• 한국식품과학회지
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• 제22권5호
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• pp.549-554
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• 1990

비이온성 수지인 Amberlite XAD-2 흡착 및 메탄올 용출법에 의해 살구로부터 배당체분획을 얻은 다음 almond ${\beta}-glucosidase$ 및 산가수분해(pH3.0) 또는 pH 3.0에서 simultaneous distillation-extraction(SDE)에 의해 얻어진 가수분해물로부터 GC 및 GC-MS에 의해 40종의 휘발성 성분을 확인하였다. 3종의 가수분해물로부터 이미 배당체로서 살구에 존재하는 것으로 알려져 있는 linalool oxide, linalool, ${\alpha}-terpineol$, nerol, geraniol, benzyl alcohol 및 2-phenylethyl 이외에도 2,6-dimethyl-3,7-octadiene-2,6-diol, 3,7-dimethyl-1,5-octadiene-3,7-diol,(E)-및 (Z)-2,6-dimethyl-2,7-octadiene-1,6-diol, $3-4-dihydro-{\beta}-ionol$ $3-oxo-{\alpha}-ionol$, $3-hydroxy-7,8-dihydro{\beta}-ionol$, $3-oxo-7,8-dihydro-{\alpha}-ionol$, $3-hydroxy-{\beta}-ionone$, eugenol, 3-hydroxyethylphenyl acetate 및 2,3-dihydrobenzofuran이 살구에서 처음으로 확인되었다.

• Bulletin of the Korean Chemical Society
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• 제17권4호
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• pp.362-365
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• 1996

Carbonyl compounds 1, alkyl- and arylaldehydes and alkyl, aryl, benzylic, and cyclic ketones were converted to the corresponding 1,3-dioxolanes 2 and 1,3-dioxanes 4 with ethylene glycol and 2,2-dimethyl-1,3-propanediol in the presence of 1-3 mol% of 1-(p-substituted)benzyl-1,1-dimethyl-2-(p-substituted)-benzoyl hydrazinium hexafluoroantimonates 3 in high yields.

• Applied Biological Chemistry
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• 제42권2호
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• pp.111-115
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• 1999

발효방법에 따른 청국장의 휘발성 성분을 비교 조사하기 위해 증자대두에 Bacillus subtilis를 접종시킨 시험구(I), 1차 종균으로서 Lactobacilli(ll) 혹은 Aspergillus oryzae(III)를 접종시켜 소정시간 발효후 Bacillus subtilis를 추가 접종시킨 시험구, 그리고 볏짚을 접종원으로 한 시험구(IV)의 청국장제품을 각각 연속증류추출장치를 사용하여 휘발성 성분을 추출 농축하고 GC와 GC/MS를 이용하여 휘발성 성분을 분석 동정하였다. 그 결과 Bacillus subtilis 단용 발효구(I)와 볏짚을 접종원으로 사용한 시험구(IV)에서 각각 35종과 46종의 휘발성 성분이 검출되었고 Lactobacilli처리구(II)에서는 29종의 휘발성 성분이 검출되었는데 시험구(I), (IV)에 비해 향미성분으로 알려진 2,3,5-trimethyl pyrazine, 2,5-dimethyl pyrazine 등의 함량이 각각 2.2배, 1.5배 증가되었다. 또한 Asp. oryzae처리구(III)에서는 총 36종의 휘발성 성분이 분리 동정되었고 이들 성분 중에서 hexadecanoic acid, 2-methyl pyrazine성분이 많이 검출된 반면 청국장의 불쾌취로 알려진 butyric valeric acid는 검출되지 않았다. 대두 품종별로 제조한 청국장의 휘발성 성분을 비교 검토한 결과 신팔달콩을 원료대두로 사용한 시험구의 청국장이 향미성분은 증가한 반면 불쾌취 성분은 감소되었다.

• Archives of Pharmacal Research
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• 제12권1호
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• pp.1-4
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• 1989

6-Arylamino-3,7-dihydro-3,7-dimethy-2-oxo-1H-purine and 2-arylimino-6-arylamino-3,7-dihydro-3,7-dimethyl-1H-purine were obtained in a one-pot reaction when 3,7-dihydro-3,7-dimethyl-1H-purine-3,6-dione, phosphorus pentaoxide, triethylamine hydrochloride and appropriate amine amino are heated at $170^{\circ}$. Some derivatives were tested for their antitumor activity.

• 대한화학회지
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• 제52권5호
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• pp.503-510
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• 2008

• 대한화학회지
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• 제38권3호
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• pp.254-259
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• 1994

Methyl기를 포함하는 새로운 5종의 crown ether를 합성하였다. 2,3,4,5: 9,10,11,12-Dibenzo-8,8-dimethyl-15,18,1-trioxacycloeicosane, 2,3,4,5: 9,10,11,12-dibenzo-8,8-dimethyl-15,18,21,1-tetraoxacyclotricosane, 2,3,4,5 : 9,10,11,12-dibenzo-8,8-dimethyl-15,18,21,24,1-pentaoxacyclohexacosane, 2,3,4,5 : 9,10,11,12 : 22,23,24,25 : 29,30,31,32-tetrabenzo-8,8,28,28-tetramethyl-15,18,21,35,38,1-hexaoxacyclotetracontane 그리고 2,3,4,5 : 9,10,11,12 : 25,26,27,28:32,33,34,35-tetrabenzo-8,8,31,31-tetramethyl-15,18,21,24,38,41,44,1-octaoxacyclohexatetracontane은 (M = Na, K)존재하에서 4,4'-isopropylidenediphenol과 di-, tri- 그리고 tetraethyleneglycol ditosylate의 반응에 의해 합성하였다. Diethyleneglycol ditosylate, triethyleneglycol ditosylate, tetraethyleneglycol ditosylate는 NaOH존재하에서 diethyleneglycol, triethyleneglycol 그리고 tetraethyleneglycol과 p-toluenesulfonylchloride의 반응에 의해 합성하였다.

• Journal of Microbiology and Biotechnology
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• 제16권4호
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• pp.538-542
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• 2006

Three new compounds were isolated from the methanol extracts of buckwheat (Fagopyrum esculentum) hull, and their structures were determined to be 6,7-dihydroxy-3,7-dimethyl-octa-2(Z),4(E)-dienoic acid (1), 6,7-dihydroxy-3,7-dimethyl-octa-2(E),4(E)-dienoic acid (2), and 4,7-dihydroxy-3,7-dimethyl-octa-2(E),5(E)-dienoic acid (3) by NMR and MS spectroscopic analyses. These compounds at $500{\mu}g$ concentration showed antimicrobial activity against Staphylococcus aureus, demonstrated by the paper disc method.

• 대한화학회지
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• 제38권7호
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• pp.521-525
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• 1994

새로운 cephalosporin 항생물질인 7-[(3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl)acetamido]-3-heterocyclothiomethyl-3-cephem-4-carboxylic acid 유도체(2a∼2d)들을 합성하여, 구조변화에 대한 항균활성을 측정하였다. 그 중에서 7-[(3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl)acetamido]-3-[(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid가 그람양성 및 음성균에 대하여 광범위한 향균능력ㅇ르 나타내었다.

• 약학회지
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• 제41권4호
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• pp.473-479
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• 1997

New cephalosporin antibiotics, 7-[(3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl)acetamido]-3-substituted-3-cephem-4-carboxylic acid derivatives 2a-2d, 7 -[(3,4-dihydro-6-ethoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl)acetamido] -3-substituted-3-cephem-4-carboxylic acid derivatives 3a-3d and 7-[(3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl-1-(S)-oxide)acetamido]-3-substituted-3-cephem-4-carboxylic acid derivatives 4a-4d were synthesized. Antibacterial activities of these new cephalosporin derivatives and the relationship between their structures and their activities were examined. Among them, 7-[(3,4-dihydro-6-methoxycaronyl-2,2-dimethyl-2H-1,4-thiazin-3-yl-1-(S)oxide)-acetamido]-3-[(1,2,3-triazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid 4d exhibited the antibacterial activities against Gram(+)and Gram(-) bacteria.

• Bulletin of the Korean Chemical Society
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• 제22권7호
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• pp.661-662
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• 2001