• Title/Summary/Keyword: 2013-2104

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Hepatocellular Carcinoma in a Tertiary Referral Hospital in Indonesia: Lack of Improvement of One-Year Survival Rates between 1998-1999 and 2013-2014

  • Loho, Imelda M;Hasan, Irsan;Lesmana, C Rinaldi A;Dewiasty, Esthika;Gani, Rino A
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.2165-2170
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    • 2016
  • Background: The survival of hepatocellular carcinoma (HCC) patients is usually low due to late diagnosis. Cipto Mangunkusumo Hospital as the largest tertiary referral hospital in Indonesia, has recently improved its modalities for advanced HCC management, but there has not been any evaluation on any improvement in HCC patient survival. Materials and Methods: A retrospective analysis on 114 HCC patients in 2013-2014 were conducted and compared with the database for 77 HCC patients in 1998-1999. Clinical characteristics and treatment received were recorded and the survival of both groups was analyzed using the Kaplan-Meier method and compared using the log-rank test. Results: The percentage of HBV positive patients had increased after fifteen years from 32.5% to 67.5%. Only two patients (1.8%) in 2013-2014 were diagnosed with HCC during surveillance program. Proportions of Barcelona Clinic Liver Cancer A, B, C, and D in 2013-2014 were 1.8%, 42%, 28.1%, and 28.1%, respectively. There was an increase in the use of potentially curative treatment, such as surgical resection or combination of loco-regional therapies. The one-year survival rate increased from 24.1% in 1998-1999 to 29.4% in 2013-2014, while the median survival decreased from 146 days to 138 days, but the difference was not statistically significant (p=0.913). Conclusions: There was no improvement in the median survival of HCC patients after fifteen years because most continued to present at late stages. There is an urgent need for a nationwide implementation of a hepatitis screening program and HCC surveillance education.

Ligand Effect in Recycled CNT-Pd Heterogeneous Catalyst for Decarboxylative Coupling Reactions

  • Kim, Ji Dang;Pyo, Ayoung;Park, Kyungho;Kim, Gwui Cheol;Lee, Sunwoo;Choi, Hyun Chul
    • Bulletin of the Korean Chemical Society
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    • v.34 no.7
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    • pp.2099-2104
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    • 2013
  • We present here an efficient and simple method for preparation of highly active Pd heterogeneous catalyst (CNT-Pd), specifically by reaction of dichlorobis(triphenylphosphine)palladium ($Pd(PPh_3)_2Cl_2$) with thiolated carbon nanotubes (CNTs). The as-prepared CNT-Pd catalysts demonstrated an excellent catalytic activity for the carbon-carbon (C-C) cross-coupling reactions (i.e. Suzuki, Stille, and decarboxylative coupling reactions) under mild conditions. The CNT-Pd catalyst could easily be removed from the reaction mixture; additionally, in the decarboxylative coupling of iodobenzene and phenylpropiolic acid, it showed a six-times recyclability, with no loss of activity. Moreover, once its activity had decreased by repeated recycling, it could easily be reactivated by the addition of phosphine ligands. The remarkable recyclability of the decarboxylative coupling reaction is attributable to the high degree of dispersion of Pd catalysts in CNTs. Aggregation of the Pd catalysts is inhibited by their strong adhesion to the thiolated CNTs during the chemical reactions, thereby permitting their recycling.

The SAR Chart Viewer design and Implementation in mobile web (모바일 웹에서의 SAR Chart Viewer 설계 및 구현)

  • Lim, Il-Kwon;Kim, Young-Hyuk;Lee, Jae-Gwang;Lee, Jae-Pil;Jang, Haeng-Jin;Lee, Jae-Kwang
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.9
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    • pp.2097-2104
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    • 2013
  • Scientific and technological research data is increasing exponentially and, Kisti(Korea Institute of Science and Technology Information) built and supported GSDC(Global Science experimental Data hub Center) depending on the needs processing large data computing and storage devices. Mobile web standards-based the MUPS was built for global community and services of gsdc to spreading mobile devices rapidly. And for analyze Operational status and system resources of GSDC at n this paper researched and implemented system resource monitor method of gsdc to mobile web environment, in this paper researched and implemented system resource monitor method of gsdc to mobile web environment. Research support system of GSDC operated by scientific linux. Sysstat resource monitoring tools create a daily report through sar(system analysis report), after sadc(system activity data collector) collected system resource utilization information. In this paper, sar reports designed and implemented in mobile web to can visualize in a mobile environment. We do not depend specific OS by implementation of the mobile web. So we are available in variety mobile OS. And through provided visual graph, this system can monitor easily and more conveniently then the existing system.