• 제목/요약/키워드: 2-azacyclopenta[b]anthracene-5,10-diones

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2-알킬-2,3-다이하이드로-1H-2-아자사이클로펜타[b]안트라센-5,10-디온계 유도체 합성 및 세포독성 (Synthesis and In Vitro Cytotoxic Activities of 2-Alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene-5,10-diones)

  • 곽재환;정은경;오주훈;정재경;홍진태;이희순
    • 약학회지
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    • 제53권1호
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    • pp.41-44
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    • 2009

  • A series of 2-alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene-5,10-diones ($3a{\sim}h$) were synthesized and evaluated in vitro cytotoxicity against colon cancer cell lines (HCT116 and SW620) and nuroblastoma cell lines (SK-N-SH and SK-N-MC). Among them, compound 3f showed significant cytotoxic activity ($IC_{50}$ against SK-N-SH; $14.8{\mu}M$, $IC_{50}$ against SK-N-MC; $11.3{\mu}M$).

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