• Toxicological Research
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• 제21권2호
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• pp.135-140
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• 2005

Although the pathogenesis of cerebral cavernous malformation (CCM) is unknown, a familial predisposition has been recognized, with up to $55\%$ of patients having an affected relatives. Genetic linkage studies have recently mapped a gene causing CCM to a segment of the long arm of chromosome 7 (7q). We report herein a genetic linkage analysis conducted on a Korean three generation family with CCM. It's first report in Korean family. A Korean family in which one member had undergone surgery for ubtracerebrak hematoma (ICH) and confirmed the CCM, was evaluated. They were examined clinically (n=18) and by magnetic resonance (MR) imaging (n=10). Polymorphic markers (D7S1813, D7S1789) spanning the CCM1 locus on 7q were genotyped by the polymerase chain reaction and analysis of linkage was performed in this family (n=17). Six had multiple lesions on brain MR image, one of them being symptomatic, and five were asymptomatic. Seven remaining members were asymptomatic and refused MR image study. One had died of ICH from presumed CCM. Analysis of the pedigree was consistent with an autosomal dominant pattern of inheritance. All affected patients were linked to CCM1. Linkage to CCM1 can account for inheritance of CCM in this family. They had some striking features with a low clinical penetrance and the presence of multiple lesions. These findings have implications for genetic testing of this disorder and represent an important step toward identification of the gene responsible for the pathogenesis of this disease.

• Journal of the Institute of Electronics and Information Engineers
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• 제49권9호
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• pp.322-327
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• 2012

Parallel-plate-type scanning sensors have been commercially used for X-ray imaging sensors. In this study, we manufactured the scan typed 1D X-ray image sensor that can be used to obtain scanning images, by using the plasma display panel (PDP) fabrication process. We fabricated drift and pixel electrodes in the glass chamber and injected Xe gas at atmospheric pressure. We evaluated the intensity of a pixel signal depending on the bias voltage on the drift electrode and investigated the characteristics of shielding effect on the single pixel using lead (Pb). The adsorption rate of X-ray photon is low (4%) on the soda lime glass (1.1mm) and the electrical signal detected on the X-ray sensor was increased in the high bias voltage. We acquired digital X-ray scanning image with our DAS (data acquisition system) and sensor scanning system.

• Journal of Sensor Science and Technology
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• 제21권6호
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• pp.413-419
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• 2012

A dynamic range extension technique is proposed based on a 3-transistor active pixel sensor (APS) with gate/body-tied p-channel metal oxide semiconductor field effect transistor (PMOSFET)-type photodetector using a feedback structure. The new APS consists of a pseudo 3-transistor APS and an additional gate/body-tied PMOSFET-type photodetector, and to extend the dynamic range, an NMOSFET switch is proposed. An additional detector and an NMOSFET switch are integrated into the APS to provide negative feedback. The proposed APS and pseudo 3-transistor APS were designed and fabricated using a $0.35-{\mu}m$ 2-poly 4-metal standard complementary metal oxide semiconductor (CMOS) process. Afterwards, their optical responses were measured and characterized. Although the proposed pixel size increased in comparison with the pseudo 3-transistor APS, the proposed pixel had a significantly extended dynamic range of 98 dB compared to a pseudo 3-transistor APS, which had a dynamic range of 28 dB. We present a proposed pixel that can be switched between two operating modes depending on the transfer gate voltage. The proposed pixel can be switched between two operating modes depending on the transfer gate voltage: normal mode and WDR mode. We also present an imaging system using the proposed APS.

• Journal of Oriental Neuropsychiatry
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• 제10권1호
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• pp.133-146
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• 1999

First I chose a patient group and a comparative group composed of 23 members each. Then the body temperature differences in these groups was taken with D.I.T.I. The results are as follows. 1. Average body temperature of the Hwa-Byung patient group is $36.6^{\circ}C$ and that of the comparative group is $36.4^{\circ}C$. So there is no meaningful body temperature difference. 2. The hwa-Byung patient group has higher temperature than the comparative group by ${\triangle}T>1.0^{\circ}C$ at the following acupunture points in these body parts upper and lower, left and right, anterior and posterior, trunk and limb. Especially, the body temperature difference was clear in the CV-17 (jun-Joong) and the GV-4(Myung-moon). 3. When the body temperature was compared in the upper and lower part of the back, it had meaningful differences at the upper and lower acupunture points of the back in the Hwa-Byung patient group but not in the comparative group. 4. When the body temperature was compared in the left and right part of the body, its average difference was ${\triangle}T>1.0^{\circ}C$ in the two groups and the result were meaningless. 5. When body temperature was compared in the anterior and posterior part of the body, its average difference was ${\triangle}T>1.0^{\circ}C$ in the two groups and the result were meaningless. 6. When body temperature was compared in the trunk and limb part of the body, its difference in the patient group was meaningful compared with the non-patient group. From the above results, I think that D.I.T.I. could be used to objectively visualize heat sensation of the Hwa-Byung patients and make an objective concept of Han Yul in oriental medicine.

• Journal of Acupuncture Research
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• 제20권4호
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• pp.134-144
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• 2003

Objective : This study designed to find out the effects of deep acupuncture in cerebrovascular hemiplegia. Methods : This study was performed on 30 patients with cerebrovascular hemiplegia to observe difference in temperature of skin surface between general acupuncture and deep acupuncture at Hapkok using digital infrared thermographic imaging(D.I.T.I.) Results : 1. Temperature of paralytic side is sigficantly higer $0.39{\pm}0.78^{\circ}C$ than that of contralateral side. 2. Thermal difference(${\Delta}T$) of paralytic side-contralateral side decreased $0.08{\pm}0.53^{\circ}C$ after general acupuncture, but there is no significant. $0.20{\pm}0.50^{\circ}C$ after deep acupuncture decreased significantly. So deep acupuncture is more effective than general acupuncture. 3. Thermal difference of paralytic side-paralytic side and contralateral side-contralateral side decreased significantly after acupuncture, and thermal difference of deep acupuncture on paralytic side-paralytic side decreased $0.42{\pm}1.07^{\circ}C$ more than that of general acupuncture. So deep acupuncture is more effective than general acupuncture. Conclusions: This study showed that deep acupuncture is more effective than general acupuncture In cerebrovascular hemiplegia, and further study is needed on clinical trials.

• The Transactions of the Korean Institute of Electrical Engineers D
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• 제55권2호
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• pp.68-71
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• 2006

Active thermography has been used for several years in the field of remote non-destructive testing. It provides thermal images for remote detection and imaging of damages. Also, it is based on propagation and reflection of thermal waves which are launched from the surface into the inspected component by absorption of modulated radiation. For energy deposition, it use external heat sources (e.g., halogen lamp or convective heating) or internal heat generation (e.g., microwaves, eddy current, or elastic wave). Among the external heat sources, the ultrasound is generally used for energy deposition because of defect selective heating up. The heat source generating a thermal wave is provided by the defect itself due to the attenuation of amplitude modulated ultrasound. A defect causes locally enhanced losses and consequently selective heating up. Therefore amplitude modulation of the injected ultrasonic wave turns a defect into a thermal wave transmitter whose signal is detected at the surface by thermal infrared camera. This way ultrasound thermography(UT) allows for selective defect detection which enhances the probability of defect detection in the presence of complicated intact structures. In this paper the applicability of UT for fast defect detection is described. Examples are presented showing the detection of defects in PCB material. Measurements are performed on various kinds of typical defects in PCB materials (both Cu metal and non-metal epoxy). The obtained thermal image reveals area of defect in row of thick epoxy material and PCB.

• Imaging Science in Dentistry
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• 제38권1호
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• pp.29-37
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• 2008

Purpose: The aim of this study was to observe the bony change in the OVX rat longitudinally and to study the alendronate effect. Materials and Methods: Eighteen Sprague-Dewley rats, eight-week old each, were randomly assigned into three groups: one of those sham-operated (N=4), the other two were OVX: saline-treated (N=7) and alendronate-treated group (N=7). The saline-treated group was administered with saline solution (0.1mL/100g) daily, while the alendronate-treated group was given alendronate (1mg/kg, Sigma-Aldrich Corp. Korea) daily. Micro-CT scannings of the lumbar were consecutively done at baseline, at 3-week intervals during 9 weeks. Two and three dimensional bony analysis were done. Bone mineral density (BMD) was measured with Piximus (GE Lunar Co. USA). The average values of these three methods were compared with each group. Results: After 6 weeks the BMD of the OVX group showed lower tendency than that of sham group. After 6 weeks many 3D parameters of micro-CT showed higher values in the OVX-alendronate group compared with the OVXsaline group. Most 2D bony parameters were higher in the OVX-alendronate group compared with the OVX-saline group at 9 weeks. Conclusion: This study showed low BMD of the OVX group after 6 weeks and showed the effect of alendronate on the BMD and bony structures of ovariectomized rats. This study also showed usefulness of in vivo micro-CT in monitoring individual bone changes over time.

• Journal of Ginseng Research
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• 제31권3호
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• pp.159-174
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• 2007

Pharmacology of Korean Red ginseng gives us unique possibility to develop new class of antiepileptic drugs today and to improve one's biological activity. The chemical structures of ginsenosides (GS) have some principal differences from well-known antiepileptic new generation drugs. The antiepileptic effect of GS was also demonstrated in all models of epilepsy in rats (young and adult), which have studied, in all models of epilepsy including status epilepticus (SE), induced by lithium - pilocarpine. In our experiments in rats new evidences on protective effects were exerted as a result of premedication by GS. Pre-treatment of several GS could induce decrease of the seizures severity and brain structural damage (by MRI), neuronal degeneration in hippocampus. Wave nature of severity of motor seizures during convulsive SE was observed during lithium-pilocarpine model of SE in rats (the first increase of seizures was 30 min after the beginning of SE and the second - 90 min after. The efficacy of treatment on SE by ginsenoside as expected was observed after no less 3 weeks by daily GS i.p. administration. It is blocked SE or significantly decrease the severity of seizures during SE. The implication of presented data is that combination of ginsenosides from Korean Red ginseng and ginseng cell culture Dan25 that could be applied for prevention of epileptical status development. However, a development of optimal ratio of different ginsenosides $(Rb_1$ Rc, Rg, Rf,) should consummate in the new antiepileptic drug development.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 한국정보통신학회 2017년도 추계학술대회
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• pp.702-704
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• 2017

In case of dismantling of nuclear power generation facility or radiation accident, the accurate information of gammaray source is essential for rapid decontamination. In order to more efficiently represent the position of the gamma ray to be removed, we create a spatial domain based on the real image. And we can perform decontamination of gamma-ray source more quickly by expressing the distribution of radiation source. The developed gamma ray imaging device overlaps with the visible image after gamma - ray detection and provides only two - dimensional image, but it does not show the distance information to the source. In this paper, we have developed a operation environment using the 3D visualization model for reporting effective decontamination operation.

• Imaging Science in Dentistry
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• 제51권1호
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• pp.27-34
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• 2021

Purpose: This study was performed to compare the ability of limited- and large-volume cone-beam computed tomography (CBCT) to display isthmuses in the apical root canals of mandibular molars. Materials and Methods: Forty human mandibular first molars with isthmuses in the apical 3 mm of mesial roots were scanned by micro-computed tomography (micro-CT), and their thickness, area, and length were recorded. The samples were examined using 2 CBCT systems, using the smallest voxels and field of view available for each device. The Mann-Whitney, Friedman, and Dunn multiple comparison tests were performed (α=0.05). Results: The 3D Accuitomo 170 and i-Cat devices detected 77.5% and 75.0% of isthmuses, respectively (P>0.05). For length measurements, there were significant differences between micro-CT and both 3D Accuitomo 170 and i-Cat(P<0.05). Conclusion: Both CBCT systems performed similarly and did not detect isthmuses in the apical third in some cases. CBCT still does not equal the performance of micro-CT in isthmus detection, but it is nonetheless a valuable tool in endodontic practice.