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Searching of the Potent Pig Pheromonal Odorants by Receptor Based Approach  

Joo, Sung-Mo (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University)
Cho, Yun-Gi (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University)
Park, Chang-Sik (Research Center for Transgenic Cloned Pigs, Chungnam National University)
Sung, Nack-Do (Department of Applied Biology & Environmental Chemistry, College of Agricultural & Life Science, Chungnam National University)
Publication Information
Reproductive and Developmental Biology / v.34, no.3, 2010 , pp. 117-122 More about this Journal
Abstract
To search the potent pig pheromonal odorants through receptor-based approach methods, molecular dockings between 680 Flavomets as substrate molecule and pig odorants binding proteins OBP (1HQP) and PBP (1GM6) as receptor, and QSPR (quantitative structure-property relationship) analyses from physico-chemical parameters of Flavomets and their docking scores (DS) were performed and discussed quantitatively. From the basis on the findings, the optimal value $(MSA)_{opt.}=407.595\;{\AA}^2$ of MSA (molecular surface area; ${\AA}$), and RB (number of rotational bond) had the Flavomets will be able to increase DS. Therefore, it is expected that the stearyl alcohol from DS and H-bond type between substrate and receptor would be shows the character as potent pig pheromonal odorant.
Keywords
Docking scores; Receptor-based approach; pOBP (1HQP) and PBP (1GM6); Potent pig pheromonal odorants; QSPR;
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Times Cited By KSCI : 3  (Citation Analysis)
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