• Applied Biological Chemistry
• /
• 제43권2호
• /
• pp.95-99
• /
• 2000

일련의 헤테로 고리 치환(X) chalcone 유도체들에 의한 farnesyl protein transferase(FPTase) 저해활성을 측정하여 분자내 styryl group의 치환기(Y) 변화에 따른 정량적인 구조와 FPTase 저해 활성과의 관계(QSARs)를 modified Free-Wilson(F-W)방법 및 Hansch 방법으로 분석 검토하였다. F-W 분석에 따르면 (X)-치환기는 FPTase 저해 활성에 기여하지 않았다 그러나 (Y)-치환기들은 ortho>meta>para 치환체의 순서로 ortho-치환체와 ${\alpha}$탄소의 알짜 전하$(C_{\alpha})$가 활성에 기여하였다. 모든 헤테로 고리 치환체에 대한 Hansch 분석에 의하면 전자 밀게(R<0)의 폭$(B_1)$이 작은 ortho-치환체로서 적정값, $(R)_{opt.}=-0.35$를 갖는 공명상수가 저해활성에 영향을 미친다는 사실을 알 수 있었다. 그리고 헤테로 치환체들 사이의 FPTase 저해활성은 모두 비례관계를 보임으로써 같은 경향으로 저해활성이 발현되었으며 비(H)치환체 45가 제일 높은 FPTase 저해활성$(pI_{50}=4.30)$을 보였다.

• 한국보건간호학회지
• /
• 제34권2호
• /
• pp.251-262
• /
• 2020

Purpose: This study attempts to provide basic data for establishing and implementing an advanced directive (AD) system that helps identify dignified death attitudes and reduces death anxiety of the preliminary, through preparation of an AD. Methods: Data were collected from 135 preliminary elderly aged 55 to 64 years, recruited from health centers and welfare facilities. All data were analyzed using SPSS 22.0. Results: Overall scores of the participants were 2.26±0.64 for death anxiety scale, and 3.16±0.44 for dignified death attitude. Scores of individuals who prepared an AD were determined to be 2.19±0.64 for death anxiety, and 3.34±0.44 for dignity of death. The difference in scores obtained for dignified death attitude was significantly higher for the group that signed an AD, as compared to the group with no AD (F=14.81, p<0.001). Conclusions: Results of this study reveal that preliminary elderly who sign an AD have a higher dignified death attitude score as compared to subjects who do not sign an AD. Additionally, the former group of participants desire a dignified end to their life. This indicates a necessity to promote public campaigns for ADs, and to develop educational programs that assist the elderly to prepare for a dignified death and make autonomous decisions.

• Journal of Chest Surgery
• /
• 제50권4호
• /
• pp.247-254
• /
• 2017

Background: Hybrid coronary revascularization (HCR) was developed to combine the advantages of coronary artery bypass graft (CABG) with percutaneous coronary intervention (PCI). However, it is still controversial whether it is more optimal to perform CABG or PCI first. The purpose of this study was to compare the clinical outcomes of these 2 approaches. Methods: Eighty patients who underwent HCR from May 2010 to December 2015 were enrolled in this retrospective analysis. The CABG-first group comprised 12 patients and the PCI-first group comprised 68 patients. Outcomes of interest included in-hospital perioperative factors, major adverse cardiac and cerebrovascular events (MACCEs), and the incidence of repeated revascularization, especially for the target vessel lesion. Results: No significant difference was found in the amount of postoperative bleeding (p=0.239). The incidence of MACCEs was similar between the CABG-first and PCI-first groups (1 of 12 [8.3%] vs. 5 of 68 [7.4%], p>0.999). Repeated revascularization was performed on 3 patients (25%) in the CABG-first and 9 patients (13.2%) in the PCI-first group (p=0.376). Conclusion: There were no significant differences in postoperative and medium-term outcomes between the CABG-first and PCI-first groups. Based on these results, it can be inferred that it is safe to opt for either CABG or PCI as the primary procedure in 2-stage HCR.

• 대한정형도수물리치료학회지
• /
• 제12권1호
• /
• pp.37-43
• /
• 2006

PURPOSE: Previous studies have documented the lack of ultrasound's non-thermal effects on nerve conduction using frequencies of 1 MHz and 870 kHz. The purpose of this study was to determine the biophysical effects of continuous ultrasound on median local forearm temperature and motor nerve conduction velocities using frequencies of 3.0 MHz. SUBJECTS: Twelve healthy subjects (6 males, 6 females, age $22.30{\pm}2.41$ yrs, weight $61.33{\pm}10.16$ kg, height $167.58{\pm}8.04$ cm) without a history of neurological or musculoskeletal injury to their dominant arm volunteered for this study. METHODS AND MATERIALS: Each subject received a total of five treatments, one each at .0, 0.5, 1.0, 1.5, 2.0 W/$cm^2$ of 3 MHz continuous ultrasound on the anterior surface of the middle area of dominant forearm for 10 minutes. Dependent measures for forearm local temperature and median motor nerve conduction velocity (MNCV) were taken pretreatment and immediately post-treatment. One-way ANOVA were used for each dependent measure. RESULTS: The posttreatment forearm local temperature were differed significantly (p<0.001) between intensities of ultrasound. The posttreatment forearm local temperature of the ultrasound treated with 1.0 w/$cm^2$, 1.5 w/$cm^2$ and 2.0 w/$cm^2$ were significantly higher than 0.5 w/$cm^2$ and 0.0 w/$cm^2$ of ultrasound (p<0.05). The posttreatment median MNCV were differed significantly from the respective pretreatment velocities (p<0.001). The MNCV of the ultrasound treated with 0.0 w/$cm^2$ and 0.5 w/$cm^2$ were significantly (p<0.05) slower than that observed pretreatment, while the three ultrasound intensities produced significantly increased posttreatment MNCV: 1.0 w/$cm^2$ and 1.5 w/$cm^2$ and 2.0 W/$cm^2$. The posttreatment MNCV at 2.0 w/$cm^2$ and 1.5 w/$cm^2$ was significantly faster than that at 0 w/$cm^2$, 0.5 w/$cm^2$ and 1.0 w/$cm^2$ (p<0.05), the MNCV at 1.0 w/$cm^2$ was significantly faster than that associated with 0 w/$cm^2$ and 0.5 w/$cm^2$ of ultrasound (p<0.05). CONCLUSIONS: The decreased median motor forearm local temperature and MNCV of the ultrasound treated with 0.0 w/$cm^2$ and 0.5 w/$cm^2$ were attributed to the cooling effect by ultrasound transmission gel. Local forearm temperature and nerve conduction velocity were directly related to the intensity of ultrasound. Alterations in MNCV from ultrasound on healthy nerves appeared to be related to temperature changes induced by thermal effects of ultrasound.

• Reproductive and Developmental Biology
• /
• 제34권3호
• /
• pp.117-122
• /
• 2010

To search the potent pig pheromonal odorants through receptor-based approach methods, molecular dockings between 680 Flavomets as substrate molecule and pig odorants binding proteins OBP (1HQP) and PBP (1GM6) as receptor, and QSPR (quantitative structure-property relationship) analyses from physico-chemical parameters of Flavomets and their docking scores (DS) were performed and discussed quantitatively. From the basis on the findings, the optimal value $(MSA)_{opt.}=407.595\;{\AA}^2$ of MSA (molecular surface area; ${\AA}$), and RB (number of rotational bond) had the Flavomets will be able to increase DS. Therefore, it is expected that the stearyl alcohol from DS and H-bond type between substrate and receptor would be shows the character as potent pig pheromonal odorant.

• 산업경영시스템학회지
• /
• 제33권3호
• /
• pp.114-122
• /
• 2010

The Probabilistic Traveling Salesman Problem (PTSP) is an important topic in the study of traveling salesman problem and stochastic routing problem. The goal of PTSP is to find a priori tour visiting all customers with a minimum expected length, which simply skips customers not requiring a visit in the tour. There are many existing researches for the homogeneous version of the problem, where all customers have an identical visiting probability. Otherwise, the researches for the heterogeneous version of the problem are insufficient and most of them have focused on search base algorithms. In this paper, we propose a simple construction algorithm to solve the heterogeneous PTSP. The Minimum Expected Length Insertion (MELI) algorithm is a construction algorithm and consists of processes to decide a sequence of visiting customers by inserting the one, with the minimum expected length between two customers already in the sequence. Compared with optimal solutions, the MELI algorithm generates better solutions when the average probability is low and the customers have different visiting probabilities. We also suggest a local search method which improves the initial solution generated by the MELI algorithm.

• 대한조선학회지
• /
• 제10권2호
• /
• pp.19-28
• /
• 1973

This paper deals with a problem for determining the bulbous bow ship from which pertains to the study of the theoretical ship form planing method. In this paper has been determined the bulbous bow ship form which is a similar in geometric particulars with the conventional liner ship G.T.10, 000 by adopting the variable method for finding the optimum ship form by A.Y.C. Lee and the streamline tracing method by T. Inui and P.C. Pien. Each resistance performance is examined by the towing test and is compared with one another. The followings are the outcome of this study: Among the 5 type models, the bulbous bow ship form M.S. B 1120 is the most excellent for the resistance performance. The effect for the wave resistance is very sharp according to the difference of the bottom flattening of theoretical ship form. The optimum value of the bulbous bow for wave resistance can be obtained by the variable method mentioned above, and for the series of(Main hull+Bulb)opt., ${\alpha}=75/25$, the value is $f{\approx}0.11$.

• 한국식품조리과학회지
• /
• 제16권4호
• /
• pp.363-366
• /
• 2000

본 연구에서는 육류연화작용이 있다고 알려진 과일인 배, 키위, 무화과, 파인애플, 파파야에 존재하는 단백질 분해효소의 특성을 상대 비교함으로써 조리에 응용할 수 있는 자료로써 이용하고자 했다. 실험 결과는 다음과 같다. 1. 각 과일에 존재하는 단백질 분해 조효소의 최적 온도를 보면 배, 무화과, 파인애플이 6$0^{\circ}C$에서 최고활성을 나타냈고 40~7$0^{\circ}C$에서 비교적 높은 활성이 있었고, 파파야는 6$0^{\circ}C$에서 최대 활성을 보이고 40~8$0^{\circ}C$ 범위에서 넓은 범위에서 높은 활성을 나타냈다. 한편 키위는 4$0^{\circ}C$에서 최대활성을 보이고 7$0^{\circ}C$까지 안정된 높은 활성을 보여주었다. 2. 단백질 분해 조효소가 나타내는 최적 pH를 비교해 보면, 배, 무화과, 파인애플, 파파야는 최적 pH가 7.0 부근이고 pH 5.0~8.0에서 높은 활성을 나타내다가 pH 8.5 이후 급격히 활성이 떨어졌다. 한편 키위는 최고 활성이 pH 3.0에서 관찰되었으며 이는 pH 4.0에서 급격히 감소했다가 다시 증가하여 다른 과일의 활성도와 비슷한 pH 5.0~8.0에서 다시 높은 활성을 나타냈다. 3. 다량 조리시 사용할 수 있는 과육의 단위 부피당 총역가를 비교해 본 결과, pineapple>kiwifruit>papaya>fig>pear로서 나타났다.

• 대한정형도수물리치료학회지
• /
• 제27권2호
• /
• pp.45-54
• /
• 2021

Background: The purpose of this study was to investigate the effects of flexi-bar exercise on shoulder pain, dysfunction, quality of life, and range of motion of women with breast cancer surgery. Methods: A total of 42 female patients who had breast cancer were included in this study. By drawing lots, subjects were divided into a flexi-bar exercise group (FBG, n=21) and a general breast cancer group (GBG, n=18). The effects of flexi-bar exercise on patients were evaluated in terms of the visual analogue scale (VAS), the shoulder pain and disability index (SPADI), the European organization for the research and treatment of cancer quality of life questionnaire (EORTC QLQ-C30), the breast cancer specific EORTC quality of life questionnaire (EORTC QLQ-BR23), and range of motion (ROM), all of which were measured pre- and post- intervention followed by evaluation. Results: A significant increase was pain, functional disability level, quality of life, ROM within the two groups (p<.01). There were pain, functional disability level, quality of life, ROM post test then invention were significant between the two groups(p<.01). Conclusion: The flexi-bar exercise has a positive treatment effect on breast cancer patients.

• Applied Biological Chemistry
• /
• 제40권1호
• /
• pp.80-84
• /
• 1997

일련의 새로이 합성된 chira핀 N-치환 benzotriazol-1-yl유도체들의 구조와 잿빛 곰광이균(Botrytis cinerea), 배 검은 무늬병균(Alternaria kikchiana) 및 고추 역병균(Phytophthora capsici) 등 3종의 곰광이균류에 대한 항균활성에 미치는 치환기의 효과를 검토한 결과, 전자끌게(${\sigma}_I$,Y>0)로써 phenoxy 또는 thiophenoxy group(X) 보다는 alkyl또는 phenyl group(Y)이 더 큰 영향을 미쳤으며 phenoxy-치환체, 1이 thiophenoxy-치환체, 2보다 높은 항균활성을 나타내었다. 항균활성에 영향을 미치는 요인으로는 소수성(${\Sigma}logP$)과 유도효과(${\sigma}_I$,Y) 및 Van der Waals(${\Sigma}Vw$) 체적(${\AA}^3$) 등 이었으며 chiral성은 활성개선에 기여하지 못하였으나 tribromomethyl-치환체, 1g는 제일 큰 활성을 나타내는 화합물이었다.