 11 flocks were 6.7-83.3% by SPA and 2.9-55.6% by enzyme linked immunosorbent assay (ELISA), and ELISA showed more lower antibody levels than SPA. Furthermore, specific antibodies produced by SG9R vaccination were detectable by SPA using SG9R antigen without cross-reaction with the PD-FT infection.